公开(公告)号：US20060160985A1

公开(公告)日：2006-07-20

申请号：US11035816

申请日：2005-01-14

Applicant: Stephen Pacetti ,  Syed Hossainy

Inventor： Stephen Pacetti ,  Syed Hossainy

IPC: C08G63/02

CPC classification number: C08L77/12 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/802 ,  C08G63/6852 ,  C08G69/44 ,  C09D167/00 ,  C08L67/04

Abstract: Polymers containing poly(hydroxyalkanoate-co-ester amides) and agents for use with medical articles are disclosed along with methods of fabricating medical articles comprising these polymers. The medical articles generally comprise an implantable substrate having a coating containing a poly(hydroxyalkanoate-co-ester amide).

Abstract translation: 公开了含有聚（羟基链烷酸酯 - 共 - 酯酰胺）的聚合物和用于医疗制品的试剂以及包含这些聚合物的医疗制品的制造方法。 医疗制品通常包括具有包含聚（羟基链烷酸酯 - 共酯酰胺）的涂层的可植入基底。

公开(公告)号：US20060135943A1

公开(公告)日：2006-06-22

申请号：US11283032

申请日：2005-11-17

Applicant: Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

Inventor： Evgenia Mandrusov ,  Deborah Kilpatrick ,  Murthy Simhambhatla ,  Syed Hossainy

IPC: A61M31/00

CPC classification number: A61M25/0084 ,  A61B2017/22081 ,  A61M25/0026 ,  A61M25/1006 ,  A61M2025/0096

Abstract: An apparatus and method to treat vulnerable plaque. In one embodiment, the apparatus has an elongated catheter body adapted for insertion in a body lumen, with a drug delivery device attached near a distal portion of the elongated body. The drug delivery device is configured to deliver a biologically active agent to stabilize a vulnerable plaque.

公开(公告)号：US20060115513A1

公开(公告)日：2006-06-01

申请号：US10999391

申请日：2004-11-29

Applicant: Syed Hossainy ,  Stephen Pacetti

Inventor： Syed Hossainy ,  Stephen Pacetti

IPC: A61K38/44 ,  A61K33/44 ,  A61K31/727 ,  A61K31/56 ,  A61K31/573 ,  A61K31/445 ,  A61K31/4745 ,  A61K31/337 ,  A61K31/728

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/608 ,  C08L77/12

Abstract: A derivatized poly(ester amide) (D-PEA) and coatings and medical devices formed therefrom are provided. The coatings and medical devices may optionally include a biobeneficial material and/or a biocompatible polymer and/or a bioactive agent. The medical devices can be implanted in a patient to treat, prevent, or ameliorate a disorder such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

公开(公告)号：US20060014720A1

公开(公告)日：2006-01-19

申请号：US11228420

申请日：2005-09-15

Applicant: Syed Hossainy ,  Ni Ding

Inventor： Syed Hossainy ,  Ni Ding

IPC: A61K31/727 ,  A61K38/17 ,  C08B37/10

CPC classification number: A61K31/727 ,  A61K47/61 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/236 ,  A61L2300/606 ,  A61L2300/80 ,  C08B37/0075 ,  C09D105/10

Abstract: A prodrug comprising a heparin and a drug is provided. The prodrug can be used to form a coating on a medical device. The prodrug can also be used with a polymeric material to form a coating on a medical device. The polymeric material can be a hydrophobic polymer, a hydrophilic polymer, a non-fouling polymer, or combinations thereof. The medical device can be implanted in a human being for the treatment of a disease such as atherosclerosis, thrombosis, restenosis, hemorrhage, vascular dissection or perforation, vascular aneurysm, vulnerable plaque, chronic total occlusion, claudication, anastomotic proliferation for vein and artificial grafts, bile duct obstruction, ureter obstruction, tumor obstruction, or combinations thereof.

