公开(公告)号：US20230353854A1

公开(公告)日：2023-11-02

申请号：US18007618

申请日：2021-06-02

Applicant: KOWA COMPANY, LTD.

Inventor： Takao Ushiyama ,  Eiji Takahashi

IPC: H04N23/56 ,  H04N23/55 ,  G03B17/12 ,  G02B19/00 ,  G02B13/00 ,  G02B3/00

CPC classification number: H04N23/56 ,  H04N23/55 ,  G03B17/12 ,  G02B19/0047 ,  G02B13/0015 ,  G02B3/0075

Abstract: An imaging device according to the present invention includes an illumination unit 20 containing a light source 21 for emitting illumination light 2, and a lens group 22 for irradiating an imaging object 1 with the illumination light 2 emitted from the light source 21, and an imaging unit 10 for imaging the imaging object 1. A part of the illumination light 2 is shielded by a light shielding component 40.

公开(公告)号：US20230320587A1

公开(公告)日：2023-10-12

申请号：US18043282

申请日：2021-10-27

Applicant: Kowa Company, Ltd.

Inventor： Naoki KAMBE ,  Atsushi KAKUUCHI

IPC: A61B3/117

CPC classification number: A61B3/117

Abstract: A medical examination device having a grip portion that is grippable by an operator in such a manner as to be sandwiched between a thumb and at least one of four fingers including an index finger, a middle finger, a ring finger, and a little finger on an index finger side of one hand, to examine a subject by performing operation in a state where the grip portion is gripped with the one hand, includes a finger hook portion provided on the grip portion to be hooked on any of the fingers located on the index finger side when the grip portion is gripped by the operator with the one hand.

公开(公告)号：US20230210369A1

公开(公告)日：2023-07-06

申请号：US18008486

申请日：2021-06-22

Applicant: KOWA COMPANY, LTD.

Inventor： Yuka SUGIURA ,  Katsumi YABUSAKI ,  Takao SHINOHARA

IPC: A61B3/16 ,  A61B5/01

CPC classification number: A61B3/16 ,  A61B5/015

Abstract: The method for estimating the fluid state of a liquid of the present invention includes a step (a) of applying heat to the liquid, a step (b) of acquiring a temperature distribution of the liquid to which the heat is applied, and a step (c) of estimating the fluid state of the liquid based on the acquired temperature distribution. The system for estimating the fluid state of a liquid of the present invention includes a heating means (1) that applies heat to the liquid, a temperature distribution acquisition means (2) that acquires a temperature distribution of the liquid to which the heat is applied, and an estimation means (3) that estimates the fluid state of the liquid based on the acquired temperature distribution. According to such method and system for estimating the fluid state of a liquid, the flow of the liquid can be estimated non-invasively.

公开(公告)号：US20230171369A1

公开(公告)日：2023-06-01

申请号：US18002429

申请日：2021-06-24

Applicant: Kowa Company, Ltd.

Inventor： Katsumi YABUSAKI ,  Takao SHINOHARA

IPC: H04N5/262 ,  G06T7/20 ,  G06T7/70 ,  G06T7/90

CPC classification number: H04N5/2624 ,  G06T7/20 ,  G06T7/70 ,  G06T7/90 ,  G06T2207/10024 ,  G06T2207/20212 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/10016 ,  G06T2207/10072

Abstract: An example apparatus comprising an image acquisition unit configured to acquire a plurality of images having temporal or spatial continuity; a channel assignment unit configured to assign a channel different from each other to at least a part of gradation information on a color and/or gradation information on brightness that can be acquired from each image of the plurality of images based on a predetermined rule; a composite image generation unit configured to generate one composite image in which gradation information on at least a part of each image can be identified by the channel by extracting and combining gradation information to which the channel is assigned from each of the plurality of images; and an inference unit configured to analyze the composite image and to infer the plurality of images.

公开(公告)号：US11622851B2

公开(公告)日：2023-04-11

申请号：US16309903

申请日：2017-06-14

Applicant: Kowa Company, Ltd.

Inventor： Haruo Ishikawa ,  Akemi Taniguchi ,  Norio Shimizu

IPC: A61F2/16

Abstract: There is provided a toric intraocular lens which improves the visibility of a toric axis. The toric intraocular lens is a toric intraocular lens including a lens body provided with an astigmatic axis. A mark indicating the astigmatic axis is formed at an optical surface of an outer rim portion of the lens body, and a length in a radial direction of the lens body and a length in a circumferential direction of the lens body of external dimensions of the mark are different from each other in top view of the optical surface.

