公开(公告)号：US20110319960A1

公开(公告)日：2011-12-29

申请号：US13225769

申请日：2011-09-06

申请人： Imad Libbus ,  Ronald W. Heil, JR. ,  Avram Scheiner

发明人： Imad Libbus ,  Ronald W. Heil, JR. ,  Avram Scheiner

IPC分类号： A61N1/372 ,  A61N1/05

CPC分类号： A61N1/0476 ,  A61N1/05 ,  A61N1/056 ,  A61N1/057 ,  A61N1/36117

摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The expandable electrode includes a plurality of electrode zones. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.

摘要翻译： 一种装置包括从近端延伸到远端的柔性引线主体，靠近远端连接的可扩张电极，所述可扩张电极具有尺寸设计成邻接肺动脉壁的扩张直径，以及电耦合的可植入脉冲发生器 到可膨胀电极。 可膨胀电极包括多个电极区。 可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。

公开(公告)号：US08055332B2

公开(公告)日：2011-11-08

申请号：US12893127

申请日：2010-09-29

申请人： Aaron R. McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron R. McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61B5/04

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US20110105933A1

公开(公告)日：2011-05-05

申请号：US13004543

申请日：2011-01-11

申请人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

发明人： Avram Scheiner ,  Qingsheng Zhu ,  Arthur L. Olive ,  Don Villalta

IPC分类号： A61B5/02

CPC分类号： A61B7/04 ,  A61B5/0002 ,  A61B5/0031 ,  A61B5/04012 ,  A61B5/04014 ,  A61B5/0402 ,  A61B5/042 ,  A61B5/044 ,  A61B5/0452 ,  A61B5/1118 ,  A61B5/742 ,  A61B7/023 ,  G06F19/00

摘要： An apparatus for outputting heart sounds includes an implantable system and an external system. The implantable system includes a sensor for generating sensed signals representing detected heart sounds, an interface circuit and a control circuit for receiving the sensed signals, generating data representing the heart sounds therefrom, and transmitting the data to the external system via the interface circuit. The external system includes an interface circuit for communicating with the implantable system, and a control circuit for receiving the data representing the heart sounds and for generating control signals that cause an output device to generate outputs representing the sounds. The implantable system may also include a sensor(s) for detecting cardiac electrical signals. In this case, outputs representing the cardiac electrical signals are also output.

摘要翻译： 用于输出心音的装置包括可植入系统和外部系统。 可植入系统包括用于产生表示检测到的心音的感测信号的传感器，接口电路和用于接收感测信号的控制电路，产生表示心音的数据，以及经由接口电路将数据发送到外部系统。 外部系统包括用于与可植入系统进行通信的接口电路，以及用于接收表示心脏声音的数据的控制电路，以及用于产生使输出设备产生表示声音的输出的控制信号。 可植入系统还可以包括用于检测心脏电信号的传感器。 在这种情况下，还输出表示心电信号的输出。

公开(公告)号：US07818051B2

公开(公告)日：2010-10-19

申请号：US11925657

申请日：2007-10-26

申请人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

发明人： Aaron McCabe ,  Avram Scheiner ,  Geng Zhang ,  Quan Ni ,  Douglas R. Daum ,  Yi Zhang

IPC分类号： A61B5/04

CPC分类号： A61B5/0402 ,  A61N1/365 ,  A61N1/3756

摘要： An implantable medical device such as an implantable pacemaker or implantable cardioverter/defibrillator includes a programmable sensing circuit providing for sensing of a signal approximating a surface electrocardiogram (ECG) through implanted electrodes. With various electrode configurations, signals approximating various standard surface ECG signals are acquired without the need for attaching electrodes with cables onto the skin. The various electrode configurations include, but are not limited to, various combinations of intracardiac pacing electrodes, portions of the implantable medical device contacting tissue, and electrodes incorporated onto the surface of the implantable medical device.

