公开(公告)号：US20130166672A1

公开(公告)日：2013-06-27

申请号：US13334237

申请日：2011-12-22

申请人： Bruce L. Beukema ,  Patrick M. Bland ,  Randolph S. Kolvick ,  James A. Marcella ,  Makoto Ono ,  Paul G. Reuland

发明人： Bruce L. Beukema ,  Patrick M. Bland ,  Randolph S. Kolvick ,  James A. Marcella ,  Makoto Ono ,  Paul G. Reuland

IPC分类号： G06F15/167

CPC分类号： G06F15/167

摘要： A computing system with physically remote shared computer memory, the computing system including: a remote memory management module, a plurality of computing devices, a plurality of remote memory modules that are external to the plurality of computing devices, and a remote memory controller, the remote memory management module configured to partition the physically remote shared computer memory amongst a plurality of computing devices; each computing device including a computer processor and a local memory controller, the local memory controller including: a processor interface, a local memory interface, and a local interconnect interface; each remote memory controller including: a remote memory interface and a remote interconnect interface, wherein the remote memory controller is operatively coupled to the data communications interconnect via the remote interconnect interface such that the remote memory controller is coupled for data communications with the local memory controller over the data communications interconnect.

摘要翻译： 一种具有物理上远程共享计算机存储器的计算系统，所述计算系统包括：远程存储器管理模块，多个计算设备，在所述多个计算设备外部的多个远程存储器模块以及远程存储器控制器， 远程存储器管理模块被配置为在多个计算设备之间划分物理上远程的共享计算机存储器; 每个计算设备包括计算机处理器和本地存储器控制器，所述本地存储器控制器包括：处理器接口，本地存储器接口和本地互连接口; 每个远程存储器控制器包括：远程存储器接口和远程互连接口，其中远程存储器控制器经由远程互连接口可操作地耦合到数据通信互连，使得远程存储器控制器被耦合用于与本地存储器控制器的数据通信 通过数据通信互连。

公开(公告)号：US20130137723A1

公开(公告)日：2013-05-30

申请号：US13814534

申请日：2011-08-05

申请人： Makoto Ono

发明人： Makoto Ono

IPC分类号： A61K31/4709 ,  C07D401/02

CPC分类号： A61K31/4709 ,  C07D401/04

摘要： It is intended to provide a salt of a compound and crystals thereof useful as a therapeutic and/or preventive agent for infectious diseases which has wide and excellent antibacterial activity and has excellent safety.[Solution]The present invention provides the hydrochloride of 7-[(1R,5S)-1-amino-5-fluoro-3-azabicyclo[3.3.0]octan-3-yl]-6-fluoro-1-[(1R,2S)-2-fluorocyclopropan-1-yl]-1,4-dihydro-8-methyl-4-oxoquinoline-3-carboxylic acid and crystals thereof, as a novel salt form of the compound and crystals thereof.

公开(公告)号：US08394821B2

公开(公告)日：2013-03-12

申请号：US13181596

申请日：2011-07-13

申请人： Makoto Ono

发明人： Makoto Ono

IPC分类号： C07D215/38 ,  A61K31/04

CPC分类号： C07D513/04 ,  A61K31/444

摘要： An object of the present invention is to provide a novel salt form of a compound that exhibits an inhibitory effect on activated blood coagulation factor X, and is useful as a preventive and/or therapeutic drug for thrombotic diseases, and crystals thereof. The present invention provides N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)ethanediamide tartrate and crystals thereof, as a novel salt form of N1-(5-chloropyridin-2-yl)-N2-((1S,2R,4S)-4-[(dimethylamino)carbonyl]-2-{[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]amino}cyclohexyl)ethanediamide and crystals thereof.

