公开(公告)号：US11778933B2

公开(公告)日：2023-10-03

申请号：US17469080

申请日：2021-09-08

Applicant: South Dakota Board of Regents

Inventor： Charles Tolle ,  Haiping Hong ,  Christian Widener ,  Greg Christensen ,  Jack Yang

IPC: H10N70/00 ,  C10M103/02 ,  H10B63/00 ,  B82Y30/00 ,  C10N20/06 ,  C10N50/10 ,  C10N20/00

CPC classification number: H10N70/8845 ,  C10M103/02 ,  H10B63/20 ,  B82Y30/00 ,  C10N2020/00 ,  C10N2050/10

Abstract: A non-volatile memory circuit in embodiments of the present invention may have one or more of the following features: (a) a logic source, and (b) a semi-conductive device being electrically coupled to the logic source, having a first terminal, a second terminal and a nano-grease with significantly reduced amount of carbon nanotube loading located between the first and second terminal, wherein the nano-grease exhibits non-volatile memory characteristics.

公开(公告)号：US11717573B2

公开(公告)日：2023-08-08

申请号：US17035293

申请日：2020-09-28

Applicant: South Dakota Board of Regents

Inventor： Khosrow Rezvani ,  Grigoriy Sereda

IPC: A61K47/60 ,  A61K9/51 ,  A61P35/00 ,  A61K47/64 ,  A61K31/435

CPC classification number: A61K47/60 ,  A61K9/5115 ,  A61K9/5161 ,  A61K9/5169 ,  A61K31/435 ,  A61K47/64 ,  A61K47/645 ,  A61P35/00

Abstract: Disclosed herein are compositions for treating cancer comprising a modified veratridine. In certain aspects, the modified veratridine comprises a polyglutamic acid (PLE) or polyethylene glycol/polyglutamic acid (PEG-PLE) conjugated to the 4′ hemiketal thereof. Further disclosed is a method of treating colorectal cancer in a subject comprising administering to a subject an effective amount of the disclosed compositions.

公开(公告)号：US20220251468A1

公开(公告)日：2022-08-11

申请号：US17713053

申请日：2022-04-04

Applicant: Novum Nano, LLC ,  South Dakota Board of Regents

Inventor： Craig Bailey ,  Greg Christensen ,  Haiping Hong

IPC: C10M169/04 ,  C10M125/02 ,  C10M125/26

Abstract: An engine oil additive includes carbon nanotubes and boron nitride particulates dispersed within a fluid. The additive is configured to be mixed with a quantity of oil such that the quantity of oil has a concentration from 0.05 to 0.5 grams of carbon nanotubes and of boron nitride particulates per quart of oil to improve the lubricity of the oil. The additive improves the horsepower and torque of the engine while reducing fuel consumption. The carbon nanotubes have an —OH functionalized exterior surface. The carbon nanotubes have a diameter from 1 nanometer to 50 nanometers and have a length from 1 micron to 1000 microns. The boron nitride particulates are hex-boron nitride structures having an average size from 30 nanometers to 500 nanometers.

公开(公告)号：US20220233612A1

公开(公告)日：2022-07-28

申请号：US17615556

申请日：2020-05-30

Applicant: SOUTH DAKOTA BOARD OF REGENTS TECHNOLOGY TRANSFER OFFICE

Inventor： Joy Scaria

IPC: A61K35/747 ,  C12N1/20 ,  C12Q1/18 ,  A61K35/744 ,  A61K35/742 ,  A61K35/741 ,  A61P31/04

Abstract: A method for identifying a microbial composition that inhibits colonization of an enteric pathogen of a first animal is disclosed. The method includes removing a microbial sample from the digestive tract of a second animal. The method further includes culturing the microbial sample, isolating, cultivating and identifying microbial species within the microbial sample. The method further includes creating compositions of one or more isolated microbial species and determining the ability of the composition to inhibit growth of an enteric pathogen in at least one of an in vitro or an in vivo assay. The method further includes identifying a microbial composition capable of inhibiting growth of enteric pathogens in a first animal. A microbial composition that inhibits colonization of an enteric pathogen of a first animal is also disclosed. The composition includes microorganisms from a group comprising Faecalicoccus, Lactobacillus, Megamonas, Staphylococcus, Bacillus, Enterococcus, Olsenella, Megasphaera, Pseudoflavonifractor, and Massiliomicrobiota.

公开(公告)号：US11292019B2

公开(公告)日：2022-04-05

申请号：US16556676

申请日：2019-08-30

Applicant: South Dakota Board of Regents

Inventor： Christian Widener ,  Victor Champagne ,  Matthew Trexler ,  Dennis Helfritch ,  Rob Hrabe

IPC: B05B7/16 ,  B05B7/14 ,  C23C24/04

Abstract: Cold spray devices and systems are disclosed. They include a flowpath having an inlet adapted for receiving communication with two or more inputs and an outlet adapted to discharge the two or more inputs. A discharge nozzle may be included in the flowpath of the outlet and a confluence may be included in the flowpath at the inlet for combining the two or more inputs. A nozzle body houses the discharge nozzle separate and downstream from the confluence of the two inputs.