摘要翻译： 诸如可植入起搏器或植入式心律转复/除颤器的可植入医疗装置包括可编程感测电路，用于通过植入电极感测接近表面心电图（ECG）的信号。 通过各种电极配置，获取近似各种标准表面ECG信号的信号，而不需要将电极与电缆连接在皮肤上。 各种电极配置包括但不限于心脏内起搏电极，可植入医疗器械接触组织的部分和结合到可植入医疗装置的表面上的电极的各种组合。

公开(公告)号：US20100114244A1

公开(公告)日：2010-05-06

申请号：US12263202

申请日：2008-10-31

申请人： Venkatesh Manda ,  Kenneth M. Anderson ,  David E. Euler ,  Avram Scheiner

发明人： Venkatesh Manda ,  Kenneth M. Anderson ,  David E. Euler ,  Avram Scheiner

IPC分类号： A61N1/36 ,  A61N1/08

CPC分类号： A61N1/36007 ,  A61N1/08 ,  A61N1/32

摘要： Electrical stimulation may be configured to decrease renal sympathetic activity by creating at least a partial functional conduction block in the efferent and/or afferent sympathetic nerve fibers that innervate the kidneys. An electrical stimulator may deliver a stimulation signal to a renal nerve of a patient. The stimulation signal may be a biphasic signal with a frequency of approximately 100 hertz to 20 kilohertz. In some examples, a sensor may sense a physiological parameter of the patient, and the stimulation generator may activate, deactivate, or adjust the stimulation signal based on the physiological parameter. The physiological parameter may be indicative of sympathetic activity within the patient.

摘要翻译： 电刺激可以被配置为通过在支配肾脏的传出和/或传入的交感神经纤维中产生至少部分功能性传导阻滞来降低肾交感活性。 电刺激器可以向患者的肾神经传递刺激信号。 刺激信号可以是频率约为100赫兹到20千赫兹的双相信号。 在一些示例中，传感器可以感测患者的生理参数，并且刺激发生器可以基于生理参数激活，去激活或调整刺激信号。 生理参数可以指示患者内的交感神经活动。

公开(公告)号：US20100114221A1

公开(公告)日：2010-05-06

申请号：US12610149

申请日：2009-10-30

申请人： Paul G. Krause ,  Avram Scheiner

发明人： Paul G. Krause ,  Avram Scheiner

IPC分类号： A61N1/08 ,  A61N1/39

CPC分类号： A61N1/36114 ,  A61N1/36514 ,  A61N1/36521

摘要： An implantable medical system that includes a cardiac therapy module and a neurostimulation therapy module may identify when neurostimulation electrodes have migrated toward a patient's heart. In some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on a physiological response to an electrical signal delivered to the patient via the neurostimulation electrodes. In addition, in some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on an electrical cardiac signal sensed via the neurostimulation electrodes.

公开(公告)号：US07680534B2

公开(公告)日：2010-03-16

申请号：US11067964

申请日：2005-02-28

申请人： Donald L. Hopper ,  John M. Voegele ,  Jesse W. Hartley ,  Avram Scheiner

发明人： Donald L. Hopper ,  John M. Voegele ,  Jesse W. Hartley ,  Avram Scheiner

IPC分类号： A61N1/362

CPC分类号： A61B5/686 ,  A61B5/0022 ,  A61B5/0024 ,  A61B5/02028 ,  A61B5/0205 ,  A61B5/04012 ,  A61B5/0402 ,  A61B5/076 ,  A61B5/0809 ,  A61B5/0816 ,  A61B5/0826 ,  A61B5/085 ,  A61B5/091 ,  A61B5/1118 ,  A61B5/4836 ,  A61B5/7275 ,  A61B5/7282 ,  A61B5/746 ,  A61B5/747 ,  A61N1/3627 ,  A61N1/36585 ,  A61N1/3702 ,  A61N1/3987 ,  G06F19/00 ,  G16H50/20 ,  G16H50/30

摘要： Cardiac monitoring and/or stimulation methods and systems employing dyspnea measurement. An implantable cardiac device may sense transthoracic impedance and determine a patient activity level. An index indicative of pulmonary function is implantably computed to detect an episode of dyspnea based on a change, trend, and/or value exceeding a threshold at a determined patient activity level. Trending one or more pulmonary function index values may be done to determine a patient's pulmonary function index profile, which may be used to adapt a cardiac therapy. A physician may be automatically alerted in response to a pulmonary function index value and/or a trend of the patient's pulmonary index being beyond a threshold. Computed pulmonary function index values and their associated patient's activity levels may be stored periodically in a memory and/or transmitted to a patient-external device.

