公开(公告)号：US11733500B2

公开(公告)日：2023-08-22

申请号：US17266475

申请日：2019-08-16

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Wu Chou ,  Ji Qi ,  Jun Tian ,  Yuecheng Zhang ,  Mingquan Wu

IPC: H04N23/51 ,  H04N23/55 ,  G02B21/00 ,  G06T7/90 ,  G06N20/00 ,  G01J3/52

CPC classification number: G02B21/0008 ,  G01J3/524 ,  G02B21/0032 ,  G06N20/00 ,  G06T7/90 ,  H04N23/51 ,  H04N23/55

Abstract: Disclosed is an apparatus and method for imaging: a side-view of a object on a surface, a Contact Angle of a liquid object, the color of an object, or combinations thereof.

公开(公告)号：US20230219084A1

公开(公告)日：2023-07-13

申请号：US18121534

申请日：2023-03-14

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Hua Tan ,  Yufan Zhang

IPC: B01L3/00 ,  B01L7/00 ,  C12Q1/686

CPC classification number: B01L3/502715 ,  B01L7/52 ,  C12Q1/686 ,  B01L2300/123 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/1805 ,  B01L2200/021

Abstract: Among other things, the present invention is related to devices and methods of performing biological and chemical assays, particularly an easy sample manipulation and/or a rapid change or a rapid thermal cycling of a sample temperature is needed (e.g. Polymerase Chain Reaction (PCR) for amplifying nucleic acids).

公开(公告)号：US11692927B2

公开(公告)日：2023-07-04

申请号：US17295562

申请日：2019-11-20

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding

IPC: G01N33/543 ,  G01N15/14 ,  G01N15/00 ,  G01N15/10

CPC classification number: G01N15/1463 ,  G01N33/54306 ,  G01N2015/008 ,  G01N2015/0038 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2333/4737

Abstract: The present invention provides diagnostic devices and methods for quantifying the amounts of an acute phase reactant (e.g., C-reactive protein (CRP) or serum amyloid A (SAA)) in a body fluid sample and/or white blood cell counts in blood sample. In particular, the present invention provides a rapid assay to detect CRP, SAA, and/or white blood cells in blood with high sensitivity and specificity.

公开(公告)号：US20230078084A1

公开(公告)日：2023-03-16

申请号：US17985654

申请日：2022-11-11

Applicant: Essenlix Corporation

Inventor： Ji Qi ,  Stephen Y. Chou ,  Wei Ding

IPC: G01N21/64

Abstract: A multi-mode illumination system, including: a first illumination module; a second illumination module; and a third illumination module, as disclosed herein.

公开(公告)号：US11604148B2

公开(公告)日：2023-03-14

申请号：US16483729

申请日：2018-02-09

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi

IPC: G01N21/78 ,  G01N21/01 ,  G01N21/25 ,  G01N33/52

Abstract: A device and a method of using the device for improving sensitivity, speed, and easy-to-use of a colorimetric assay of a liquid sample are provided. The device includes a first plate and a second plate, spacers, and a textured surface. The two plates each have a sample contact surface and are movable relative to each other into an open configuration or a closed configuration. The sample is deposited on one or both plates in the open configuration. Thereafter, the closed configuration is formed where the plates compress at least part of the deposited sample into a continuous layer. The textured surface is disposed on the sample contact surface of the second plate and has a textured structure that scatters light, from which an optical signal such as a colorimetric or fluorescent signal can be obtained for analyzing the sample.

公开(公告)号：US11536941B2

公开(公告)日：2022-12-27

申请号：US17424123

申请日：2020-02-14

Applicant: Essenlix Corporation

Inventor： Ji Qi ,  Stephen Y. Chou ,  Wei Ding

IPC: G02B21/08 ,  G01N21/64 ,  F21V8/00

Abstract: A device, including: an end-emitting optical fiber including a first end and a second end; a light extraction plate including a light scattering structure; and a light diffuser film disposed above the light scattering structure. Also disclosed are systems including the device.

公开(公告)号：US20220407988A1

公开(公告)日：2022-12-22

申请号：US17896973

申请日：2022-08-26

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Jun Tian ,  Wei Dong

IPC: H04N5/225 ,  G01N21/84

Abstract: The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.

公开(公告)号：US11326989B2

公开(公告)日：2022-05-10

申请号：US16758938

申请日：2018-10-26

Applicant: Essenlix Corporation

Inventor： Stephen Chou ,  Wei Ding ,  Ji Li

IPC: G01N33/50 ,  G01N1/31 ,  G01N1/36 ,  G06K9/00 ,  H04M1/72409 ,  G01N1/30 ,  G01N21/76

Abstract: Devices and systems are provided herein relating to a novel and rapid assay for tissue staining. Methods for using the devices and systems for analyzing tissue samples are also disclosed.

公开(公告)号：US11237113B2

公开(公告)日：2022-02-01

申请号：US16172472

申请日：2018-10-26

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yuecheng Zhang

IPC: G01N21/80 ,  G06T7/00 ,  G06T7/90 ,  H04B1/3888 ,  G06K9/00 ,  G01N21/77 ,  G01N21/03

Abstract: Among other things, certain embodiments of the present disclosure are related to devices and methods of performing biological and chemical assays, such as but not limited to pH measurement of bio/chemical samples.

公开(公告)号：US20210138474A1

公开(公告)日：2021-05-13

申请号：US17150730

申请日：2021-01-15

Applicant: Essenlix Corporation

Inventor： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Hua Tan

IPC: B01L7/00 ,  C12Q1/686

Abstract: The present invention provides devices, systems, and methods for rapid and easy-to-use in sample thermal cycling or temperature changes for the facilitation of reactions such as but not limited to PCR.