公开(公告)号：US07886937B2

公开(公告)日：2011-02-15

申请号：US12685359

申请日：2010-01-11

申请人： Daniel Py

发明人： Daniel Py

IPC分类号： B65D88/54

CPC分类号： G01F11/021 ,  B05B11/3001 ,  B05B11/3015 ,  B05B11/3032 ,  B05B11/3047 ,  B05B11/3074 ,  B65D47/2031 ,  B65D83/00 ,  B65D83/0033 ,  B65D83/0072 ,  G01F11/02

摘要： A dispenser has a housing, and a variable-volume storage chamber formed within the housing and defining a substantially fluid-tight seal between the chamber and exterior of the housing for storing a substance to be dispensed. A piston is mounted within the housing, and a one-way valve is mounted within the housing and coupled in fluid communication with the variable-volume storage chamber. A compression chamber is coupled in fluid communication between the piston and one-way valve, and at least one of the piston and valve is manually depressible relative to the other between (i) a first position in which the piston is located at least partially outside of the compression chamber for permitting substance to flow from the variable-volume storage chamber into the compression chamber, and (ii) a second position in which the piston is located at least partially within the compression chamber for pressurizing substance within the compression chamber above a valve opening pressure and, in turn, dispensing substance through the one-way valve and out of the dispenser.

摘要翻译： 分配器具有壳体和形成在壳体内的可变容积的储存室，并且在壳体的室和外部之间限定基本上流体密封的密封，用于存储待分配的物质。 活塞安装在壳体内，并且单向阀安装在壳体内并且与可变容积存储室流体连通地联接。 压缩室在活塞和单向阀之间流体连通地联接，并且活塞和阀门中的至少一个在第一位置之间相对于另一个手动地相对地被压下，其中活塞位于至少部分外部 的压缩室，用于允许物质从可变容积的储存室流入压缩室，以及（ii）第二位置，其中活塞至少部分地位于压缩室内，用于将压缩室内的物质加压在压缩室的上方 打开阀门的压力，并通过单向阀分配物质并从分配器中分出物质。

公开(公告)号：US07874129B2

公开(公告)日：2011-01-25

申请号：US12371601

申请日：2009-02-14

申请人： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

发明人： Daniel Py ,  Benoit Adamo ,  John Guthy ,  Nathaniel Houle ,  M. Jeffrey Willey

IPC分类号： B65B3/02 ,  B65B5/02

CPC分类号： B65B3/022

摘要： Apparatus for molding and filling a device having a body defining an opening in communication with an interior chamber for receiving a substance therein, and a closure including a penetrable and resealable portion for sealing the opening and substance received in the device. A mold includes within the aseptic chamber plural mold cavities shaped to form the closure and body, and substantially sterile surfaces extending about and contiguous to the peripheries of the mold cavities. An assembly device including end-of-arm tooling having an engaging portion engageable with each of the body and closure is movable relative to the mold to engage and de-mold the substantially sterile closures and bodies from the mold cavities. Flexible barriers are coupled to the mold and the tool to substantially prevent the passage of contaminants from the molding machine and tool therethrough.

摘要翻译： 用于模制和填充具有本体的装置的装置，该主体限定与用于在其中容纳物质的内部腔室连通的开口;以及封闭件，包括用于密封容纳在装置中的开口和物质的可穿透和可重新密封的部分。 模具包括在无菌室内的多个模具腔，其形状形成封闭件和主体，以及基本上无菌的表面，其围绕并邻近模具腔的周边延伸。 包括端臂工具的组装装置具有可与主体和闭合件中的每一个接合的接合部分，其可相对于模具移动以将基本无菌的闭合件和主体与模腔接合和脱模。 柔性屏障耦合到模具和工具，以基本上防止污染物从模制机器和工具通过。

