公开(公告)号：US4371699A

公开(公告)日：1983-02-01

申请号：US214780

申请日：1980-12-09

申请人： Takehisa Ohashi ,  Masami Shimazaki ,  Kazunori Kan ,  Hideo Kondo ,  Kiyoshi Watanabe

发明人： Takehisa Ohashi ,  Masami Shimazaki ,  Kazunori Kan ,  Hideo Kondo ,  Kiyoshi Watanabe

IPC分类号： C07C51/60 ,  C07D207/16 ,  C07D211/60 ,  C07D277/06 ,  C07K5/078

CPC分类号： C07K5/06165 ,  C07C51/60 ,  C07D207/16 ,  C07D211/60 ,  C07D277/06

摘要： A process is disclosed wherein an optically active N-mercaptoalkanoylamino acid is prepared by(1) reacting an optically active .beta.-hydroxyalkanoic acid, with a halogenating reagent to prepare an optically active .beta.-haloalkanoyl halide(2) reacting the .beta.-haloalkanoyl halide with an amino acid to produce an optically active N-.beta.-haloalkanoylamino acid and(3) reacting the N-.beta.-haloalkanoylamino acid with a reagent capable of converting the halogen into the thiol group, the configuration of the formulas (II), (III), (IV), (V), and (VI) being retained in all the optically active compounds throughout the process to prepare the compound represented by formula (I). The product of the present invention, for example, N-(3-mercapto-2-D-methylpropanoyl)-L-proline inhibits the enzymatic conversion of angiotensin I into angiotensin II and therefore is useful for relieving angiotensin-related hypertension.

摘要翻译： 公开了一种方法，其中光学活性N-巯基烷酰基氨基酸通过（1）使光学活性β-羟基链烷酸与卤化试剂反应制备光学活性β-卤代烷酰基卤化物（2）使β-卤代烷酰卤与 氨基酸以产生光学活性的N-β-卤代烷酰基氨基酸和（3）使N-β-卤代烷酰基氨基酸与能够将卤素转化成硫醇基团的试剂反应，式（II），（III ），（IV），（V）和（VI）在整个过程中保留在所有光学活性化合物中以制备由式（I）表示的化合物。 本发明的产物，例如N-（3-巯基-2-D-甲基丙酰基）-L-脯氨酸抑制血管紧张素I的酶促转化为血管紧张素II，因此可用于缓解血管紧张素相关的高血压。

公开(公告)号：US4369177A

公开(公告)日：1983-01-18

申请号：US208842

申请日：1980-11-20

申请人： Yuichi Kozaki ,  Shingo Hata ,  Hajime Kawaharada ,  Kiyoshi Watanabe

发明人： Yuichi Kozaki ,  Shingo Hata ,  Hajime Kawaharada ,  Kiyoshi Watanabe

IPC分类号： C07H19/16 ,  A61K31/70

CPC分类号： C07H19/16 ,  Y10S514/97 ,  Y10S514/973

摘要： A stable composition of S-adenosyl-L-methionine is disclosed which includes a salt of S-adenosyl-L-methionine and a pharmaceutically acceptable, water-soluble salt of a bivalent or trivalent metal. The salt of S-adenosyl-L-methionine is, for example, a salt of S-adenosyl-L-methionine with hydrochloric acid, sulfuric acid, p-toluenesulfonic acid, phosphoric acid, formic acid, acetic acid, citric acid, tartaric acid, or maleic acid; or a double salt of S-adenosyl-L-methionine with the foregoing acids. The salt of a bivalent or trivalent metal is, for example, calcium chloride, ferric chloride, magnesium chloride, or magnesium sulfate. A process for preparing the composition is also disclosed. The composition is suitable for preparing pharmaceutical preparations of S-adenosyl-L-methionine.

