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131 条记录 (耗时 0.046 秒)

    Method for agitating the contents of a reaction receptacle within a temperature-controlled environment
    111.
    发明授权
    Method for agitating the contents of a reaction receptacle within a temperature-controlled environment 有权
    在温度控制环境下搅拌反应容器的内容物的方法

    公开(公告)号：US08318500B2

    公开(公告)日：2012-11-27

    申请号：US11875306

    申请日：2007-10-19

    申请人： Kelly G. Ammann ,  Robert E. Schneider ,  Robert J. Smith

    发明人： Kelly G. Ammann ,  Robert E. Schneider ,  Robert J. Smith

    IPC分类号： G01N35/02

    CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

    摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

    摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品的台站，在规定温度下培养样品规定的时间，进行分析物分离程序，并确定目标分析物的存在。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

    Temperature-Controlled Incubator Having Rotatable Door
    115.
    发明申请
    Temperature-Controlled Incubator Having Rotatable Door 有权
    具有可旋转门的温度控制孵化器

    公开(公告)号：US20090130749A1

    公开(公告)日：2009-05-21

    申请号：US11772453

    申请日：2007-07-02

    申请人： Kelly G. Ammann ,  Robert E. Schneider ,  Robert J. Smith

    发明人： Kelly G. Ammann ,  Robert E. Schneider ,  Robert J. Smith

    IPC分类号： C12M1/00

    CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

    摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, performing an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

    摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品，在规定温度下规定时间孵育样品，进行分析物分离程序，以及确定目标分析物的存在的站。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

    Process for the hydrogenation of hop resin acids
    117.
    发明授权
    Process for the hydrogenation of hop resin acids 有权
    啤酒花树脂酸氢化方法

    公开(公告)号：US07344746B1

    公开(公告)日：2008-03-18

    申请号：US10130515

    申请日：1999-11-18

    申请人： Richard J. H. Wilson ,  Robert J. Smith

    发明人： Richard J. H. Wilson ,  Robert J. Smith

    IPC分类号： A23L1/28 ,  C12C3/00

    CPC分类号： C12C3/00 ,  C12C9/025

    摘要： A process for the direct hydrogenation of hop resin acids in the absence of a liquid, organic solvent by reacting the hop resin acids which hydrogen in the presence of a noble metal catalyst at a temperature at which the resin acids are sufficiently fluid to allow easy mixing with the catalyst and suitably facilitate the hydrogenation reaction. Alternatively, the necessary fluidity may be achieved at relatively low temperature by subjecting the reactants to a high pressure of CO2 gas such that the quantity of this gas that dissolves into the resin is sufficient to substantially reduce its viscosity. Particularly useful applications for the process are the conversion is iso-α-acids to tetrahydroiso-α-acids and rho-iso-α-acids into hexahydroiso-α-acids. The resinous products of the hydrogenation process may be readily converted to aqueous, alkaline solutions suitable for use in brewing beer. The process may also be worked in a continuous manner, wherein hop resin acids in suitably fluid state and under high pressure are contacted with hydrogen gas and the resultant mixture passed over a bed of noble metal catalyst particles. The necessary fluidity is achieved either by heating the hop resin acid or by dissolving CO2 gas into it or a combination of both. The resinous product of the hydrogenation reaction is collected by depressurisation of the fluid exiting the catalyst bed, conveniently causing release of any excess dissolved gas.

    摘要翻译： 在不存在液体有机溶剂的情况下，通过在树脂酸充分流动的温度下使贵金属催化剂存在下的氢的啤酒花树脂酸反应以使容易混合的方法直接氢化啤酒花树脂酸 与催化剂合适地促进氢化反应。 或者，可以通过使反应物经受高压的CO 2气体在相对低的温度下实现所需的流动性，使得溶解到树脂中的这种气体的量足以显着降低其粘度 。 该方法的特别有用的应用是将异-α-酸转化为四氢异-α-酸和rho-异-α-酸转化成六氢异-α-酸。 氢化方法的树脂产物可以容易地转化成适用于酿造啤酒的水性碱性溶液。 该方法也可以以连续的方式进行，其中在适当的流体状态和高压下的啤酒花树脂酸与氢气接触，所得混合物通过贵金属催化剂颗粒床。 必要的流动性通过加热啤酒花树脂酸或将CO 2/2气体加入其中或两者的组合来实现。 通过对离开催化剂床的流体减压来收集加氢反应的树脂产物，方便地释放任何过量的溶解气体。

    Incubator for use in an automated diagnostic analyzer
    118.
    发明授权
    Incubator for use in an automated diagnostic analyzer 有权
    用于自动诊断分析仪的孵化器

    公开(公告)号：US07267795B2

    公开(公告)日：2007-09-11

    申请号：US10073346

    申请日：2002-02-13

    申请人： Kelly G. Ammann ,  Robert E. Schneider ,  Robert J. Smith

    发明人： Kelly G. Ammann ,  Robert E. Schneider ,  Robert J. Smith

    IPC分类号： C12M1/36

    CPC分类号： C12Q1/6834 ,  B01F9/0001 ,  B01F9/0014 ,  B01F9/0021 ,  B01F2009/0074 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/06 ,  B01L2200/147 ,  B01L2300/1822 ,  B01L2300/1827 ,  B03C1/282 ,  B03C1/288 ,  B03C1/30 ,  B03C2201/26 ,  C12Q1/6813 ,  C12Q1/6832 ,  C12Q2537/10 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1065 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0437 ,  G01N2035/0455 ,  G01N2035/103 ,  Y10T29/53657 ,  Y10T29/53683 ,  Y10T29/53843 ,  Y10T156/1105 ,  Y10T156/1906 ,  Y10T436/11 ,  Y10T436/111666 ,  Y10T436/113332 ,  Y10T436/114998 ,  Y10T436/119163 ,  Y10T436/2575