公开(公告)号：US20100331808A1

公开(公告)日：2010-12-30

申请号：US12874744

申请日：2010-09-02

申请人： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan

发明人： Daniel Py ,  Norbert M. Assion ,  Julian V. Chan

IPC分类号： A61M5/31 ,  G01F11/12 ,  B67D3/00

CPC分类号： B65D51/002 ,  A45D34/04 ,  A45D2200/055 ,  A61J1/1406 ,  A61J7/0053 ,  B05B11/02 ,  B67D99/00 ,  G01F11/027

摘要： A dispenser is provided for the delivery of controlled, metered amounts of any of numerous different substances to humans or animals, such as medicaments, pharmaceuticals, cosmetics, and food products, or to deliver materials that may react upon exposure to air, such as glue. Means are provided in the dispenser to effect controlled delivery of a pre-determined amount of the substance contained in the dispenser. A one-way valve is provided to hermetically seal the portion of the dispenser containing the substance to be dispensed.

摘要翻译： 提供分配器用于向人或动物（例如药物，药物，化妆品和食品）递送受控量的计量量的任何不同物质，或者输送在暴露于空气中可能反应的材料，例如胶 。 在分配器中提供装置以实现预定量的包含在分配器中的物质的受控输送。 提供单向阀以气密地密封包含待分配物质的分配器的部分。

公开(公告)号：USD628689S1

公开(公告)日：2010-12-07

申请号：US29346863

申请日：2009-11-06

申请人： Daniel Py ,  Norbert M. Assion

设计人： Daniel Py ,  Norbert M. Assion

公开(公告)号：US20100280466A1

公开(公告)日：2010-11-04

申请号：US12724370

申请日：2010-03-15

申请人： Daniel Py ,  Julian V. Chan ,  Jeffrey M. Atwood

发明人： Daniel Py ,  Julian V. Chan ,  Jeffrey M. Atwood

IPC分类号： A61M35/00 ,  A61F9/00

CPC分类号： B05B11/007 ,  A61F9/0008 ,  A61M11/007 ,  A61M15/08 ,  A61M35/003 ,  A61M2210/0612 ,  B05B11/00412 ,  B05B11/00416 ,  B05B11/0056 ,  B05B11/0072 ,  B05B11/3004 ,  B05B11/3056 ,  B05B11/307 ,  B05B11/3074 ,  B05B11/3077

摘要： An ophthalmic delivery device includes a body defining a fluid reservoir and a pump in fluid communication with the reservoir. The delivery device also includes a nozzle that includes a dosage chamber for holding a dosage of fluid, a valve seat, and a valve cover. The valve cover extends about the valve seat and forms an interface therebetween and the valve seat includes an outlet aperture. The interface is in fluid communication with the outlet aperture and the dosage chamber, and at least part of the valve cover is movable between (i) a closed position with the valve cover engaging the valve seat to close the interface and form a fluid-tight seal therebetween, and (ii) an open position with at least part of the valve cover spaced away from the valve seat in response to fluid flowing through the outlet aperture at a pressure greater than a valve opening pressure to allow the passage of pressurized fluid therebetween. The valve seat and the valve cover are dimensioned to dispense the dosage of fluid through the interface at a velocity of equal to or less than 6 meters per second.

摘要翻译： 眼科输送装置包括限定流体储存器的主体和与储存器流体连通的泵。 输送装置还包括喷嘴，该喷嘴包括用于保持流体用量的剂量室，阀座和阀盖。 阀盖围绕阀座延伸并且在它们之间形成界面，并且阀座包括出口孔。 所述界面与所述出口孔和所述剂量室流体连通，并且所述阀盖的至少一部分可在（i）与所述阀盖接合所述阀座的关闭位置之间移动以关闭所述界面并形成流体密封 密封在其间，和（ii）打开位置，其中阀盖的至少一部分响应于流体以大于阀打开压力的压力流过出口孔而与阀座间隔开，以允许加压流体在其间通过 。 阀座和阀盖的尺寸设计为以等于或小于6米/秒的速度通过界面分配流体的剂量。

