公开(公告)号：US12186368B2

公开(公告)日：2025-01-07

申请号：US16825221

申请日：2020-03-20

Applicant: The Regents of the University of California

Inventor： Michael E. Selsted ,  Dat Q. Tran

IPC: A61K38/17 ,  A61K9/00 ,  A61K38/10 ,  A61K38/12 ,  A61K38/55 ,  C07K14/47 ,  F01P5/04 ,  F24F5/00 ,  F24F6/16 ,  B63J3/00

Abstract: A method is provided for a condition related to the activity of a protease through the administration of a θ-defensin, analog, or derivative is described. Suitable proteases include metalloproteases and cysteine proteases such as Cathepsin-C. The θ-defensin, analog, or derivative can be effectively administered parenterally, topically, or orally.

公开(公告)号：US20250006989A1

公开(公告)日：2025-01-02

申请号：US18882544

申请日：2024-09-11

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Ping Liu ,  Yejing Li

IPC: H01M10/0565 ,  H01M4/134 ,  H01M10/0562 ,  H01M50/414 ,  H01M50/434 ,  H01M50/449 ,  H01M50/497

Abstract: A solid-state battery and process of forming the same is provided. The solid-state battery includes a first electrode. The solid-state battery includes a first mixed conductor disposed on the first electrode. The first mixed conductor includes a mixture of ionic and electronic conductors. The solid-state battery includes an ionic conductor disposed on the first mixed conductor. The solid-state battery includes a second electrode disposed on top of the ionic conductor disposed on the first mixed conductor.

公开(公告)号：US20250003953A1

公开(公告)日：2025-01-02

申请号：US18580417

申请日：2022-07-22

Applicant: The Regents of the University of California

Inventor： Hani Goodarzi ,  Johnny Yu

IPC: G01N33/50 ,  C12N5/00 ,  C12Q1/6869 ,  G16B20/00 ,  G16B25/10

Abstract: Provided herein are in-vitro, in-vivo, and ex-vivo models systems, methods of creating such model systems, and methods of using such model systems for assessing one or more therapeutic properties of a candidate agent or identifying a new therapeutic target. Also provided are computer-readable media and systems that find use, e.g., in practicing the methods of the present disclosure.

公开(公告)号：US20250001592A1

公开(公告)日：2025-01-02

申请号：US18761149

申请日：2024-07-01

Applicant: The Regents of the University of California

Inventor： Dennis Hong ,  Taoyuanmin Zhu ,  Gabriel Ikaika Fernandez

IPC: B25J9/16 ,  B25J15/00 ,  B62D57/032

Abstract: Arm-like robots and systems and methods that can move objects using multiple cooperating robots in accordance with various embodiments of the invention are described. In one embodiment, the arm-like robot includes a body having two ends, where the body comprises a plurality of actuated joints. In addition, the arm-like robot can include end-effectors attached at each end of the body, where each of the end-effectors is capable of both anchoring the arm-like robot to form a base and connecting to an object. The arm-like robot can also include at least one controller configured to control motion of the plurality of actuated joints and end-effectors so that one of the end-effectors can anchor the arm-like robot and form a base and the other end-effector can connect to a target object.

公开(公告)号：US12180583B2

公开(公告)日：2024-12-31

申请号：US18062274

申请日：2022-12-06

Applicant: The Regents of the University of California ,  Merck Patent GmbH

Inventor： Andrew Kummel ,  Cheng-Hsuan Kuo ,  SeongUk Yun ,  Ravindra Kanjolia ,  Mansour Moinpour ,  Daniel Moser

IPC: C23C16/30 ,  C23C16/04 ,  C23C16/34 ,  C23C16/52

Abstract: A method of forming a conformal layer including TiN in a via includes introducing a precursor into a reaction chamber according to a first exposure schedule. The precursor includes non-halogenated metal-organic titanium. The first exposure schedule indicates precursor exposure periods. Each precursor exposure period is associated with a particular duration of time and a particular duty cycle over which to introduce the precursor during the particular duration of time. The method includes introducing a co-reactant into the reaction chamber according to a second exposure schedule. The co-reactant includes nitrogen. The second exposure schedule indicates co-reactant exposure periods. Each co-reactant exposure period is associated with a particular duration of time and a particular duty cycle over which to introduce the co-reactant during the particular duration of time. The method includes providing the conformal layer including TiN in the via based on said introducing the precursor and the co-reactant.

