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    ELECTRICAL RENAL AUTONOMIC BLOCKADE
    1.
    发明申请
    ELECTRICAL RENAL AUTONOMIC BLOCKADE 审中-公开
    电气自动化BLOCKADE

    公开(公告)号：US20100114244A1

    公开(公告)日：2010-05-06

    申请号：US12263202

    申请日：2008-10-31

    申请人： Venkatesh Manda ,  Kenneth M. Anderson ,  David E. Euler ,  Avram Scheiner

    发明人： Venkatesh Manda ,  Kenneth M. Anderson ,  David E. Euler ,  Avram Scheiner

    IPC分类号： A61N1/36 ,  A61N1/08

    CPC分类号： A61N1/36007 ,  A61N1/08 ,  A61N1/32

    摘要： Electrical stimulation may be configured to decrease renal sympathetic activity by creating at least a partial functional conduction block in the efferent and/or afferent sympathetic nerve fibers that innervate the kidneys. An electrical stimulator may deliver a stimulation signal to a renal nerve of a patient. The stimulation signal may be a biphasic signal with a frequency of approximately 100 hertz to 20 kilohertz. In some examples, a sensor may sense a physiological parameter of the patient, and the stimulation generator may activate, deactivate, or adjust the stimulation signal based on the physiological parameter. The physiological parameter may be indicative of sympathetic activity within the patient.

    摘要翻译： 电刺激可以被配置为通过在支配肾脏的传出和/或传入的交感神经纤维中产生至少部分功能性传导阻滞来降低肾交感活性。 电刺激器可以向患者的肾神经传递刺激信号。 刺激信号可以是频率约为100赫兹到20千赫兹的双相信号。 在一些示例中，传感器可以感测患者的生理参数，并且刺激发生器可以基于生理参数激活，去激活或调整刺激信号。 生理参数可以指示患者内的交感神经活动。

    High frequency stimulation to block laryngeal stimulation during vagal nerve stimulation
    2.
    发明授权
    High frequency stimulation to block laryngeal stimulation during vagal nerve stimulation 有权
    高频刺激阻滞喉管刺激迷路神经刺激

    公开(公告)号：US09370654B2

    公开(公告)日：2016-06-21

    申请号：US12360680

    申请日：2009-01-27

    申请人： Avram Scheiner ,  David E. Euler

    发明人： Avram Scheiner ,  David E. Euler

    IPC分类号： A61N1/05 ,  A61N1/36 ,  A61B5/00

    CPC分类号： A61N1/0556 ,  A61B5/4035 ,  A61B5/4047 ,  A61B5/7217 ,  A61N1/36114

    摘要： An implantable medical device and associated method deliver a therapy to an autonomic nerve. The therapy delivery includes delivering therapeutic low frequency (LF) electrical stimulation pulses to the autonomic nerve and delivering a high frequency electrical signal to the autonomic nerve during the LF frequency stimulation pulse delivery. The high frequency stimulation signal blocks activation of autonomic nerve fibers innervating a non-targeted tissue during the therapeutic LF stimulation pulse delivery.

    摘要翻译： 可植入医疗装置和相关方法将治疗递送至自主神经。 治疗递送包括在LF频率刺激脉冲传送期间向自主神经递送治疗性低频（LF）电刺激脉冲并将高频电信号传送到自主神经。 高频刺激信号阻止在治疗性LF刺激脉冲输送期间支配非目标组织的自主神经纤维的活化。

    HIGH FREQUENCY STIMULATION TO BLOCK LARYNGEAL STIMULATION DURING VAGAL NERVE STIMULATION
    3.
    发明申请
    HIGH FREQUENCY STIMULATION TO BLOCK LARYNGEAL STIMULATION DURING VAGAL NERVE STIMULATION 有权
    高频刺激在血管神经刺激期间进行块状淋巴结刺激

    公开(公告)号：US20100191311A1

    公开(公告)日：2010-07-29

    申请号：US12360680

    申请日：2009-01-27

    申请人： Avram Scheiner ,  David E. Euler

    发明人： Avram Scheiner ,  David E. Euler

    IPC分类号： A61N1/36

    CPC分类号： A61N1/0556 ,  A61B5/4035 ,  A61B5/4047 ,  A61B5/7217 ,  A61N1/36114

    摘要： An implantable medical device and associated method deliver a therapy to an autonomic nerve. The therapy delivery includes delivering therapeutic low frequency (LF) electrical stimulation pulses to the autonomic nerve and delivering a high frequency electrical signal to the autonomic nerve during the LF frequency stimulation pulse delivery. The high frequency stimulation signal blocks activation of autonomic nerve fibers innervating a non-targeted tissue during the therapeutic LF stimulation pulse delivery.

    摘要翻译： 可植入医疗装置和相关方法将治疗递送至自主神经。 治疗递送包括在LF频率刺激脉冲传送期间向自主神经递送治疗性低频（LF）电刺激脉冲并将高频电信号传送到自主神经。 高频刺激信号阻止在治疗性LF刺激脉冲输送期间支配非目标组织的自主神经纤维的活化。

    Therapy system including cardiac rhythm therapy and neurostimulation capabilities
    5.
    发明授权
    Therapy system including cardiac rhythm therapy and neurostimulation capabilities 有权
    治疗系统包括心律治疗和神经刺激能力

    公开(公告)号：US09026206B2

    公开(公告)日：2015-05-05

    申请号：US12610160

    申请日：2009-10-30

    申请人： Paul G. Krause ,  Avram Scheiner

    发明人： Paul G. Krause ,  Avram Scheiner

    IPC分类号： A61N1/362 ,  A61N1/36 ,  A61N1/365

    CPC分类号： A61N1/36114 ,  A61N1/36514 ,  A61N1/36521

    摘要： An implantable medical system that includes a cardiac therapy module and a neurostimulation therapy module may identify when neurostimulation electrodes have migrated toward a patient's heart. In some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on a physiological response to an electrical signal delivered to the patient via the neurostimulation electrodes. In addition, in some examples, the system may determine whether the neurostimulation electrodes have migrated toward the patient's heart based on an electrical cardiac signal sensed via the neurostimulation electrodes.