公开(公告)号：US06979346B1

公开(公告)日：2005-12-27

申请号：US09925046

申请日：2001-08-08

Applicant: Syed Hossainy ,  Daryush Mirzaee

Inventor： Syed Hossainy ,  Daryush Mirzaee

IPC: A61F2/00 ,  A61F2/06 ,  A61F2/90 ,  A61L31/14

CPC classification number: A61L31/14 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/30322 ,  A61F2002/91508 ,  A61F2002/91516 ,  A61F2002/91533 ,  A61F2002/91575 ,  A61F2002/9583 ,  A61F2250/0025 ,  A61F2250/0026

Abstract: An implantable medical device, such as a stent, having roughened areas on an inner surface of the device for enhancing frictional contact between the medical device and a delivery system, such as a balloon catheter to secure the medical device to the delivery system during delivery of the medical device to a body lumen of a patient. Various methods for forming the roughened areas are also provided. The roughened areas may be coated with a material, such as a non-thrombogenic material, to enhance the compatibility of the inner surface of the medical device with fluid flowing through the vessel lumen of the patient.

Abstract translation: 可植入的医疗装置，例如支架，在装置的内表面上具有粗糙区域，用于增强医疗装置与输送系统之间的摩擦接触，例如气囊导管，以将医疗装置固定在输送系统期间 医疗装置到患者的体腔。 还提供了用于形成粗糙化区域的各种方法。 粗糙区域可以涂覆有诸如非血栓形成材料的材料，以增强医疗装置的内表面与流过患者血管腔的流体的相容性。

公开(公告)号：US20050245637A1

公开(公告)日：2005-11-03

申请号：US10835656

申请日：2004-04-30

Applicant: Syed Hossainy ,  Yiwen Tang ,  Harshad Borgankow ,  Jessica DesNoyer ,  Stephen Pacetti

Inventor： Syed Hossainy ,  Yiwen Tang ,  Harshad Borgankow ,  Jessica DesNoyer ,  Stephen Pacetti

IPC: A61F2/00 ,  A61L27/18 ,  A61L27/34 ,  A61L31/00 ,  A61L31/06 ,  A61L31/10

CPC classification number: A61L31/10 ,  A61L27/18 ,  A61L27/34 ,  A61L31/06

Abstract: Methods for modulating and enhancing thermal and mechanical properties and biocompatibilities of coatings on implantable devices are disclosed. Implantable devices containing the enhanced thermal and mechanical properties and biocompatibilities are also described. The implantable devices can be used to treat a medical condition such as vulnerable plaque or restenosis.

Abstract translation: 公开了用于调节和增强可植入装置上的涂层的热机械性能和生物相容性的方法。 还描述了包含增强的热和机械性能和生物相容性的可植入装置。 可植入装置可用于治疗诸如易损斑块或再狭窄的医疗状况。

公开(公告)号：US20050208093A1

公开(公告)日：2005-09-22

申请号：US10807362

申请日：2004-03-22

Applicant: Thierry Glauser ,  Stephen Pacetti ,  Syed Hossainy ,  Ni Ding

Inventor： Thierry Glauser ,  Stephen Pacetti ,  Syed Hossainy ,  Ni Ding

IPC: A61L27/34 ,  A61L31/10 ,  C08G63/91 ,  A61K31/785 ,  A61K31/765 ,  C08G63/48

CPC classification number: A61L31/10 ,  A61L27/34 ,  A61L31/148 ,  A61L31/16 ,  A61L33/0011 ,  A61L33/08 ,  A61L2300/40 ,  A61L2300/42 ,  A61L2300/604 ,  A61L2300/606 ,  A61L2400/18 ,  C08L33/14

Abstract: A polymer comprising phospholipid moieties and a biocompatible polymer backbone, a composition comprising the polymer and optionally a bioactive agent, an implantable devices such as a DES comprising thereon a coating comprising the polymer and optionally a bioactive agent, and a method of using the device for the treatment of a disorder in a human being are provided.

