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140 条记录 (耗时 0.045 秒)

    Recombinant human anti-Lewis Y antibodies
    103.
    发明授权
    Recombinant human anti-Lewis Y antibodies 失效
    重组人抗Lewis Y抗体

    公开(公告)号：US06310185B1

    公开(公告)日：2001-10-30

    申请号：US08207861

    申请日：1994-03-08

    申请人： Thomas P. Wallace ,  Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

    发明人： Thomas P. Wallace ,  Kathryn Lesley Armour ,  Francis Joseph Carr ,  Lloyd J. Old ,  Elisabeth Stockert ,  Sydney Welt ,  Kunio Kitamura ,  Pilar Garin-Chesa

    IPC分类号： C07K1630

    CPC分类号： C07K16/34 ,  C07K16/30 ,  C07K2317/24 ,  C07K2319/00

    摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen Lewis Y, which is recognized by murine atibodies specific for the Lewis Y antigen. The Lewis Y antigen is expressed in normal tissues but the level of expression is higher in certain tumour types so that the antigen can be used as a marker for cells of some breast, colon, gastric, esophageal, pancreatic, duodenal, lung, bladder and renal carcinomas and gastric and islet cell neuroendocrine tumours. The invention also provides for numerous polynucleotide encoding humanized Lewis Y specific antibodies, expression vectors for producing humanized Lewis Y specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis Y specific antibodies. Additionally, the invention provides methods of treating cancer using humanized Lewis Y specific antibodies.

    摘要翻译： 本发明提供了对抗原Lewis Y特异性的几种人源化鼠抗体的产生，其被Lewis Y抗原特异性的鼠抗体识别。 Lewis Y抗原在正常组织中表达，但在某些肿瘤类型中表达水平较高，因此抗原可用作乳腺癌，结肠癌，胃癌，食管癌，胰腺癌，十二指肠癌，肺癌，膀胱癌， 肾癌和胃和胰岛细胞神经内分泌肿瘤。 本发明还提供编码人源化Lewis Y特异性抗体的许多多核苷酸，用于产生人源化Lewis Y特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供使用人源化Lewis Y特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供使用人源化Lewis Y特异性抗体治疗癌症的方法。

    Isolated nucleic acid molecules which encode human anti-Lewis b antibodies
    106.
    发明授权
    Isolated nucleic acid molecules which encode human anti-Lewis b antibodies 失效
    编码人抗Lewis B抗体的分离的核酸分子

    公开(公告)号：US6025481A

    公开(公告)日：2000-02-15

    申请号：US80554

    申请日：1998-05-18

    申请人： T. Paul Wallace ,  William J. Harris ,  Frank J. Carr ,  Lloyd J. Old ,  Sydney Welt ,  Kunio Kitamura

    发明人： T. Paul Wallace ,  William J. Harris ,  Frank J. Carr ,  Lloyd J. Old ,  Sydney Welt ,  Kunio Kitamura

    IPC分类号： C07K16/30 ,  C07H21/02 ,  C12N1/20 ,  C12N5/00 ,  C12N15/00

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： The invention provides for the production of several humanized murine antibodies specific for the Lewis b antigen, which is recognized by the murine antibody 58-1066. The antigen is expressed on cell lines from colon, lung, bladder, breast, renal, pancreatic and ovarian cancers. The expression of the antigen is greatly increased in cancer tissues as compared to its expression in the corresponding normal tissue. The invention also provides for numerous polynucleotide encoding humanized Lewis b antigen specific antibodies, expression vectors for producing humanized Lewis b antigen specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis b antigen specific antibodies. Additionally, the invention provides methods of treating cancer using Lewis b antigen specific antibodies.

    摘要翻译： 本发明提供了生产针对Lewis b抗原特异性的几种人源化鼠抗体，其被鼠抗体58-1066识别。 抗原在结肠癌，肺癌，膀胱癌，乳腺癌，肾癌，胰腺癌和卵巢癌的细胞系中表达。 与其相应的正常组织中的表达相比，癌组织中抗原的表达大大增加。 本发明还提供编码人源化Lewis B抗原特异性抗体的许多多核苷酸，用于产生人源化Lewis B抗原特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供使用人源化Lewis B抗原特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供了使用Lewis b抗原特异性抗体治疗癌症的方法。

    Recombinant human anti-Lewis b antibodies
    108.
    发明授权
    Recombinant human anti-Lewis b antibodies 失效
    重组人抗Lewis B抗体