摘要翻译： 公开了S-腺苷-L-甲硫氨酸的稳定组合物，其包括S-腺苷-L-甲硫氨酸的盐和二价或三价金属的药学上可接受的水溶性盐。 S-腺苷-L-甲硫氨酸的盐例如是S-腺苷-L-甲硫氨酸与盐酸，硫酸，对甲苯磺酸，磷酸，甲酸，乙酸，柠檬酸，酒石酸的盐 酸或马来酸; 或S-腺苷-L-甲硫氨酸与上述酸的双重盐。 二价或三价金属的盐是例如氯化钙，氯化铁，氯化镁或硫酸镁。 还公开了制备该组合物的方法。 该组合物适用于制备S-腺苷-L-甲硫氨酸的药物制剂。

公开(公告)号：US4310635A

公开(公告)日：1982-01-12

申请号：US201337

申请日：1980-10-27

申请人： Junzo Hasegawa ,  Masahiro Ogura ,  Shigeki Hamaguchi ,  Masami Shimazaki ,  Hajime Kawaharada ,  Kiyoshi Watanabe

发明人： Junzo Hasegawa ,  Masahiro Ogura ,  Shigeki Hamaguchi ,  Masami Shimazaki ,  Hajime Kawaharada ,  Kiyoshi Watanabe

IPC分类号： C12P7/42

CPC分类号： C12P7/42 ,  Y10S435/911 ,  Y10S435/913 ,  Y10S435/917 ,  Y10S435/921 ,  Y10S435/938 ,  Y10S435/94 ,  Y10S435/942

摘要： A process is disclosed wherein D(-)-.beta.-hydroxyisobutyric acid is produced fermentatively from isobutyric acid or methacrylic acid by the stereoselective action of microorganisms having the ability to convert isobutyric acid or methacrylic acid into D(-)-.beta.-hydroxyisobutyric acid in an aqueous medium, and D(-)-.beta.-hydroxyisobutyric acid is recovered from the aqueous medium.

摘要翻译： 公开了一种方法，其中通过具有将异丁酸或甲基丙烯酸转化为D（ - ） - β-羟基异丁酸的能力的微生物的立体选择性作用，从（异）酸或甲基丙烯酸发酵得到D（ - ） - β-羟基异丁酸） 从水介质中回收水性介质和D（ - ） - β-羟基异丁酸。

公开(公告)号：US4259319A

公开(公告)日：1981-03-31

申请号：US936835

申请日：1978-08-25

申请人： Hamao Umezawa ,  Tomio Takeuchi ,  Masaaki Ishizuka ,  Kiyoshi Watanabe ,  Toshiaki Yamashita ,  Noriyuki Naoi ,  Takayoshi Hidaka

发明人： Hamao Umezawa ,  Tomio Takeuchi ,  Masaaki Ishizuka ,  Kiyoshi Watanabe ,  Toshiaki Yamashita ,  Noriyuki Naoi ,  Takayoshi Hidaka

IPC分类号： C12P21/00 ,  A61K38/00 ,  A61P35/00 ,  C07G11/00 ,  C12P1/06

CPC分类号： C12P1/06

摘要： A new antibiotic designated as auromomycin is prepared from the culture broth of Streptomyces macromomyceticus, a macromomycin-producing strain, as yellow crystals. Auromomycin is recovered in pure form from the culture broth by using hydrophobic chromatography with Octyl Sephalose CL-4B or Phenyl Sepharose CL-4B.

摘要翻译： 从黄曲霉大麻霉菌（S​​treptomyces macromomyceticus）的培养液中制备一种新的抗生素，称为黄霉素，为黄色晶体。 通过使用具有辛基海藻糖CL-4B或苯基琼脂糖CL-4B的疏水层析从培养液中回收Auromomycin。

公开(公告)号：US08913202B2

公开(公告)日：2014-12-16

申请号：US13396105

申请日：2012-02-14

申请人： Masao Ozeki ,  Tokihito Sawada ,  Takashi Yuchi ,  Kiyoshi Watanabe

发明人： Masao Ozeki ,  Tokihito Sawada ,  Takashi Yuchi ,  Kiyoshi Watanabe

IPC分类号： G02F1/1335 ,  G02F1/1343 ,  G02F1/1333 ,  G06F3/041 ,  G06F3/045 ,  G06K11/06 ,  G08C21/00 ,  G06F3/044

CPC分类号： G06F3/0412 ,  G02F1/13338 ,  G06F3/044

摘要： It is characterized in that there is provided a liquid crystal panel including a pair of transparent substrates having electrodes for liquid crystal display disposed thereon, respectively, the electrodes for liquid crystal display being made of a transparent conductive film and serving as electrodes for liquid crystal display, and a liquid crystal sandwiched between the pair of transparent substrates; and that one of the pair of transparent substrates has an electrode for a projection capacitive sensor disposed on a side thereof with the electrode for liquid crystal display disposed thereon, the electrode for a projection capacitive sensor being made of the same conductive film as the electrode for liquid crystal display and serving as an electrode for a projection capacitive sensor.

