公开(公告)号：US10416183B2

公开(公告)日：2019-09-17

申请号：US15823746

申请日：2017-11-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ahmed Hassan

IPC: G01N35/10 ,  G01N35/04 ,  B65G54/02 ,  G01N35/00 ,  B01L9/06

Abstract: A laboratory sample distribution system is presented. The system comprises a number of sample container carriers to carry one or more sample containers. Each sample container carrier comprises at least one magnetically active device. The system also comprises a transport plane to support the sample container carriers and a number of electro-magnetic actuators stationary arranged below the transport plane. The electro-magnetic actuators move the sample container carriers on top of the transport plane by applying a magnetic force to the sample container carriers. The system also comprises a rotating device comprising a rotating surface and a rotating drive to cause a rotational movement of the rotating surface. The system also comprises a control device to drive the electro-magnetic actuators, such that a sample container carrier to be rotated moves on the rotating surface, and to control the rotating drive such that a rotation of the sample container carrier is caused.

公开(公告)号：US20190271713A1

公开(公告)日：2019-09-05

申请号：US16416844

申请日：2019-05-20

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Fabian Heinemann ,  Stefan Kobel ,  Sven Dahlmanns ,  Jean-Philippe Vert ,  Yunlong Jiao

IPC: G01N35/00 ,  G16H50/20 ,  G16H40/40

Abstract: A method for predicting a failure state of an automated analyzer for analyzing a biological sample is disclosed. The method includes obtaining a prediction algorithm for predicting a failure state of an automated analyzer. The prediction algorithm is configured to predict a failure state of the automated analyzer based on calibration data and/or quality control data generated by an automated analyzer. The method also includes obtaining calibration data and/or quality control data of the automated analyzer and processing the calibration data and/or quality control data by using the prediction algorithm to predict a failure state of the automated analyzer.

公开(公告)号：US10379014B2

公开(公告)日：2019-08-13

申请号：US15356694

申请日：2016-11-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Andreas Calatzis ,  Harald Leyser

IPC: G01N1/00 ,  G01N1/30 ,  G01N1/31 ,  G01N35/00

Abstract: A method for preparing a biological sample for analysis is provided that includes moving a continuous substrate film past a sample applicator unit including one or more sample applicators and applying at least one trace of a biological sample to be analyzed onto the continuous substrate film by the sample applicator unit.

公开(公告)号：US20190156943A1

公开(公告)日：2019-05-23

申请号：US16178178

申请日：2018-11-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Gerrit Kocherscheidt ,  Stephan Korner ,  Ulrich Porsch ,  Chris Steinert ,  Hermann Hofstetter

IPC: G16H40/67 ,  G16H40/63 ,  G06K9/62 ,  H04W4/029 ,  G06F17/30

Abstract: A computer implemented method for localizing handheld analytical devices in a point of care environment is presented. The method comprises associating a location identifier to a plurality of locations within the point of care environment and storing the location identifier into a database, at each of the plurality of locations, capturing signal patterns using signal receiver(s) of the handheld analytical devices, storing all signal patterns captured in a database, capturing a current signal pattern using signal receiver(s) of a handheld analytical device to be localized, and providing a descriptive localization by a control unit indicative of its position relative to one or more of the plurality of locations within the point of care environment associated with one or more signal pattern(s) stored in the database matching the current signal pattern.

公开(公告)号：US20190086413A1

公开(公告)日：2019-03-21

申请号：US16204681

申请日：2018-11-29

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Barbara Upmeier ,  Toralf Zarnt ,  Manfred Ginter ,  Ralf Bollhagen

IPC: G01N33/576 ,  G01N33/84

Abstract: The present disclosure relates to a method for detecting a core polypeptide of a hepatitis C virus (HCV) in a sample from a subject with the steps of (a) contacting the sample with a surfactant comprising a cationic detergent; (b) contacting the sample with a binding compound; and (c) detecting a core polypeptide of the HCV in the sample; wherein step a) is immediately followed by step b). The present disclosure further relates to a method for pre-processing a sample from a subject for detection of an HCV core polypeptide, involving (a) contacting the sample with a surfactant comprising a cationic detergent and, optionally, with an agent inducing a pH shift, immediately followed by (b) contacting the sample with a binding compound. Moreover, the present disclosure further relates to uses, devices, and analytical systems related to aforesaid methods.