    摘要翻译： 包括心脏治疗模块和神经刺激治疗模块的可植入医疗系统可以识别神经刺激电极何时向患者的心脏移动。 在一些示例中，系统可以基于对通过神经刺激电极递送给患者的电信号的生理反应来确定神经刺激电极是否已经向患者的心脏迁移。 此外，在一些示例中，系统可以基于经由神经刺激电极感测的电心脏信号来确定神经刺激电极是否已经向患者的心脏迁移。

    Implantable and rechargeable neural stimulator
    7.
    发明授权
    Implantable and rechargeable neural stimulator 有权
    可植入和可充电的神经刺激器

    公开(公告)号：US08634921B2

    公开(公告)日：2014-01-21

    申请号：US13402196

    申请日：2012-02-22

    申请人： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

    发明人： Abhi V. Chavan ,  Anthony V. Caparso ,  Avram Scheiner

    IPC分类号： A61N1/05

    CPC分类号： A61N1/36117 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36135 ,  A61N1/37205 ,  A61N1/37217 ,  A61N1/37288 ,  A61N1/3787

    摘要： One aspect of the present subject matter relates to an implantable medical device. An embodiment of the device comprises a rechargeable power supply adapted to be recharged through an ultrasound signal, a neural stimulator connected to the rechargeable power supply, and a controller connected to the rechargeable power supply. The neural stimulator is adapted to generate a neural stimulation signal for delivery to a neural stimulation target through an electrode. The controller is further connected to the neural stimulator to control the neural stimulator according to a neural stimulation protocol. Other aspects are provided herein.

    摘要翻译： 本主题的一个方面涉及可植入医疗装置。 该装置的实施例包括适于通过超声信号再充电的可再充电电源，连接到可再充电电源的神经刺激器和连接到可再充电电源的控制器。 神经刺激器适于产生用于通过电极递送到神经刺激靶的神经刺激信号。 控制器进一步连接到神经刺激器，以根据神经刺激方案来控制神经刺激器。 本文提供了其他方面。

    Cardiac rhythm management system and method
    8.
    发明授权
    Cardiac rhythm management system and method 有权

    公开(公告)号：US08583235B2

    公开(公告)日：2013-11-12

    申请号：US13494785

    申请日：2012-06-12

    申请人： Qingsheng Zhu ,  Avram Scheiner

    发明人： Qingsheng Zhu ,  Avram Scheiner

    IPC分类号： A61N1/00

    CPC分类号： A61N1/3712

    摘要： A system and method for cardiac rhythm management, which includes an electrode system having at least one electrode and control circuitry coupled to the electrode system from which a first cardiac signal is sensed. The control circuitry includes a pulse circuit to produce electrical pulses at a first value to be delivered to the electrode system in a first cardiac region. At least one cardiac signal is sensed from a second cardiac region, where the cardiac signal includes indications of cardiac depolarizations from the second cardiac region which occurs in direct reaction to the electrical pulses delivered to the first cardiac region. The first value of the electrical pulses are then modified by a pulse adjustment circuit when a cardiac depolarization which occurs in direct reaction to the electrical pulse delivered to the first cardiac region is detected from the second cardiac region.

    Lead for stimulating the baroreceptors in the pulmonary artery
    10.
    发明授权
    Lead for stimulating the baroreceptors in the pulmonary artery 有权
    用于刺激肺动脉中的压力感受器的铅

    公开(公告)号：US08473076B2

    公开(公告)日：2013-06-25

    申请号：US13225769

    申请日：2011-09-06

    申请人： Imad Libbus ,  Ronald W. Heil, Jr. ,  Avram Scheiner

    发明人： Imad Libbus ,  Ronald W. Heil, Jr. ,  Avram Scheiner

    IPC分类号： A61N1/05 ,  A61N1/04

    CPC分类号： A61N1/0476 ,  A61N1/05 ,  A61N1/056 ,  A61N1/057 ,  A61N1/36117

    摘要： An apparatus includes a flexible lead body extending from a proximal end to a distal end, an expandable electrode coupled proximate the distal end, the expandable electrode having an expanded diameter dimensioned to abut a wall of a pulmonary artery, and an implantable pulse generator electrically coupled to the expandable electrode. The expandable electrode includes a plurality of electrode zones. The plurality of zones can be tested to determine which zone delivers the best baroreflex response. At least one of the electrode zones can be selected to deliver a stimulation signal based on the testing. The implantable pulse generator is adapted to deliver a baroreflex stimulation signal to a baroreceptor in the pulmonary artery via the electrode.

    摘要翻译： 一种装置包括从近端延伸到远端的柔性引线主体，靠近远端连接的可扩张电极，所述可扩张电极具有尺寸设计成邻接肺动脉壁的扩张直径，以及电耦合的可植入脉冲发生器 到可膨胀电极。 可膨胀电极包括多个电极区。 可以测试多个区域以确定哪个区域提供最佳的压力反射响应。 可以选择至少一个电极区域以基于测试传递刺激信号。 可植入脉冲发生器适于通过电极将压力反射刺激信号传递给肺动脉中的压力感受器。