公开(公告)号：US08642023B2

公开(公告)日：2014-02-04

申请号：US12742444

申请日：2008-11-12

Applicant: Takayuki Omura ,  Mihoshi Yokoo

Inventor： Takayuki Omura ,  Mihoshi Yokoo

IPC: A61K31/74

CPC classification number: A61K8/87 ,  A61K2800/5424 ,  A61K2800/5428 ,  A61Q19/00 ,  A61Q19/08 ,  C08G18/0823 ,  C08G18/12 ,  C08G18/2865 ,  C08G18/3212 ,  C08G18/3275 ,  C08G18/4808 ,  C08G18/4833 ,  C08G18/61 ,  C08G18/6692 ,  C08G18/755 ,  C08G18/302

Abstract: Problem To provide a skin cosmetic which exerts a feeling of ameliorating effect on skin wrinkles and sagging by application, and is free from uncomfortable feelings in use, such as stickiness, twisting of the cosmetic applied on the skin, and squeakiness.Means for Solution A skin cosmetic is provided, which comprises an aqueous liquid of an anionic or amphoteric urethane resin dissolved or dispersed in water and wherein the anionic or amphoteric urethane resin is prepared by reacting (a) an isocyanate compound with (b) a polyol compound containing the following components (b-1) to (b-3) or the following components (b-1) to (b-4) and having a ratio of (b-1)/(b-2) of 0.15-3.0 (by mass, in terms of charge): [(b-1): cyclohexanedimethanol, (b-2): polypropylene glycol having a molecular weight of 1000-3000, (b-3): a compound having an active hydrogen and a carboxyl group in one molecule, (b-4): a compound having an active hydrogen and a tertiary amino group in one molecule.].

Abstract translation: 问题提供一种皮肤化妆品，其通过施用发挥对皮肤皱纹和下垂的改善作用的感觉，并且在使用中没有不适感的感觉，例如粘着性，施加在皮肤上的化妆品的扭曲和吱吱声。 用于溶液的方法提供一种皮肤化妆品，其包含溶解或分散在水中的阴离子或两性聚氨酯树脂的水性液体，其中所述阴离子或两性聚氨酯树脂通过（a）异氰酸酯化合物与（b）多元醇 含有以下组分（b-1）至（b-3）或以下组分（b-1）至（b-4）并且具有（b-1）/（b-2） 3.0（以质量计）：[（b-1）：环己烷二甲醇，（b-2）：分子量为1000-3000的聚丙二醇，（b-3）：具有活性氢的化合物和 一个分子中的羧基，（b-4）：在一个分子中具有活性氢和叔氨基的化合物。

公开(公告)号：US20140017191A1

公开(公告)日：2014-01-16

申请号：US14007651

申请日：2012-03-29

Applicant: Ayako Ibe ,  Masaki Kitajima ,  Kei Watanabe

Inventor： Ayako Ibe ,  Masaki Kitajima ,  Kei Watanabe

IPC: A61K8/06

CPC classification number: A61K8/064 ,  A61K8/31 ,  A61K2800/10 ,  A61Q19/00

Abstract: The present invention provides a water-in-oil emulsion cosmetic that is excellent in the resilient and supple (in other words, firm and tensional) feels and also excellent in the moisturizing effect and feeling in use. The water-in-oil emulsion cosmetic of the present invention is characterized by comprising the following (A) to (D): (A) 0.5 to 10 mass % of hydrogenated polyisobutene (B) an oil containing (b1) (b1) a volatile oil of low compatibility with (A) (C) an emulsifying agent and (D) 60 to 90 mass % of an aqueous component, wherein the percentage of component (b1) is 45 to 85% with respect to component (A) and component (B).

Abstract translation: 本发明提供一种在弹性和柔软（换句话说，牢固和张力）感觉上优异且在保湿效果和使用感中也优异的油包水乳液化妆品。 本发明的油包水乳液化妆品的特征在于，含有下述（A）〜（D）：（A）0.5〜10质量％的氢化聚异丁烯（B）含有（b1）（b1）a 与（A）（C）乳化剂和（D）60〜90质量％的水性成分的相容性低的挥发性油，其中组分（b1）的百分比相对于组分（A）为45-85％ 组分（B）。

