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132 条记录 (耗时 0.035 秒)

    Electronically keyed dispensing systems and related methods of installation and use
    101.
    发明授权
    Electronically keyed dispensing systems and related methods of installation and use 失效
    电子钥匙分配系统及相关的安装和使用方法

    公开(公告)号：US07028861B2

    公开(公告)日：2006-04-18

    申请号：US10737869

    申请日：2003-12-16

    申请人： Richard C. Sayers ,  Shane Obitts ,  William A. Hudgins ,  Paul Waterhouse ,  Michael J. Dolan ,  Spencer W. Allen ,  R. Victor Sulkowski

    发明人： Richard C. Sayers ,  Shane Obitts ,  William A. Hudgins ,  Paul Waterhouse ,  Michael J. Dolan ,  Spencer W. Allen ,  R. Victor Sulkowski

    IPC分类号： G01F11/00

    CPC分类号： G07C9/00896 ,  A47K5/1217 ,  B41J2/17513 ,  B41J2/17546 ,  B41J2/17553 ,  B41J2/17559

    摘要： Dispensing systems are disclosed which utilize electronically powered key devices and/or identification codes associated with a refill container to preclude the need for mechanical keys. A first embodiment of the device utilizes a matching code stored in a radio frequency identification tag or bar code associated with a fluid refill container and an identification code associated with the dispenser housing. Matching of the codes by a controller allows for continued use of the dispenser via some type of operational mechanism. Another embodiment employs a key which carries the matching code wherein matching of the codes allows for actuation of a motor actuated pumping device. Yet another embodiment employs a blocking mechanism to prevent use of a dispenser's push bar if a key and dispenser housing do not have matching codes. And yet another embodiment requires the use of a key that has a matching code that matches the dispenser's identification code in order to permit initial access to the dispenser housing.

    摘要翻译： 公开了分配系统，其使用与再填充容器相关联的电动关键装置和/或识别代码来排除对机械钥匙的需要。 设备的第一实施例利用存储在与流体再充填容器相关联的射频识别标签或条形码中的匹配代码以及与分配器壳体相关联的识别代码。 通过控制器匹配代码允许通过某种类型的操作机构继续使用分配器。 另一个实施例采用携带匹配代码的密钥，其中代码的匹配允许致动电动机致动的泵送装置。 另一个实施例采用阻塞机构来防止使用分配器的推杆，如果钥匙和分配器外壳不具有匹配的代码。 又一个实施例要求使用具有与分配器的识别码匹配的匹配代码的密钥，以允许初始访问分配器壳体。

    Micro-electrophoresis chip for moving and separating nucleic acids and other charged molecules
    102.
    发明授权
    Micro-electrophoresis chip for moving and separating nucleic acids and other charged molecules 失效
    用于移动和分离核酸和其他带电分子的微电泳芯片

    公开(公告)号：US06261430B1

    公开(公告)日：2001-07-17

    申请号：US09505659

    申请日：2000-02-17

    申请人： Thomas D. Yager ,  Paul Waterhouse ,  Alexandre M. Izmailov ,  Bruno C. Maruzzo ,  John K. Stevens ,  Marina T. Larson

    发明人： Thomas D. Yager ,  Paul Waterhouse ,  Alexandre M. Izmailov ,  Bruno C. Maruzzo ,  John K. Stevens ,  Marina T. Larson

    IPC分类号： G01N2726

    CPC分类号： G01N27/44773 ,  G01N27/44704 ,  G01N27/44791

    摘要： A microelectrophoresis chip comprises a substrate in which there are formed one or more channels, one channel for each sample to be evaluated. The channels extend for the length of the chip, a distance of generally around 1 cm, and are about 1 to 10 &mgr;m wide and 1 to 10 &mgr;m in depth. The channels are filled with a homogeneous separation matrix which acts as an obstacle to the electrophoretic migration of the charged molecules. Microelectrodes disposed in the channels are used to induce an electric filed within the homogeneous separation medium. When a voltage is applied across two or more of the microelectrodes, the charged molecules are induced to move and separate according to the electric field density, the type of solvent film, and the charge, shape and size of the charged molecule. The chip may further comprise detectors, such as light polarization detectors, fluorescence emission detectors, biosensors, electrochemical sensors or other microcomponents which may include sites for enzymatic or chemical manipulation of the moved or separated charged molecules.