公开(公告)号：US11554109B2

公开(公告)日：2023-01-17

申请号：US17708706

申请日：2022-03-30

Applicant: Kowa Company, Ltd.

Inventor： Ryu Oshima ,  Masatoshi Ito ,  Chisato Nagai

IPC: A61K31/423 ,  A61K31/34 ,  A61K31/4152 ,  A61K31/427 ,  A61K31/4353 ,  A61K31/4402 ,  A61K31/4433 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/513 ,  A61K31/7034 ,  A61K38/13 ,  A61P3/06 ,  A61K31/7048 ,  A61K45/06

Abstract: To provide a medicament for safely treating a patient in need of treatment with pemafibrate, a salt thereof, or a solvate of any of these (hereinafter also referred to as pemafibrate therapy).
A medicament for treating a patient in need of pemafibrate therapy, the medicament comprising the step of avoiding or suspending concomitant use of pemafibrate, a salt thereof, or a solvate of any of these as an active ingredient in order to suppress an increase in plasma concentration of pemafibrate when the treatment is combined with a medicament containing an OATP1B inhibitor, or the step of reducing the dose of pemafibrate, a salt thereof, or a solvate of any of these.

公开(公告)号：US20220054459A1

公开(公告)日：2022-02-24

申请号：US17515945

申请日：2021-11-01

Applicant: Kowa Company, Ltd.

Inventor： Yusuke Sasaki ,  Masato Asahiyama ,  Toshiya Tanaka

IPC: A61K31/423 ,  A61P1/16

Abstract: The present invention addresses the problem of providing a medicinal composition and a drug combination by which nonalcoholic fatty liver disease and nonalcoholic steatohepatitis can be prevented and/or treated. The present invention provides a combination of a peroxisome proliferator-activated receptor (PPAR) α agonist with a sodium glucose cotransporter 2 (SGLT2) inhibitor, which is to be used for preventing and/or treating nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

公开(公告)号：US20220023286A1

公开(公告)日：2022-01-27

申请号：US17498822

申请日：2021-10-12

Applicant: National University Corporation Hamamatsu University School of Medicine ,  Kowa Company, Ltd.

Inventor： Naoki Unno ,  Hiroki Tanaka ,  Tatsuro Yata ,  Keisuke Inoue ,  Yuichi Makinose ,  Noboru Kaneta

IPC: A61K31/4704 ,  A61P9/14

Abstract: The present invention addresses the problem of providing a therapeutic agent for abdominal aortic aneurysms, with which pharmacotherapy is possible.
The present invention provides a therapeutic agent for an aortic aneurysm comprising, as an active component, (−)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2(1H)-quinolinone or a salt thereof, or a solvate of these.

公开(公告)号：US20220000786A1

公开(公告)日：2022-01-06

申请号：US17418091

申请日：2019-12-27

Applicant: KOWA COMPANY, LTD.

Inventor： Chisa NISHIDA

IPC: A61K9/20 ,  A61K9/16 ,  A61K31/423

Abstract: Provided is a technique for suppressing the composition changes between pemafibrate, a salt thereof or a solvate thereof and (meth)acrylic acid-based polymers. A pharmaceutical preparation is provided by storing a pharmaceutical composition containing the following components (A) and (B) in a tight package: (A) pemafibrate, a salt thereof or a solvate thereof; and (B) a (meth)acrylic acid-based polymer.

公开(公告)号：US11166948B2

公开(公告)日：2021-11-09

申请号：US16647448

申请日：2018-09-13

Applicant: National University Corporation Hamamatsu University School of Medicine ,  Kowa Company, Ltd.

Inventor： Naoki Unno ,  Hiroki Tanaka ,  Tatsuro Yata ,  Keisuke Inoue ,  Yuichi Makinose ,  Noboru Kaneta

IPC: A61K31/4704 ,  A61P9/14 ,  C07D215/227

Abstract: The present invention addresses the problem of providing a therapeutic agent for abdominal aortic aneurysms, with which pharmacotherapy is possible.
The present invention provides a therapeutic agent for an aortic aneurysm comprising, as an active component, (−)-6-[3-[3-cyclopropyl-3-[(1R,2R)-2-hydroxycyclohexyl]ureido]propoxy]-2(1H)-quinolinone or a salt thereof, or a solvate of these.