摘要翻译： 其特征在于，提供一种液晶面板，其分别包括一对具有设置在其上的液晶显示器用电极的透明基板，液晶显示用电极由透明导电膜构成，作为液晶显示用电极 和夹在所述一对透明基板之间的液晶; 并且一对透明基板中的一个具有设置在其侧面上的用于液晶显示器的电极的用于投影电容传感器的电极，用于投影电容传感器的电极由与电极的电极相同的导电膜制成 液晶显示器，用作投影电容式传感器的电极。

公开(公告)号：US08818257B2

公开(公告)日：2014-08-26

申请号：US12824660

申请日：2010-06-28

申请人： Kiyoshi Watanabe ,  Kenichi Hayashi ,  Yusuke Obuchi ,  Rikiya Takemasa ,  Akito Sekigawa

发明人： Kiyoshi Watanabe ,  Kenichi Hayashi ,  Yusuke Obuchi ,  Rikiya Takemasa ,  Akito Sekigawa

IPC分类号： G03G15/00

CPC分类号： B26D7/1818 ,  B26D1/08 ,  B26D5/00 ,  B26D7/025 ,  B26D7/0625 ,  B26D7/088 ,  B26D2007/0018 ,  B41J11/66 ,  B65H45/28 ,  B65H2301/543 ,  B65H2801/27 ,  G03G15/6582 ,  G03G2215/00426 ,  G03G2215/00814 ,  Y10T83/242 ,  Y10T83/9319 ,  Y10T83/9321

摘要： A cutting apparatus configured to cut a sheet or a sheet bundle includes a cutting blade whose blade surface has a plurality of grooves. In the cutting apparatus, a scraping member enters the grooves provided on the blade surface to scrape off cutting scraps remaining after a cutting operation. Accordingly, the cutting apparatus can scrape off cutting scraps from the cutting blade even if the adhesive force of the cutting scraps is great.

摘要翻译： 构造成切割片材或片材束的切割装置包括其刀片表面具有多个凹槽的切割刀片。 在切割装置中，刮削构件进入设置在叶片表面上的凹槽，以刮除切割操作后残留的切割屑。 因此，即使切割废料的粘附力大，切割装置也可以从切割刀片刮下切屑。

公开(公告)号：US08459630B2

公开(公告)日：2013-06-11

申请号：US13105281

申请日：2011-05-11

申请人： Kiyoshi Watanabe ,  Hideto Abe

发明人： Kiyoshi Watanabe ,  Hideto Abe

IPC分类号： B31F1/00

CPC分类号： B65H45/18 ,  B65H2301/51232 ,  B65H2701/13212 ,  B65H2801/27

摘要： A sheet processing apparatus and an image forming apparatus are provided which can stabilize the shape of the spine after a squaring process. To square a spine Sb of a sheet bundle S, a spine processing apparatus 400 which squares the spine Sb performs squaring of the spine by moving the spine Sb which projects from a pair of first nipping rollers 405 and 406 while pressing the spine Sb by means of a pressing roller 411 in a state where the spine Sb is nipped by a pair of second nipping rollers 403 and 404.

摘要翻译： 提供一种片材处理装置和图像形成装置，其可以在平直处理之后稳定脊柱的形状。 为了使片材摞S的脊部Sb成正方形，对脊柱Sb进行平坦化的脊椎处理装置400通过移动从一对第一夹持辊405和406突出的脊部Sb，同时按压脊柱Sb来进行脊柱的平坦化 在脊柱Sb被一对第二夹持辊403和404夹持的状态下的加压辊411。

公开(公告)号：US08350826B2

公开(公告)日：2013-01-08

申请号：US12769922

申请日：2010-04-29

申请人： Kiyoshi Watanabe

发明人： Kiyoshi Watanabe

IPC分类号： G06F3/045

CPC分类号： G06F3/044 ,  G06F3/0418 ,  G06F2203/04104 ,  G06F2203/04111

摘要： Disclosed is a capacitive touch panel device having a sensing control unit that performs a scan sequence on individual sensor electrodes to measure sensor output values. The sensing control unit exercises control to measure sensor output values, with setup performed to avoid the detection of sensitivity slope, by executing a first scan sequence on all sensor electrodes. If the result of the first scan sequence indicates that multiple points are touched, the sensing control unit exercises control to measure sensor output values again, with setup performed to allow the detection of sensitivity slope, by executing a second scan sequence on the sensor electrodes related to a plurality of touch position candidate coordinates derived from multiple point touches, and identify and eliminate erroneously detected coordinates in accordance with the sensor output values measured upon the execution of the second scan sequence and with the tendency of sensitivity slope.