摘要翻译： 本发明的目的是提供对活化凝血因子X具有抑制作用的化合物的新型盐形式，可用作血栓性疾病的预防和/或治疗药物及其结晶。 本发明提供N1-（5-氯吡啶-2-基）-N2 - （（1S，2R，4S）-4 - [（二甲基氨基）羰基] -2 - {[（5-甲基-4,5,6 ，7-四氢噻唑并[5,4-c]吡啶-2-基）羰基]氨基}环己基）乙二胺酒石酸盐及其晶体，作为N1-（5-氯吡啶-2-基）-N2-（ （1S，2R，4S）-4 - [（二甲基氨基）羰基] -2 - {[（5-甲基-4,5,6,7-四氢噻唑并[5,4-c]吡啶-2-基）羰基] 氨基}环己基）乙二胺及其晶体。

公开(公告)号：US20130019048A1

公开(公告)日：2013-01-17

申请号：US13183776

申请日：2011-07-15

申请人： Patrick M. Bland ,  Dhruv M. Desai ,  Jimmy G. Foster, SR. ,  Makoto Ono

发明人： Patrick M. Bland ,  Dhruv M. Desai ,  Jimmy G. Foster, SR. ,  Makoto Ono

IPC分类号： G06F12/02

CPC分类号： G06F9/3824 ,  G06F3/061 ,  G06F3/0659 ,  G06F3/0679 ,  G06F12/0868 ,  G06F12/0891 ,  G06F2212/1016 ,  G06F2212/305 ,  G06F2212/311

摘要： Methods, apparatuses, and computer program products for memory access to a dual in-line memory module (DIMM) form factor flash memory are provided. Embodiments include receiving, by a controller from a processor through cacheable memory in the processor, a read request; transmitting, by the controller, the read request to the DIMM form factor flash memory; polling, by the controller, a read queue in the DIMM form factor flash memory until data is ready for the read request; copying from the DIMM form factor flash memory, by the controller, the data corresponding to the read request to a read queue in the controller; transmitting, by the controller on an interface between the controller and the processor, an invalidate command for the cacheable memory; and in response to receiving the invalidate command, reading by the processor the data stored in the read queue in the controller.

摘要翻译： 提供了用于存储器访问双列直插存储器模块（DIMM）形状因子闪存的方法，装置和计算机程序产品。 实施例包括由控制器从处理器通过处理器中的可缓存存储器接收读取请求; 由控制器将读请求传送到DIMM外形闪存; 由控制器轮询DIMM形状因子闪存中的读取队列，直到数据准备好读取请求; 通过控制器将与DIMM读写请求对应的数据从DIMM形状因子闪存复制到控制器中的读取队列; 由控制器在控制器和处理器之间的接口上发送用于可缓存存储器的无效命令; 并且响应于接收到无效命令，由处理器读取存储在控制器中的读取队列中的数据。

公开(公告)号：US20120117010A1

公开(公告)日：2012-05-10

申请号：US13376390

申请日：2010-07-08

申请人： Makoto Ono ,  Yohei Minekawa ,  Junko Konishi ,  Takehiro Hirai ,  Yuya Isomae

发明人： Makoto Ono ,  Yohei Minekawa ,  Junko Konishi ,  Takehiro Hirai ,  Yuya Isomae

IPC分类号： G06F15/18

CPC分类号： G06T7/001 ,  G06T2207/10056 ,  G06T2207/20076 ,  G06T2207/30148

摘要： Disclosed is a technique wherein an object that requires adjustment in order to increase the reliability of automatic classification can be easily identified. A device (140) for adjusting classification classifies defects into a first class group according to the feature amount of the defects that are obtained from image data obtained from an electron microscope (110), and classifies the defects into a second class group according to the feature amount of the defects classified into the first class group. And, the device (140) for adjusting the classification calculates classification performance by comparing the defects that have been classified into the second class group, and outputs the calculated classification performance in a predetermined display format to an output unit (180).

摘要翻译： 公开了一种技术，其中可以容易地识别为了增加自动分类的可靠性而需要调整的对象。 用于调整分类的装置（140）根据从电子显微镜（110）获得的图像数据获得的缺陷的特征量，将缺陷分类为第一类别组，并根据 分类为第一类组的缺陷的特征量。 并且，用于调整分类的装置（140）通过比较已分类为第二类组的缺陷，并将计算出的分类性能以预定显示格式输出到输出单元（180）来计算分类性能。

公开(公告)号：US20110276162A1

公开(公告)日：2011-11-10

申请号：US13131141

申请日：2009-11-04

申请人： Youichi Nonaka ,  Makoto Ono ,  Hisaya Ishibashi ,  Attila Lengyel ,  Yuuichi Suginishi ,  Tomotoshi Ishida

