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    Gastric reflux resistant dosage forms
    122.
    发明授权
    Gastric reflux resistant dosage forms 有权

    公开(公告)号：US09192582B2

    公开(公告)日：2015-11-24

    申请号：US14507327

    申请日：2014-10-06

    申请人： Banner Pharmacaps Inc.

    发明人： Nachiappan Chidambaram

    IPC分类号： A61K9/48 ,  A61K9/52 ,  A61K35/60 ,  A61K47/36 ,  A61K47/10 ,  A61K47/42

    CPC分类号： A61K9/4825 ,  A61K9/4816 ,  A61K9/4833 ,  A61K35/60 ,  A61K47/10 ,  A61K47/36 ,  A61K47/42

    摘要： Gastric resistant film-forming compositions are described herein. The composition comprises a gastric resistant natural polymer, a film-forming natural polymer, and optionally a gelling agent. Suitable gastric resistant natural polymers include polysaccharides such as pectin and pectin-like polymers. The film-forming composition can be used to prepare soft or hard shell gelatin capsules which can encapsulate a liquid or semi-solid fill material or a solid tablet (Softlet®) comprising an active agent and one or more pharmaceutically acceptable excipients. Alternatively, the composition can be administered as a liquid with an active agent dissolved or dispersed in the composition. The compositions are not only gastric resistant but may also prevent gastric reflux associated with odor causing liquids, such as fish oil or garlic oil, encapsulated in a unit dosage form and esophageal irritation due to the reflux of irritant drugs delivered orally.

    CHEWABLE SOFT CAPSULES
    126.
    发明申请
    CHEWABLE SOFT CAPSULES 有权
    可燃软胶囊

    公开(公告)号：US20150313840A1

    公开(公告)日：2015-11-05

    申请号：US14790624

    申请日：2015-07-02

    申请人： BANNER LIFE SCIENCES LLC

    发明人： EmadEldin M. Hassan ,  Warren Walter Kindt ,  Roger E. Gordon

    IPC分类号： A61K9/00 ,  A61K31/135 ,  A61K31/192 ,  A61K9/48 ,  A61K31/167

    CPC分类号： A61K9/4816 ,  A61K9/0056 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/135 ,  A61K31/137 ,  A61K31/167 ,  A61K31/19 ,  A61K31/192

    摘要： A matrix formulation for a soft chewable capsule is provided which includes a gel-forming composition, a plasticizer, a polymer modifier, and water. The polymer modifier may be a carboxylic acid or other organic compound that alters the physical and/or chemical properties of the capsule formulation. A chewable soft capsule is also provided, having enhanced organo-leptic and processing properties. An active material may be delivered to a user using this dosage form. A method of forming the chewable soft capsule is also provided.

    摘要翻译： 提供了一种用于软咀嚼胶囊的基质制剂，其包括凝胶形成组合物，增塑剂，聚合物改性剂和水。 聚合物改性剂可以是改变胶囊制剂的物理和/或化学性质的羧酸或其它有机化合物。 还提供了咀嚼软胶囊，具有增强的有机光和加工性能。 可以使用该剂型将活性物质递送给使用者。 还提供了形成可咀嚼软胶囊的方法。

    PHARMACEUTICAL COMPOSTIONS OF DICLOFENAC OR SALTS THEREOF
    129.
    发明申请
    PHARMACEUTICAL COMPOSTIONS OF DICLOFENAC OR SALTS THEREOF 审中-公开
    DICLOFENAC或其销售的药物组合物

    公开(公告)号：US20150250750A1

    公开(公告)日：2015-09-10

    申请号：US14430939

    申请日：2013-05-03

    申请人： WOCKHARDT LIMITED

    发明人： Moinuddin Syed ,  Nitin Martandrao Mehetre ,  Rahul Sudhakar Dabre ,  Girish Kumar Jain