    公开(公告)号：US5795961A

    公开(公告)日：1998-08-18

    申请号：US388672

    申请日：1995-02-14

    申请人： T. Paul Wallace ,  William J. Harris ,  Frank J. Carr ,  Lloyd J. Old ,  Sydney Welt ,  Kunio Kitamura

    发明人： T. Paul Wallace ,  William J. Harris ,  Frank J. Carr ,  Lloyd J. Old ,  Sydney Welt ,  Kunio Kitamura

    IPC分类号： C07K16/30 ,  C07K14/00 ,  A61K38/16 ,  C12P21/08

    CPC分类号： C07K16/30 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2319/00

    摘要： The invention provides for the production of several humanized murine antibodies specific for the Lewis b antigen, which is recognized by the murine antibody 58-1066. The antigen is expressed on cell lines from colon, lung, bladder, breast, renal, pancreatic and ovarian cancers. The expression of the antigen is greatly increased in cancer tissues as compared to its expression in the corresponding normal tissue. The invention also provides for numerous polynucleotide encoding humanized Lewis b antigen specific antibodies, expression vectors for producing humanized Lewis b antigen specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized Lewis b antigen specific antibodies. Additionally, the invention provides methods of treating cancer using Lewis b antigen specific antibodies.

    摘要翻译： 本发明提供了生产针对Lewis b抗原特异性的几种人源化鼠抗体，其被鼠抗体58-1066识别。 抗原在结肠癌，肺癌，膀胱癌，乳腺癌，肾癌，胰腺癌和卵巢癌的细胞系中表达。 与其相应的正常组织中的表达相比，癌组织中抗原的表达大大增加。 本发明还提供编码人源化Lewis B抗原特异性抗体的许多多核苷酸，用于产生人源化Lewis B抗原特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供使用人源化Lewis B抗原特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供了使用Lewis b抗原特异性抗体治疗癌症的方法。

    Recombinant human anti-LK26 antibodies
    110.
    发明授权
    Recombinant human anti-LK26 antibodies 失效
    重组人抗LK26抗体

    公开(公告)号：US5646253A

    公开(公告)日：1997-07-08

    申请号：US207996

    申请日：1994-03-08

    申请人： Thomas Paul Wallace ,  William Joseph Harris ,  Francis Joseph Carr ,  Wolfgang J. Rettig ,  Pilar Garin-Chesa ,  Lloyd J. Old

    发明人： Thomas Paul Wallace ,  William Joseph Harris ,  Francis Joseph Carr ,  Wolfgang J. Rettig ,  Pilar Garin-Chesa ,  Lloyd J. Old

    IPC分类号： G01N33/574 ,  G01N33/68 ,  C07K16/46

    CPC分类号： G01N33/6854 ,  G01N33/57484 ,  G01N33/6833

    摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen LK26, which is recognized by the murine antibody LK26. This antigen is expressed on all choriocarcinoma, teratocarcinoma and renal cancer cell lines whereas it is not expressed on cell lines of leukaemias, lymphomas, neuroectodermally-derived and epithelial tumour cell lines (excepting a small subset of epithelial cell lines). Furthermore, whereas renal cancer cell lines express the LK26 antigen, normal renal epithelial cells do not. Similarly, with the exception of the trophoblast, all normal adult and fetal tissues tested are negative for the LK26 phenotype. The invention also provides for numerous polynucleotide encoding humanized LK26 specific antibodies, expression vectors for producing humanized LK26 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized LK26 specific antibodies. Additionally, the invention provides methods of treating cancer using LK26 specific antibodies.

    摘要翻译： 本发明提供了针对抗原LK26特异的几种人源化鼠抗体的产生，其被鼠抗体LK26识别。 该抗原在所有绒毛膜癌，畸胎癌和肾癌细胞系中表达，而不在白血病，淋巴瘤，神经外胚层衍生的和上皮性肿瘤细胞系的细胞系（除了上皮细胞系的一小部分之外）上表达。 此外，肾癌细胞株表达LK26抗原时，肾上皮细胞不正常。 类似地，除了滋养层之外，所有正常的成年和胎儿组织检测对于LK26表型是阴性的。 本发明还提供编码人源化LK26特异性抗体的许多多核苷酸，用于产生人源化LK26特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供了使用人源化LK26特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供使用LK26特异性抗体治疗癌症的方法。