公开(公告)号：US10946189B2

公开(公告)日：2021-03-16

申请号：US16619396

申请日：2018-07-23

Applicant: Galvani Bioelectronics Limited

Inventor： Faisal Zaidi ,  Sabastien Ouchouche ,  Paul Matteucci, Jr.

IPC: A61N1/05 ,  A61K9/00 ,  A61K31/56 ,  A61N1/36 ,  A61N1/375

Abstract: An extravascular or intravascular neural interface is disclosed and can include three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce nerve compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.

公开(公告)号：US20200306534A1

公开(公告)日：2020-10-01

申请号：US16619392

申请日：2018-12-20

Applicant: Galvani Bioelectronics Limited

Inventor： Refet Firat YAZICIOGLU ,  Rizwan BASHIRULLAH ,  Gerald Edwin HUNSBERGER, Jr.

IPC: A61N1/36 ,  A61N1/05

Abstract: A system for stimulation of a nerve and measuring impedance. The system includes a neural interface device including a plurality of electrodes; a voltage or current source operatively connected to at least a subset of the electrodes, wherein the voltage or current source is configured to generate an electrical signal to be applied to the electrodes; an impedance measuring module operatively connected to at least a subset of the electrodes, wherein the impedance measurement module is configured to measure the impedance between the electrodes; and a controller arranged to determine an amplitude of an action potential induced in the nerve, via the electrical signal, based on the measured impedance and to adjust the electrical signal in order to induce an action potential having a target amplitude.

公开(公告)号：US20200246622A1

公开(公告)日：2020-08-06

申请号：US16643877

申请日：2018-09-14

Applicant: CASE WESTERN RESERVE UNIVERSITY ,  Galvani Bioelectronics Limited

Inventor： Arun SRIDHAR ,  Stephen J. LEWIS ,  Ibrahim SALMAN

IPC: A61N1/36

Abstract: Modulation of neural activity of a subject's aortic depressor nerve (ADN) and/or carotid sinus nerve (CSN) can modulate baroreceptor reflex function, thereby providing ways of treating or preventing disorders associated with malfunction or loss of the baroreceptor reflex.

公开(公告)号：US20200016404A1

公开(公告)日：2020-01-16

申请号：US16485673

申请日：2018-02-12

Applicant: Galvani Bioelectronics Limited

Inventor： Brian Marc PEPIN ,  Shiv SABESAN

IPC: A61N1/36

Abstract: This disclosure relates to implantable neuromodulation systems and methods, and in particular to systems and methods for sensing blood-based parameter changes triggered by neural stimulation and subsequently optimizing the stimulation parameters based on feedback from the sensed blood-based parameter changes. Embodiments are directed to a method that includes delivering neural stimulation to a nerve or artery/nerve plexus based on a first set of stimulation parameters, monitoring a response to the neural stimulation that includes monitoring responses of the nerve or artery/nerve plexus and blood-based parameters of the artery, modifying the first set of the stimulation parameters based on the blood-based parameters to create a second set of stimulation parameters, and delivering the neural stimulation based on the second set of the stimulation parameters.

公开(公告)号：US20190290913A1

公开(公告)日：2019-09-26

申请号：US16347940

申请日：2017-11-08

Applicant: GALVANI BIOELECTRONICS LIMITED ,  UNIVERSITÉ DE NICE SOPHIA-ANTIPOLIS ,  CENTRE NATIONALE DE LA RECHERCHE SCIENTIFIQUE

Inventor： Philippe BLANCOU ,  Nicolas GLAICHENHAUS ,  Arun SRIDHAR

IPC: A61N1/36

Abstract: Stimulation of neural signalling of an apical splenic nerve can modulate pro- and anti-inflammatory molecules levels, thereby reducing inflammation and providing ways of treating inflammatory disorders.

公开(公告)号：US20190275330A1

公开(公告)日：2019-09-12

申请号：US16349540

申请日：2017-11-13

Applicant: Galvani Bioelectronics Limited

Inventor： Shivkumar SABESAN ,  Kedar SHAH

IPC: A61N1/36 ,  A61N1/375 ,  A61N1/372 ,  A61N1/05 ,  A61B5/04 ,  A61B5/00

Abstract: The present invention relates to implantable neuromodulation systems and methods, and in particular to modular neuromodulation systems suitable for implantation in a minimally invasive manner, methods of manufacturing the modular neuromodulation systems, and methods of treating rheumatoid arthritis using the modular neuromodulation systems. Particularly, aspects of the present invention are directed to a medical device that includes an implantable neurostimulator including a housing having a width of less than 10 mm and a height of less than 10 mm, one or more feedthroughs that pass through the housing, and an electronics module within the housing and connected to the one or more feedthroughs. The medical device further includes a lead assembly including a lead body including a conductor material, a lead connector that connects the conductor material to the one or more feedthroughs, and one or more electrodes connected to the conductor material.