    摘要翻译： 微电泳芯片包括其中形成一个或多个通道的基底，每个待评估样品的通道一个通道。 通道延长芯片的长度，通常约1厘米的距离，宽度约为1至10微米，深度为1至10毫米。 通道充满均匀的分离基质，其作为电荷分子的电泳迁移的障碍。 设置在通道中的微电极用于诱导均匀分离介质内的电场。 当电压施加到两个或更多个微电极上时，根据电场密度，溶剂膜的类型和带电分子的电荷，形状和尺寸，诱导带电分子移动和分离。 芯片还可以包括诸如光偏振检测器，荧光发射检测器，生物传感器，电化学传感器或其它微元件的检测器，其可以包括用于酶或分离带电分子的酶或化学操作的位点。

    High dynamic range apparatus for separation and detection of polynucleotide fragments
    103.
    发明授权
    High dynamic range apparatus for separation and detection of polynucleotide fragments 失效
    用于分离和检测多核苷酸片段的高动态范围装置

    公开(公告)号：US6014213A

    公开(公告)日：2000-01-11

    申请号：US819910

    申请日：1997-03-18

    申请人： Paul Waterhouse ,  Alexandre M. Izmailov ,  Henryk Zaleski ,  John A. Renfrew ,  James W. Cassidy

    发明人： Paul Waterhouse ,  Alexandre M. Izmailov ,  Henryk Zaleski ,  John A. Renfrew ,  James W. Cassidy

    IPC分类号： G01N27/447 ,  G01N30/86 ,  G01N21/00

    CPC分类号： G01N30/8603 ,  G01N27/44721

    摘要： A high dynamic range apparatus for separation and detection of polynucleotide fragments has a housing adapted to receive an electrophoresis gel holder containing an electrophoresis gel loaded with fluorophore-labeled samples; one or more laser diodes for providing radiation of a frequency suitable for excitation of the fluorophore which irradiates a an array of excitation/detection sites on the electrophoresis gel; an array of detectors aligned with the excitation/detection sites for collecting fluorescent emissions; and one or more components for increasing the dynamic range of the instrument by at least an order of magnitude. These components, which can be used individually or in combination include detectors that are connected to a signal processing system that modulates the period of signal integration employed so that large signals are totaled at short time intervals and smaller signals are totaled at longer time intervals; the use of a beam splitter to produces a high intensity beam of emitted light and a low intensity beam of emitted light from each excitation/detection site; and a device for modulating the intensity of the excitation beam can be used to improve the dynamic range of the instrument.

    摘要翻译： 用于分离和检测多核苷酸片段的高动态范围装置具有适于接收含有装载有荧光团标记的样品的电泳凝胶的电泳凝胶保持器的壳体; 用于提供适于激发荧光团的频率的辐射的一个或多个激光二极管，其照射电泳凝胶上的激发/检测位点阵列; 与用于收集荧光发射的激发/检测部位对准的检测器阵列; 以及用于将仪器的动态范围增加至少一个数量级的一个或多个组件。 可以单独或组合使用的这些组件包括连接到信号处理系统的检测器，该信号处理系统调制所采用的信号积分的周期，以便以较短的时间间隔合计大信号，并以更长的时间间隔合计较小的信号; 使用分束器产生高强度发射光束和来自每个激发/检测部位的低强度发射光束; 并且可以使用用于调制激发光束的强度的装置来改善仪器的动态范围。

    Automated electrophoresis and fluorescence detection apparatus and method
    104.
    发明授权
    Automated electrophoresis and fluorescence detection apparatus and method 失效