公开(公告)号：US20100276035A1

公开(公告)日：2010-11-04

申请号：US12837329

申请日：2010-07-15

申请人： Daniel Py

发明人： Daniel Py

IPC分类号： B65B3/04

CPC分类号： A61M5/3129 ,  A61J1/2041 ,  A61J1/2044 ,  A61J1/2055 ,  A61J1/2093 ,  A61M5/1782 ,  A61M5/284 ,  A61M2005/3123

摘要： A syringe and a reconstitution syringe are provided for the delivery of controlled doses of any of numerous different sterile substances, such as vaccines, medicaments, pharmaceutical preparations, cosmetics, and food products. A plunger of the syringe defines a resealable stopper frictionally and slidably received within a hollow syringe body for dispensing the medicament or other substance through a dispensing tip of the syringe upon movement of the plunger. The resealable stopper defines a heat-sealable portion to allow the stopper to be penetrated by a needle or other filling device to fill the syringe with a medicament or other substance, and in turn allow the hole remaining upon withdrawal of the needle to be heat sealed by transmission of laser energy thereon. A reconstitution syringe defines within a syringe body plural compartments, wherein each compartment stores a respective component of a multi-component medicament or other preparation.

摘要翻译： 提供注射器和重组注射器用于递送受控剂量的许多不同的无菌物质，例如疫苗，药物，药物制剂，化妆品和食品中的任何一种。 注射器的柱塞限定了摩擦并可滑动地容纳在中空注射器主体内的可再密封塞子，用于在柱塞移动时通过注射器的分配尖端分配药物或其它物质。 可重新密封的止动件限定了可热封部分，以允许止动器被针或其他填充装置穿透，以用药物或其它物质填充注射器，并且进而允许在针头被热封时提供剩余的孔 通过在其上传输激光能量。 重建注射器在注射器主体内限定多个隔室，其中每个隔室存储多组分药物或其它制剂的相应组分。

公开(公告)号：USD625200S1

公开(公告)日：2010-10-12

申请号：US29352148

申请日：2009-12-17

申请人： Daniel Py ,  Julian V. Chan

设计人： Daniel Py ,  Julian V. Chan

公开(公告)号：US07810677B2

公开(公告)日：2010-10-12

申请号：US11650102

申请日：2007-01-05

申请人： Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

发明人： Daniel Py ,  Julian V. Chan ,  Benoit Adamo ,  Nathaniel Houle

IPC分类号： B65D37/00

CPC分类号： B67D1/108 ,  B05B11/00444 ,  B65B39/004 ,  B65D51/002 ,  B65D51/1616 ,  B67D1/0004 ,  B67D1/0007 ,  B67D1/0009 ,  B67D1/0082 ,  B67D1/0801 ,  B67D1/10 ,  B67D1/1279 ,  B67D3/0067 ,  B67D3/04 ,  B67D2001/0827 ,  F04B53/1037

摘要： A flexible pouch defining a variable volume storage chamber and one-way valve assembly for aseptically storing a substance, dispensing multiple portions of the stored substance therefrom in cooperation with a pump, and maintaining substance remaining in the pouch in an aseptic condition sealed with respect to ambient atmosphere. The one-way valve includes a valve seat and elastic valve cover portion overlying the valve seat forming an interference fit therewith defining a normally-closed seam therebetween. The valve portion is movable radially between (i) a normally closed position with the valve portion engaging the valve seat, and (ii) an open position with at least a segment of the valve portion spaced radially away from the valve seat to allow substance from the storage chamber through the valve opening. The one-way valve maintains substance remaining in the variable-volume storage chamber in an aseptic condition sealed with respect to the ambient atmosphere.

摘要翻译： 柔性袋，其限定可变体积存储室和用于无菌存储物质的单向阀组件，与泵协作地分配多个储存物质的部分，并将残留在袋中的物质保持在相对于 环境气氛。 单向阀包括阀座和覆盖阀座的弹性阀盖部分，形成过盈配合，从而限定了它们之间的常闭接缝。 阀部分可以在（i）常闭位置之间径向移动，阀部分接合阀座，和（ii）打开位置，其中阀部分的至少一段与阀座径向间隔开，从而允许物质从 储存室通过阀门开口。 单向阀在相对于环境大气密封的无菌状态下保持残留在可变容积储存室中的物质。

