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公开(公告)号：US5575810A
公开(公告)日：1996-11-19
申请号：US528805
申请日：1995-09-15
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00083 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00839 , A61B2018/1437 , A61B2018/1467 , A61B2018/1497
摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.
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102.发明授权Composite structures and methods for ablating tissue to form complex lesion patterns in the treatment of cardiac conditions and the like 失效用于在治疗心脏病况等中烧蚀组织以形成复杂病变图案的复合结构和方法公开(公告)号：US07837684B2
公开(公告)日：2010-11-23
申请号：US11923373
申请日：2007-10-24
IPC分类号： A61B18/14
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00083 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00839 , A61B2018/1437 , A61B2018/1467 , A61B2018/1497
摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.
摘要翻译： 心脏中消融组织以治疗心房颤动的方法将所选择的心房引入能量发射元件。 该方法将该元件暴露于心房壁的一个区域，并向该元件施加消融能量以热破坏组织。 该方法形成包括细长的直线损伤和细长的曲线损伤的褶皱病变图案。 病变图案沿着激活心房心肌的路径引导心房心肌内的电脉冲，同时中断再入电路，如果不中断，将引起原纤维化。 该方法模拟外科迷宫手术，但适用于不需要开放心脏手术技术的基于导管的手术。 用于执行该方法的复合结构使用在平面图中显示用于组织的期望损伤图案的模板来形成。 间隔开的元件阵列放置在模板上。 在模板的指导下，在元件上形成能量发射和非能量发射区。 通过覆盖元件，形成复合结构，其可以引入体内以使用基于导管的血管通路技术来烧蚀组织。
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103.发明授权公开(公告)号：US06652513B2
公开(公告)日：2003-11-25
申请号：US09962662
申请日：2001-09-24
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/1402 , A61B18/1492 , A61B2018/00083 , A61B2018/00095 , A61B2018/00791 , A61B2018/00803 , A61N1/403
摘要： Systems and methods heat or ablate body tissue by positioning an electrode to transmit heat or ablation energy to a tissue region. The systems and methods measure a first temperature using a temperature sensing element associated with the electrode. The systems and methods also measure a second temperature using a temperature sensing element associated with the electrode. The systems and methods process at least one of the first and second temperatures to derive a prediction of maximum temperature of the tissue region. The systems and methods generate an output that controls the transmission of the heating or ablation energy based, at least in part, upon the maximum tissue temperature prediction.
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104.发明授权Tissue heating and ablation systems and methods which predict maximum tissue temperature 失效组织加热和消融系统和预测最大组织温度的方法公开(公告)号：US06293943B1
公开(公告)日：2001-09-25
申请号：US09034977
申请日：1998-03-04
IPC分类号： A61B1739
CPC分类号： A61B18/1206 , A61B18/1402 , A61B18/1492 , A61B2018/00083 , A61B2018/00095 , A61B2018/00791 , A61B2018/00803 , A61N1/403
摘要： Systems and methods heat or ablate body tissue by positioning an electrode to transmit heat or ablation energy to a tissue region. The systems and methods measure a first temperature using a temperature sensing element associated with the electrode. The systems and methods also measure a second temperature using a temperature sensing element associated with the electrode. The systems and methods process at least one of the first and second temperatures to derive a prediction of maximum temperature of the tissue region. The systems and methods generate an output that controls the transmission of the heating or ablation energy based, at least in part, upon the maximum tissue temperature prediction.
摘要翻译： 系统和方法通过将电极定位以将热量或消融能量传递到组织区域来加热或消融身体组织。 系统和方法使用与电极相关联的温度感测元件来测量第一温度。 系统和方法还使用与电极相关联的温度感测元件测量第二温度。 系统和方法处理第一和第二温度中的至少一个以导出组织区域的最大温度的预测。 系统和方法至少部分地基于最大组织温度预测产生控制加热或消融能量传递的输出。
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公开(公告)号：US06241754B1
公开(公告)日：2001-06-05
申请号：US08752162
申请日：1996-11-18
IPC分类号： A61F712
CPC分类号： A61B18/1492 , A61B2017/003 , A61B2018/00083 , A61B2018/00196 , A61B2018/00214 , A61B2018/00267 , A61B2018/00577 , A61B2018/00839 , A61B2018/1437 , A61B2018/1467 , A61B2018/1497
摘要： A method of ablating tissue in the heart to treat atrial fibrillation introduces into a selected atrium an energy emitting element. The method exposes the element to a region of the atrial wall and applies ablating energy to the element to thermally destroy tissue. The method forms a convoluted lesion pattern comprising elongated straight lesions and elongated curvilinear lesions. The lesion pattern directs electrical impulses within the atrial myocardium along a path that activates the atrial myocardium while interrupting reentry circuits that, if not interrupted, would cause fibrillation. The method emulates the surgical maze procedure, but lends itself to catheter-based procedures that do not require open heart surgical techniques. A composite structure for performing the method is formed using a template that displays in planar view a desired lesion pattern for the tissue. An array of spaced apart element is laid on the template. Guided by the template, energy emitting and non-energy emitting zones are formed on the elements. By overlaying the elements, the composite structure is formed, which can be introduced into the body to ablate tissue using catheter-based, vascular access techniques.
