公开(公告)号：US20080146669A1

公开(公告)日：2008-06-19

申请号：US11815413

申请日：2006-02-02

申请人： Wei Wang ,  Ge Li ,  John P. Clancy ,  Kevin L. Kirk

发明人： Wei Wang ,  Ge Li ,  John P. Clancy ,  Kevin L. Kirk

IPC分类号： A61K31/12 ,  A61K31/195 ,  A61P11/00

CPC分类号： A61K31/4439

摘要： Described is a method for treating and/or preventing disease states and conditions associated with defects in the activity of chloride channels, such as the CFTR channel. The present disclosure also described compounds useful in such treatment and prevention methods and methods for the identification of compounds for use in such methods. These compounds disclosed are NPPB, NPPB-Am, NPPB-sulf and curcumin, and derivatives of the foregoing. These compounds are shown to activate the activity of both wild-type and mutant CFTR channels under a range of conditions.

摘要翻译： 描述了用于治疗和/或预防与氯通道（例如CFTR通道）的活性缺陷相关的疾病状态和病症的方法。 本公开还描述了可用于这种治疗的化合物和用于鉴定用于这些方法的化合物的预防方法和方法。 所公开的这些化合物是NPPB，NPPB-Am，NPPB-硫酸和姜黄素及其衍生物。 显示这些化合物在一定条件下激活野生型和突变CFTR通道的活性。

公开(公告)号：US20080133218A1

公开(公告)日：2008-06-05

申请号：US11935938

申请日：2007-11-06

申请人： Ming Zhou ,  Jin-Xia Huang ,  Chang Ning (Tom) Huang ,  Wei Wang

发明人： Ming Zhou ,  Jin-Xia Huang ,  Chang Ning (Tom) Huang ,  Wei Wang

IPC分类号： G06F17/27

CPC分类号： G06F17/2827

摘要： The present invention performs machine translation by matching fragments of a source language sentence to be translated to source language portions of an example in example base. When all relevant examples have been identified in the example base, the examples are subjected to phrase alignment in which fragments of the target language sentence in each example are aligned against the matched fragments of the source language sentence in the same example. A translation component then substitutes the aligned target language phrases from the matched examples for the matched fragments in the source language sentence.

摘要翻译： 本发明通过将要翻译的源语言句子的片段与实例中的示例的源语言部分相匹配来执行机器翻译。 当在示例基础中已经确定了所有相关的示例时，对这些示例进行短语对齐，其中每个示例中的目标语言句子的片段与相同示例中的源语言句子的匹配片段对齐。 然后，翻译组件将匹配的示例中的对齐目标语言短语替换为源语言句中的匹配片段。

公开(公告)号：US20080117347A1

公开(公告)日：2008-05-22

申请号：US11942140

申请日：2007-11-19

申请人： Mi Zhang ,  Wei Wang

发明人： Mi Zhang ,  Wei Wang

IPC分类号： G02F1/1368 ,  H01L21/77

CPC分类号： G02F1/136213 ,  G02F1/136209 ,  G02F2201/40 ,  H01L27/124 ,  H01L27/1255

摘要： Provided are a TFT LCD array substrate and manufacturing method thereof. The TFT LCD array substrate comprises a substrate, a gate line and a data line formed on the substrate and crossing each other so as to define a pixel area, a pixel electrode formed in the pixel area, a TFT formed in the pixel area, a common electrode formed on the substrate and extending parallel to the data line. The common electrode is not formed in the central portion of a pixel area, thus improving the aperture ratio.

摘要翻译： 提供一种TFT LCD阵列基板及其制造方法。 TFT LCD阵列基板包括基板，栅极线和数据线，其形成在基板上并且彼此交叉以限定像素区域，形成在像素区域中的像素电极，形成在像素区域中的TFT， 公共电极形成在基板上并且平行于数据线延伸。 公共电极不形成在像素区域的中心部分，因此提高了开口率。

公开(公告)号：US07376649B2

公开(公告)日：2008-05-20

申请号：US11347193

申请日：2006-02-02

申请人： Tao Yang ,  Wei Wang ,  Apostolos Gerasoulis

发明人： Tao Yang ,  Wei Wang ,  Apostolos Gerasoulis

IPC分类号： G06F17/30

CPC分类号： G06F17/30864 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99935

摘要： Techniques to retrieve, rank and display data objects retrieved form a database are described. In particular, methods to assign a global ranking value to a data object based on a combination of that object's link-based (e.g., vector-space cluster analysis) and text-based (e.g., word frequency) ranks are described. Additional techniques to determine a set of concepts, topics or key words associated with each retrieved data objects are described.