发明人： Youichi Nonaka ,  Makoto Ono ,  Hisaya Ishibashi ,  Attila Lengyel ,  Yuuichi Suginishi ,  Tomotoshi Ishida

IPC分类号： G06F19/00

CPC分类号： G06Q10/109

摘要： Disclosed are a device, a system, and a method for setting standard work times that take real-world manufacturing capabilities into account. Provided is a standard work time calculation device (10), which analyzes fluctuations in production line assessment indices on a per time period basis, and computes standard work times for each region, as classified according to the degree of fluctuation. The standard work time calculation device (10) comprises a fluctuation coefficient computation unit (111), which computes coefficients of fluctuation for the assessment indices, a fluctuation region identification unit (112), which identifies regions of fluctuation with coefficients of fluctuation that are greater than or equal to predetermined thresholds, and a standard work time computation unit (113), which computes standard work times for regions of fluctuation.

摘要翻译： 公开了一种设备，系统和方法，用于设定将实际制造能力纳入考量的标准工作时间。 提供了一种标准工​​作时间计算装置（10），其根据每个时间段分析生产线评估指标的波动，并且根据波动程度分类计算每个区域的标准工作时间。 标准工作时间计算装置（10）包括：计算评价指标的波动系数的变动系数计算部（111）;波动区域识别部（112），其识别出波动范围大的变动范围大于 大于或等于预定阈值的标准工作时间计算单元（113），其计算波动区域的标准工作时间。

公开(公告)号：US07893279B2

公开(公告)日：2011-02-22

申请号：US12574907

申请日：2009-10-07

申请人： Makoto Ono ,  Shigeru Noguchi

发明人： Makoto Ono ,  Shigeru Noguchi

IPC分类号： C07D209/02

CPC分类号： C07D403/12

摘要： The present invention provides a VLA-4 inhibitor having high water-solubility and excellent long-term stability; i.e., sodium trans-4-[1-[2,5-dichloro-4-[(1-methyl-1H-3-indolylcarbonyl)amino]phenylacetyl]-(4S)-methoxy-(2S)-pyrrolidinylmethoxy]cyclohexanecarboxylate pentahydrate.

摘要翻译： 本发明提供了具有高水溶性和优异的长期稳定性的VLA-4抑制剂; 即反式-4- [1- [2,5-二氯-4 - [（1-甲基-1H-吲哚基羰基）氨基]苯基乙酰基] - （4S） - 甲氧基 - （2S） - 吡咯烷基甲氧基]环己烷羧酸酯五水合物 。

公开(公告)号：US07576135B2

公开(公告)日：2009-08-18

申请号：US10540259

申请日：2003-12-25

申请人： Toshiharu Ohta ,  Satoshi Komoriya ,  Toshiharu Yoshino ,  Kouichi Uoto ,  Yumi Nakamoto ,  Hiroyuki Naito ,  Akiyoshi Mochizuki ,  Tsutomu Nagata ,  Hideyuki Kanno ,  Noriyasu Haginoya ,  Kenji Yoshikawa ,  Masatoshi Nagamochi ,  Syozo Kobayashi ,  Makoto Ono

发明人： Toshiharu Ohta ,  Satoshi Komoriya ,  Toshiharu Yoshino ,  Kouichi Uoto ,  Yumi Nakamoto ,  Hiroyuki Naito ,  Akiyoshi Mochizuki ,  Tsutomu Nagata ,  Hideyuki Kanno ,  Noriyasu Haginoya ,  Kenji Yoshikawa ,  Masatoshi Nagamochi ,  Syozo Kobayashi ,  Makoto Ono

IPC分类号： A61K31/13

CPC分类号： C07D498/04 ,  C07D213/75 ,  C07D401/12 ,  C07D401/14 ,  C07D409/04 ,  C07D409/12 ,  C07D413/12 ,  C07D413/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/14 ,  C07D519/00