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公开(公告)号：US5797905A
公开(公告)日：1998-08-25
申请号：US558131
申请日：1995-11-13
IPC分类号： A61B5/042 , A61B17/00 , A61B18/00 , A61B18/14 , A61N1/05 , A61N1/06 , A61N1/40 , G01K1/02 , G01K3/14 , A61B17/36
CPC分类号： A61B18/1492 , A61B5/0422 , A61B5/6858 , A61N1/056 , A61N1/06 , A61N1/40 , G01K1/026 , G01K3/14 , A61B2017/00088 , A61B2017/00092 , A61B2017/0088 , A61B2018/00083 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00791 , A61B2018/1435
摘要： Devices and methods for ablating body tissue use wire wound about a support body in adjacent windings to form one or more elongated electrodes. A connection couples the wire to a source of ablation energy for transmission by the elongated electrode to ablate tissue. The adjacent windings are spaced apart to impart enhanced flexibility to the elongated electrode during use.
摘要翻译： 用于烧蚀身体组织的装置和方法使用缠绕在相邻绕组中的支撑体的线以形成一个或多个细长电极。 连接将电线耦合到消融能量源，以通过细长电极传输以消融组织。 相邻的绕组间隔开以在使用期间赋予细长电极增强的柔性。
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107.发明授权Systems and methods for sensing multiple temperature conditions during tissue ablation 失效在组织消融期间感测多种温度条件的系统和方法
公开(公告)号：US5688267A
公开(公告)日：1997-11-18
申请号：US432091
申请日：1995-05-01
CPC分类号： A61B18/1492 , A61N1/403 , A61B18/1206 , A61B2017/00084 , A61B2017/00243 , A61B2018/00023 , A61B2018/00029 , A61B2018/0069 , A61B2018/00761 , A61B2018/00886 , A61B2018/126 , A61B2018/1861
摘要： Systems and methods for ablating body tissue use an electrode for contacting tissue to form a tissue-electrode interface. The electrode is adapted to be connected to a source of ablation energy to conduct ablation energy for transmission by the electrode into tissue at the tissue-electrode interface. The electrode is preferably cooled. The systems and methods include multiple temperature sensing elements. One element senses tissue temperature. A second element senses electrode temperature. A third element senses the rate at which the electrode is cooled. The systems and methods control the supply of ablation energy to the electrode based, at least in part, upon the multiple temperatures sensed by the different temperature sensing elements.
摘要翻译： 用于烧蚀身体组织的系统和方法使用用于接触组织的电极以形成组织 - 电极界面。 电极适于连接到消融能量源，以传导消融能量，以将电极传输到组织 - 电极界面处的组织中。 电极优选被冷却。 系统和方法包括多个温度感测元件。 一个元素感测组织温度。 第二个元件感应电极温度。 第三个元件感测电极被冷却的速率。 系统和方法至少部分地基于由不同温度感测元件感测的多个温度来控制向电极提供消融能量。
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108.发明授权公开(公告)号：US06447506B1
公开(公告)日：2002-09-10
申请号：US09460296
申请日：1999-12-10
IPC分类号： A61B1818
CPC分类号： A61B18/1492 , A61B5/6858 , A61B18/1402 , A61B18/1815 , A61B2017/00084 , A61B2017/00292 , A61B2017/003 , A61B2018/00107 , A61B2018/00148 , A61B2018/0016 , A61B2018/00214 , A61B2018/00755 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1435 , A61B2018/1861 , A61L29/085 , A61L29/145 , A61L31/10 , A61L31/145 , A61N1/06 , A61N1/403 , C08L1/02
摘要： A device for creating the lesions in body tissue includes a support element having an electromagnetic energy emitting region. When caused to emit electromagnetic energy, the region creates a single continuous lesion that is long and thin, having a length that is substantially greater than its width.