摘要翻译： 描述从数据库检索的检索，排序和显示数据对象的技术。 特别地，描述了基于该对象的基于链路（例如，向量空间聚类分析）和基于文本（例如，字频率）等级的组合来将全局排序值分配给数据对象的方法。 描述了确定与每个检索到的数据对象相关联的一组概念，主题或关键词的附加技术。

公开(公告)号：US20080111223A1

公开(公告)日：2008-05-15

申请号：US11559157

申请日：2006-11-13

申请人： Guoqing Yu ,  Youjun Wang ,  Qinqin Xu ,  Qingwei Wang ,  Wei Wang

发明人： Guoqing Yu ,  Youjun Wang ,  Qinqin Xu ,  Qingwei Wang ,  Wei Wang

IPC分类号： H01L23/02

CPC分类号： H01L23/525 ,  H01L23/3114 ,  H01L2924/0002 ,  H01L2924/00

摘要： The present invention disclosed a wafer level chip size packaged chip device with a double-layer lead structure and methods of fabricating the same. The double-layer lead is designed to meet a tendency of increasing quantity per area of peripheral arrayed compatible pads on a semiconductor chip, and also to save more space for layout of lead on the chip bottom surface for avoiding potential short inbetween which happen in increasing probability with increasing quantity per area on the condition of one-layer lead.

摘要翻译： 本发明公开了具有双层引线结构的晶片级芯片尺寸封装芯片器件及其制造方法。 双层引线被设计为满足在半导体芯片上的周边阵列兼容焊盘面积增加的趋势，并且还可以在芯片底部表面上节省更多的用于布局引线的空间，以避免在增加中发生的潜在的短路 在单层铅条件下每面积数量增加的概率。

公开(公告)号：US07371364B2

公开(公告)日：2008-05-13

申请号：US10918009

申请日：2004-08-13

申请人： Chun Li ,  Wei Wang ,  Shi Ke

发明人： Chun Li ,  Wei Wang ,  Shi Ke

IPC分类号： A61K51/00 ,  A61K38/00 ,  A61K38/12 ,  C07K5/00 ,  C07K7/00 ,  C07K16/00 ,  C07K17/00

CPC分类号： A61K49/0032 ,  A61K49/0034 ,  A61K49/0056 ,  A61K51/08 ,  A61K51/082 ,  A61K51/088 ,  C07K7/56 ,  C07K14/8146

摘要： The present invention relates to novel cyclic peptides that may be conjugated with imaging agents, including novel imaging agents. Specifically, it includes c(KRGDf; SEQ ID NO. 3) NIR imaging compositions and novel cyclic HWGFTL (SEQ ID NO. 5) polypeptides which may be used inter alia in NIR, MRI and nuclear imaging as well as therapy. Additionally, the invention includes novel imaging agents, such as TS-ICG derivatives. The invention also relates to methods of making and using such compounds. Such uses include both pre-operative and intraoperative detection of tumor cells and treatment monitoring.

摘要翻译： 本发明涉及可与成像剂缀合的新型环肽，包括新型成像剂。 具体地说，它包括可以特别用于NIR，MRI和核成像以及治疗的c（KRGDf; SEQ ID NO.3）NIR成像组合物和新的循环HWGFTL（SEQ ID NO.5）多肽。 此外，本发明包括新型成像剂，例如TS-ICG衍生物。 本发明还涉及制备和使用这些化合物的方法。 这些用途包括手术前和术中检测肿瘤细胞和治疗监测。

公开(公告)号：US20080075726A1

公开(公告)日：2008-03-27

申请号：US11882751

申请日：2007-08-03

申请人： Ernest Smith ,  Wei Wang

发明人： Ernest Smith ,  Wei Wang

IPC分类号： A61K39/395 ,  A61P35/00 ,  C07K16/00 ,  C12N15/13 ,  C12N15/85 ,  C12N5/10 ,  C12P21/08

CPC分类号： C07K16/248 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73

摘要： The present invention provides novel monoclonal antibodies that bind specifically to IL-6. The antibodies of the invention comprise a variable heavy chain (VH) region selected from any of the VH regions disclosed herein as well as amino acid variants thereof, and/or a variable light chain (VL) region selected from any of the VL regions disclosed herein as well as amino acid variants thereof. The invention also provides methods of treating diseases and disorders associated with IL-6 expression and/or activity.