摘要翻译： 使用呼吸困难测量的心脏监测和/或刺激方法和系统。 可植入的心脏装置可以感测经胸​​阻抗并确定患者活动水平。 基于在确定的患者活动水平的超过阈值的变化，趋势和/或值来植入式地计算指示肺功能的指标以检测呼吸困难发作。 可以进行一个或多个肺功能指数值的变化以确定患者的肺功能指数分布，其可用于适应心脏疗法。 响应于肺功能指数值和/或患者肺部指数的趋势超过阈值，医生可以自动地被警报。 计算的肺功能指数值及其相关的患者的活动水平可以周期性地存储在存储器中和/或被发送到患者外部设备。

公开(公告)号：US20090276025A1

公开(公告)日：2009-11-05

申请号：US12433768

申请日：2009-04-30

申请人： John E. Burnes ,  Mary M. Morris ,  Michael R.S. Hill ,  Avram Scheiner ,  Ruth N. Klepfer ,  Matthew D. Bonner

发明人： John E. Burnes ,  Mary M. Morris ,  Michael R.S. Hill ,  Avram Scheiner ,  Ruth N. Klepfer ,  Matthew D. Bonner

IPC分类号： A61N1/05

CPC分类号： A61N1/36053 ,  A61M25/09 ,  A61N1/05 ,  A61N1/0551 ,  A61N1/0558 ,  A61N1/057 ,  A61N1/36085 ,  A61N1/36114 ,  A61N1/36125 ,  A61N1/36128

摘要： This disclosure is directed to extra, intra, and transvascular medical lead placement techniques for arranging medical leads and electrical stimulation and/or sensing electrodes proximate nerve tissue within a patient.

公开(公告)号：US07606619B2

公开(公告)日：2009-10-20

申请号：US11422526

申请日：2006-06-06

申请人： Avram Scheiner

发明人： Avram Scheiner

IPC分类号： A61N1/00

CPC分类号： A61N1/37 ,  A61N2001/083

摘要： An apparatus, system, and method may operate to provide a connection signal using a first contact, measure a waveshape associated with a corresponding connection signal arising from the connection signal at a second contact connected to a first electrode using a lead, and provide a comparison result after determining whether the lead is a preselected lead type based on the waveshape.

摘要翻译： 设备，系统和方法可以操作以使用第一接触提供连接信号，测量与使用引线连接到第一电极的第二接触处由连接信号产生的相应连接信号相关联的波形，并提供比较 在确定引线是否是基于波形的预选引线类型后的结果。

公开(公告)号：US20080281372A1

公开(公告)日：2008-11-13

申请号：US11746263

申请日：2007-05-09

申请人： Imad Libbus ,  Avram Scheiner

发明人： Imad Libbus ,  Avram Scheiner

IPC分类号： A61N1/362

CPC分类号： A61N1/36114 ,  A61B5/02405 ,  A61B5/4035 ,  A61N1/36592 ,  A61N2001/083

摘要： Various embodiments relate to a device to analyze an implantable neural stimulation system that includes an implantable neural stimulation lead for an implantable neural stimulator to be implanted into a patient. Various device embodiments comprise an external housing, a pacing circuit in the housing, and a sensing circuit in the housing. The pacing circuit is adapted to deliver a test neural stimulation signal. At least one test lead cable is adapted to electrically connect the pacing circuit and the implantable neural stimulation lead to enable the test neural stimulation signal to be delivered to a neural target through the test lead cable and the implantable neural stimulation lead. At least one physiological sensor is adapted to sense a physiological response to stimulation of the neural target. At least one sensor cable is adapted to electrically connect the sensing circuit and the at least one physiological sensor.

摘要翻译： 各种实施例涉及一种用于分析可植入神经刺激系统的装置，其包括可植入的神经刺激导管，用于植入患者体内的可植入神经刺激器。 各种装置实施例包括外壳，壳体中的起搏电路和壳体中的感测电路。 起搏电路适于提供测试神经刺激信号。 至少一个测试导线电缆适于电连接起搏电路和可植入的神经刺激引线，使测试神经刺激信号能够通过测试导线和可植入的神经刺激引线传递到神经靶。 至少一个生理传感器适于感测对神经目标的刺激的生理反应。 至少一个传感器电缆适于将感测电路和至少一个生理传感器电连接。