公开(公告)号：US20140010901A1

公开(公告)日：2014-01-09

申请号：US14004977

申请日：2012-03-14

Applicant: Toshihiko Hibino ,  Shoko Yamada ,  Hidekazu Fukushima

Inventor： Toshihiko Hibino ,  Shoko Yamada ,  Hidekazu Fukushima

IPC: A61K36/756 ,  A61K31/047 ,  A61K31/197 ,  A61K36/53 ,  A61K36/23

CPC classification number: A61K36/23 ,  A61K8/345 ,  A61K8/46 ,  A61K8/97 ,  A61K31/047 ,  A61K31/19 ,  A61K31/197 ,  A61K36/232 ,  A61K36/236 ,  A61K36/53 ,  A61K36/738 ,  A61K36/756 ,  A61Q19/007 ,  A61K2300/00

Abstract: Provided is a novel bleomycin hydrolase production promoter.Provided is a bleomycin hydrolase production promoter, natural moisturizing factor production promoter, and dry skin remedy, comprising as an active ingredient thereof one or a plurality of ingredients selected from the group consisting of chestnut rose extract, angelica root extract, cork tree bark extract, lamium album extract, rosemary extract, benzenesulfonyl GABA and erythritol.

Abstract translation: 提供了一种新型博来霉素水解酶生产促进剂。 本发明提供一种博来霉素水解酶生产促进剂，天然保湿因子生产促进剂和干性皮肤补救剂，其包含选自栗子提取物，当归提取物，软木树皮提取物中的一种或多种成分的活性成分， 苎麻提取物，迷迭香提取物，苯磺酰基GABA和赤藓糖醇。

公开(公告)号：US20140004210A1

公开(公告)日：2014-01-02

申请号：US13822762

申请日：2012-06-28

Applicant: Masato Iino ,  Nobuhiko Ochiai ,  Makoto Tsunenaga

Inventor： Masato Iino ,  Nobuhiko Ochiai ,  Makoto Tsunenaga

IPC: A61K8/97 ,  A61K8/67 ,  A61Q19/08

CPC classification number: A61K8/97 ,  A61K8/671 ,  A61K2800/782 ,  A61Q19/007 ,  A61Q19/08

Abstract: The present invention relates to providing a hyaluronidase inhibitor having a good hyaluronidase inhibiting activity. Specifically, the present invention provides with a hyaluronidase inhibitor comprising rosemary extract having a hyaluronidase inhibitory activity, and retinol acetate, which can enhances the hyaluronidase inhibitory activity of rosemary extract.

Abstract translation: 本发明涉及提供具有良好的透明质酸酶抑制活性的透明质酸酶抑制剂。 具体而言，本发明提供了含有透明质酸酶抑制活性的迷迭香提取物和乙酸视黄醇的透明质酸酶抑制剂，其能够增强迷迭香提取物的透明质酸酶抑制活性。

公开(公告)号：US08598535B2

公开(公告)日：2013-12-03

申请号：US13823438

申请日：2011-07-13

Applicant: Yoshimasa Miura ,  Masato Hatao

Inventor： Yoshimasa Miura ,  Masato Hatao

IPC: G01J1/42

CPC classification number: G01N21/59 ,  G01N17/004 ,  G01N21/33

Abstract: An evaluation method for evaluating the ultraviolet protection effect of a measurement sample applied on a substrate includes measuring, at predetermined wavelength intervals, a change over time of a spectral transmission spectrum of the measurement sample within a predetermined wavelength range by irradiating light from a light source that includes ultraviolet light, visible light, and infrared light under a predetermined irradiation condition; establishing, based on the change over time of the spectral transmission spectrum, a correlation between a light irradiation time and an erythema effective dose per unit time, which is obtained by dividing an erythema effective dose of the measurement sample by an erythema effective dose per 1 MED; and calculating an in vitro rSPF predictive value for the measurement sample on the basis of a time until a cumulative erythema effective dose, which is obtained through time integration based on the correlation, reaches 1 MED.

Abstract translation: 用于评估施加在基板上的测量样品的紫外线保护效果的评估方法包括：以预定波长间隔，通过照射来自光源的光来测量在预定波长范围内的测量样品的光谱透射光谱的变化 其包括在预定照射条件下的紫外光，可见光和红外光; 基于光谱透射光谱随时间的变化建立光照射时间和每单位时间红斑有效剂量之间的相关性，其通过将测量样品的红斑有效剂量除以每1个红斑有效剂量而获得 MED; 并且基于通过基于相关性的时间积分获得的累积红斑有效剂量之间的时间达到1 MED，计算测量样品的体外rSPF预测值。

公开(公告)号：US20130315850A1

公开(公告)日：2013-11-28

申请号：US13954176

申请日：2013-07-30

Applicant: Shiseido Company, Ltd.

