公开(公告)号：US11491343B2

公开(公告)日：2022-11-08

申请号：US16842124

申请日：2020-04-07

Applicant: THE UNIVERSITY OF TOKYO ,  OSAKA UNIVERSITY

Inventor： Youichi Saitoh ,  Masaki Sekino ,  Keita Yamamoto

IPC: A61N2/02 ,  A61N1/40 ,  A61N2/00 ,  A61F2/04 ,  A61B5/00

Abstract: A coil apparatus for use in a transcranial magnetic stimulation apparatus is provided to further increase an electric field intensity on a head surface. The coil apparatus includes a wound-wire coil disposed on or near a head surface so as to generate a current by an induced electric field through electromagnetic induction in a magnetic stimulation-target region of a brain for stimulating neurons. The wound-wire coil includes a near-head-surface conductive wire portion disposed on or near the head surface, and a far-head-surface conductive wire portion disposed farther from the head surface than the near-head-surface conductive wire portion. A distance between the near-head-surface conductive wire portion and the far-head-surface conductive wire portion is set to be changed so that an intensity of the induced electric field becomes larger than that of a surrounding region of the magnetic stimulation-target region.

公开(公告)号：US20220346427A1

公开(公告)日：2022-11-03

申请号：US17763366

申请日：2020-09-25

Applicant: OSAKA UNIVERSITY

Inventor： Keisuke HAGIHARA ,  Katsufumi KAJIMOTO

IPC: A23L33/12 ,  A23L33/17 ,  A23L33/00

Abstract: The present invention provides a sugar-restricted, high-fat diet for improving chronic kidney disease. In the sugar-restricted, high-fat diet, daily fat intake may be set at 120 g or more based on a real body weight of 50 kg or set at an amount corresponding to 70% or more of the total daily energy intake. The sugar-restricted, high-fat diet can increase glomerular filtration rate and reduce blood creatinine level in chronic kidney disease patients.

公开(公告)号：US20220341825A1

公开(公告)日：2022-10-27

申请号：US17761052

申请日：2020-09-24

Applicant: OSAKA UNIVERSITY

Inventor： Michiya MATSUSAKI

IPC: G01N1/30

Abstract: A method for transparentizing biological tissue in a living state, which comprises applying a solution to the biological tissue, the solution containing one or more compounds selected from the group consisting of a nucleotide, a nucleotide derivative, a macromolecule containing a nucleotide or a nucleotide derivative, and a nucleotide polymer; a composition for transparentizing biological tissue in a living state, which comprises the aforementioned compound; and a kit for transparentizing biological tissue in a living state, which comprises the aforementioned compound.

公开(公告)号：US20220323385A1

公开(公告)日：2022-10-13

申请号：US17620406

申请日：2020-06-19

Applicant: KINKI UNIVERSITY ,  YASHIRO CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Nobuhiro ZAIMA ,  Hirona KUGO ,  Motohiro KITANO ,  Yoshinori HIROTA ,  Ken-ichi HIRANO

IPC: A61K31/19 ,  A61P9/14 ,  A61K38/00

Abstract: An aortic aneurysm has few noticeable symptoms and is at high risk for rupture without a sign of abnormality. Further, if it ruptures, it causes a shock state due to massive blood loss and results in a very low survival rate. Thus, when the aortic aneurysm is found by physical examination or the like, a surgery with a stent graft or the like needs to be performed according to the state of its progression.
A pharmaceutical composition for preventing an aortic aneurysm including a medium chain fatty acid as a main component has an effect of inhibiting the occurrence and progression of the aortic aneurysm. Thus, when the aortic aneurysm is found, the composition through continuous intake can exhibit effects including inhibition of the progression of the aortic aneurysm and improvement in the vital prognosis.

公开(公告)号：US11466306B2

公开(公告)日：2022-10-11

申请号：US14767068

申请日：2013-09-06

Applicant: OSAKA UNIVERSITY

Inventor： Hodaka Fujii ,  Toshitsugu Fujita

IPC: C12Q1/68 ,  C12Q1/6806 ,  C12N15/10 ,  G01N33/53 ,  C12Q1/6809

Abstract: A method comprising (A) fragmenting genomic DNA in a state where the interaction of the genomic DNA and molecules interacting therewith is maintained, and (B) bringing genomic DNA into contact with an exogenous molecule capable of binding to a specific endogenous DNA sequence in the genomic DNA. According to the method, with the use of an endogenous DNA sequence present inside or in the vicinity of a target genomic region in cells to be analyzed, any genomic region can be specifically isolated in a state where the interaction of the genomic region and molecules interacting therewith is maintained, without the need of inserting a recognition sequence of an exogenous DNA-binding molecule into the vicinity of the target genomic region in the cells to be analyzed.