摘要翻译： 用于在身体组织中产生损伤的装置包括具有电磁能发射区域的支撑元件。 当引起发射电磁能时，该区域产生长且薄的单个连续病变，其长度远大于其宽度。
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109.发明授权
公开(公告)号：US6146379A
公开(公告)日：2000-11-14
申请号：US763170
申请日：1996-12-10
CPC分类号： A61B5/6858 , A61B5/0422 , A61N1/056 , A61N1/06 , A61N1/40 , A61N1/403 , A61B2017/00084 , A61B2017/003 , A61B2018/00107 , A61B2018/1435 , A61B2018/1861
摘要： Systems and methods ablate tissue within the body using a flexible guide element having an axis. A mechanism flexes the element along its axis. The flexible element carries a region for emitting energy. The region creates a lesion having a contour that follows the flexure of the element. The region creates a single continuous lesion that is curvilinear, long and thin. Manipulating such systems and methods creates diverse, specially shaped lesions in body tissue.
摘要翻译： 系统和方法使用具有轴的柔性引导元件来消融体内的组织。 机构沿其轴线弯曲元件。 柔性元件携带用于发射能量的区域。 该区域产生具有跟随元件弯曲的轮廓的损伤。 该区域创建一个单一的连续病变，其曲线，长而薄。 操纵这种系统和方法在身体组织中产生不同的，特别形状的损伤。
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110.发明授权Systems and methods for obtaining desired lesion characteristics while ablating body tissue 失效用于在消融身体组织时获得所需病变特征的系统和方法
公开(公告)号：US6056745A
公开(公告)日：2000-05-02
申请号：US962918
申请日：1997-10-27
CPC分类号： A61B18/00 , A61B18/12 , A61B18/1206 , A61B18/1492 , A61B2017/00017 , A61B2017/00084 , A61B2018/00011 , A61B2018/00023 , A61B2018/00029 , A61B2018/00047 , A61B2018/00083 , A61B2018/00095 , A61B2018/00208 , A61B2018/00351 , A61B2018/00577 , A61B2018/00642 , A61B2018/0066 , A61B2018/00666 , A61B2018/00684 , A61B2018/00702 , A61B2018/00744 , A61B2018/00761 , A61B2018/00791 , A61B2018/00815 , A61B2018/00886 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2018/1861 , A61B2218/002 , A61M2230/50
摘要： Systems and methods for ablating body tissue use an electrode for contacting tissue to form a tissue-electrode interface. The electrode is coupled to a source of ablation energy for transmitting ablation energy at a prescribed ablation power level into tissue to form, over a prescribed ablation time period, a therapeutic result. The therapeutic result includes a lesion that extends beneath the tissue-electrode interface to a boundary depth between viable and nonviable tissue and a maximum tissue temperature developed within the lesion between the tissue-electrode interface and the boundary depth. The systems and methods include an element to cool the electrode. An input element inputs a desired therapeutic result including at least a targeted lesion boundary depth. The systems and methods employ a processing element that retains a function correlating an observed relationship among lesion boundary depth, ablation power level, ablation time, actual or predicted sub-surface tissue temperature, and electrode temperature. The processing element compares the desired therapeutic result to the function. The processing element selects an operating condition based upon the comparison to achieve the desired therapeutic result without exceeding a prescribed actual or predicted sub-surface tissue temperature, at least in part by cooling the electrode to control electrode temperature while the electrode transmits ablation energy.
摘要翻译： 用于烧蚀身体组织的系统和方法使用用于接触组织的电极以形成组织 - 电极界面。 电极耦合到消融能量源，用于以规定的消融功率电平将消融能量传输到组织中，以在规定的消融时间段内形成治疗结果。 治疗结果包括在组织 - 电极界面下方延伸到存活组织和非活动组织之间的边界深度的病变以及在组织 - 电极界面和边界深度之间的损伤之内形成的最大组织温度。 该系统和方法包括用于冷却电极的元件。 输入元件输入包括至少目标病变边界深度的所需治疗结果。 系统和方法采用处理元件，该处理元件保持与损伤边界深度，消融功率水平，消融时间，实际或预测的子表面组织温度和电极温度之间的观察到的关系相关的功能。 处理元件将期望的治疗结果与功能进行比较。 所述处理元件至少部分地通过冷却所述电极来控制电极温度，同时所述电极传输消融能量，而基于所述比较选择操作条件以实现期望的治疗结果而不超过规定的实际或预测的子表面组织温度。
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