Inventor： Rikako Suzuki ,  Kiyotaka Hasegawa ,  Kiyoshi Sato ,  Tokiya Yokoi ,  Ken Kusakari

IPC: A61K8/97 ,  A61Q19/02

CPC classification number: A61K8/97 ,  A61K36/11 ,  A61Q19/02 ,  A61Q19/08

Abstract: The present invention is directed to an extrace of Psilotum spp., as a skin whitening agent. Whitening agents according to the invention exhibit superior effects, for example, by lightening and whitening skin pigmentation, lightening and whitening aging spots, freckles, chloasma, or the like after sunburn. The Psilotum spp. extract of the invention has a superior free radical scavenging ability permitting the extract to control skin aging and skin diseases caused by active oxygen (free radicals), while having a high level of safety.

Abstract translation: 本发明涉及Psilotum spp。作为皮肤增白剂。 根据本发明的美白剂显示出优异的效果，例如通过在晒伤后减轻和增白皮肤色素沉着，减轻和增白老化点，雀斑，黄褐斑等。 Psilotum属 本发明的提取物具有优异的自由基清除能力，其允许提取物控制皮肤老化和由活性氧（自由基）引起的皮肤疾病，同时具有高水平的安全性。

公开(公告)号：US08592642B2

公开(公告)日：2013-11-26

申请号：US13060824

申请日：2009-07-31

Applicant: Kenji Hamase ,  Kiyoshi Zaitsu ,  Masashi Mita ,  Yutaka Ashida ,  Yousuke Toujo

Inventor： Kenji Hamase ,  Kiyoshi Zaitsu ,  Masashi Mita ,  Yutaka Ashida ,  Yousuke Toujo

IPC: G01N33/00 ,  A01K67/027

CPC classification number: G01N33/5088 ,  A01K67/0276 ,  A01K2217/03 ,  A01K2217/075 ,  A01K2217/15 ,  A01K2227/105 ,  A01K2267/0331 ,  A01K2267/0356 ,  C07K14/4702 ,  C12N9/0024 ,  C12N15/8509 ,  C12Q1/26 ,  G01N2333/90644 ,  G01N2500/10

Abstract: Disclosed is an evaluation method which can rapidly discriminate a Dao−/− homozygote from a large number of animals produced in a mating experiment between a DAO enzyme deficient mouse and other disease model mice, to rapidly perform a quantitative measurement of the D-amino acids contained in a large number of samples. The invention provides a method for evaluating the effect of a test condition on a mouse tissue, or cultured tissue cells derived from the tissue. The method comprises the steps of: providing a Dao1−/− mouse or the like; exposing the tissue from the Dao1−/− mouse or the like, to the test condition; and analyzing the effect of exposing the tissue from the Dao1−/− mouse or the like, to the test condition.

Abstract translation: 公开了一种评估方法，其可以快速区分DAO- / - 纯合子与DAO酶缺陷小鼠和其他疾病模型小鼠之间的交配实验中产生的大量动物，以快速进行D-氨基酸的定量测量 包含在大量样品中。 本发明提供了一种用于评估测试条件对小鼠组织或来自组织的培养的组织细胞的影响的方法。 该方法包括以下步骤：提供Dao1 - / - 鼠标等; 将来自Dao1 / / - 小鼠等的组织暴露于测试条件; 并分析将来自Dao1 - / - 小鼠等的组织暴露于测试条件的效果。

公开(公告)号：US08592582B2

公开(公告)日：2013-11-26

申请号：US13520203

申请日：2011-01-05

Applicant: Hirotada Fukunishi ,  Naoto Hanyu ,  Masaru Suetsugu ,  Takuya Hiruma

Inventor： Hirotada Fukunishi ,  Naoto Hanyu ,  Masaru Suetsugu ,  Takuya Hiruma

IPC: C07D403/04

CPC classification number: C07D403/04

Abstract: The present invention provides a method for producing a pyrimidinylpyrazole compound (1), wherein aminoguanidine (2) or its salt is reacted with a β-diketone compound (3) to produce the pyrimidinylpyrazole compound: wherein R1 and R3 are each independently an alkyl group having 1 to 4 carbon atoms, and R2 is a hydrogen atom or an alkyl group having 1 to 4 carbon atoms. The method is excellent in the environmental compatibility and economic efficiency.