公开(公告)号：US20190201692A1

公开(公告)日：2019-07-04

申请号：US16302941

申请日：2017-05-19

Applicant: Galvani Bioelectronics Limited ,  The Johns Hopkins University

Inventor： Arun SRIDHAR ,  Liansheng LIU ,  Pankaj Jay PASRICHA

IPC: A61N1/36

CPC classification number: A61N1/36034 ,  A61N1/36017 ,  A61N1/3606 ,  A61N1/36085 ,  A61N1/36171

Abstract: A method for treating conditions associated with impaired glucose control, involving inhibition of signalling by the greater splanchnic nerve leads to a significant improvement in oral glucose tolerance.

公开(公告)号：US20190054296A1

公开(公告)日：2019-02-21

申请号：US16080203

申请日：2017-02-27

Applicant: GALVANI BIOELECTRONICS LIMITED ,  CASE WESTERN RESERVE UNIVERSITY

Inventor： Alessandra GIAROLA ,  Yee-Hsee HSIEH ,  Stephen J. LEWIS ,  Arun SRIDHAR

IPC: A61N1/36 ,  A61B5/08 ,  A61B5/00 ,  A61N1/05

Abstract: This disclosure provides an apparatus or system for the modulation of neural activity in the cervical sympathetic chain (CSC) or superior cervical ganglion (SCG) or SCG post-ganglionic branch(es) and for the treatment of sleep apnoea, as well as methods for their use.

公开(公告)号：US20180236224A1

公开(公告)日：2018-08-23

申请号：US15752502

申请日：2016-08-18

Applicant: GALVANI BIOELECTRONICS LIMITED

Inventor： Michael John CARR ,  Kevin K. KWONG ,  Gerald E. HUNSBERGER

IPC: A61N1/20 ,  A61B5/00 ,  A61B5/087 ,  A61B5/145 ,  A61B5/08 ,  A61B5/091

CPC classification number: A61N1/205 ,  A61B5/04001 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/087 ,  A61B5/091 ,  A61B5/14542 ,  A61B5/4035 ,  A61B5/4836 ,  A61N1/36053 ,  A61N1/36057 ,  A61N1/3611 ,  A61N1/36171

Abstract: The present invention provides devices and methods that can prevent or ameliorate bronchoconstriction by stimulating neural activity, in contrast to those techniques based on denervation, ablation or blocking of neural activity. Methods and devices according to the invention may act responsively or on demand, can preserve neuronal structure and function and will be associated with minimal collateral side-effects. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve, for example the cervical vagus nerve or the pulmonary branch of the vagus nerve, in order to stimulate neural activity in the vagal nerve.

公开(公告)号：US20170333708A1

公开(公告)日：2017-11-23

申请号：US15523914

申请日：2015-11-03

Applicant: GALVANI BIOELECTRONICS LIMITED ,  FACULDADE DE CIÊNCIAS MÉDICAS DA UNIVERSIDADA NOVA DE LISBOA

Inventor： Silvia Margarida Vilares Santos CONDE ,  Daniel John CHEW ,  Hans Jakob Kristoffer FAMM ,  Maria Pedro Sucena GUARINO ,  Brad HOLINSKI ,  Sonal PATEL

IPC: A61N1/36 ,  A61B18/12 ,  A61N1/05 ,  A61B18/00

CPC classification number: A61N1/3606 ,  A61B18/12 ,  A61B2018/00434 ,  A61N1/05 ,  A61N1/36

Abstract: The invention refers to a device for inhibiting the neural activity of a carotid sinus nerve (CSN) or carotid body of a subject, the device comprising: one or more transducers configured to apply a signal to the CSN or associated carotid body of the subject, optionally at least two such transducers; and a controller coupled to the one or more transducers, the controller controlling the signal to be applied by the one or more transducers, such that the signal inhibits the neural activity of the CSN or carotid body to produce a physiological response in the subject, wherein the physiological response is one or more of the group consisting of: an increase in insulin sensitivity in the subject, an increase in glucose tolerance in the subject, a decrease in (fasting) plasma glucose concentration in the subject, a reduction in subcutaneous fat content in the subject, and a reduction in obesity in the subject.