公开(公告)号：US20130171245A1

公开(公告)日：2013-07-04

申请号：US13538793

申请日：2012-06-29

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61K38/27 ,  A61M25/10

CPC分类号： A61K38/27 ,  A61K9/0053 ,  A61K9/4808 ,  A61L27/54 ,  A61M25/10 ,  A61M31/002

摘要： Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.

公开(公告)号：US20130116512A1

公开(公告)日：2013-05-09

申请号：US13457456

申请日：2012-04-26

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61B5/00

CPC分类号： A61B5/0002 ,  A61B5/0816 ,  A61B5/14551 ,  A61B5/6803 ,  A61B5/682 ,  A61B2562/0204 ,  A61B2562/0238 ,  B63C11/186 ,  B63C11/26

摘要： Embodiments of the invention provide a system, apparatus and methods for measurement of biometric data of a diver. In many embodiments, the system includes a mouthpiece having a sensor device comprising a light emitter and detector configured to emit and detect light at a wavelength having an absorbance correlated with a level of a blood gas saturation e.g., oxygen, nitrogen, CO2. The emitter is positioned to emit light onto oral tissue of the diver and the detector positioned to detect light which is received from the oral tissue either by transmittance of light through the oral tissue or by reflection of light from the tissue. The target oral tissue can include one or both of gum or buccal tissue. Such embodiments allow data to be collected without having to wear additional sensors or measurement devices and allow for measurement of blood gas levels as the diver breaths through their mouthpiece.

摘要翻译： 本发明的实施例提供了一种用于测量潜水员的生物特征数据的系统，装置和方法。 在许多实施例中，该系统包括具有传感器装置的接口管，该传感器装置包括光发射器和检测器，该发射器和检测器被配置为发射和检测具有与血液饱和度例如氧气，氮气和二氧化碳水平相关的吸光度的波长的光。 发射器被定位成将光发射到潜水员的口腔组织上，并且检测器被定位成通过透过口腔组织的光的透射或通过来自组织的光的反射来检测从口腔组织接收的光。 目标口腔组织可以包括口香糖或口腔组织中的一种或两种。 这样的实施例允许收集数据，而不必佩戴附加的传感器或测量装置，并允许当潜水员通过其喉舌呼吸时测量血液气体水平。

公开(公告)号：US08414849B2

公开(公告)日：2013-04-09

申请号：US13448235

申请日：2012-04-16

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： F04F5/48

CPC分类号： B01L3/50273 ,  B01J19/0093 ,  B01J2219/00783 ,  B01J2219/00869 ,  B01J2219/00873 ,  B01J2219/00891 ,  B01J2219/00961 ,  B01J2219/00966 ,  B01J2219/00981 ,  B01J2219/00986 ,  B01L3/502715 ,  B01L3/502738 ,  B01L2200/0621 ,  B01L2200/10 ,  B01L2300/022 ,  B01L2300/023 ,  B01L2300/0627 ,  B01L2300/0636 ,  B01L2300/0816 ,  B01L2300/0838 ,  B01L2300/0867 ,  B01L2300/087 ,  B01L2300/0877 ,  B01L2300/18 ,  B01L2300/1827 ,  B01L2300/1866 ,  B01L2400/0442 ,  B01L2400/049 ,  B01L2400/06 ,  B01L2400/0605 ,  F04B19/006 ,  Y10T137/2877 ,  Y10T137/7559 ,  Y10T137/85978 ,  Y10T137/85986 ,  Y10T137/86075

摘要： Embodiments described herein provide micro-fluidic systems and devices for use in performing various diagnostic and analytical tests. According to one embodiment, the micro-fluidic device includes a sample chamber for receiving a sample, and a reaction chamber for performing a chemical reaction. A bubble jet pump is structured on the device to control delivery of a fluid from the sample chamber to the reaction chamber. The pump is fluidically coupled to one or more chambers of the device using a fluidic channel such as a capillary. A valve may be coupled to one or more chambers to control flow into and out of those chambers. Also, a sensor may be positioned in one or more of the chambers, such as the reactant chamber, for sensing a property of the fluid within the chamber as well as the presence of a chemical within the chamber.

公开(公告)号：US08337488B2

公开(公告)日：2012-12-25

申请号：US12564859

申请日：2009-09-22

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61K9/22

CPC分类号： F04B45/024 ,  A61M5/14216 ,  A61M5/14224 ,  A61M5/14276 ,  A61M5/16809 ,  A61M2205/3653 ,  F04B43/0072 ,  F04B43/043 ,  F04B43/084

摘要： Embodiments of the invention provide apparatus, systems and methods for delivering drugs using an implantable diaphragm based drug pump which can deliver precisely controlled doses of drug to selected target tissue sites in the brain, digestive system, blood stream heart or other selected site. Various embodiments of the pump include multi-chamber bellows or other diaphragm based pumps which can rapidly deliver drug to the selected target tissue site.