    IPC分类号： A61K31/196 ,  A61K47/14 ,  A61K47/22 ,  A61K9/48 ,  A61K47/10

    CPC分类号： A61K31/196 ,  A61K9/4825 ,  A61K9/4858 ,  A61K9/4866 ,  A61K47/10 ,  A61K47/14 ,  A61K47/22 ,  A61K47/44

    摘要： The present invention refers to an improved pharmaceutical composition of diclofenac or pharmaceutically acceptable salt and pharmaceutically acceptable excipients wherein the composition is substantially free of dispersing agents. By judicially using pharmaceutical excipients other than dispersing agent, pharmaceutical composition of diclofenac or its salts with rapid and uniform gastrointestinal absorption of diclofenac can be achieved. The composition of the invention can also minimize the controllable side effects of diclofenac.

    摘要翻译： 本发明涉及双氯芬酸或其药学上可接受的盐和药学上可接受的赋形剂的改进的药物组合物，其中所述组合物基本上不含分散剂。 通过司法使用分散剂以外的药用赋形剂，可以实现双氯芬酸或其盐类药物组合物对双氯芬酸的快速均匀胃肠吸收。 本发明的组合物还可以最小化双氯芬酸的可控副作用。

    Doxycycline Formulations, and Methods of Treating Rosacea
    130.
    发明申请
    Doxycycline Formulations, and Methods of Treating Rosacea 审中-公开
    强力霉素配方和治疗红斑痤疮的方法

    公开(公告)号：US20150245998A1

    公开(公告)日：2015-09-03

    申请号：US14711375

    申请日：2015-05-13

    申请人： Galderma S.A. ,  Cerovene, Inc.

    发明人： Jean-Pierre Etchegaray ,  Nathalie Wagner ,  Manish S. Shah ,  Ray J. Difalco

    IPC分类号： A61K9/48 ,  A61K31/65

    CPC分类号： A61K31/65 ,  A61K9/0053 ,  A61K9/4808 ,  A61K9/4825 ,  A61K9/4866 ,  A61K9/4891

    摘要： The present invention is directed to a pharmaceutical composition in unit dose form for orally delivering doxycycline to a human, the pharmaceutical composition comprising: a capsule, wherein the capsule is coated with a delayed release layer; wherein the delayed release layer comprises about 4 to 6 mg of doxycycline monohydrate and a binding agent, and wherein the delayed release layer is coated with an enteric coating; wherein the enteric coating dissolves at pH of about 5 to 6, and wherein the enteric coating is coated with an immediate release layer; wherein the immediate release layer comprises about 32 mg of doxycycline monohydrate and a binding agent, wherein the relative mean Cmax of the pharmaceutical composition is within 80.00% to 125.00% of a Cmax value of 510±220.7 ng/mL, after administration of a single dose of the pharmaceutical composition to humans in a fasting state; and wherein the relative mean AUC(0-∞) of the pharmaceutical composition is within 80.00% to 125.00% of a AUC(0-∞) value of 9227±3212.8 ng·hr/mL, after administration of a single dose of the pharmaceutical composition to humans in a fasting state.

    摘要翻译： 本发明涉及用于向人口服输送多西环素的单位剂量形式的药物组合物，所述药物组合物包含：胶囊，其中所述胶囊被涂覆有延迟释放层; 其中所述延迟释放层包含约4至6mg的多西环素一水合物和结合剂，并且其中所述延迟释放层涂覆有肠溶衣; 其中所述肠溶衣在约5至6的pH下溶解，并且其中所述肠溶衣涂覆有速释层; 其中立即释放层包含约32mg的多西环素一水合物和结合剂，其中药物组合物的相对平均C max在给予单一药物后的C max值为510±220.7ng / mL的80.00％至125.00％ 药物组合物在禁食状态下的剂量; 并且其中药物组合物的相对平均AUC（0-∞）在给予单剂量的药物后在AUC（0-∞）值为9227±3212.8ng·hr / mL的80.00％至125.00％ 组合到禁食状态的人类。