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    METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION
    105.
    发明申请
    METHODS AND COMPOSITIONS FOR RNA-GUIDED TREATMENT OF HIV INFECTION 有权

    公开(公告)号：US20220313795A1

    公开(公告)日：2022-10-06

    申请号：US17329137

    申请日：2021-05-24

    Applicant: Temple University of The Commonwealth System of Higher Education

    Inventor： Kamel Khalili ,  Wenhui Hu

    IPC: A61K38/46 ,  C12N15/11 ,  A61K48/00 ,  A61K9/00 ,  A61K35/12 ,  A61K45/06 ,  C12N7/00 ,  C12N9/22

    Abstract: A method of preventing transmission of a retrovirus from a mother to her offspring, by administering to the mother a therapeutically effective amount of a composition comprising a Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated endonuclease, and the two or more different multiplex gRNAs, wherein each of the at least two gRNAs is complementary to a different target nucleic acid sequence in a long terminal repeat (LTR) of proviral DNA of the virus that is unique from the genome of the host cell, cleaving a double strand of the proviral DNA at a first target protospacer sequence with the CRISPR-associated endonuclease, cleaving a double strand of the proviral DNA at a second target protospacer sequence with the CRISPR-associated endonuclease, excising an entire HIV-1 proviral genome, eradicating the HIV-1 proviral DNA from the host cell, and preventing transmission of the proviral DNA to the offspring.

    Silanated silica-ceramic materials, and methods of making and using the same
    108.
    发明授权
    Silanated silica-ceramic materials, and methods of making and using the same 有权

    公开(公告)号：US11387520B2

    公开(公告)日：2022-07-12

    申请号：US16340735

    申请日：2017-10-09

    Applicant: Temple University—Of The Commonwealth System of Higher Education

    Inventor： Stephanie Wunder ,  Mike Zdilla ,  Parameswara Rao Chinnam

    IPC: H01M50/446 ,  H01M50/403 ,  H01M10/0525 ,  C04B41/00 ,  C04B41/48 ,  C04B41/50 ,  C04B41/52 ,  C04B41/89

    Abstract: The invention provides a novel ceramic-metal oxide-polymer composite material. A functionalized metal oxide nanolayer coating can be bonded between LICGCs and polymers/oligomers, which protects the LICGC from corrosion, has a low interfacial resistance to Li+ migration, and can be a SIC. Hybrid ceramic-polymer electrolytes were formed by engineering the interface between a LICGC and a polymer, polyethylene oxide (PEO), by sputter coating a 200 nm thick SiO2 layer onto a lithium ion conducting glass ceramic (LICGC) and silanating the SiO2 with a functionalized PEG in the presence of LiTFSI. A low interfacial resistance (Rinterfacial) was measured, the same as that obtained for a SiO2 interface soaked with liquid tetraglyme/LiTFSI. The pegylated SiO2 interface (unlike the tetraglyme/LiTFSI interface) protected the LICGC from corrosion by Li0 metal. The (PEG-LiTFSI)—SiO2-LICGC could be bonded with polyethylene oxide/LiTFSI. This procedure provides a general method to bond other LICGCs to PEO-based polymers, and to incorporate other functionalities such as single ion conductivity into the interface via the incorporation of coupling agents with pendant anions.

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