摘要： A compound represented by formula (1): Q1-Q2-T0-N(R1)-Q3-N(R2)-T1-Q4  (1) [wherein R1 and R2 are hydrogen atoms or the like; Q1 is a saturated or unsaturated, 5- or 6-membered cyclic hydrocarbon group which may be substituted, or the like; Q2 is a single bond or the like; Q3 represents the following group: (wherein Q5 is an alkylene group having 1 to 8 carbon atoms, or the like); and T0 and T1 are carbonyl groups or the like], a salt thereof, a solvate thereof, or an N-oxide thereof. The compound is useful as an agent for preventing and/or treating cerebral infarction, cerebral embolism, myocardial infarction, angina pectoris, pulmonary infarction, pulmonary embolism, Buerger's disease, deep venous thrombosis, disseminated intravascular coagulation syndrome, thrombus formation after artificial valve or joint replacement, thrombus formation and reocclusion after angioplasty, systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), thrombus formation during extracorporeal circulation, or blood clotting upon blood drawing.

摘要翻译： Q1-Q2-T0-N（R1）-Q3-N（R2）-T1由式（1）表示的化合物：<？in-line-formula description =“In-line formula”end =“lead” -Q4（1）<？in-line-formula description =“In-line Formulas”end =“tail”？> [其中R1和R2是氢原子等; Q1是可以被取代的饱和或不饱和的5或6元环烃基，等等; Q2是单键等; Q3表示以下基团：（其中Q5为碳原子数为1〜8的亚烷基等）; 并且T0和T1是羰基等]，其盐，其溶剂合物或其N-氧化物。 该化合物可用作预防和/或治疗脑梗塞，脑栓塞，心肌梗死，心绞痛，肺梗塞，肺栓塞，Buerger病，深静脉血栓形成，弥散性血管内凝血综合征，人工瓣膜或关节后血栓形成 血管成形术后的替代，血栓形成和再闭塞，全身炎症反应综合征（SIRS），多器官功能障碍综合征（MODS），体外循环期间的血栓形成或血液抽血时的凝血。

公开(公告)号：US07483988B2

公开(公告)日：2009-01-27

申请号：US09802252

申请日：2001-03-08

申请人： Makoto Ono

发明人： Makoto Ono

IPC分类号： G06F15/16 ,  G06F9/445 ,  G06F15/173

CPC分类号： H04L63/062 ,  G06F21/10 ,  G06F2221/2137 ,  H04L63/083

摘要： A user is permitted to execute a predetermined program only within a limited time that corresponds to a period wherein the user maintains a valid contract for a connection with a specific network provider. When a user activates or executes a program that is provided by a network provider, or an entity having a tie-up with the network provider, the user must refer to a licensing key that can halt at least a part of the functions of the program when a predetermined licensing (halting) condition is matched. The licensing key can be updated by making a connection with the network provider.

公开(公告)号：US20060176324A1

公开(公告)日：2006-08-10

申请号：US11053222

申请日：2005-02-08

申请人： Makoto Ono

发明人： Makoto Ono

IPC分类号： G09G5/02

CPC分类号： G06Q10/00 ,  G06F3/14 ,  G09G2340/0407 ,  H04N21/440263

摘要： A display system, method and apparatus having a demand-based resolution for displaying an image having a resolution greater than a predetermined resolution, in which a user computer has display hardware capable of generating a display signal. The display signal is of one of a low resolution display signal and a high resolution display signal corresponding to the resolution greater than the predetermined resolution. A display monitor is in electrical communication with the user computer. The display monitor has a usage manager that tracks an available quantity of high resolution display units and allows the display monitor to display one of a high resolution image and a low resolution image based on the available quantity of high resolution display units and the display signal.

摘要翻译： 一种具有用于显示具有大于预定分辨率的分辨率的图像的基于需求的分辨率的显示系统，方法和装置，其中用户计算机具有能够产生显示信号的显示硬件。 显示信号是分辨率大于预定分辨率的低分辨率显示信号和高分辨率显示信号之一。 显示器与用户计算机电气通信。 显示监视器具有跟踪可用数量的高分辨率显示单元的使用管理器，并且允许显示监视器基于高分辨率显示单元和显示信号的可用数量来显示高分辨率图像和低分辨率图像之一。