摘要翻译： 本发明提供了特异性结合IL-6的新单克隆抗体。 本发明的抗体包含选自本文公开的任何VH区的可变重链（VH）区及其氨基酸变体，和/或选自公开的任何VL区的可变轻链（VL）区 本文以及其氨基酸变体。 本发明还提供了治疗与IL-6表达和/或活性相关的疾病和病症的方法。

公开(公告)号：US20080071742A1

公开(公告)日：2008-03-20

申请号：US11524011

申请日：2006-09-19

申请人： Tao Yang ,  Wei Wang

发明人： Tao Yang ,  Wei Wang

IPC分类号： G06F17/30

CPC分类号： G06F17/30864

摘要： Systems and methods for aggregating search results are disclosed herein. The systems and methods include receiving a user search query, analyzing the user search query to identify a plurality of properties of the user search query, identifying a plurality of search results that match the user search query, each search result being based on a different scheme, and aggregating the search results to produce a search results list. The search results list may be a combined and selected results list. Feedback-based optimization is also disclosed.

摘要翻译： 本文公开了用于聚合搜索结果的系统和方法。 所述系统和方法包括接收用户搜索查询，分析用户搜索查询以识别用户搜索查询的多个属性，识别与用户搜索查询匹配的多个搜索结果，每个搜索结果基于不同的方案 ，并汇总搜索结果以产生搜索结果列表。 搜索结果列表可以是组合和选择的结果列表。 还公开了基于反馈的优化。

公开(公告)号：US20080040765A1

公开(公告)日：2008-02-14

申请号：US11838064

申请日：2007-08-13

申请人： Peter Bradshaw ,  Wei Wang ,  Paul Ta ,  Bill Tang ,  Alvin Wang

发明人： Peter Bradshaw ,  Wei Wang ,  Paul Ta ,  Bill Tang ,  Alvin Wang

IPC分类号： H04N7/173

CPC分类号： H04L5/16 ,  H04L69/324

摘要： A method provides a bidirectional communication protocol for data communication between a first device and a second device. The method includes: during a first time interval, transmitting data from the first device to the second device; and during a second time interval, (a) after the occurrence of a first event, (i) suspending data transmission from the first device to the second device; and (ii) transmitting control data from the second device to the first device; and (b) after the occurrence of a second event, transmitting control data from the first device to the second device.

摘要翻译： 一种方法提供用于第一设备和第二设备之间的数据通信的双向通信协议。 该方法包括：在第一时间间隔期间，将数据从第一设备发送到第二设备; 并且在第二时间间隔期间，（a）在发生第一事件之后，（i）暂停从第一设备到第二设备的数据传输; 和（ii）将控制数据从第二设备发送到第一设备; 和（b）在第二事件发生之后，将控制数据从第一设备发送到第二设备。

公开(公告)号：US07330849B2

公开(公告)日：2008-02-12

申请号：US11250341

申请日：2005-10-13

申请人： Apostolos Gerasoulis ,  Wei Wang ,  Hyun-Ju Seo

发明人： Apostolos Gerasoulis ,  Wei Wang ,  Hyun-Ju Seo

IPC分类号： G06F17/30

CPC分类号： G06F17/30595 ,  G06F17/30867 ,  Y10S707/99933 ,  Y10S707/99934 ,  Y10S707/99935

摘要： Techniques to assign a ranking value to objects in a database such as a collection of cross referencing documents, the World-Wide Web or a hyperlinked database are described. The ranking value assigned to a given data object represents a cross-cluster strength metric and is a function of the object's importance across all groups or clusters in which the object is classified. The cross-cluster strength metric may be particularly beneficial in enhancing the performance of web-based search engines because it emphasizes the importance of objects that appear in multiple groups while de-emphasizing the importance of objects that, while highly linked within one or a few groups, are relatively unlinked to objects in other groups.

摘要翻译： 对诸如交叉引用文档集合，万维网或超链接数据库的数据库中的对象分配排序值的技术进行了描述。 分配给给定数据对象的排名值表示交叉聚类强度度量，并且是对象在对象被分类的所有组或群集上的重要性的函数。 跨群集强度度量可能特别有利于提高基于网络的搜索引擎的性能，因为它强调出现在多个组中的对象的重要性，同时不强调对象的重要性，尽管在一个或几个 组相对于其他组中的对象相对取消关联。