摘要翻译： 公开了具有感测控制单元的电容式触摸屏设备，其在各个传感器电极上执行扫描序列以测量传感器输出值。 感测控制单元通过在所有传感器电极上执行第一扫描序列来进行控制以测量传感器输出值，进行设置以避免灵敏度斜率的检测。 如果第一扫描序列的结果指示多个点被触摸，则感测控制单元进行控制以再次测量传感器输出值，通过执行设置来允许检测灵敏度斜率，通过在传感器电极上执行第二扫描顺序 涉及从多点触摸导出的多个触摸位置候选坐标，并且根据在执行第二扫描序列时测量的传感器输出值和灵敏度斜率的趋势来识别和消除错误检测的坐标。

公开(公告)号：US20120146942A1

公开(公告)日：2012-06-14

申请号：US13323181

申请日：2011-12-12

申请人： Kenta KAMOSHIDA ,  Kiyoshi Watanabe

发明人： Kenta KAMOSHIDA ,  Kiyoshi Watanabe

IPC分类号： G06F3/045

CPC分类号： G06F3/044 ,  G06F2203/04111

摘要： A capacitive touch panel has a plurality of first transparent electrodes and a plurality of second transparent electrodes on a transparent substrate. At crossing portions between the first and second electrodes, adjacent electrodes of the second electrodes have no interruption, and adjacent electrodes of the first electrodes are interrupted. An interlayer insulating film is disposed as an upper layer on the second electrodes, and a bridge electrode is disposed as an upper layer on the interlayer insulating film to connect interrupted portions of the first electrodes at the crossing portions. The material constituting the bridge electrode contains an element that is more susceptible to oxidation than elements contained in a material constituting the second electrodes. Constant voltage is applied to the first electrodes, and a pulse voltage having a low potential equal to or higher than the potential of the first electrodes is applied to the second electrodes.

摘要翻译： 电容式触摸面板在透明基板上具有多个第一透明电极和多个第二透明电极。 在第一和第二电极之间的交叉部分，第二电极的相邻电极没有中断，并且第一电极的相邻电极被中断。 在第二电极上设置层间绝缘膜作为上层，并且在层间绝缘膜上设置桥电极作为上层，以在交叉部分连接第一电极的中断部分。 构成桥电极的材料含有比构成第二电极的材料中包含的元素更易于氧化的元素。 对第一电极施加恒定电压，并且将具有等于或高于第一电极的电位的低电位的脉冲电压施加到第二电极。

公开(公告)号：US20120139874A1

公开(公告)日：2012-06-07

申请号：US13396105

申请日：2012-02-14

申请人： Masao OZEKI ,  Tokihito Sawada ,  Takashi Yuchi ,  Kiyoshi Watanabe

发明人： Masao OZEKI ,  Tokihito Sawada ,  Takashi Yuchi ,  Kiyoshi Watanabe

IPC分类号： G06F3/044 ,  G09G3/36 ,  G02F1/1343

CPC分类号： G06F3/0412 ,  G02F1/13338 ,  G06F3/044

摘要： It is characterized in that there is provided a liquid crystal panel including a pair of transparent substrates having electrodes for liquid crystal display disposed thereon, respectively, the electrodes for liquid crystal display being made of a transparent conductive film and serving as electrodes for liquid crystal display, and a liquid crystal sandwiched between the pair of transparent substrates; and that one of the pair of transparent substrates has an electrode for a projection capacitive sensor disposed on a side thereof with the electrode for liquid crystal display disposed thereon, the electrode for a projection capacitive sensor being made of the same conductive film as the electrode for liquid crystal display and serving as an electrode for a projection capacitive sensor.

摘要翻译： 其特征在于，提供一种液晶面板，其分别包括一对具有设置在其上的液晶显示器用电极的透明基板，液晶显示用电极由透明导电膜构成，作为液晶显示用电极 和夹在所述一对透明基板之间的液晶; 并且一对透明基板中的一个具有设置在其侧面上的用于液晶显示器的电极的用于投影电容传感器的电极，用于投影电容传感器的电极由与电极的电极相同的导电膜制成 液晶显示器，用作投影电容式传感器的电极。