摘要翻译： 本发明的实施方案提供了使用可植入隔膜的药物泵递送药物的装置，系统和方法，其可将准确控制剂量的药物递送至脑，消化系统，血流心脏或其他选定部位中的选定靶组织部位。 泵的各种实施例包括多室波纹管或其它隔膜式泵，其可以快速地将药物输送到所选择的靶组织部位。

公开(公告)号：US20120180788A1

公开(公告)日：2012-07-19

申请号：US13352249

申请日：2012-01-17

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A62B18/08

CPC分类号： H04R1/44 ,  B63C11/26 ,  H04B11/00 ,  H04R1/083 ,  H04R1/46 ,  H04R17/02 ,  H04R2217/03 ,  H04R2410/07 ,  H04R2460/13

摘要： Embodiments of the invention provide a system, apparatus and methods for underwater voice communication by a diver to other divers and surface ships. In many embodiments, the system includes a mouthpiece voice communication apparatus having a microphone for sensing the diver's voice and an acoustic transducer that conducts sound via conduction through the diver's teeth and skull to the cochlea so as to allow the diver to hear sounds. The mouthpiece is adapted to be easily attached to portions of a SCUBA or other underwater breathing apparatus. It may also be attached to or integral with a snorkel or similar apparatus.

摘要翻译： 本发明的实施例提供了一种潜水员对其他潜水员和水面舰艇进行水下声音通信的系统，装置和方法。 在许多实施例中，该系统包括具有用于感测潜水员声音的麦克风的接口语音通信设备和通过导电通过潜水员的牙齿和头骨传导到耳蜗的声音换能器，以允许潜水员听到声音。 喉舌适于容易地附接到SCUBA或其他水下呼吸器的部分。 它也可以附着在浮体或类似装置上或与其一体。

公开(公告)号：US08190252B2

公开(公告)日：2012-05-29

申请号：US12537243

申请日：2009-08-06

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61N1/30

CPC分类号： A61N1/325 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/4468 ,  A61K31/5517 ,  A61K31/616 ,  A61K31/635 ,  A61K33/00 ,  A61K33/26 ,  A61K38/26 ,  A61K38/28 ,  A61K41/0047 ,  A61K47/34 ,  A61M37/00 ,  A61M2037/0007 ,  A61N1/0448 ,  A61N1/30 ,  A61N1/327

摘要： An embodiment of a system includes a power source and at least two electrode assembles. The power source that an output current that alternates between a maximum current value and a minimum current value; a pair of electrode assemblies. Each electrode assembly is configured to be held in contact with a skin layer of a user. Additionally, each electrode assembly includes an electrode that is coupled to the power source to receive the output current from the power source. At least one of the electrode assemblies in the pair includes a medium that carries an active agent having a charge, the medium being provided on the at least one electrode assembly to enable the output current to repel the active agent into the skin layer for a duration in which the output current has a polarity that is the same as a polarity of the active agent.

摘要翻译： 系统的一个实施例包括电源和至少两个电极组件。 输出电流在最大电流值和最小电流值之间交替的电源; 一对电极组件。 每个电极组件构造成与使用者的皮肤层保持接触。 另外，每个电极组件包括耦合到电源以接收来自电源的输出电流的电极。 该对中的至少一个电极组件包括承载具有电荷的活性剂的介质，介质设置在至少一个电极组件上，以使得输出电流能够将活性剂排斥到皮肤层中持续一段时间 其中输出电流具有与活性剂的极性相同的极性。

公开(公告)号：US20100331759A1

公开(公告)日：2010-12-30

申请号：US12824146

申请日：2010-06-25

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61N1/30

CPC分类号： A61N1/0428 ,  A61N1/0436 ,  A61N1/044 ,  A61N1/048 ,  A61N1/0492 ,  A61N1/0496

摘要： Embodiments of the invention provide electrode assemblies and associated methods for the iontophoretic transdermal delivery of therapeutic agents. Many embodiments provide a corrosion resistant electrode for the iontophoretic transdermal delivery of various therapeutic agents. Such embodiments allow for the iontophoretic transdermal delivery of therapeutic agents such as iron compounds for prolonged periods without any substantial corrosion of the electrode, impedance increases or discoloration or irritation of the skin. Embodiments of the invention are particularly useful for the long term treatment of various chronic medical conditions such as iron deficient anemia.

公开(公告)号：US20100268295A1

公开(公告)日：2010-10-21

申请号：US12427733

申请日：2009-04-21

申请人： Mir Imran ,  Joel Harris

发明人： Mir Imran ,  Joel Harris

IPC分类号： A61N1/365

CPC分类号： A61N1/36514 ,  A61B5/046 ,  A61N1/056 ,  A61N1/0573 ,  A61N1/3621 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/3702 ,  A61N1/395

摘要： An embodiment of the invention provides an apparatus for the detection and treatment of atrial arrhythmia comprising an electrical lead having proximal and distal portions. The distal portion is positionable in an atrial chamber and the end of the proximal portion is configured to be coupled to a pacemaker. The lead comprises a plurality of conductive wires clad with an insulative coating and has sufficient flexibility to be positioned in the atria from a percutaneous introductory site. The conductive wires are coupled to a plurality of pairs of bipolar electrodes positioned on a membrane attachable to an endocardial wall. The electrode pairs are distributed in a pattern defining an area for detecting a location of a foci of aberrant electrical activity located within or adjacent the area and sending a pacing signal to that location to prevent or stop an occurrence of atrial fibrillation caused by that foci.

