公开(公告)号：US4292549A

公开(公告)日：1981-09-29

申请号：US3120

申请日：1979-01-12

申请人： Takeshi Wada ,  Masanori Ienaka ,  Yasuo Kominami ,  Yukihiko Miyamoto ,  Tsuneo Yamada

发明人： Takeshi Wada ,  Masanori Ienaka ,  Yasuo Kominami ,  Yukihiko Miyamoto ,  Tsuneo Yamada

IPC分类号： H03K3/013 ,  H03D3/04 ,  H03K3/02 ,  H03K3/023 ,  H03K3/0232 ,  H03K5/04 ,  H03K9/06 ,  H03K5/08 ,  H03K3/033

CPC分类号： H03D3/04 ,  H03K3/023 ,  H03K5/04 ,  H03K9/06

摘要： A monostable multivibrator circuit including a time constant circuit which includes a capacitor, an amplifier circuit which receives an output signal of the time constant circuit, and a positive feedback circuit which is connected between an output end of the amplifier circuit and an input end of the time constant circuit, characterized in that a trigger circuit is incorporated in a part of a circuit loop which is constructed of the time constant circuit, the amplifier circuit and the positive feedback circuit, the trigger circuit comprising an emitter-follower transistor which receives a feedback signal, another emitter-follower transistor which receives a trigger signal and whose emitter is connected to an emitter of the first-mentioned emitter-follower transistor in common, and a constant-current circuit which supplies a constant current to the emitters connected in common. Thus, the monostable multivibrator circuit can provide a predetermined pulse signal without any interference attributable to a trigger input circuit.

摘要翻译： 一种单稳态多谐振荡器电路，包括时间常数电路，其包括电容器，接收时间常数电路的输出信号的放大器电路和连接在放大器电路的输出端和放大器电路的输入端之间的正反馈电路 时间常数电路，其特征在于，触发电路被并入由时间常数电路，放大器电路和正反馈电路构成的电路回路的一部分中，触发电路包括发射极跟随器晶体管，其接收反馈 信号，另一发射极跟随器晶体管，其接收触发信号并且其发射极共同连接到所述射极跟随器晶体管的发射极;以及恒定电流电路，其向共同连接的发射极提供恒定电流。 因此，单稳态多谐振荡器电路可以提供预定的脉冲信号，而不受归因于触发输入电路的任何干扰。

公开(公告)号：US10428019B2

公开(公告)日：2019-10-01

申请号：US13825627

申请日：2011-09-22

申请人： Takeshi Wada ,  Mamoru Shimizu

发明人： Takeshi Wada ,  Mamoru Shimizu

IPC分类号： C07H21/02 ,  C07H21/00 ,  C07H19/00 ,  C07H19/04 ,  C07H19/20 ,  C07D221/06 ,  C07D217/22 ,  C07D211/56 ,  C07D211/40 ,  C07D221/18 ,  C07D209/56 ,  C09B7/02 ,  C07D207/12 ,  C07D207/16 ,  C07D211/44 ,  C07D211/62 ,  C07D217/24 ,  C07H19/06 ,  C07H19/16 ,  C07D209/62 ,  C07D211/42 ,  C07D221/10 ,  C07H1/00 ,  C07H21/04

摘要： The disclosed and claimed compounds are chiral auxiliaries useful for efficiently producing a phosphorus atom-modified nucleic acid derivative with high stereoregularity. The disclosed and claimed compounds include those represented by the following formula (I) or formula (XI) for introducing the chiral auxiliaries.

公开(公告)号：US09394333B2

公开(公告)日：2016-07-19

申请号：US13131591

申请日：2009-12-02

申请人： Takeshi Wada ,  Mamoru Shimizu

发明人： Takeshi Wada ,  Mamoru Shimizu

IPC分类号： C07H21/00 ,  C07H21/02 ,  C07H21/04 ,  C12Q1/68

CPC分类号： C07H21/00 ,  C07H1/00

摘要： Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide.

