公开(公告)号：US11078498B2

公开(公告)日：2021-08-03

申请号：US16938739

申请日：2020-07-24

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Andrew Garst ,  Ryan T Gill

IPC: C12N15/90 ,  C12N15/10 ,  C40B40/08 ,  C12N15/11 ,  C12N9/22

Abstract: Described herein are method for generating a vector for editing a cell. The method comprises ligating into a vector that encodes a portion of a gRNA a cassette comprising at least one editing cassette, a promoter, and a gene encoding another portion of the gRNA. Upon ligation, the portion of the gRNA from the editing cassette and the other portion of the gRNA are ligated and form a functional gRNA.

公开(公告)号：US11076948B2

公开(公告)日：2021-08-03

申请号：US16017295

申请日：2018-06-25

Applicant: ClarVista Medical, Inc. ,  The Regents of the University of Colorado, a body corporate

Inventor： Malik Y. Kahook ,  Glenn Sussman ,  Rudolph F. Zacher ,  Paul J. McLean ,  Harvey Uy ,  Robert Cionni ,  Kerry Solomon

IPC: A61F2/16 ,  A61F2/14

Abstract: Modular IOL systems including a base and a lens, wherein the lens includes tabs for connection to the base. The modular IOL allows for the lens to be adjusted or exchanged while leaving the base in place, either intra-operatively or post-operatively.

公开(公告)号：US20210213673A1

公开(公告)日：2021-07-15

申请号：US16967395

申请日：2019-02-11

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Kambez Benam ,  Alexander Kaiser

IPC: B29C64/106 ,  C12M1/26 ,  C12M3/00 ,  B29C64/245 ,  B29C64/209 ,  B29C64/232 ,  B29C64/236 ,  B29C64/393 ,  B33Y10/00 ,  B33Y30/00 ,  B33Y50/02 ,  B33Y70/00

Abstract: A bioprinter for manufacturing an organomimetic device includes at least one extruder configured to extrude a material, a three-dimensional movement assembly, and a build-plate mounted to the three-dimensional movement assembly. The build-plate may be configured to support the organomimetic device being manufactured. The bioprinter may further include a controller operably coupled to and configured to control the at least one extruder, the three-dimensional movement assembly, and the build-plate. The at least one extruder may be non-movably fixed to the cabinet.

公开(公告)号：US20210206813A1

公开(公告)日：2021-07-08

申请号：US17141321

申请日：2021-01-05

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Jerome Fox ,  Ankur Sarkar ,  Akarawin Hongdusit ,  Edward Kim

IPC: C07K14/005 ,  C07K14/47 ,  C12N1/20

Abstract: This invention relates to the field of genetic engineering. Specifically, the invention relates to the construction of operons to produce biologically active agents. For example, operons may be constructed to produce agents that control the function of biochemical pathway proteins (e.g., protein phosphatases, kinases and/or proteases). Such agents may include inhibitors and modulators that may be used in studying or controlling phosphatase function associated with abnormalities in a phosphatase pathway or expression level. Fusion proteins, such as light activated protein phosphatases, may be genetically encoded and expressed as photoswitchable phosphatases. Systems are provided for use in controlling phosphatase function within living cells or in identifying small molecule inhibitors/activator/modulator molecules of protein phosphatases associated with cell signaling.

公开(公告)号：US20210204922A1

公开(公告)日：2021-07-08

申请号：US17198000

申请日：2021-03-10

Applicant: The Regents of the University of Colorado, a Body Corporate

Inventor： Amir Tehrani ,  Edward A. Jasion

IPC: A61B10/04 ,  A61B5/00 ,  A61B17/34 ,  A61B90/11 ,  A61B1/00 ,  A61B1/04 ,  A61B1/06 ,  A61B1/07 ,  A61B5/06 ,  A61B6/12 ,  A61B8/08 ,  A61B8/12 ,  A61B8/00 ,  A61B10/02

Abstract: A surgical method including positioning an optical probe within a tissue at a target location in a body of a patient; emitting electromagnetic radiation from the optical probe toward the tissue; and receiving a spectra at the optical probe; generating, based on the spectra, by a tissue classification system, a diagnosis classification indicative of a condition of the tissue and treating the tissue with a treatment modality selected based on the diagnosis classification. The spectra is generated by the tissue in response to the emitted electromagnetic radiation.

