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1.发明授权Isolated nucleic acid molecule encoding an esophageal cancer associated antigen, the antigen itself, and uses thereof 失效编码食管癌相关抗原的分离的核酸分子，抗原本身及其用途
公开(公告)号：US6069233A
公开(公告)日：2000-05-30
申请号：US13150
申请日：1998-01-26
申请人： Yao-tseng Chen , Matthew Scanlan , Ali O. Gure , Lloyd J. Old , Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
发明人： Yao-tseng Chen , Matthew Scanlan , Ali O. Gure , Lloyd J. Old , Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
IPC分类号： A61K39/00 , C07K14/47 , C07K14/435
CPC分类号： C07K14/4748 , A61K39/00 , Y10S530/806
摘要： The invention relates to the isolation of a nucleic acid molecule which encodes an esophageal cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen.
摘要翻译： 本发明涉及分离编码食管癌相关抗原的核酸分子。 本发明的一部分也是抗原本身，以及核酸分子和抗原的用途。
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2.发明授权公开(公告)号：US06291658B1
公开(公告)日：2001-09-18
申请号：US08851138
申请日：1997-05-05
申请人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
发明人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
IPC分类号： C07H2102
CPC分类号： C07K14/47
摘要： The invention relates to members of the SSX family of genes, as well as their uses.
摘要翻译： 本发明涉及SSX家族基因的成员及其用途
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公开(公告)号：US06339140B1
公开(公告)日：2002-01-15
申请号：US09796780
申请日：2001-03-01
申请人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
发明人： Ali O. Gure , Ozlem Tureci , Ugur Sahin , Solam Tsang , Matthew J. Scanlan , Alexander Knuth , Michael Pfreundschuh , Lloyd J. Old , Yao-Tseng Chen
IPC分类号： C07K100
CPC分类号： C07K14/47
摘要： The invention relates to members of the SSX family of genes, as well as their uses.
摘要翻译： 本发明涉及SSX家族基因的成员及其用途
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公开(公告)号：US06274145B1
公开(公告)日：2001-08-14
申请号：US08937263
申请日：1997-09-15
申请人： Yao-tseng Chen , Matthew Scanlan , Ali Guré , Lloyd J. Old , Elke Jäger , Knuth Alexander , Jan W. Drijfhout , Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
发明人： Yao-tseng Chen , Matthew Scanlan , Ali Guré , Lloyd J. Old , Elke Jäger , Knuth Alexander , Jan W. Drijfhout , Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
IPC分类号： A61K3900
摘要： The invention relates to the isolation of a nucleic acid molecule which encodes a cancer associated antigen. Also a part of the invention is the antigen itself, and the uses of the nucleic acid molecule and the antigen, and peptides derived from it.
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5.发明授权Methods for determining presence of cancer in a sample by determining expression of an SSX gene 失效通过确定SSX基因表达来确定样品中癌症存在的方法公开(公告)号：US06287756B1
公开(公告)日：2001-09-11
申请号：US09105839
申请日：1998-06-26
申请人： Özlem Türeci , Yao-Tseng Chen , Ugur Sahin , Ali O. Gure , Lloyd J. Old , Michael Pfreundschuh
发明人： Özlem Türeci , Yao-Tseng Chen , Ugur Sahin , Ali O. Gure , Lloyd J. Old , Michael Pfreundschuh
IPC分类号： G01N3353
CPC分类号： C07K14/82 , A61K38/00 , G01N33/57484 , G01N2333/82
摘要： The invention relates to members of the SSX family of genes, as well as to their uses.
摘要翻译： 本发明涉及SSX家族基因的成员以及它们的用途
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公开(公告)号：US6140050A
公开(公告)日：2000-10-31
申请号：US105907
申请日：1998-06-26
申请人： Ugur Sahin , Ozlem Tureci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
发明人： Ugur Sahin , Ozlem Tureci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
IPC分类号： C07K14/47 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P19/34
CPC分类号： G01N33/57415 , C07K14/4748 , C12Q1/6886 , C12Q2600/106
摘要： The invention relates to assays for determining breast cancer or melanoma. It has been found that the accuracy of such assays can be improved by assaying samples for three or more known tumor rejection antigen precursors. For breast cancer, the tumor rejection antigen precursors known as SCP-1, NY-ESO-1, and SSX-2 are assayed. For melanoma, SSX-2, NY-ESO-1, and MAGE-3 are assayed. Additional known tumor rejection antigen precursors can also be determined to confirm the assays. It is preferred to carry these out via polymerase chain reactions.