公开(公告)号：US20220059823A1

公开(公告)日：2022-02-24

申请号：US17404796

申请日：2021-08-17

Applicant: South Dakota Board of Regents

Inventor： Alevtina Smirnova ,  Abu Md Numan-Al-Mobin

IPC: H01M4/36 ,  H01M4/62 ,  H01M10/0525 ,  H01M10/052 ,  H01M10/0562 ,  H01M4/58 ,  H01M4/136

Abstract: The present disclosure relates to mixed ionically and electronically conducting solid-state phases for their application in electrochemical devices, such as lithium-metal or lithium ion batteries. The solid-state mixed phase comprises of active cathode and carbon-based structures functionalized by a heteropolyacid (HPA) or a metal salt of a heteropolyacid (Me-HPA) to form a solid-state architecture with incorporated ceramic or glass-ceramic electrolyte for enhanced ionic and electronic conductivity pathways. Combining the solid-state phase components in melted solid-state electrolyte results in perfect distribution, improved adhesion between particles, and improved characteristics of the electrochemical device, such as high charge rates, long-term performance, and broad voltage window.

公开(公告)号：US11214646B2

公开(公告)日：2022-01-04

申请号：US16277437

申请日：2019-02-15

Applicant: South Dakota Board of Regents

Inventor： Zhengtao Zhu ,  Yichun Ding ,  Daniel Heglund

IPC: C08G12/32 ,  C08J3/24 ,  C08K3/16 ,  C08K3/28 ,  C08J9/28 ,  C08J9/00 ,  B01J20/26 ,  C08J9/40 ,  C09K3/32

Abstract: This disclosure is related to a class of metal-ion induced hydrophobic polymers and method of producing such class of compounds by a one-step solution immersion process. Specifically, a metal-ion Induced hydrophobic polymer or melamine sponge (MII-HMS) is disclosed. Such polymer or sponge is demonstrated to be highly hydrophobic and oleophilic and exhibits excellent oil absorption capabilities, being able to absorb a wide range of oils and organic solvents up to 71 to 157 times of its own weight.

公开(公告)号：US20210363649A1

公开(公告)日：2021-11-25

申请号：US17394711

申请日：2021-08-05

Applicant: South Dakota Board of Regents

Inventor： Alevtina Smirnova ,  Michael McGraw ,  Praveen Kolla

IPC: C25B3/00 ,  H01M4/90 ,  H01M4/60 ,  C08G61/12 ,  H01L51/00 ,  H01G11/48 ,  H01G11/86 ,  H01G9/028 ,  C25B11/055

Abstract: The present invention relates to a one-step process for preparation of “in-situ” or “ex-situ” self-organized and electrically conducting polymer nanocomposites using thermally initiated polymerization of a halogenated 3,4-ethylenedioxythiophene monomer or its derivatives. This approach does not require additional polymerization initiators or catalysts, produce gaseous products that are naturally removed without affecting the polymer matrix, and do not leave by-product contaminants. It is demonstrated that self-polymerization of halogenated 3,4-ethylenedioxythiophene monomer is not affected by the presence of a solid-state phase in the form of nanoparticles and results in formation of 3,4-polyethylenedioxythiophene (PEDOT) nanocomposites.

公开(公告)号：US20210261936A1

公开(公告)日：2021-08-26

申请号：US17184187

申请日：2021-02-24

Applicant: South Dakota Board of Regents

Inventor： Xuejun Wang

IPC: C12N9/50 ,  A61K47/68

Abstract: Disclosed herein is a method of enhancing the ubiquitin proteasome system (“UPS”) in a subject in need thereof, comprising administering an effective amount of a composition comprising neprilysin and a cell targeting moiety, wherein administration of the composition delivers the composition into the intracellular space of one or more cells of the subject and wherein the subject suffers from a condition associated with a UPS deficiency.

公开(公告)号：US20210184202A1

公开(公告)日：2021-06-17

申请号：US17249276

申请日：2021-02-25

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： David R. Salem ,  Gregory Lee Christensen ,  Ruidong Yang

IPC: H01M4/133 ,  H01M4/36 ,  H01M4/52 ,  H01M4/62 ,  H01M4/04 ,  H01M4/38 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/583 ,  H01M10/052 ,  H01M4/131 ,  H01M4/134 ,  H01M4/1391 ,  H01M4/1393 ,  H01M4/66 ,  H01M4/70 ,  H01M10/0525 ,  H01M10/0585

Abstract: An electrode comprises carbon nanoparticles and at least one of metal particles, metal oxide particles, metalloid particles and/or metalloid oxide particles. A surfactant attaches the carbon nanoparticles and the metal particles, metal oxide particles, metalloid particles and/or metalloid oxide particles to form an electrode composition. A binder binds the electrode composition such that it can be formed into a film or membrane. The electrode has a specific capacity of at least 450 mAh/g of active material when cycled at a charge/discharge rate of about 0.1 C.