摘要翻译： 本发明的一个实施方案提供了用于检测和治疗心房心律失常的装置，其包括具有近端部分和远端部分的电引线。 远侧部分可定位在心房中，并且近端部分的端部被配置为联接到起搏器。 引线包括用绝缘涂层包覆的多个导线，并且具有足够的灵活性，以便从经皮引导位置定位在心房中。 导电线耦合到多个双极电极对，其位于可附接到心内膜壁的膜上。 电极对以限定用于检测位于该区域内或邻近该区域的异常电活动焦点的位置的区域的图案分布，并向该位置发送起搏信号以防止或停止由该焦点引起的心房颤动的发生。

公开(公告)号：US20100268291A1

公开(公告)日：2010-10-21

申请号：US12757865

申请日：2010-04-09

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61N1/365 ,  A61N1/39

CPC分类号： A61N1/36514 ,  A61B5/046 ,  A61N1/056 ,  A61N1/0573 ,  A61N1/3621 ,  A61N1/3622 ,  A61N1/3624 ,  A61N1/36578 ,  A61N1/3684 ,  A61N1/3702 ,  A61N1/395

摘要： Embodiments of the invention provide methods for the detection and treatment of atrial fibrillation (AF) and related conditions. One embodiment provides a method comprising measuring electrical activity of the heart using electrodes arranged on the heart surface to define an area for detecting aberrant electrical activity (AEA) and then using the measured electrical activity (MEA) to detect foci of AEA causing AF. A pacing signal may then be sent to the foci to prevent AF onset. Atrial wall motion characteristics (WMC) may be sensed using an accelerometer placed on the heart and used with MEA to detect AF. The WMC may be used to monitor effectiveness of the pacing signal in preventing AF and/or returning the heart to normal sinus rhythm (NSR). Also, upon AF detection, a cardioversion signal may be sent to the atria using the electrodes to depolorize an atrial area causing AF and return the heart to NSR.

摘要翻译： 本发明的实施方案提供了用于检测和治疗心房颤动（AF）和相关病症的方法。 一个实施例提供了一种方法，其包括使用布置在心脏表面上的电极来测量心脏的电活动，以限定用于检测异常电活动（AEA）的区域，然后使用测量的电活动（MEA）来检测导致AF的AEA的焦点。 然后可以将起搏信号发送到病灶以防止AF发作。 可以使用放置在心脏上的加速度计来感测心房壁运动特征（WMC），并与MEA一起使用以检测AF。 WMC可用于监测起搏信号在预防AF和/或使心脏恢复正常窦性心律（NSR）方面的有效性。 此外，在AF检测时，可以使用电极将心脏复律信号发送到心房，以使引起AF的心房区域脱色并将心脏返回到NSR。

公开(公告)号：US20100204678A1

公开(公告)日：2010-08-12

申请号：US12705529

申请日：2010-02-12

申请人： Mir Imran

发明人： Mir Imran

IPC分类号： A61M5/31

CPC分类号： A61M37/00 ,  A61M37/0069

摘要： Embodiments described herein provide a skin penetrating device and method for the subcutaneous delivery of therapeutic agents in solid form. One embodiment provides such a device comprising an elongated shaft having proximal and distal ends and a skin penetrating element detachably coupled to the shaft. At least a portion of the penetrating element is fabricated from a solid form therapeutic agent composition that dissolves in body tissue and is absorbed into the blood stream so as to produce a therapeutic effect. The penetrating element has shape for penetrating and lodging beneath the skin when inserted through the skin by force applied from the shaft. The penetrating element is configured to detach from the shaft when the shaft is pulled away from the skin so as to leave the element in place beneath the skin where it is absorbed by body tissue and the therapeutic agent is released.

摘要翻译： 本文所述的实施方案提供了用于以固体形式皮下递送治疗剂的皮肤穿透装置和方法。 一个实施例提供了这样的装置，其包括具有近端和远端的细长轴和可拆卸地联接到轴的皮肤穿透元件。 穿透元件的至少一部分由固体形式的治疗剂组合物制成，其溶解在身体组织中并被吸收到血流中以产生治疗效果。 穿透元件具有通过从轴施加的力插入穿过皮肤时在皮肤下方穿透和倒伏的形状。 穿透元件构造成当轴被从皮肤拉开时从轴脱离，以将元件放置在皮肤下面的位置，在身体组织吸收并释放治疗剂。