公开(公告)号：US11052060B2

公开(公告)日：2021-07-06

申请号：US16357397

申请日：2019-03-19

Applicant: ImmunoMolecular Therapeutics, INC. ,  The Regents of the University of Colorado, a body corporate

Inventor： Steve Orndorff ,  Aaron Michels

IPC: A61K31/216 ,  A61K45/06 ,  A61P37/00 ,  A61P3/10 ,  A61K31/198

Abstract: Compounds and compositions useful in methods of treating, ameliorating, or inhibiting the development of autoimmune diseases or Celiac disease by modulating the binding of DQ8 MHC class II molecules to antigenic peptides or fragments of antigenic peptides.

公开(公告)号：US20210119582A1

公开(公告)日：2021-04-22

申请号：US17053679

申请日：2019-05-07

Applicant: The Regents of the University of Colorado, a body corporate ,  Alma Mater Studiorum - Università di Bologna

Inventor： Tommaso Cappello ,  Corrado Florian ,  Zorana Popovic

IPC: H03F1/02 ,  H03F3/24

Abstract: A multi-level supply modulator for RF power amplifiers requires only a single independent voltage supply along with one or more flying capacitors to achieve multiple output levels. The flying capacitor is used to store the intermediate voltage level between the DC supply level and ground. A switch network is connected between the DC voltage supply and the power amplifier and is configured to provide power at variable, discrete DC voltages, for example the DC voltage supply level, ground, and a level halfway between the DC voltage supply level and ground. The flying capacitor is connected to switches in the switch network, and a sensing circuit detects the voltage across the flying capacitor and generates a feedback signal. Control circuitry controls the switch network (and thus the power supplied to the amplifier) based on the feedback signal.

公开(公告)号：US10935559B2

公开(公告)日：2021-03-02

申请号：US15149868

申请日：2016-05-09

Applicant: Haemonetics Corporation ,  The Regents of the University of Colorado, a body corporate

Inventor： Michael P. Chapman ,  Ernest E. Moore ,  Katherine M. Norem

IPC: G01N33/86 ,  G01N33/49 ,  C12Q1/56

Abstract: In some embodiments, the invention provides a container adapted for detecting hyperfibrinolysis or fibrinolysis in a blood sample using viscoelastic analysis comprising an interior having a coating comprises an inhibitor of fibrinolysis.

公开(公告)号：US20210055187A1

公开(公告)日：2021-02-25

申请号：US16958421

申请日：2018-12-27

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE ,  AEROSOL DEVICES, INC.

Inventor： Mark Hernandez ,  Patricia B. Keady

IPC: G01N1/22

Abstract: This invention relates generally to characterizing bioaerosols and, more particularly, to a system for recovering, quantifying, identifying, and assessing the metabolic activities of bioaerosols based on their major biopolymer profiles (lipids, carbohydrate and protein) and more specific their genetic materials (DNA/RNA), such as airborne viruses, bacteria, fungi and pollens.

公开(公告)号：US20210038255A1

公开(公告)日：2021-02-11

申请号：US16766248

申请日：2018-12-03

Applicant: THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE

Inventor： Omer Mei-Dan ,  Jacob Segil

IPC: A61B17/34 ,  A61B17/00 ,  A61B17/32

Abstract: A slotted cannula for surgical procedures is disclosed. The slotted cannula has an elongated semi-circular body comprising a cavity extending along a longitudinal axis of the semi-circular body, the cavity having an open distal end and an open proximate end and an integrally formed outward bend extending curvilinear from the cavity on the proximate end and at least one fold line across the width of the cannula, perpendicular to the longitudinal axis. The cannula can be bent or broken along the at least one fold line to adjust the operable length of the cannula during a surgical procedure.