公开(公告)号：US11927560B2

公开(公告)日：2024-03-12

申请号：US16484256

申请日：2018-02-08

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang

IPC分类号： G01N27/403 ,  B01L3/00 ,  G01N1/28 ,  G01N1/38 ,  G01N21/84 ,  G01N33/49 ,  G01N33/543 ,  G01N35/00

CPC分类号： G01N27/403 ,  B01L3/502761 ,  G01N1/2813 ,  G01N1/286 ,  G01N1/38 ,  G01N21/8483 ,  G01N33/4905 ,  G01N33/5438 ,  G01N35/00 ,  B01L2200/0668 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0415

摘要： Described are methods and devices that can accelerate the process and quantify the parameters for bio/chemical material samples. In some embodiments, a QMAX (Q: quantification; M: magnifying; A: adding reagents; X: acceleration) device having two or more electrodes capable of accelerating the electrical measurement process of the samples. In addition, the electrical measurement technology of the QMAX device enables for extraction, separation, and purification of sample components, such as but not limited to nucleic acids. In some embodiments, the QMAX device includes a plate for hosting a small sensing chip to facilitate a bio/chemical sensing of the sensing chip.

公开(公告)号：US11796538B2

公开(公告)日：2023-10-24

申请号：US17300945

申请日：2021-12-15

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Ji Li ,  Yufan Zhang

IPC分类号： G01N1/00 ,  G01N33/543 ,  G01N1/28 ,  G01N1/02

CPC分类号： G01N33/54386 ,  G01N1/2813 ,  G01N2001/028

摘要： The present invention provides devices, systems, and methods, for performing biological and chemical assays.

公开(公告)号：US11648551B2

公开(公告)日：2023-05-16

申请号：US16772396

申请日：2018-12-12

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Hua Tan ,  Yufan Zhang

IPC分类号： B01L3/00 ,  B01L7/00 ,  C12Q1/686

CPC分类号： B01L3/502715 ,  B01L7/52 ,  C12Q1/686 ,  B01L2200/021 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2300/123 ,  B01L2300/1805

摘要： Among other things, the present invention is related to devices and methods of performing biological and chemical assays, particularly an easy sample manipulation and/or a rapid change or a rapid thermal cycling of a sample temperature is needed (e.g. Polymerase Chain Reaction (PCR) for amplifying nucleic acids).

公开(公告)号：US11567066B2

公开(公告)日：2023-01-31

申请号：US17478595

申请日：2021-09-17

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Ji Li ,  Yufan Zhang

IPC分类号： G01N33/543 ,  C12Q1/6804 ,  C12Q1/6869 ,  G06V20/69

摘要： Among other things, the present disclosure is related to devices and methods of performing biological and chemical assays, such as but not limited to immunoassays and nucleic assay acid, particularly a homogeneous assay that does not use a wash step and that is fast (e.g., 60 seconds from dropping a sample to displaying results). The present disclosure is related to both competitive and non-competitive homogeneous assays.

公开(公告)号：US11523752B2

公开(公告)日：2022-12-13

申请号：US16485126

申请日：2018-02-16

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi

IPC分类号： A61B5/097 ,  A61B5/083 ,  A61B5/00 ,  G01N1/22 ,  G01N1/30 ,  G01N1/31 ,  G01N33/543 ,  G01N33/497 ,  G16H10/40 ,  G16H40/67 ,  B01L3/00 ,  G01N21/01 ,  G01N21/27 ,  G01N21/64 ,  G01N21/78 ,  G06Q40/08 ,  G01N21/17

摘要： The present invention relates to provide, among other things, the methods, devices, and systems that can simply and quickly collecting and analyzing a tiny amount of vapor condensates (e.g. exhaled breath condensate (EBC)).

公开(公告)号：US11408028B2

公开(公告)日：2022-08-09

申请号：US16483833

申请日：2018-02-08

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Yufan Zhang ,  Ji Li

IPC分类号： C12Q1/68 ,  C12Q1/6837 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/686 ,  G01N21/65

摘要： Provided herein is a method and device for performing a homogeneous nucleic acid detection assay. The device can contain a pair of plates where one of the plates comprises (i) surface amplification surface; and (ii) target-specific nucleic acid probes that are immobilized on said amplification surface and that specifically binds to a part of the target nucleic acid; and the second plate comprises a sample contact area comprising a reagent storage site that comprises target-specific nucleic acid detection agents that specifically binds to another part of the target nucleic acid. In some embodiments, the device can be read without a washing unbound label from the surface of the device.

公开(公告)号：US20200038859A1

公开(公告)日：2020-02-06

申请号：US16484620

申请日：2018-02-08

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang

IPC分类号： B01L3/00 ,  C12Q1/686 ,  G01N33/53

摘要： Provided herein is a method and device for partitioning a fluidic sample. The device contains a plate containing microwells. The method comprises depositing a sample on one or both of the plates when the plates are in an open configuration, wherein the deposition is in the form of a single or multiple droplet of the sample, wherein at least one of the droplets has a volume that occupies more than two microwells and closing the plates to the closed configuration to partition the sample in the microwells.

公开(公告)号：US12120407B2

公开(公告)日：2024-10-15

申请号：US17896973

申请日：2022-08-26

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Jun Tian ,  Wei Dong

IPC分类号： H04N23/51 ,  G01N21/84 ,  H04N23/55 ,  H04N23/56 ,  H04N23/57

CPC分类号： H04N23/51 ,  G01N21/8483 ,  H04N23/55 ,  H04N23/56 ,  H04N23/57

摘要： The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.

公开(公告)号：US11940382B2

公开(公告)日：2024-03-26

申请号：US16484803

申请日：2018-02-08

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Ji Li

IPC分类号： G01N21/65 ,  G01N21/64 ,  G01N21/66 ,  G01N33/543 ,  G01N33/58

CPC分类号： G01N21/65 ,  G01N21/64 ,  G01N21/66 ,  G01N33/54366 ,  G01N33/582 ,  G01N2201/06113

摘要： A homogeneous assay method that employs a device is provided. In some embodiments, the device contains a pair of plates that can be opened and closed. The sample is placed between two plates. In some embodiments, the thickness of the sample in a closed configuration, the concentration of labels, and amplification factor of the amplification surface are configured to make the label(s) bound on the amplification surface visible without washing away of the unbound labels.

公开(公告)号：US11369968B2

公开(公告)日：2022-06-28

申请号：US17150730

申请日：2021-01-15

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Hua Tan

IPC分类号： B01L7/00 ,  C12Q1/68 ,  C12Q1/686

摘要： The present invention provides devices, systems, and methods for rapid and easy-to-use in sample thermal cycling or temperature changes for the facilitation of reactions such as but not limited to PCR.