    摘要： An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations, or modules, in which discrete aspects of the assay are performed on fluid samples contained in reaction receptacles. The analyzer includes stations for automatically preparing a specimen sample, incubating the sample at prescribed temperatures for prescribed periods, preforming an analyte isolation procedure, and ascertaining the presence of a target analyte. An automated receptacle transporting system moves the reaction receptacles from one station to the next. The analyzer further includes devices for carrying a plurality of specimen tubes and disposable pipette tips in a machine-accessible manner, a device for agitating containers of target capture reagents comprising suspensions of solid support material and for presenting the containers for machine access thereto, and a device for holding containers of reagents in a temperature controlled environment and presenting the containers for machine access thereto. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte. The process is performed by automatically moving each of a plurality of reaction receptacles containing a solid support material and a fluid sample between stations for incubating the contents of the reaction receptacle and for separating the target analyte bound to the solid support from the fluid sample. An amplification reagent is added to the separated analyte after the analyte separation step and before a final incubation step.

    摘要翻译： 用于执行多个诊断测定的自动分析仪同时包括多个站或模块，其中对反应容器中包含的流体样品进行分析方面的分析。 分析仪包括用于自动准备标本样品，在规定温度下规定时间孵育样品，预处理分析物分离程序以及确定目标分析物的存在的站。 自动插座输送系统将反应容器从一个站移动到另一个站。 分析仪还包括用于以机器可接近的方式携带多个样本管和一次性移液管尖端的装置，用于搅拌包含固体支持材料的悬浮液并用于提供用于机器通入的容器的靶捕获试剂的容器的装置，以及 用于在温度受控的环境中容纳试剂容器的装置，并且提供用于机器通入的容器。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化方法。 该过程通过在站之间自动移动包含固体支持材料和流体样品的多个反应容器中的每一个来进行，用于孵育反应容器的内容物并将与固体支持物结合的目标分析物与流体样品分离。 在分析物分离步骤之后和最终孵育步骤之前，将分离的分析物加入扩增试剂。

    Remote sensing and signaling of the presence of wildfire
    119.
    发明授权
    Remote sensing and signaling of the presence of wildfire 失效
    遥感和信号的野火存在

    公开(公告)号：US07123154B1

    公开(公告)日：2006-10-17

    申请号：US10792048

    申请日：2004-03-03

    申请人： Robert J. Smith

    发明人： Robert J. Smith

    IPC分类号： G08B17/12

    CPC分类号： G08B17/12

    摘要： Detecting a wildfire and an electrical arc, which are characterized by emission of ultraviolet (UV) radiation at a given wavelength, are described using a light sensor having a pulse output responsive to the given wavelength and generating an intermediate output responsive to the pulse output in a way which tracks a trend in the pulse output, irrespective of any increase in the relative number of pulses in the pulse output that is responsive to extraneous sources other than wildfire or electrical arc. The intermediate output is generated responsive to pulses occurring within an event window that continuously terminates at present time and extends backward therefrom by a selected time duration. An alarm signal is produced based on a predetermined characteristic of the intermediate output. Packaging of the sensor and alarm arrangement is described along with photo-detection tube optimization. Further, atmospheric transmission of the detected wavelength is described.

    摘要翻译： 使用具有响应于给定波长的脉冲输出的光传感器来描述以给定波长发射紫外（UV）辐射为特征的野火和电弧，并产生响应于脉冲输出的中间输出 跟踪脉冲输出趋势的方式，而不管响应于野火或电弧以外的外来来源的脉冲输出中脉冲的相对数量的任何增加。 响应于在当前时间持续地终止并在其中向后延伸所选择的持续时间的在事件窗口内发生的脉冲产生中间输出。 基于中间输出的预定特性产生报警信号。 描述传感器和报警装置的封装以及光检测管优化。 此外，描述检测到的波长的大气透射。

    Anti-leak dust cover and closure used therewith
    120.
    发明授权
    Anti-leak dust cover and closure used therewith 失效

    公开(公告)号：US07011221B2

    公开(公告)日：2006-03-14

    申请号：US09683761

    申请日：2002-02-11

    申请人： Robert J. Smith ,  Matthew E. Stebick

    发明人： Robert J. Smith ,  Matthew E. Stebick

    IPC分类号： B65D39/00

    CPC分类号： B65D47/243 ,  B65D2101/0038

    摘要： A container closure includes a shell attachable to a container around a container opening thereof. The shell has a shell opening in fluid communication with the container opening when the shell is attached to the container. A tip is received on the shell movable between a closed position sealing the shell opening and an open position. A cover is releasably attached to the shell in a manner indicative of the tip being positioned in the closed position when the cover is attached to the shell. The cover includes rib engaging ribs for maintaining the cover tip and shell in proper alignment when the cover is attached to the shell.