公开(公告)号：US20220297230A1

公开(公告)日：2022-09-22

申请号：US17693953

申请日：2022-03-14

Applicant: SHIMADZU CORPORATION ,  OSAKA UNIVERSITY

Inventor： Masahiro TSUKAMOTO ,  Yuji SATO ,  Keisuke TAKENAKA ,  Ritsuko HIGASHINO ,  Koji TOJO

IPC: B23K26/06 ,  B23K26/067 ,  G02B27/10 ,  G02B19/00

Abstract: A laser apparatus includes six first laser devices that output respective blue laser beams for preliminary heating of an object, and a second laser device that outputs an infrared laser beam for main heating of the object. At least one of a relative positional relationship and each of respective first irradiation positions of the blue laser beams is changeable, the relative positional relationship being a relative positional relationship between the respective first irradiation positions of the six first laser beams in the object and a second irradiation position of the infrared laser beam in the object.

公开(公告)号：US11441115B2

公开(公告)日：2022-09-13

申请号：US17042301

申请日：2019-03-12

Applicant: DAI NIPPON PRINTING CO., LTD. ,  OSAKA UNIVERSITY ,  TERUMO KABUSHIKI KAISHA

Inventor： Taro Nagai ,  Yoshiki Sawa ,  Shigeru Miyagawa ,  Kenji Oyama

IPC: C12M1/00 ,  C12M1/22 ,  C12M1/34 ,  C12M1/38 ,  C12M3/00 ,  C12M3/06 ,  C12M1/02 ,  C12M1/36

Abstract: When detachment of a cell sheet from a culture dish has started at an unintended timing, immediately detach the cell sheet from the culture dish while preventing generation of wrinkles and the like in the cell sheet. A cell culture device captures an image of cells in the culture dish, and controls a cooling mechanism and a shaking mechanism based on the image so as to shake the cells while cooling them.

公开(公告)号：US20220283181A1

公开(公告)日：2022-09-08

申请号：US17624948

申请日：2020-07-07

Applicant: MEIJI CO., LTD. ,  THE NISSHIN OILLIO GROUP, LTD. ,  OSAKA UNIVERSITY

Inventor： Keisuke HAGIHARA ,  Satoshi OSAGA ,  Noriyuki IKEDA ,  Satoshi TAKASUGI ,  Kinya ASHIDA ,  Kentaro NAKAMURA

IPC: G01N33/68 ,  G01N33/66

Abstract: An object of the present invention is to provide a method for predicting prognosis for a cancer patient. The present invention provides a method for predicting prognosis for a cancer patient, wherein at least one index selected from the group consisting of an index of nutritional state, an index of sugar metabolism state, and an index of inflammatory state in the cancer patient is used as an index of prognosis. The index of nutritional state is preferably a concentration of albumin in the blood, the index of sugar metabolism state is preferably a concentration of glucose in the blood, and the index of inflammatory state is preferably a concentration of CRP in the blood.

公开(公告)号：US20220283083A1

公开(公告)日：2022-09-08

申请号：US17686802

申请日：2022-03-04

Applicant: SYSMEX CORPORATION ,  OSAKA UNIVERSITY ,  NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY

Inventor： Masaya OKADA ,  Yuki SHIMAOKA ,  Shigeki IWANAGA ,  Kazuki BANDO ,  Katsumasa FUJITA ,  Yasunori NAWA ,  Satoshi FUJITA

IPC: G01N21/31 ,  G01N21/25

Abstract: Disclosed is an analytical method for analyzing a test substance contained in a measurement sample, the method comprising: generating a data set based on a plurality of optical spectra acquired from a plurality of locations in the measurement sample; inputting the data set into a deep learning algorithm having a neural network structure; and outputting information on the test substance, on the basis of an analytical result from the deep learning algorithm.

公开(公告)号：US20220272963A1

公开(公告)日：2022-09-01

申请号：US17664194

申请日：2022-05-19

Applicant: Saraya Co., Ltd. ,  Osaka University

Inventor： Asuka Nogami ,  Motoki Tatsumi ,  Nanase Ishii ,  Mizuyuki Ryu ,  Yoshihiko Hirata ,  Yoshiki Sawa ,  Shigeru Miyagawa ,  Atsuhiro Saito ,  Hirotatsu Ohkawara

IPC: A01N1/02 ,  C12N1/04 ,  C12N5/0775

Abstract: A cell cryopreservation method including adding a 1 volume % of a composition comprising 0.01 wt % to 20 wt % of a sophorose lipid to cells in a cell culture medium just before or up to 6 hours before cryopreserving the cells; and cryopreserving the cell culture medium, wherein the composition improves cell viability after cryopreservation compared to cells that are cryopreserved with a similar composition that does not contain the sophorose lipid.