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7.发明授权Methods for determining breast cancer and melanoma by assaying for a plurality of antigens associated therewith 有权通过测定与其相关的多种抗原来确定乳腺癌和黑素瘤的方法公开(公告)号：US06338947B1
公开(公告)日：2002-01-15
申请号：US09578378
申请日：2000-05-25
申请人： Ugur Sahin , Özlem Türeci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
发明人： Ugur Sahin , Özlem Türeci , Yao-Tseng Chen , Lloyd J. Old , Michael Pfreundschuh
IPC分类号： G01N3353
CPC分类号： G01N33/57415 , C07K14/4748 , C12Q1/6886 , C12Q2600/106
摘要： The invention relates to assays for determining breast cancer or melanoma. It has been found that the accuracy of such assays can be improved by assaying samples for three or more known tumor rejection antigen precursors. For breast cancer, the tumor rejection antigen precursors known as SCP-1, NY-ESO-1, and SSX-2 are assayed. For melanoma, SSX-2, NY-ESO-1, and MAGE-3 are assayed. Additional known tumor rejection antigen precursors can also be determined to confirm the assays. It is preferred to carry these out via polymerase chain reactions.
摘要翻译： 本发明涉及用于确定乳腺癌或黑素瘤的测定法。 已经发现，通过测定三种或更多种已知的肿瘤排斥抗原前体的样品，可以提高这些测定的准确性。 对于乳腺癌，测定称为SCP-1，NY-ESO-1和SSX-2的肿瘤排斥抗原前体。 对于黑素瘤，测定SSX-2，NY-ESO-1和MAGE-3。 还可以确定另外已知的肿瘤排斥抗原前体以确认测定。 优选通过聚合酶链反应进行这些操作。
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8.发明授权Isolated nucleic acid molecules encoding isolated peptides which correspond to contiguous amino acids of an SSX molecule or NY-ESO-1 and uses thereof 有权编码分离的肽的分离的核酸分子，其对应于SSX分子或NY-ESO-1的连续氨基酸并且其用途公开(公告)号：US07270819B2
公开(公告)日：2007-09-18
申请号：US10177277
申请日：2002-06-21
摘要： The invention relates to members of the SSX family of genes, as well as their uses. Also a part of the invention are peptides derived from SSX molecules and the NY-ESO-1 molecule, which form complexes with HLA molecules, leading to lysis of cells presenting these complexes, by cytolytic T cells.
摘要翻译： 本发明涉及SSX家族基因的成员及其用途。 本发明的一部分也是衍生自SSX分子和NY-ESO-1分子的肽，其与HLA分子形成复合物，导致细胞溶解性T细胞裂解呈现这些复合物的细胞。
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公开(公告)号：US06214983B1
公开(公告)日：2001-04-10
申请号：US09177325
申请日：1998-10-22
申请人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
发明人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
IPC分类号： C07H2102
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/4748 , C07K16/18 , C12Q1/6886 , C12Q2600/158
摘要： The invention involves the recognition of a previously unidentified protein family which belongs to, the human SCP family. The members of the family, such as SCP-2 and rat SCP-3 homolog are markers for cell transformation. Diagnostic and therapeutic uses of these protein and related molecules are taught.
摘要翻译： 本发明涉及一种属于人类SCP家族的以前未知的蛋白质家族的识别。 家族成员，如SCP-2和大鼠SCP-3同系物是细胞转化的标志物。 教导了这些蛋白质和相关分子的诊断和治疗用途。
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公开(公告)号：US06306389B1
公开(公告)日：2001-10-23
申请号：US09590113
申请日：2000-06-08
申请人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
发明人： Ozlem Tureci , Ugur Sahin , Michael Pfreundschuh
IPC分类号： C12Q168
CPC分类号： G01N33/6872 , A61K38/00 , C07K14/4748 , C07K16/18 , C12Q1/6886 , C12Q2600/158
摘要： The invention involves the recognition of a previously unidentified protein family which belongs to, the human SCP family. The members of the family, such as SCP-2 and rat SCP-3 homolog are markers for cell transformation. Diagnostic and therapeutic uses of these protein and related molecules are taught.
摘要翻译： 本发明涉及一种属于人类SCP家族的以前未知的蛋白质家族的识别。 家庭成员，如SCP-2和大鼠SCP-3同源物是细胞转化的标志物。 教导了这些蛋白质和相关分子的诊断和治疗用途。
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