公开(公告)号：US12180516B2

公开(公告)日：2024-12-31

申请号：US18049221

申请日：2022-10-24

Applicant: The Regents of the University of California

Inventor： James U. Bowie ,  Meaghan Valliere ,  Tyler P. Korman ,  Nicholas Woodall

IPC: C12N9/10 ,  C12P7/22 ,  C12P7/42 ,  C12P9/00 ,  C12P17/06

Abstract: Provided is an enzyme useful for prenylation and recombinant pathways for the production of cannabinoids, cannabinoid precursors and other prenylated chemicals in a cell free system as well and recombinant microorganisms that catalyze the reactions.

公开(公告)号：US12179199B2

公开(公告)日：2024-12-31

申请号：US16988179

申请日：2020-08-07

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Abraham P. Lee ,  Xuan Li

IPC: B01L3/00

Abstract: A microfluidic device having an array for cell trapping is used to analyze cell-cell interaction at single-cell level. The microfluidic trapping array efficiently pairs single cells in isolated compartments in an easy-to-operate manner. A first cell is squeezed through an opening of a first cavity by a strong forward flow. Subsequently, a second cell is pushed into a second cavity by a low reverse flow. The trapped cell pairs are sealed by an oil phase or hydrogel into isolated compartments, thereby eliminating interference from other cell pairs or the surrounding media.

公开(公告)号：US12178887B2

公开(公告)日：2024-12-31

申请号：US18160202

申请日：2023-01-26

Applicant: CITY OF HOPE ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Paul Yazaki ,  Jack Shively ,  Michael Bouvet ,  Jonathan Delong ,  Yuman Fong

IPC: A61K49/00 ,  A61B5/00 ,  A61B6/03 ,  A61B6/40 ,  A61B34/20 ,  A61K39/00 ,  A61K51/10 ,  C07K16/30

Abstract: Disclosed is a tumor-specific antibody and fluorophore conjugate for detecting, localizing and imaging of various tumors. Also disclosed are methods for detecting, localizing and imaging a solid tumor before or during a tumor resection surgery using the antibody-fluorophore conjugate.

公开(公告)号：US12178422B2

公开(公告)日：2024-12-31

申请号：US17894861

申请日：2022-08-24

Applicant: The Regents of the University of California

Inventor： Shanglei Liu ,  Mohamad Ramzi Abdul Majit ,  Santiago Horgan ,  Michael Tolley ,  William Weston-Dawkes ,  Esmeralda Ochoa

IPC: A61B17/02 ,  A61B17/00

Abstract: A retraction device, e.g., a programmable stiffness state tissue displacement device, for providing increased visibility during an operation is provided. The device includes one or more strips of compliant jammable layer components connected in parallel, and encapsulated within a flexible envelope such that each of the one or more strips of compliant jammable layer components are pneumatically connected. The device further includes a negative pressure pump coupled to the flexible envelope, such that the application of negative pressure to the flexible envelope by the negative pressure pump causes the one or more strips of compliant jammable layer components to jam and thereby transition the retraction device from a malleable state to a rigid state.

公开(公告)号：US20240428456A1

公开(公告)日：2024-12-26

申请号：US18749898

申请日：2024-06-21

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Saad Manzur ,  Wayne Brian HAYES

IPC: G06T7/73 ,  G06T15/20

Abstract: A device receives a real image (e.g., photograph or video frame) that includes a human. The device creates a synthetic image corresponding to the real image. The synthetic image includes a synthetic environment and a humanoid shape that correspond to the human. The device predicts, using a trained viewpoint neural network and based on the synthetic image, a predicted viewpoint heatmap. The device predicts, using a trained pose neural network and based on the synthetic image, a predicted pose heatmap. The device provides, as input to a random synthetic environment, the predicted viewpoint heatmap and the predicted pose heatmap and creates a reconstructed three-dimensional pose based on the predicted viewpoint heatmap, the predicted pose heatmap, and the random synthetic environment. The device classifies the reconstructed three-dimensional pose as a particular type of pose of the human in the real image.