Abstract translation: 包含磷脂部分和生物相容性聚合物骨架的聚合物，包含聚合物和任选的生物活性剂的组合物，可植入装置，例如包含其上的包含聚合物和任选的生物活性剂的涂层的DES，以及使用该装置的方法 提供了人类疾病的治疗。

公开(公告)号：US20050106204A1

公开(公告)日：2005-05-19

申请号：US10718278

申请日：2003-11-19

Applicant: Syed Hossainy ,  Yiwen Tang

Inventor： Syed Hossainy ,  Yiwen Tang

IPC: A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61F2/00

CPC classification number: A61L31/10 ,  C08L71/02 ,  C08L101/04 ,  C08L67/02

Abstract: Coatings for an implantable medical device and a method of fabricating the coatings are disclosed. The coatings comprise a fluorinated polymer and a biologically beneficial polymer, an example of which includes poly(ethylene-glycol)-block poly(butylene terephthalate)-block poly(ethylene-glycol). A biologically active agent can be additionally conjugated to the biologically beneficial polymer.

Abstract translation: 公开了用于可植入医疗装置的涂层和制造涂层的方法。 涂层包含氟化聚合物和生物有益的聚合物，其实例包括聚（乙二醇） - 嵌段聚（对苯二甲酸丁二醇酯） - 嵌段聚（乙二醇）。 生物活性剂可另外缀合到生物有益的聚合物上。

公开(公告)号：US20050106203A1

公开(公告)日：2005-05-19

申请号：US10176504

申请日：2002-06-21

Applicant: Wouter Roorda ,  Ni Ding ,  Stephen Pacetti ,  Eugene Michal ,  Ashok Shah ,  Syed Hossainy

Inventor： Wouter Roorda ,  Ni Ding ,  Stephen Pacetti ,  Eugene Michal ,  Ashok Shah ,  Syed Hossainy

IPC: A61L31/00 ,  A61F2/84 ,  A61K31/436 ,  A61L27/34 ,  A61L31/10 ,  A61L31/16 ,  A61K47/32

CPC classification number: A61L31/16 ,  A61L31/10 ,  A61L2300/416 ,  A61L2300/602 ,  A61L2300/606 ,  A61L2300/608 ,  A61L2420/08 ,  C08L33/10 ,  C08L33/06

Abstract: A coating for a medical device, particularly for a drug eluting stent, is described. The coating can include a polyacrylate, a blend of polyacrylates, or a blend of the polyacrylate with other polymers, for example, poly(ethylene-co-vinyl alcohol).

Abstract translation: 描述了用于医疗装置的涂层，特别是用于药物洗脱支架的涂层。 涂层可以包括聚丙烯酸酯，聚丙烯酸酯的共混物或聚丙烯酸酯与其它聚合物的共混物，例如聚（乙烯 - 共 - 乙烯醇）。

公开(公告)号：US06805898B1

公开(公告)日：2004-10-19

申请号：US09675092

申请日：2000-09-28

Applicant: Steven Z. Wu ,  Sameer Harish ,  Deborra Sanders-Millare ,  Judy A. Guruwaiya ,  Daryush Mirzaee ,  Syed Hossainy ,  Charlene Chen

Inventor： Steven Z. Wu ,  Sameer Harish ,  Deborra Sanders-Millare ,  Judy A. Guruwaiya ,  Daryush Mirzaee ,  Syed Hossainy ,  Charlene Chen

IPC: B05D300

CPC classification number: A61F2/0077 ,  A61F2/848 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2230/0013 ,  A61F2250/0067 ,  A61F2250/0068 ,  Y10S623/901

Abstract: An implantable medical device, such as a stent or graft, having asperities on a designated region of its outer surface is disclosed. The asperities can serve to improve retention of one or more layers of a coating on the device and to increase the amount of coating that can be carried by the device. The asperities can be formed by using a stream of pressurized grit to roughen the surface. The asperities can also be formed by removing material from the outer surface, for example, by chemical etching with or without a patterned mask. Alternatively, the asperities can be formed by adding material to the outer surface, for example, by welding powder particles to the outer surface or sputtering.

Abstract translation: 公开了一种在其外表面的指定区域上具有凹凸的可植入医疗装置，例如支架或移植物。 粗糙度可用于改善设备上一层或多层涂层的保留性并增加该装置可承载的涂层量。 可以通过使用加压砂粒流粗糙表面来形成凹凸。 也可以通过从外表面去除材料来形成凹凸，例如通过具有或不具有图案化掩模的化学蚀刻来形成。 或者，可以通过向外表面添加材料，例如通过将粉末颗粒焊接到外表面或溅射来形成凹凸。