公开(公告)号：US10954247B2

公开(公告)日：2021-03-23

申请号：US15983519

申请日：2018-05-18

Applicant: Research Triangle Institute

Inventor： Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  James Barnwell Thomas ,  Kenneth S. Rehder ,  Srinivas Olepu

IPC: C07D491/107 ,  C07D403/04 ,  A61K31/5377 ,  C07D401/12 ,  C07D403/14 ,  C07D405/12 ,  C07D417/04 ,  C07D409/04 ,  C07D403/12 ,  C07D417/12 ,  C07D403/06 ,  C07D231/14 ,  C07D471/08 ,  C07D413/12 ,  C07D401/14 ,  C07D417/14 ,  A61K45/06 ,  C07D487/08 ,  C07D407/12 ,  A61K31/55 ,  A61K31/427 ,  A61K31/422 ,  A61K31/415 ,  A61K31/4245 ,  A61K31/4196 ,  A61K31/454 ,  A61K31/497 ,  A61K31/4439 ,  A61K31/439 ,  C07D413/04

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20210070767A1

公开(公告)日：2021-03-11

申请号：US17082650

申请日：2020-10-28

Applicant: Research Triangle Institute

Inventor： Scott P. RUNYON ,  Rangan MAITRA ,  Sanju NARAYANAN ,  James Barnwell THOMAS ,  Kenneth S. REHDER ,  Srinivas OLEPU

IPC: C07D491/107 ,  C07D403/12 ,  C07D231/14 ,  C07D403/06 ,  C07D407/12 ,  C07D413/12 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/12 ,  C07D409/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20210053024A1

公开(公告)日：2021-02-25

申请号：US17054590

申请日：2019-05-17

Applicant: Research Triangle Institute

Inventor： Ignacio LUZ MINGUEZ ,  Mustapha SOUKRI ,  Marty LAIL ,  Lora Goon TOY

IPC: B01J20/22 ,  B01D53/02 ,  B01D53/22 ,  B01J20/28

Abstract: A method for making a metal organic framework suspension is described herein. The method includes providing a hybrid material comprising a nano-crystalline metal organic framework comprising micropores and a mesoporous polymeric material comprising mesopores, wherein the nano-crystalline metal organic framework is homogeneously dispersed and substantially present only within the mesopores or void spaces of the mesoporous polymeric material; and wherein the hybrid material has a weight percentage of the metal organic framework in the range of 5-50% relative to the total weight of the hybrid material. The method includes contacting the hybrid material with a solvent in which the mesoporous polymeric material is soluble, thereby forming a polymeric solution in which the nano-crystalline metal organic framework is substantially homogeneously dispersed and suspended.

公开(公告)号：US20200255961A1

公开(公告)日：2020-08-13

申请号：US16786150

申请日：2020-02-10

Applicant: Research Triangle Institute

Inventor： Aravind Villava Rayer Rabindran ,  Elliot Reid ,  Ignacio Luz Minguez ,  Mustapha Soukri ,  Marty Lail ,  Shaojun James Zhou

IPC: C25B3/04 ,  B01J31/16 ,  B01J37/08 ,  C09D11/52 ,  C25B11/12

Abstract: A carbon dioxide reduction reaction electrocatalyst comprises a pyrolyzed copper-based metal-organic framework (MOF) that produces isopropanol from electrochemical reduction of carbon dioxide. A process for producing isopropanol from electrochemical reduction of carbon dioxide comprises applying a potential in an electrochemical cell in the range of about −2V to about −3V versus a silver chloride electrode.

公开(公告)号：US20200246745A1

公开(公告)日：2020-08-06

申请号：US16748111

申请日：2020-01-21

Applicant: Research Triangle Institute

Inventor： Marty Lail ,  Aravind Villava Rayer Rabindran ,  Samuel John Thompson

IPC: B01D53/14 ,  B01D53/18

Abstract: The disclosure provides methods and systems for decreasing nitrosamine content, e.g., in the context of non-aqueous solvent systems. It includes a method including receiving a non-aqueous solvent system and contacting the non-aqueous solvent system with a composition including one or more alkoxides to give a treated solvent system having a nitrosamine content that is lower than the starting nitrosamine content. Similarly, it includes a system including a first unit configured to remove undesirable components from a gas stream; a second unit holding a composition including one or more alkoxides, and a conduit to connect these units.

