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公开(公告)号：US07960531B2
公开(公告)日：2011-06-14
申请号：US12760354
申请日：2010-04-14
CPC分类号： A61K39/3955 , A61K38/00 , A61K38/1808 , C07K14/52 , C07K16/22 , C07K2317/76 , G01N33/74 , G01N2500/00
摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
摘要翻译： 本发明涉及本文称为EG-VEGF的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了筛选EG-VEGF调节剂的方法。 此外，本文描述了涉及调节细胞增殖和趋化性的方法和相关的治疗方法。
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公开(公告)号：US07736645B2
公开(公告)日：2010-06-15
申请号：US11537472
申请日：2006-09-29
IPC分类号： A61K39/395 , A61K39/00
CPC分类号： A61K39/3955 , A61K38/00 , A61K38/1808 , C07K14/52 , C07K16/22 , C07K2317/76 , G01N33/74 , G01N2500/00
摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
摘要翻译： 本发明涉及本文称为EG-VEGF的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了筛选EG-VEGF调节剂的方法。 此外，本文描述了涉及调节细胞增殖和趋化性的方法和相关的治疗方法。
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公开(公告)号：US07446168B2
公开(公告)日：2008-11-04
申请号：US10692299
申请日：2003-10-22
CPC分类号： C07K14/52 , A61K38/1866 , C07K14/475 , G01N33/74 , G01N2333/515 , G01N2500/04
摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
摘要翻译： 本发明涉及本文称为EG-VEGF的新型多肽和编码那些多肽的核酸分子。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了筛选EG-VEGF调节剂的方法。 此外，本文描述了涉及调节细胞增殖和趋化性的方法和相关的治疗方法。
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公开(公告)号：US20050244852A1
公开(公告)日：2005-11-03
申请号：US11040638
申请日：2005-01-21
申请人： Victoria Smith , Colin Watanabe
发明人： Victoria Smith , Colin Watanabe
IPC分类号： C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K17/00 , C12M1/34 , C12N5/06 , C12N5/16 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/85 , C12N15/87 , C12P21/00 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/574 , G09G5/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US07727536B2
公开(公告)日：2010-06-01
申请号：US11537382
申请日：2006-09-29
CPC分类号： C07K14/52 , A61K38/1866 , C07K14/475 , G01N33/74 , G01N2333/515 , G01N2500/04
摘要： The present invention is directed to novel polypeptides designated herein as EG-VEGF and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Also provided herein are methods of screening for modulators of EG-VEGF. Furthermore, methods and related methods of treatment are described herein which pertain to regulating cellular proliferation and chemotaxis.
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公开(公告)号：US20050214819A1
公开(公告)日：2005-09-29
申请号：US11030464
申请日：2005-01-05
申请人： Victoria Smith , Colin Watanabe
发明人： Victoria Smith , Colin Watanabe
IPC分类号： C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K17/00 , C12M1/34 , C12N5/06 , C12N5/16 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/85 , C12N15/87 , C12P21/00 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/574 , G09G5/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050176041A1
公开(公告)日：2005-08-11
申请号：US11026279
申请日：2004-12-30
申请人： Victoria Smith , Colin Watanabe
发明人： Victoria Smith , Colin Watanabe
IPC分类号： C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K17/00 , C12M1/34 , C12N5/06 , C12N5/16 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/85 , C12N15/87 , C12P21/00 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/574 , G09G5/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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公开(公告)号：US20050164266A1
公开(公告)日：2005-07-28
申请号：US11036582
申请日：2005-01-13
申请人： Victoria Smith , Colin Watanabe
发明人： Victoria Smith , Colin Watanabe
IPC分类号： C07H21/02 , C07H21/04 , C07K1/00 , C07K14/00 , C07K14/435 , C07K14/47 , C07K16/18 , C07K17/00 , C12M1/34 , C12N5/06 , C12N5/16 , C12N9/00 , C12N15/00 , C12N15/09 , C12N15/12 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/85 , C12N15/87 , C12P21/00 , C12P21/02 , C12P21/06 , C12Q1/68 , C12Q1/6816 , C12Q1/6883 , C12Q1/6886 , G01N33/50 , G01N33/53 , G01N33/567 , G01N33/574 , G09G5/00
摘要： The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention.
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