公开(公告)号：US20160232280A1

公开(公告)日：2016-08-11

申请号：US15098081

申请日：2016-04-13

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman ,  Siavosh Rezvan Behbahani

IPC: G06F19/12 ,  C12Q1/68 ,  G06F19/00 ,  G06F19/28

CPC classification number: G16H10/40 ,  C12Q1/6883 ,  C12Q2600/112 ,  G01N2800/044 ,  G01N2800/32 ,  G06F19/00 ,  G06F19/24 ,  G06F19/28 ,  G06F19/3418 ,  G16H50/20 ,  H01L27/3211 ,  H01L27/322 ,  H01L27/3272 ,  H01L51/0097 ,  H01L51/5234 ,  H01L51/5265 ,  H01L51/5281 ,  H01L51/5284 ,  H01L2251/5338 ,  Y02A90/26

Abstract: A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

Abstract translation: 一种至少一种在至少一个受试者中表征，诊断和治疗心血管疾病状况的方法，所述方法包括：从受试者群体接收一组生物样品; 为受试者群体生成微生物组合数据集和微生物群功能分集数据集中的至少一个; 基于从至少一个微生物组合数据集和微生物组合功能分集数据集提取的特征，产生心血管疾病状况的表征; 基于表征，产生配置用于校正心血管疾病状况的治疗模型; 并且在与受试者相关联的输出装置处，基于表征和治疗模型促进对受试者的治疗。

公开(公告)号：US20160224748A1

公开(公告)日：2016-08-04

申请号：US15098027

申请日：2016-04-13

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman ,  Siavosh Rezvan Behbahani

IPC: G06F19/00 ,  G06F19/12 ,  G06F19/28 ,  C40B30/02

CPC classification number: G06F19/345 ,  C40B30/02 ,  G06F19/00 ,  G06F19/24 ,  G06F19/28 ,  G06F19/3418 ,  G16H50/20 ,  Y02A90/26

Abstract: A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the autoimmune condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

Abstract translation: 一种至少一种在至少一个受试者中表征，诊断和治疗自身免疫疾病的方法，所述方法包括：从受试者群体接收一组生物样品; 为受试者群体生成微生物组合数据集和微生物群功能分集数据集中的至少一个; 基于从至少一个微生物组合数据集和微生物组合功能分集数据集提取的特征产生自身免疫病症的表征; 基于表征，产生配置用于校正自身免疫状况的治疗模型; 并且在与受试者相关联的输出装置处，基于表征和治疗模型促进对受试者的治疗。

公开(公告)号：US10388407B2

公开(公告)日：2019-08-20

申请号：US15819190

申请日：2017-11-21

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Rodrigo Ortiz ,  Catalina Valdivia ,  Inti Pedroso ,  Paz Tapia

IPC: G01N33/48 ,  G16H10/40 ,  G16H15/00 ,  G16B50/00 ,  C12Q1/6883 ,  C12Q1/689 ,  G06F19/00 ,  G16B99/00 ,  G06G7/58

Abstract: Embodiments of a method and/or system for characterizing a headache-related condition for a user can include one or more of: generating a microbiome dataset for each of an aggregate set of biological samples associated with a population of subjects, based on sample processing of the biological samples; processing a supplementary dataset associated with one or more headache-related conditions for the set of users; and performing a characterization process for the one or more headache-related conditions, based on the supplementary dataset and microbiome features extracted from the microbiome dataset.

公开(公告)号：US20190237159A1

公开(公告)日：2019-08-01

申请号：US16376355

申请日：2019-04-05

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Rodrigo Ortiz

IPC: G16B30/00 ,  C12N15/10 ,  C40B50/06

CPC classification number: G16B30/00 ,  C12N15/1065 ,  C12N15/1093 ,  C12Q1/6869 ,  C12Q2600/156 ,  C40B50/06 ,  G16B30/20

Abstract: Embodiments of a method and/or system for improving fragment assembly and/or sequence identification includes: collecting a sample including a set of nucleic acid components associated with a set of microorganisms; generating a set of tagged sequence fragments; amplifying the set of tagged sequence fragments and sequencing the set of tagged sequence fragments; based upon the set of identifier tags, generating a set of branched assemblies of candidate sequence fragments, wherein each of the set of branched assemblies includes a set of ordered nodes and a set of branches distributed across the set of nodes; implementing a threshold criterion to reduce the set of branched assemblies to a set of branch-reduced assemblies; and identifying a set of sequences corresponding to the set of branch-reduced assemblies and/or generating an analysis informative of the set of microorganisms associated with the sample.

公开(公告)号：US10366789B2

公开(公告)日：2019-07-30

申请号：US15621420

申请日：2017-06-13

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: G01N33/48 ,  G16H40/67 ,  G06F19/00 ,  G16B35/00 ,  G16B40/00 ,  G16B50/00 ,  G16C20/60 ,  G16H50/20 ,  G16H50/50 ,  G16H20/00 ,  G16B50/50 ,  G06G7/58

Abstract: A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US10354757B2

公开(公告)日：2019-07-16

申请号：US15849186

申请日：2017-12-20

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: G01N33/48 ,  G16H50/20 ,  G06F19/00 ,  C12Q1/6874 ,  G16B40/00 ,  G16B50/10 ,  G16H10/40 ,  G06G7/58

Abstract: A method for at least one of characterizing, diagnosing, and treating a cutaneous condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cutaneous condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cutaneous condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US20190211378A1

公开(公告)日：2019-07-11

申请号：US16084965

申请日：2016-09-09

Applicant: UBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Siavosh Rezvan Behbahani

IPC: C12Q1/689

CPC classification number: C12Q1/689 ,  C12Q2600/158 ,  C12Q2600/16 ,  G16B20/00 ,  G16B30/00 ,  G16B40/00 ,  G16H50/20 ,  G16H50/50

Abstract: Methods, compositions, and systems are provided for detecting one or more a cognition health issues by characterizing the microbiome of an individual, monitoring such effects, and/or determining, displaying, or promoting a therapy for the cognition health issue. Methods, compositions, and systems are also provided for generating and comparing microbiome composition and/or functional diversity datasets. Methods, compositions, and systems are also provided for generating a characterization model and/or therapy model for insomnia issues, light sleep issues, headache issues, sinusitis issues, and poor concentration issues.

公开(公告)号：US10347368B2

公开(公告)日：2019-07-09

申请号：US15848824

申请日：2017-12-20

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: G01N33/48 ,  G16H10/40 ,  C12Q1/6883 ,  G06F19/00 ,  G16B40/00 ,  G16B50/00 ,  G16H50/20 ,  H01L27/32 ,  H01L51/00 ,  H01L51/52 ,  G06G7/58

Abstract: A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US10347366B2

公开(公告)日：2019-07-09

申请号：US15816041

申请日：2017-11-17

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: G01N33/48 ,  G16H10/40 ,  C12Q1/6883 ,  G06F19/00 ,  G16B40/00 ,  G16B50/00 ,  G16H50/20 ,  H01L27/32 ,  H01L51/00 ,  H01L51/52 ,  G06G7/58

Abstract: A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US10347362B2

公开(公告)日：2019-07-09

申请号：US15655640

申请日：2017-07-20

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: G01N33/48 ,  G16B30/00 ,  C12Q1/689 ,  G06F19/00 ,  G16B5/00 ,  G16B40/00 ,  G16B50/00 ,  G16H50/20 ,  G06G7/58

Abstract: A method for at least one of characterizing, diagnosing, and treating an endocrine system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the endocrine system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the endocrine system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.