利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

140 条记录 (耗时 0.053 秒)

    Human sarcoma-associated antigens
    103.
    发明授权
    Human sarcoma-associated antigens 失效
    人肉瘤相关抗原

    公开(公告)号：US07662917B2

    公开(公告)日：2010-02-16

    申请号：US10529655

    申请日：2003-09-30

    申请人： Matthew J. Scanlan ,  Cynthia H. Scanlan, legal representative ,  Sang-Yull Lee ,  Lloyd J. Old

    发明人： Matthew J. Scanlan ,  Sang-Yull Lee ,  Lloyd J. Old

    IPC分类号： C07K14/00

    CPC分类号： C07K14/4748 ,  A61K38/00 ,  G01N33/57488 ,  Y10T436/143333

    摘要： The invention relates to sarcoma-associated antigens and the nucleic acid molecules that encode them. The invention further relates to the use of the nucleic acid molecules, polypeptides and fragments thereof associated with sarcoma in methods and compositions for the diagnosis and treatment of diseases, such as cancer. More specifically, the invention relates to the discovery of a novel cancer/testis (CT) antigen, NY-SAR-35.

    摘要翻译： 本发明涉及肉瘤相关抗原和编码它们的核酸分子。 本发明进一步涉及与肉瘤相关的核酸分子，多肽及其片段在用于诊断和治疗诸如癌症的疾病的方法和组合物中的用途。 更具体地，本发明涉及新型癌/睾丸（CT）抗原NY-SAR-35的发现。

    Small cell lung cancer associated antigens and uses therefor
    105.
    发明授权
    Small cell lung cancer associated antigens and uses therefor 有权
    小细胞肺癌相关抗原及其用途

    公开(公告)号：US07314721B2

    公开(公告)日：2008-01-01

    申请号：US10761169

    申请日：2004-01-20

    申请人： Ali O. Gure ,  Elisabeth Stockert ,  Matthew J. Scanlan ,  Dirk Jager ,  Lloyd J. Old ,  Yao-Tseng Chen

    发明人： Ali O. Gure ,  Elisabeth Stockert ,  Matthew J. Scanlan ,  Dirk Jager ,  Lloyd J. Old ,  Yao-Tseng Chen

    IPC分类号： G01N33/53 ,  C07K1/00 ,  C07K16/00

    CPC分类号： G01N33/574 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  G01N33/57423

    摘要： Cancer associated antigens have been identified by autologous antibody screening of libraries of nucleic acids expressed in small cell lung cancer cells using antisera from cancer patients. The invention relates to nucleic acids and encoded polypeptides which are cancer associated antigens expressed in patients afflicted with small cell lung cancer. The invention provides, among other things, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more cancer associated antigens.

    摘要翻译： 已经通过使用来自癌症患者的抗血清的小细胞肺癌细胞中表达的核酸文库的自身抗体筛选来鉴定癌症相关抗原。 本发明涉及在患有小细胞肺癌的患者中表达的癌症相关抗原的核酸和编码多肽。 本发明尤其提供了分离的核酸分子，含有这些分子的表达载体和用这些分子转染的宿主细胞。 本发明还提供分离的蛋白质和肽，这些蛋白质和肽的抗体以及识别蛋白质和肽的细胞毒性T淋巴细胞。 还提供了前述的片段，包括功能片段和变体。 另外提供了含有上述分子的试剂盒。 本发明提供的分子可用于诊断，监测，研究或治疗以一种或多种癌症相关抗原表达为特征的病症。

    Recombinant human anti-LK26 antibodies
    110.
    发明授权
    Recombinant human anti-LK26 antibodies 失效
    重组人抗LK26抗体

    公开(公告)号：US5646253A

    公开(公告)日：1997-07-08

    申请号：US207996

    申请日：1994-03-08

    申请人： Thomas Paul Wallace ,  William Joseph Harris ,  Francis Joseph Carr ,  Wolfgang J. Rettig ,  Pilar Garin-Chesa ,  Lloyd J. Old

    发明人： Thomas Paul Wallace ,  William Joseph Harris ,  Francis Joseph Carr ,  Wolfgang J. Rettig ,  Pilar Garin-Chesa ,  Lloyd J. Old

    IPC分类号： G01N33/574 ,  G01N33/68 ,  C07K16/46

    CPC分类号： G01N33/6854 ,  G01N33/57484 ,  G01N33/6833

    摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen LK26, which is recognized by the murine antibody LK26. This antigen is expressed on all choriocarcinoma, teratocarcinoma and renal cancer cell lines whereas it is not expressed on cell lines of leukaemias, lymphomas, neuroectodermally-derived and epithelial tumour cell lines (excepting a small subset of epithelial cell lines). Furthermore, whereas renal cancer cell lines express the LK26 antigen, normal renal epithelial cells do not. Similarly, with the exception of the trophoblast, all normal adult and fetal tissues tested are negative for the LK26 phenotype. The invention also provides for numerous polynucleotide encoding humanized LK26 specific antibodies, expression vectors for producing humanized LK26 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized LK26 specific antibodies. Additionally, the invention provides methods of treating cancer using LK26 specific antibodies.

    摘要翻译： 本发明提供了针对抗原LK26特异的几种人源化鼠抗体的产生，其被鼠抗体LK26识别。 该抗原在所有绒毛膜癌，畸胎癌和肾癌细胞系中表达，而不在白血病，淋巴瘤，神经外胚层衍生的和上皮性肿瘤细胞系的细胞系（除了上皮细胞系的一小部分之外）上表达。 此外，肾癌细胞株表达LK26抗原时，肾上皮细胞不正常。 类似地，除了滋养层之外，所有正常的成年和胎儿组织检测对于LK26表型是阴性的。 本发明还提供编码人源化LK26特异性抗体的许多多核苷酸，用于产生人源化LK26特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。 本发明还提供了使用人源化LK26特异性抗体检测癌细胞（体外和体内）的方法。 另外，本发明提供使用LK26特异性抗体治疗癌症的方法。