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公开(公告)号：US06951921B2
公开(公告)日：2005-10-04
申请号：US10006041
申请日：2001-12-06
申请人： Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Colin K. Watanabe , William I. Wood
发明人： Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Colin K. Watanabe , William I. Wood
IPC分类号： A61K38/00 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K16/46 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/64 , C12N15/66
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07193045B2
公开(公告)日：2007-03-20
申请号：US10036342
申请日：2001-12-26
申请人： Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Colin K. Watanabe , William I. Wood
发明人： Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Colin K. Watanabe , William I. Wood
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C12N2799/026
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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103.发明授权公开(公告)号：US06946263B2
公开(公告)日：2005-09-20
申请号：US10015671
申请日：2001-12-11
申请人： Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Colin K. Watanabe , William I. Wood
发明人： Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Colin K. Watanabe , William I. Wood
IPC分类号： A61K38/00 , C07K14/00 , C07K14/47 , C07K14/705 , C07K16/28 , C07K16/46 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/64 , C12N15/66
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptide of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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104.发明授权公开(公告)号：US07241862B2
公开(公告)日：2007-07-10
申请号：US10035958
申请日：2001-12-26
申请人： Dan L. Eaton , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Colin K. Watanabe , William I. Wood
发明人： Dan L. Eaton , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , James Pan , Colin K. Watanabe , William I. Wood
IPC分类号： C07K14/435 , C07K19/00
CPC分类号： C07K14/47 , A61K38/00 , C07K14/4703 , C07K14/52 , C07K14/54 , C07K14/545 , C07K14/70578 , C07K16/18 , C07K2317/24 , C07K2319/00 , C12N2799/026
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US06686451B1
公开(公告)日：2004-02-03
申请号：US09902775
申请日：2001-07-10
申请人： Luc Desnoyers , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Jennie P. Mather , P. Mickey Williams , William I. Wood
发明人： Luc Desnoyers , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Jennie P. Mather , P. Mickey Williams , William I. Wood
IPC分类号： C07K1600
CPC分类号： C07K14/47 , C07K14/705 , C07K2319/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US06348351B1
公开(公告)日：2002-02-19
申请号：US09202089
申请日：1998-12-08
申请人： Sherman Fong , Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth Hillan , P. Mickey Williams
发明人： Sherman Fong , Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth Hillan , P. Mickey Williams
IPC分类号： C07K14475
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligand homologues NL2, NL3 and NL6 (FLS139), the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
摘要翻译： 本发明涉及编码新型TIE配体同源物NL2，NL3和NL6（FLS139）的分离的核酸分子，由这种核酸分子编码的蛋白质，以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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公开(公告)号：US6074873A
公开(公告)日：2000-06-13
申请号：US143068
申请日：1998-08-28
申请人： Sherman Fong , Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth Hillan , P. Mickey Williams
发明人： Sherman Fong , Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth Hillan , P. Mickey Williams
IPC分类号： G01N33/53 , A61K38/00 , A61K38/22 , A61K39/395 , A61K49/00 , A61P9/00 , A61P9/10 , A61P17/02 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/475 , C07K16/18 , C07K16/22 , C07K16/46 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/12 , C12P21/08 , C12N15/11
CPC分类号： C07K14/475 , A61K38/00 , C07K2319/00
摘要： The present invention concerns isolated nucleic acid molecules encoding the novel TIE ligand homologues NL2, NL3 andNL6 (FLS139), the proteins encoded by such nucleic acid molecules, as well as methods and means for making and using such nucleic acid and protein molecules.
摘要翻译： 本发明涉及编码新型TIE配体同源物NL2，NL3和N6（FLS139）的分离的核酸分子，由这种核酸分子编码的蛋白质以及用于制备和使用该核酸和蛋白质分子的方法和手段。
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公开(公告)号：US06828146B2
公开(公告)日：2004-12-07
申请号：US09906618
申请日：2001-07-16
申请人： Luc Desnoyers , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , William I. Wood
发明人： Luc Desnoyers , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , William I. Wood
IPC分类号： C12N1500
CPC分类号： C07K14/4748
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US07368558B2
公开(公告)日：2008-05-06
申请号：US10899671
申请日：2004-07-27
申请人： David Botstein , Audrey Goddard , Paul J. Godowski , Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Margaret Ann Roy , William I. Wood
发明人： David Botstein , Audrey Goddard , Paul J. Godowski , Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Margaret Ann Roy , William I. Wood
CPC分类号： C07K14/47 , C07K14/705
摘要： The present invention is directed to secreted and transmembrane polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
摘要翻译： 本发明涉及分泌和跨膜多肽以及编码这些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。
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公开(公告)号：US06965015B2
公开(公告)日：2005-11-15
申请号：US09903562
申请日：2001-07-11
申请人： Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , William I. Wood
发明人： Napoleone Ferrara , Audrey Goddard , Paul J. Godowski , Austin L. Gurney , Kenneth J. Hillan , William I. Wood
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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