公开(公告)号：US20100236193A1

公开(公告)日：2010-09-23

申请号：US12791629

申请日：2010-06-01

申请人： Daniel Py ,  Norbert M. Assion

发明人： Daniel Py ,  Norbert M. Assion

IPC分类号： B65B3/02 ,  B65B55/08 ,  B65B51/10

CPC分类号： B65B3/003 ,  A61J1/1406 ,  A61J1/1412 ,  A61J1/1425 ,  A61J1/1431 ,  A61J1/1468 ,  A61J1/18 ,  A61J1/201 ,  A61J1/2013 ,  A61J1/2055 ,  A61J1/2075 ,  A61J1/2096 ,  A61M2207/00 ,  A61M2209/045 ,  B65B3/027 ,  B65B7/161 ,  B65B51/10 ,  B65B55/08 ,  B65B2039/009 ,  B65D51/002

摘要： Disclosed is a container and method for filling same. The container includes a thermally resealable portion that is fusible in response to thermal energy, and a container body having a sealed empty chamber in fluid communication with the resealable portion for receiving therein a substance. The container also includes a base, a mid-portion, and an upper portion axially spaced from the base on an opposite side of the mid-portion relative to the base. Each of the base and upper portion define a laterally-extending dimension greater than a maximum laterally-extending dimension of the mid-portion. The method of filling the container includes penetrating the resealable portion with an injection member and introducing a substance into the chamber, withdrawing the injection member while engaging the base of the body to substantially prevent axial movement of the body, and applying thermal energy to the resealable portion to thermally fuse the penetrated region thereof.

摘要翻译： 公开了一种容器及其填充方法。 该容器包括能够响应于热能而易熔的可热再密封部分，以及具有密封空腔的容器主体，其与可再密封部分流体连通，用于在其中容纳物质。 容器还包括基部，中间部分和与基部相对于基部在中间部分的相对侧上轴向间隔开的上部。 基部和上部中的每一个限定大于中间部分的最大横向延伸尺寸的横向延伸的尺寸。 填充容器的方法包括用注射构件穿透可重新密封的部分并将物质引入腔室中，在与身体的基部接触的同时取出注射构件，以基本上防止身体的轴向移动，并将热能施加到可重新密封 部分，以热熔融其穿透区域。

公开(公告)号：US07775398B2

公开(公告)日：2010-08-17

申请号：US11588968

申请日：2006-10-26

申请人： Daniel Py ,  Miles J. Flamenbaum ,  Eric E. Hartman ,  Nathaniel Houle

发明人： Daniel Py ,  Miles J. Flamenbaum ,  Eric E. Hartman ,  Nathaniel Houle

IPC分类号： B67D1/00

CPC分类号： B65D51/227 ,  B65D47/205 ,  B65D2251/0025 ,  B65D2251/0093

摘要： A device for storing and dispensing a substance includes a storage chamber for the substance. The container includes a passageway in fluid communication with the storage chamber. The container includes a pierceable wall located on an opposite side of the passageway relative to the storage chamber. The device includes a one-way valve assembly including a piercing portion. At least one of the piercing portion and the pierceable wall is movable relative to the other between a first position wherein the pierceable portion is not piercing the pierceable wall, and a second position wherein the pierceable portion is piercing the pierceable wall allowing the flow of substance from the storage chamber. A removable member is disposed intermediate the valve and the container that prevents movement of at least one of the piercing portion and pierceable wall to the second position until the removable member is removed.

摘要翻译： 用于存储和分配物质的装置包括用于物质的储存室。 容器包括与储存室流体连通的通道。 容器包括位于通道相对于储存室的相对侧上的可刺穿的壁。 该装置包括一个包括穿刺部分的单向阀组件。 所述穿刺部分和所述可刺穿壁中的至少一个在所述可刺穿部分不穿透所述可刺穿壁的第一位置与所述可刺穿部分穿透所述可刺穿壁之间允许物质流动的第二位置之间相对于另一个可移动 从储存室。 可拆卸构件设置在阀和容器之间，防止至少一个刺穿部分和可刺穿的壁移动到第二位置，直到可移除构件被移除。