Abstract translation: 本发明提供一种制备嘧啶基吡唑化合物（1）的方法，其中氨基胍（2）或其盐与β-二酮化合物（3）反应以产生嘧啶基吡唑化合物：其中R 1和R 3各自独立地为烷基 具有1至4个碳原子，并且R 2是氢原子或具有1至4个碳原子的烷基。 该方法在环境兼容性和经济效益上优异。

公开(公告)号：US08591414B2

公开(公告)日：2013-11-26

申请号：US13405807

申请日：2012-02-27

Applicant: Naomi Kitamura ,  Yuji Masuda ,  Hiroyuki Ohnishi

Inventor： Naomi Kitamura ,  Yuji Masuda ,  Hiroyuki Ohnishi

IPC: A61B5/00 ,  G06K9/00

CPC classification number: A61B5/442 ,  A61B5/0082 ,  A61B5/743 ,  A61B5/7435 ,  G06F19/00 ,  G06F19/321 ,  G16H50/20

Abstract: A skin state analyzing method for analyzing the skin state of an examinee using an image of the skin of the examinee includes an analyzing step of analyzing at least one of texture/pores, spots, skin tone, and sebum of the skin from the image, a storing step of storing the image and an analysis result obtained from the analyzing step in association with skin examination date/time information and examinee information, a display screen generating step of generating a screen displaying the image and the analysis result of the examinee stored in the storing step, and an output step of outputting the information generated in the display screen generating step.

Abstract translation: 使用受检者皮肤的图像分析受检者的皮肤状态的皮肤状态分析方法包括分析步骤，从图像分析皮肤的纹理/毛孔，斑点，肤色和皮脂中的至少一种， 存储步骤，用于存储与皮肤检查日期/时间信息和受检者信息相关联的从分析步骤获得的图像和分析结果;显示屏幕生成步骤，生成显示图像的屏幕和存储在该图像中的受检者的分析结果 存储步骤，以及输出步骤，输出在显示画面生成步骤中生成的信息。

公开(公告)号：US08574918B2

公开(公告)日：2013-11-05

申请号：US13055720

申请日：2009-07-28

Applicant: Aya Hirayama ,  Osamu Shirota ,  Masashi Mita ,  Kazuhiko Mibayashi

Inventor： Aya Hirayama ,  Osamu Shirota ,  Masashi Mita ,  Kazuhiko Mibayashi

IPC: G01N30/16 ,  G01N30/18

CPC classification number: G01N30/20 ,  G01N30/16 ,  G01N30/24 ,  G01N35/1004 ,  G01N35/1097

Abstract: A sample injection part connected to a column to inject a sample into the column; a sample injection needle attachable to the sample injection part; a sample suction part connectable to the sample injection needle and configured to cause a predetermined amount of the sample to be drawn by suction into the sample injection needle upon connecting to the sample connection needle; a mobile phase supply part configured to supply the column with a mobile phase; a first switching valve for selectively connecting the sample injection needle to one of the sample suction part and the mobile phase supply part; and a second switching valve, including the sample injection part, for supplying the sample and the mobile phase to the column via the sample injection needle in the case of having the sample injection needle attached to the sample injection part and for supplying the mobile phase to the column via the first switching valve in the case of having the sample injection needle removed from the sample injection part are included.

Abstract translation: 连接到柱上以将样品注入柱中的样品注入部分; 可注入样品的样品注射针; 样品抽吸部分，其可连接到样品注射针，并且构造成在连接到样品连接针时使预定量的样品通过抽吸被抽吸到样品注射针中; 流动相供应部分，配置成向柱提供流动相; 第一切换阀，用于选择性地将样品注射针连接到样品吸入部分和流动相供应部分中的一个; 以及第二切换阀，包括样本注入部，用于在将样品注射针附接到样品注射部分并将流动相供给到样品注射部分的情况下经由样品注射针将样品和流动相供给到柱中 包括在从样品注射部分移除样品注射针的情况下经由第一切换阀的柱。