公开(公告)号：US20180244770A1

公开(公告)日：2018-08-30

申请号：US15756043

申请日：2016-08-26

Applicant: Alector LLC

Inventor： Kate MONROE ,  Helen LAM ,  Arnon ROSENTHAL ,  Seung-Joo LEE ,  Francesca AVOGADRI-CONNORS ,  William MONTEITH

IPC: C07K16/28 ,  A61K39/395 ,  A61K45/06

CPC classification number: C07K16/2803 ,  A61K39/39558 ,  A61K45/06 ,  A61K2039/505 ,  A61P25/00 ,  A61P35/00 ,  A61P37/02 ,  C07K2317/24 ,  C07K2317/30 ,  C07K2317/76

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-7 protein, e.g., human Siglec-7 or a mammalian Siglec-7, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US12297277B2

公开(公告)日：2025-05-13

申请号：US17836707

申请日：2022-06-09

Applicant: Alector LLC

Inventor： Tina Schwabe ,  Michael Kurnellas ,  Arnon Rosenthal ,  Robert Pejchal ,  Anthony B. Cooper

IPC: C07K16/28

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20250092144A1

公开(公告)日：2025-03-20

申请号：US18957413

申请日：2024-11-22

Applicant: Alector LLC

Inventor： Arnon ROSENTHAL ,  Tina SCHWABE ,  Michael KURNELLAS ,  Robert PEJCHAL ,  Anthony B. COOPER

IPC: C07K16/28 ,  A61K31/7088

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Sortilin protein, e.g., human Sortilin or a mammalian Sortilin, and use of such compostions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US20250084165A1

公开(公告)日：2025-03-13

申请号：US18806118

申请日：2024-08-15

Applicant: Alector LLC

Inventor： Michael F. WARD ,  Sam JACKSON

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28 ,  G01N33/543 ,  G01N33/68

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured, humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a TREM2 protein, e.g., human TREM2, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.

公开(公告)号：US20240279341A1

公开(公告)日：2024-08-22

申请号：US18570865

申请日：2022-06-15

Applicant: ALECTOR LLC

Inventor： Seung-Joo LEE ,  Tarangsri NIVITCHANYONG ,  Wei-Hsien HO ,  Wei LI ,  Marina K. ROELL ,  Spencer LIANG

IPC: C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C07K16/40

CPC classification number: C07K16/2827 ,  A61P35/00 ,  C07K16/40 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/54 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include bispecific antibodies, e.g., monoclonal antibodies, that specifically bind a MerTK polypeptide (e.g., a mammalian MerTK or human MerTK) and a PDL1 polypeptide (e.g. a mammalian PDL1 polypeptide or human PDL1 polypeptide), and use of such compositions in treating an individual in need thereof.

公开(公告)号：US20240270866A1

公开(公告)日：2024-08-15

申请号：US18423604

申请日：2024-01-26

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/28 ,  G01N33/68

CPC classification number: C07K16/2896 ,  A61P25/28 ,  G01N33/6854 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/92

Abstract: The present disclosure provides antibodies and antibody fragments that bind to human SIRPA. In some embodiments, the antibodies are SIRPA agonists. The antibodies and antibody fragments disclosed herein may be used for the treatment and/or diagnosis of diseases, disorders, and conditions associated with reduced SIRPA activity.

公开(公告)号：US12004494B2

公开(公告)日：2024-06-11

申请号：US17475116

申请日：2021-09-14

Applicant: Alector LLC

Inventor： Arnon Rosenthal ,  Seung-Joo Lee

IPC: A01K67/027 ,  A01K67/0275 ,  A01K67/0276 ,  C07K14/705 ,  C12N15/85

CPC classification number: A01K67/0276 ,  A01K67/0275 ,  C07K14/7056 ,  C07K14/70596 ,  C12N15/8509 ,  A01K2207/15 ,  A01K2217/05 ,  A01K2217/052 ,  A01K2217/07 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/01 ,  A01K2267/03

Abstract: Provided herein are transgenic non-human animals whose genomes comprise two or more human genes selected from CD33, Siglec-5, Siglec-7, Siglec-9, Siglec-11, Siglec-14, and Siglec-16, to methods of screening candidate agents that bind to and/or modulate the function and/or activity of at least one of the human genes in the transgenic non-human animals, and to methods of screening candidate agents to determine their effect on one or more activities and/or functions associated with expression of at least one of the human genes in the transgenic non-human animals. Further provided herein are methods of recapitulating a human Siglec immune system in a non-human animal, and methods of generating a non-human animal disease model comprising a human Siglec repertoire.

公开(公告)号：US11987612B2

公开(公告)日：2024-05-21

申请号：US17088149

申请日：2020-11-03

Applicant: Alector LLC

Inventor： Spencer Liang ,  Samuel Nalle ,  Jeonghoon Sun ,  Hua Long ,  Rashmi Bankoti

IPC: C07K14/705 ,  A61K38/17 ,  A61K39/00 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  C07K16/28

CPC classification number: C07K14/70503 ,  A61K38/1774 ,  A61K45/06 ,  A61P35/00 ,  A61P35/04 ,  C07K16/2818 ,  C07K16/2827 ,  A61K2039/545 ,  C07K2317/76 ,  C07K2319/30

Abstract: The present disclosure is generally directed to Siglec-9 ECDs and Siglec-9 ECD fusion molecules, and methods of treatment using Siglec-9 ECDs and Siglec-9 ECD fusion molecules.

公开(公告)号：US11976119B2

公开(公告)日：2024-05-07

申请号：US17707637

申请日：2022-03-29

Applicant: Alector LLC

Inventor： Andrew Pincetic ,  Wei-Hsien Ho ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  C07K16/24 ,  C07K16/40 ,  C07K16/42 ,  C12N15/85

CPC classification number: C07K16/283 ,  C07K16/246 ,  C07K16/2818 ,  C07K16/2827 ,  C07K16/40 ,  C07K16/4283 ,  C12N15/85 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/32 ,  C07K2317/55 ,  C07K2317/567 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a SIRPA polypeptide, e.g., a mammalian SIRPA or human SIRPA, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.

公开(公告)号：US11965023B2

公开(公告)日：2024-04-23

申请号：US17740100

申请日：2022-05-09

Applicant: Alector LLC

Inventor： Kate Monroe ,  Helen Lam ,  Patricia Culp ,  Arnon Rosenthal

IPC: C07K16/28 ,  A61K39/00 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00

CPC classification number: C07K16/2803 ,  A61P25/00 ,  A61P25/08 ,  A61P25/28 ,  A61P29/00 ,  A61P31/04 ,  A61P35/00 ,  A61P37/00 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/567 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, chimeric, humanized antibodies, antibody fragments, etc., that specifically bind on or more epitopes within a Siglec-5 protein, e.g., human Siglec-5 or a mammalian Siglec-5, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.