摘要翻译： 本文描述了合成包含手性X-膦酸酯部分的磷原子修饰的核酸的方法。 本文描述的方法通过包含化学稳定的H-膦酸酯部分与核苷/核苷酸的非手性分子的不对称反应提供具有高度对映纯度的骨架修饰的核酸。

公开(公告)号：US08509877B2

公开(公告)日：2013-08-13

申请号：US12260630

申请日：2008-10-29

申请人： Kensaku Mori ,  Takayuki Kitasaka ,  Shunya Akimoto ,  Kouhei Ebe ,  Takeshi Wada

发明人： Kensaku Mori ,  Takayuki Kitasaka ,  Shunya Akimoto ,  Kouhei Ebe ,  Takeshi Wada

IPC分类号： A61B5/05

CPC分类号： A61B1/04 ,  A61B1/00009 ,  A61B1/2676 ,  A61B5/103 ,  A61B5/418

摘要： According to the invention, a VOI (Volume of Interest) generation setting section disposed in an endoscope insertion support apparatus comprises a VOI setting function section, a VOI extending function section, a VOI direction determining function section, a VOI branch determining function section, a VOI resetting function section, a VOI information storage function section, a VOI size determining function section and a VOI branch extracting function section. This configuration enables a VOI to be effectively set in a tubular organ having a strictured part and tubular path area information on the tubular organ to be extracted.

摘要翻译： 根据本发明，设置在内窥镜插入支持装置中的VOI（感兴趣的体积）生成设定部包括VOI设定功能部，VOI延伸功能部，VOI方向决定功能部，VOI分支决定功能部， VOI复位功能部分，VOI信息存储功能部分，VOI大小确定功能部分和VOI分支提取功能部分。 这种构造使得能够将VOI有效地设置在管状器官中，所述管状器具具有狭缝部分和管状路径区域信息，用于待提取的管状器官。

公开(公告)号：US20120225117A1

公开(公告)日：2012-09-06

申请号：US13510845

申请日：2010-11-15

申请人： Takeshi Isoda ,  Yasuyuki Motokui ,  Takeshi Wada

发明人： Takeshi Isoda ,  Yasuyuki Motokui ,  Takeshi Wada

IPC分类号： A61K9/133 ,  A61K31/7068 ,  A61P35/00 ,  A61P31/04 ,  A61P29/00 ,  A61P3/02 ,  A61P39/06 ,  A61K31/365 ,  A61P31/10 ,  B82Y40/00 ,  B82Y5/00

CPC分类号： B01J13/04 ,  A61K9/113 ,  A61K9/127 ,  B01J13/12

摘要： The present invention provides a liposome production process which enables production of a liposome that has a nano-size particle diameter and a high water-soluble drug encapsulation rate. The process for producing a W1/O/W2 emulsion of the present invention includes the steps of (1) emulsifying an organic solvent (O) that is a volatile organic solvent, an aqueous solvent (W1) and a mixed lipid component (F1) to give a W1/O emulsion; and (2) dispersing the W1/O emulsion produced in step (1) in an aqueous solvent (W2) by use of a porous membrane, to give a W1/O/W2 emulsion, wherein the porous membrane has been surface-treated with a hydrophilic drug so as to allow its surface to have a water contact angle of 0 to 42° in the air.

摘要翻译： 本发明提供了能够生产具有纳米尺寸粒径和高水溶性药物包封率的脂质体的脂质体制造方法。 制备本发明的W1 / O / W2乳液的方法包括以下步骤：（1）乳化作为挥发性有机溶剂的有机溶剂（O），水性溶剂（W1）和混合脂质成分（F1） 得到W1 / O乳液; 和（2）通过使用多孔膜将步骤（1）中制备的W1 / O乳液分散在水性溶剂（W2）中，得到W1 / O / W2乳液，其中多孔膜已经用 一种亲水药物，以使其表面在空气中具有0至42°的水接触角。

公开(公告)号：US20110041011A1

公开(公告)日：2011-02-17

申请号：US12281751

申请日：2007-03-06

申请人： Takeshi Wada ,  Masahiko Dohi

发明人： Takeshi Wada ,  Masahiko Dohi

IPC分类号： G06F11/07

CPC分类号： G01R31/31813

摘要： The present invention is to provide a test signal generating apparatus which can generate a test signal for testing a device that dynamically change its operational state in response to a signal or the like. The test signal generating apparatus includes: a pattern storage unit 20 having patterns; a pattern selecting unit 23 for selecting a pattern from among the patterns; a test signal generating unit 25 for generating a test signal having a pattern selected by the pattern selecting unit 23, a trigger signal receiving unit 21 for receiving at least one trigger signal, and a pattern map storage unit 22 having a pattern map defining the number of repetitions for each pattern and a pattern corresponding to a test signal to be generated by the test signal generating unit after the test signal generating unit repeats the test signal on the basis of the number of repetitions.