公开(公告)号：US10234464B2

公开(公告)日：2019-03-19

申请号：US15054255

申请日：2016-02-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Dirk Block ,  Hans-Peter Brunner ,  Thomas Dieterle ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg ,  Andre Ziegler

IPC: G01N33/50 ,  G01N33/68 ,  A61K31/40 ,  G01N33/62

Abstract: The present invention is directed to a method of identifying a patient having heart failure as likely to respond to a therapy comprising a statin. The method is based on measuring the level of at least one marker selected from GDF-15 (Growth Differentiation Factor 15), Urea, SHBG (Sex Hormone-Binding Globulin), Uric acid, PLGF (Placental Growth Factor), IL-6 (Interleukin-6), Transferrin, a cardiac Troponin, sFlt-1 (Soluble fms-like tyrosine kinase-1), Prealbumin, Ferritin, Osteopontin, sST2 (soluble ST2), and hsCRP (high sensitivity C-reactive protein) in a sample from a patient. Further envisaged is a method of predicting the risk of a patient to suffer from death or hospitalization, wherein said patient has heart failure and undergoes a therapy comprising a statin. The method is also based on the measurement of the level of at least one of the aforementioned markers.

公开(公告)号：US10231639B2

公开(公告)日：2019-03-19

申请号：US15132318

申请日：2016-04-19

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Mathias Emil Egermark ,  Edelgard Anna Kaiser ,  Ursula-Henrike Wienhues-Thelen ,  Christian Zaugg ,  Andre Ziegler ,  Marten Rosenquist ,  Viveka Frykmann-Kull ,  Emma Svennberg ,  Leif Friberg

IPC: A61B5/04 ,  A61B5/046 ,  A61B5/0404 ,  A61B5/0408 ,  G01N33/74

Abstract: The present invention relates to a method of diagnosing whether a subject with no known history of atrial fibrillation is suffering from atrial fibrillation, or not, said method comprising the steps of a) determining the amount of a BNP-type peptide in a sample of said subject; b) comparing the amount the BNP-type peptide to a reference, and c) assessing intermittent ECG recordings obtained from said subject over a period of at least one week by using a handheld ECG device.

公开(公告)号：US10228384B2

公开(公告)日：2019-03-12

申请号：US15278252

申请日：2016-09-28

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Jonathan Baer

IPC: G01N35/04 ,  B65G47/244 ,  G01N35/00 ,  B65G54/02

Abstract: A method of rotating a sample container carrier on a transport plane of a laboratory sample distribution system is presented. The sample container carrier is rotated by using a movement relative to a number of rotator elements. A laboratory sample distribution system being able to perform such a method and a laboratory automation system comprising such a laboratory sample distribution system are also presented.

公开(公告)号：US10185850B2

公开(公告)日：2019-01-22

申请号：US15380136

申请日：2016-12-15

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Riccardo Leone Benedetti ,  Gregor Hotz

IPC: H04Q5/22 ,  G06K7/10 ,  G16H10/40 ,  G06K19/073 ,  G06F19/00

Abstract: A method for storing temporary data in a memory of a RFID tag associated with a consumable of a laboratory instrument for processing a reagent or biological sample is disclosed. The method comprises providing the RFID tag associated with the consumable. The RFID tag comprises a memory. The memory comprises a user memory configured to store user data and a system memory configured to store system data. The laboratory instrument writes the temporary data into the system memory. The temporary data are associated with a process to be carried out by the laboratory instrument. Further, a system comprising a laboratory instrument for processing a reagent or biological sample, a consumable and a RFID tag associated with the consumable is disclosed. The laboratory instrument is configured to carry out the method.

公开(公告)号：US20190004026A1

公开(公告)日：2019-01-03

申请号：US16106608

申请日：2018-08-21

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Kai Hebestreit ,  Sylvia Saecker ,  Klaus Thome ,  Werner Heidt

IPC: G01N33/487 ,  G01N27/327 ,  A61B5/145 ,  A61B5/1477

Abstract: A test element analysis system for an analytical examination of a sample, in particular of a body fluid, is disclosed. The test element analysis system comprises an evaluation device with a test element holder for positioning a test element containing the sample and a measuring device for measuring a change in a measuring zone of the test element, the change being characteristic for an analyte. The test element holder contains contact elements with contact surfaces which allow an electrical contact between contact surfaces of the test element and the contact surfaces of the test element holder. The contact surfaces of the contact elements of the test element holder are provided with an electrically conductive surface containing metallic ruthenium.