公开(公告)号：US20240309369A1

公开(公告)日：2024-09-19

申请号：US18388193

申请日：2023-11-09

申请人： Essenlix Corporation

发明人： Stephen Y. CHOU ,  Wei DING ,  Ji QI ,  Jun Tian ,  Wu Chou

IPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/54 ,  A61P31/04

CPC分类号： C12N15/113 ,  A61K31/7088 ,  A61K45/06 ,  A61K47/554 ,  A61P31/04 ,  C12N15/1137 ,  C12N2310/127 ,  C12N2310/3515 ,  C12Y305/02006

摘要： Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.

公开(公告)号：US11933720B2

公开(公告)日：2024-03-19

申请号：US17621216

申请日：2020-06-22

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Jun Tian ,  Wu Chou ,  Hongbing Li

IPC分类号： G01N21/31 ,  G01N21/03

CPC分类号： G01N21/31 ,  G01N21/03 ,  G01N2021/0346 ,  G01N2021/3129

摘要： The disclosure provides an apparatus, a device, and methods for improving optical analysis of a thin layer of a sample between two plates, particularly for multiple wavelengths.

公开(公告)号：US11733151B2

公开(公告)日：2023-08-22

申请号：US17284083

申请日：2020-04-06

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wu Chou ,  Xing Li ,  Hongbing Li ,  Yuecheng Zhang ,  Mingquan Wu ,  Wei Ding ,  Jun Tian

IPC分类号： G01N15/14 ,  G06T7/62 ,  G06T7/00 ,  G06T7/40 ,  G06T7/10 ,  G06N20/00

CPC分类号： G01N15/1475 ,  G06N20/00 ,  G06T7/0012 ,  G06T7/10 ,  G06T7/40 ,  G06T7/62 ,  G06T2207/10056 ,  G06T2207/30004 ,  G06T2207/30024 ,  G06T2207/30204

摘要： The present invention is related to, among other things, the devices and methods that improve the accuracy and reliability of an assay, even when the assay device and/or the operation of the assay device has certain errors, and in some embodiments the errors are random.

公开(公告)号：US11846582B2

公开(公告)日：2023-12-19

申请号：US17858931

申请日：2022-07-06

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Jun Tian ,  Wu Chou

IPC分类号： G01N21/03 ,  G01N1/28 ,  G01N21/25 ,  G01N21/64 ,  G01N33/49

CPC分类号： G01N21/0303 ,  G01N1/2813 ,  G01N21/25 ,  G01N21/6458 ,  G01N33/49 ,  G01N2021/035 ,  G01N2021/6439 ,  G01N2201/0221

摘要： Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.

公开(公告)号：US11463608B2

公开(公告)日：2022-10-04

申请号：US17179319

申请日：2021-02-18

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Qi ,  Jun Tian ,  Wei Dong

IPC分类号： H04N5/225 ,  G01N21/84

摘要： The present disclosure relates to devices, apparatus and methods of improving the accuracy of an image-based assay. One aspect of the present invention is to sandwich a sample between two plates and add reference marks in the sample areas of the plates, with at least one of the geometric and/optical properties of the reference marks being predetermined and known, and taking images of the sample with the reference marks, and applying a machine learning model in the analysis of the image-based assay.

公开(公告)号：US20210140957A1

公开(公告)日：2021-05-13

申请号：US16621185

申请日：2018-06-12

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Yufan Zhang ,  Ji Li ,  Ji Qi ,  Jun Tian

IPC分类号： G01N33/543 ,  G06T7/00

摘要： Among other things, the present invention is related to devices and methods of performing biological and chemical assays, such as but not limited to immunoassays and nucleic assay acid, particularly the homogeneous assay that does not use the step of wash and that is fast (e.g. 60 seconds from dropping a sample to displaying results).

公开(公告)号：US10955334B2

公开(公告)日：2021-03-23

申请号：US16771502

申请日：2018-12-14

申请人： Essenlix Corporation

发明人： Stephen Chou ,  Wei Ding ,  Ji Qi ,  Jun Tian ,  Wu Chou

IPC分类号： G01N21/03 ,  G01N1/28 ,  G01N21/25 ,  G01N21/64 ,  G01N33/49

摘要： Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.

公开(公告)号：US20200378886A1

公开(公告)日：2020-12-03

申请号：US16771502

申请日：2018-12-14

申请人： Essenlix Corporation

发明人： Stephen CHOU ,  Wei DING ,  Ji QI ,  Jun Tian ,  Wu Chou

IPC分类号： G01N21/03 ,  G01N21/25 ,  G01N21/64 ,  G01N33/49 ,  G01N1/28

摘要： Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between containing between two plates.

公开(公告)号：US20240159999A1

公开(公告)日：2024-05-16

申请号：US18539243

申请日：2023-12-13

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Yuechang Zhang ,  Wu Chou ,  Mingquan Wu ,  Xing Li ,  Jun Tian

IPC分类号： G02B21/34 ,  G01N33/543

CPC分类号： G02B21/34 ,  G01N33/54386 ,  G01N33/5094 ,  G01N2496/05

摘要： A method of assaying an analyte in a sample is disclosed. The method includes having a sample holder with a sample contact area for contacting a sample with an analyte, having a plurality of calibration structures on the sample contact area of the sample holder, imaging a part of the sample contact area that has the calibration structures, and using an algorithm that includes an image, calibration structures in the image, and artificial intelligence and/or machine learning to identify the analyte and/or determine the analyte concentration.

公开(公告)号：US11415504B2

公开(公告)日：2022-08-16

申请号：US17175585

申请日：2021-02-12

申请人： Essenlix Corporation

发明人： Stephen Y. Chou ,  Wei Ding ,  Ji Qi ,  Jun Tian ,  Wu Chou

IPC分类号： G01N21/03 ,  G01N1/28 ,  G01N21/25 ,  G01N21/64 ,  G01N33/49

摘要： Among other things, the present invention is related to devices and methods for improving optical analysis of a thin layer of a sample sandwiched between two plates.