摘要翻译： 本发明是提供一种测试信号发生装置，其可以生成用于测试响应于信号等动态地改变其操作状态的装置的测试信号。 测试信号产生装置包括：具有图案的图案存储单元20; 模式选择单元23，用于从模式中选择模式; 用于产生具有由模式选择单元23选择的模式的测试信号的测试信号产生单元25，用于接收至少一个触发信号的触发信号接收单元21以及具有定义数字的模式映射的模式图存储单元22 在测试信号生成单元根据重复次数重复测试信号之后，对于每个模式的重复以及与由测试信号生成单元生成的测试信号相对应的模式。

公开(公告)号：US20110003980A1

公开(公告)日：2011-01-06

申请号：US12659425

申请日：2010-03-09

申请人： Takeshi Wada ,  Rintaro Iwata

发明人： Takeshi Wada ,  Rintaro Iwata

IPC分类号： C07G11/00 ,  C07H21/00 ,  C07H19/00

CPC分类号： C07H15/18 ,  C07H15/04

摘要： An oligo-aminosaccharide compound formed by binding 3 to 6 saccharides, such as 2,6-diamino-2,6-dideoxy-α-(1→4)-D-glucopyranose oligomers, or a salt thereof, which has high affinity to a double-stranded nucleic acid.

摘要翻译： 通过结合3〜6个糖类形成的寡氨基糖化合物，例如2,6-二氨基-2,6-二脱氧-α-（1→4）-D-吡喃葡萄糖低聚物或其盐，其对 双链核酸。

公开(公告)号：US20100059127A1

公开(公告)日：2010-03-11

申请号：US12585208

申请日：2009-09-08

申请人： Makoto Shibata ,  Takeshi Wada ,  Michihiro Kumagae

发明人： Makoto Shibata ,  Takeshi Wada ,  Michihiro Kumagae

IPC分类号： F04B43/04

CPC分类号： F04B43/046 ,  Y10T137/85986

摘要： To provide a piezoelectric pump including: a structure including a piezoelectric element and a support member that supports the piezoelectric element; and a first substrate and a second substrate that sandwich the structure, wherein the piezoelectric pump has: a pump chamber surrounded by the second substrate and the structure; and a first opening and a second opening that are communicated with the pump chamber, and wherein a space is provided so that the structure flexes in a direction opposite to the pump chamber according to an operation of the piezoelectric element.

摘要翻译： 提供一种压电泵，包括：包括压电元件和支撑压电元件的支撑构件的结构; 以及夹着所述结构的第一基板和第二基板，其中所述压电泵具有：由所述第二基板和所述结构围绕的泵室; 以及与所述泵室连通的第一开口和第二开口，并且其中设置有空间，使得所述结构根据所述压电元件的操作沿与所述泵室相反的方向弯曲。

公开(公告)号：US07492553B2

公开(公告)日：2009-02-17

申请号：US11670266

申请日：2007-02-01

申请人： Takeshi Wada ,  Takashi Honda

发明人： Takeshi Wada ,  Takashi Honda

IPC分类号： G11B21/16

CPC分类号： G11B5/4813

摘要： A suspension includes a multilayered plate member formed by at least three layers laminated together. The modulus of elasticity of neighboring layers of the at least three layers are different from each other. Both side edges of only a part of the layers of the multilayered plate member within a stiffness-required region are bent to form ribs.

摘要翻译： 悬架包括通过层叠在一起的至少三层形成的多层板构件。 至少三层的相邻层的弹性模量彼此不同。 在刚度要求区域内的多层板构件的仅一部分层的两个侧边缘被弯曲以形成肋。

公开(公告)号：US20080174935A1

公开(公告)日：2008-07-24

申请号：US12007831

申请日：2008-01-16

申请人： Masaaki Togashi ,  Takeshi Wada

发明人： Masaaki Togashi ,  Takeshi Wada

IPC分类号： H01G4/232

CPC分类号： H01G4/232 ,  H01G4/012 ,  H01G4/30

摘要： A multilayer capacitor has a capacitor element, inner electrodes arranged within the capacitor element, and first terminal electrodes and second terminal electrodes arranged on the capacitor element. The capacitor element has an element part held between the inner electrodes. The first terminal electrodes and second terminal electrodes have electrode parts. When seen in a second direction, the electrode parts are arranged on first and second side faces in any of a plurality of areas holding the element part therebetween in a third direction and not overlapping the element part.

摘要翻译： 层叠电容器具有电容器元件，布置在电容器元件内的内部电极，以及布置在电容器元件上的第一端子电极和第二端子电极。 电容器元件具有保持在内部电极之间的元件部分。 第一端子电极和第二端子电极具有电极部分。 当从第二方向看时，电极部分被布置在第一和第二侧面中的多个区域中的任何一个区域中，在第三方向上保持元件部分，并且不与元件部分重叠。