    公开(公告)号：US6005663A

    公开(公告)日：1999-12-21

    申请号：US849662

    申请日：1997-08-18

    申请人： Paul Waterhouse ,  John A. Renfrew ,  John K. Stevens

    发明人： Paul Waterhouse ,  John A. Renfrew ,  John K. Stevens

    IPC分类号： G01N21/64 ,  G01N27/447 ,  G01N21/00

    CPC分类号： G01N27/44721

    摘要： Improved detection methods and apparatus which may be used individually or in combinations enhance the ability of the electrophoresis apparatus to detect fluorophore-labeled materials in short periods of time. One such apparatus comprises a housing adapted to receive an electrophoresis gel holder; an excitation source of electromagnetic radiation having a frequency effective to induce emission of electromagnetic radiation from the fluorophore; a plurality of optical fibers for delivering electromagnetic radiation from the excitation source to a linear array of excitation/detection sites on the gel holder, optical switching means for sequentially directing electromagnetic radiation into one of several pre-defined groups of the optical fibers; detection means such as a photomultiplier tube, or an array of photomultiplier tubes for detecting emission from the fluorophore induced by a radiation from the excitation source; and means for correlating a detected emission with the switching of the excitation electromagnetic radiation such that a given emission may be linked with the excitation/detection site being irradiated. For example, the optical switching means may alternate between directing radiation from the source into every other optical fiber, or may provide radiation in rotation to every third or fourth fiber. Alternatively, a spot array generation grating can be used for dividing an incident beam of coherent radiation into an array of excitation beamlets and directing each excitation beamlets to an excitation/detection site on the electrophoresis gel. Light emitting diode disposed to deliver excitation energy to an array of excitation/detection sites may also be used. This latter form of the apparatus is particularly advantageous due to the low costs of light emitting diodes (LEDs) compared to coherent light sources (e.g. lasers).

    Microgels for use in medical diagnosis and methods of making and using same
    105.
    发明授权
    Microgels for use in medical diagnosis and methods of making and using same 失效
    用于医学诊断的微凝胶及其制造和使用方法

    公开(公告)号：US5885431A

    公开(公告)日：1999-03-23

    申请号：US836269

    申请日：1997-05-01

    申请人： John A. Renfrew ,  Paul Waterhouse ,  John K. Stevens ,  Henryk Zaleski

    发明人： John A. Renfrew ,  Paul Waterhouse ,  John K. Stevens ,  Henryk Zaleski

    IPC分类号： G01N27/447 ,  G01N27/26

    CPC分类号： G01N27/44743 ,  G01N27/44704 ,  G01N27/44747

    摘要： An electrophoresis microgel is formed in a gel holder. The gel holder comprises a top substrate, a bottom substrate and a spacer disposed between the top substrate and the bottom substrate. The spacer establishes a separation of from 25 to 250 microns between the top substrate and the bottom substrate. A gel compartment is formed by partially sealing the top substrate to the bottom substrate, while leaving an opening for the introduction of unpolymerized gel. The gel compartment is then filled with an unpolymerized gel, which is polymerized in the gel compartment. Electrodes may be printed on the substrates, may be contacts to an exposed edge of gel, or may be applied through windows cut into one of the substrates. One type of gel holder makes use of graded beads having a diameter of 25 to 250 microns slurried in an adhesive such as an acrylate adhesive as the spacer. The slurry is printed onto the surface of one or both substrates to form a spacer of the desired shape, and then hardened using heat or light. If desired, the spacer can establish lanes within the gel.

    摘要翻译： PCT No.PCT / US95 / 14531 Sec。 371日期1997年5月1日 102（e）日期1997年5月1日PCT提交1995年10月31日PCT公布。 出版物WO96 / 日期1996年5月9日在凝胶保持器中形成电泳微凝胶。 凝胶保持器包括顶部基底，底部基底和设置在顶部基底和底部基底之间的间隔物。 间隔物在顶部基底和底部基底之间建立了从25至250微米的间隔。 通过将顶部基底部分地密封到底部基底而形成凝胶室，同时留下用于引入未聚合凝胶的开口。 然后用凝胶隔室填充未聚合的凝胶，其在凝胶隔室中聚合。 电极可以印刷在基底上，可以与凝胶的暴露边缘接触，或者可以通过切割成一个基底的窗口来施加。 一种类型的凝胶保持器使用在诸如丙烯酸酯粘合剂的粘合剂中作为间隔物浆化的直径为25至250微米的分级珠粒。 将浆料印刷到一个或两个基材的表面上以形成所需形状的间隔物，然后使用热或光硬化。 如果需要，间隔物可以在凝胶内建立泳道。