公开(公告)号：US20200246268A1

公开(公告)日：2020-08-06

申请号：US16620160

申请日：2018-06-07

Applicant: PAI Life Sciences Inc. ,  Infectious Disease Research Institute ,  Research Triangle Institute

Inventor： Darrick CARTER ,  Anthony James HICKEY ,  Phillip Gregory DURHAM ,  Ragan PITNER

IPC: A61K9/14 ,  A61K31/7076 ,  A61K38/12 ,  A61K9/00

Abstract: Capreomycin sulfate and CPZEN-45, which act in non-identical manners to treat tuberculosis infection, are combined into particles by spray drying thereby giving an intimate mixture for combination drug therapy. The spray dried combination powder is prepared in an aerodynamic particle size range (such as 1-5 μm) suitable for pulmonary delivery when delivered from an inhaler.

公开(公告)号：US20200232406A1

公开(公告)日：2020-07-23

申请号：US16652307

申请日：2018-09-24

Applicant: Research Triangle Institute

Inventor： John Reeves Carpenter ,  David Douglas Barbee ,  Apoorv Agarwal

IPC: F02D41/06 ,  F02D41/00 ,  F02P5/14 ,  F02D41/14 ,  F02B37/12 ,  F02M31/16

Abstract: An internal combustion engine is operated at fuel-rich conditions by adjusting one or more operating parameters such as, for example, a throttle, an ignition timing, a load coupled to the engine, a fuel pressure, power to a supercharger, and power to a preheater to maintain a specified engine speed and a temperature of an exhaust gas. Operating the engine under these conditions allows the engine to function as a reformer producing a synthesis gas comprising hydrogen and carbon monoxide.

公开(公告)号：US20200072669A1

公开(公告)日：2020-03-05

申请号：US16557399

申请日：2019-08-30

Applicant: Research Triangle Institute

Inventor： Kelley Jo Rountree ,  James Lynn Davis ,  Karmann Cressman Mills ,  Georgiy Bobashev ,  Robert Furberg ,  Anthony Clint Clayton

IPC: G01J3/28 ,  G01J3/02 ,  G01J3/46

Abstract: A mannikin-based optical analyzer for analyzing an exposure of a subject to an environmental lighting condition. The analyzer has a mannikin with an outer surface replicating a facial profile of the subject, an interior inside the outer surface, and at least one pupil for admission of light into the interior of the mannikin. The analyzer has at least one optical detector configured to acquire and wavelength analyze light directed through the at least one pupil.

公开(公告)号：US20200030287A1

公开(公告)日：2020-01-30

申请号：US16485570

申请日：2018-02-13

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Yanan Zhang ,  Thuy Nguyen

IPC: A61K31/40 ,  A61P25/00

Abstract: Neuropeptide FF receptor modulators based on a proline scaffold are provided which offer NPFF receptor potencies in the nanomolar range and antagonistic selectivity for the NPFF1 receptor. Methods, compounds and compositions for modulating the function of neuropeptide FF receptors are provided for pharmacotherapies capable of influencing conditions or disorders affected by the neuropeptide FF receptors.

公开(公告)号：US20190263781A1

公开(公告)日：2019-08-29

申请号：US16333849

申请日：2017-09-15

Applicant: Research Triangle Institute

Inventor： Frank Ivy Carroll ,  Chad M. Kormos ,  Pauline W. Ondachi ,  Scott P. Runyon ,  Hernan A. Navarro ,  James B. Thomas ,  S. Wayne Mascarella

IPC: C07D401/12 ,  C07D413/12 ,  A61P25/18 ,  A61P25/24 ,  A61P25/32 ,  A61P25/34 ,  A61P25/36 ,  C07D217/26 ,  C07D211/18

Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.