    Electrophoresis gels and gel holders having fiber spacers and method of making same
    106.
    发明授权
    Electrophoresis gels and gel holders having fiber spacers and method of making same 失效
    具有纤维间隔物的电泳凝胶和凝胶保持器及其制造方法

    公开(公告)号：US5618398A

    公开(公告)日：1997-04-08

    申请号：US571297

    申请日：1995-12-12

    申请人： Alexandre M. Izmailov ,  Paul Waterhouse ,  Henryk Zaleski

    发明人： Alexandre M. Izmailov ,  Paul Waterhouse ,  Henryk Zaleski

    IPC分类号： G01N21/64 ,  G01N27/447 ,  G01N27/26

    CPC分类号： G01N27/44721 ,  G01N27/44704

    摘要： Gel holders for electrophoresis gels are made using clad fibers, particularly glass fibers as spacers between substrates. A plurality of fibers with an high-melting interior core and a low-melting external cladding are placed between a first planar substrate and a second planar substrate. The fibers are heated to a temperature sufficient to at least soften the exterior cladding of the fibers without softening the interior core of the fibers, and then cooled while they are in contact with the first and second substrates to resolidify the exterior cladding. This adheres the fibers to the first and second substrates, and forms a gel chamber between said first and second substrates. The gel chamber has a thickness defined by interior core of the fibers. The fibers may be heated before or after the second substrate is placed over the top of the fibers. The gel holders thus formed may be filled immediately with a gel forming solution such as a polyacrylamide, or they may be stored indefinitely and used as needed.

    摘要翻译： 电泳凝胶的凝胶保持器使用包覆纤维制成，特别是作为衬底之间的间隔物的玻璃纤维。 具有高熔点内芯和低熔点外包层的多根纤维被放置在第一平面基板和第二平面基板之间。 将纤维加热到足以至少软化纤维的外包层的温度，而不软化纤维的内芯，然后在与第一和第二基底接触的同时冷却，以重新固化外包层。 这将纤维粘附到第一和第二基底上，并在所述第一和第二基底之间形成凝胶室。 凝胶室具有由纤维的内芯限定的厚度。 纤维可以在将第二基底放置在纤维顶部之前或之后被加热。 如此形成的凝胶保持器可立即用诸如聚丙烯酰胺的凝胶形成溶液填充，或者可以无限期地储存并根据需要使用。

    Product, dispenser and method of dispensing product
    107.
    发明授权
    Product, dispenser and method of dispensing product 有权
    产品，分配器和分配产品的方法

    公开(公告)号：US08165716B1

    公开(公告)日：2012-04-24

    申请号：US12636047

    申请日：2009-12-11

    申请人： Harold J. Goeking ,  Daniel J. Geddes ,  Paul J. Ruthven ,  Kang Chang Yeh ,  Alexandre Izmailov ,  Paul Waterhouse ,  Panagiotis Zosimadis

    发明人： Harold J. Goeking ,  Daniel J. Geddes ,  Paul J. Ruthven ,  Kang Chang Yeh ,  Alexandre Izmailov ,  Paul Waterhouse ,  Panagiotis Zosimadis

    IPC分类号： G06F17/00

    CPC分类号： A47K10/34

    摘要： A method of dispensing product includes determining by a processor if product loaded into a dispenser is authorized for use in the dispenser by identifying a reference indication associated with the product; in response to determination that the product is authorized, dispense a first amount of product; and in response to determination that the sheet product is unauthorized, dispense a second amount of sheet product, wherein the second amount of sheet product is different than the first amount. To determine if the sheet product is authorized, a pigment is excited to emit a light with an intensity signature. A portion of the intensity signature is measured and compared to a desired value. If the portion is substantially equal to the desired value, the sheet product is authenticated.

    摘要翻译： 分配产品的方法包括：通过识别与产品相关联的参考指示，由处理器确定加载到分配器中的产品是否被授权用于分配器中; 响应确定产品获得授权，分配第一批产品; 并且响应于片材产品未经授权的确定，分配第二量的片材产品，其中第二量的片材产品不同于第一量。 为了确定片材产品是否被授权，颜料被激发以发射具有强度特征的光。 测量强度特征的一部分并将其与期望值进行比较。 如果该部分基本上等于期望值，则该片材产品被认证。