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    HYDROGEL BASED SENSOR PROBE FOR DETECTING AN ENVIRONMENTAL STATE
    132.
    发明申请
    HYDROGEL BASED SENSOR PROBE FOR DETECTING AN ENVIRONMENTAL STATE 失效
    用于检测环境状态的基于HYDROGEL的传感器探测器

    公开(公告)号：US20100162834A1

    公开(公告)日：2010-07-01

    申请号：US12600881

    申请日：2008-05-22

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Szabolcs Deladi ,  Ralph Kurt ,  Jan Frederik Suijver

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Szabolcs Deladi ,  Ralph Kurt ,  Jan Frederik Suijver

    IPC分类号： G01D21/00 ,  G01B11/22

    CPC分类号： G01N21/7703 ,  A61B5/0084 ,  A61B5/14539 ,  G01N2021/772 ,  G01N2021/7723 ,  G01N2021/773 ,  G01N2021/7779

    摘要： The invention relates to a sensor probe (100,110,120,130,140,150) for detecting an environmental state within a bodily lumen. The sensor probe (100,110,120,130,140,150) having an elongated body (9) comprises an optical guide (1) having an outcoupling surface (11), which is part of an end surface (3) of the elongated body (9), facing a reflective surface of an overhanging part (22,42,52,62), a photodetector which detects a property of light which is composed of light (32) in the optical guide (1) that is reflected from the outcoupling surface (11) of the optical guide (1) and of light (33) in the optical guide (1) that is reflected from the overhanging part (22,42,52,62), and a hydrogel material (2) of which a property changes when getting into contact with an environmental material and/or when detecting an environmental change, and which is provided between the end surface (3) of the elongated body (9) and the overhanging part (22,42,52,62). In this way a sensor probe (100,110,120,130,140,150) is provided that, because of its compactness, can be applied inside the bodily lumen for detecting and characterizing parameters that are vital indicators for the state of the human or animal body, and to which the hydrogel material (2) is responsive.

    摘要翻译： 本发明涉及一种用于检测体腔内的环境状态的传感器探针（100,110,120,130,140,​​150）。 具有细长主体（9）的传感器探针（100,110,130,140,​​150）包括具有外耦合表面（11）的光导（1），该外耦合表面（11）是细长主体（9）的端表面（3）的一部分，面向反射表面 突出部分（22,42,52,62）的光检测器，其检测由光导（1）中的光（32）组成的光的属性，所述光从光耦合表面（11）反射 在导光体（1）中从突出部分（22,42,52,62）反射的导光体（1）和光（33）以及在接触时性质发生变化的水凝胶材料（2） 和环境材料和/或当检测到环境变化时，并且设置在细长体（9）的端面（3）与伸出部分（22,42,52,62）之间。 以这种方式，提供传感器探针（100,110,120,130,140,​​150），由于其紧凑性，可以在身体内部施加以检测和表征作为人体或动物体状态的重要指标的参数，并且将水凝胶材料 （2）有反应。

    METHOD AND DEVICE FOR OPTICAL ANALYSIS OF A TISSUE
    133.
    发明申请
    METHOD AND DEVICE FOR OPTICAL ANALYSIS OF A TISSUE 有权
    用于组织的光学分析的方法和装置

    公开(公告)号：US20100033719A1

    公开(公告)日：2010-02-11

    申请号：US12528088

    申请日：2008-02-22

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Antonius Theodorus Martinus Van Gogh

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Antonius Theodorus Martinus Van Gogh

    IPC分类号： G01N21/55 ,  G01J3/30

    CPC分类号： G01N21/49 ,  A61B5/0068 ,  G02B21/0064

    摘要： The invention relates to a method and device for analyzing a tissue (70), which comprises: —irradiating the tissue (70) with light focused on a focal region (40); —collecting light coming back from the focal region (40) into a first detection device (100A), the first detection device (100A) being arranged to only collect the light coming back from the focal region (40), on a first detection area (140A), by confocal spectroscopy, in order to generate a first signal, containing information on an optical property of the tissue (70); —collecting light, scattered from the focal region (40) to at least a second region (60), coming back from the second region (60), into a second detection device (100B), the second detection device (100B) being arranged to only collect the light coming back from the second region (60), on a second detection area (140B), in order to generate a second signal, —using the first and second signals in order to get information on the scattering and/or absorption coefficients of the tissue (70) in the region between the focal region (40) and the second region (60). Thanks to the invention, information can be gathered on the scattering and/or absorption properties of the tissue.

    摘要翻译： 本发明涉及一种用于分析组织（70）的方法和装置，其包括：用聚焦在聚焦区域（40）上的光照射组织（70）; - 从聚焦区域（40）返回到第一检测装置（100A）中的收集光，第一检测装置（100A）被布置成仅在第一检测区域收集从焦点区域（40）回来的光 （140A），通过共焦光谱法，以产生包含关于组织（70）的光学性质的信息的第一信号; - 从所述焦点区域（40）散射到从所述第二区域（60）返回到至少第二区域（60）的收集光转换成第二检测装置（100B），所述第二检测装置（100B）被布置 以仅在第二检测区域（140B）上收集从第二区域（60）返回的光，以便产生第二信号， - 使用第一和第二信号，以获得关于散射和/或 在聚焦区域（40）和第二区域（60）之间的区域中的组织（70）的吸收系数。 由于本发明，可以收集关于组织的散射和/或吸收性质的信息。

    CAPSULE CAMERA WITH VARIABLE ILLUMINATION OF THE SURROUNDING TISSUE
    135.
    发明申请
    CAPSULE CAMERA WITH VARIABLE ILLUMINATION OF THE SURROUNDING TISSUE 有权
    胶囊相机与周边组织的可变照明

    公开(公告)号：US20090177033A1

    公开(公告)日：2009-07-09

    申请号：US12374506

    申请日：2007-04-12

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Michael Harald Kuhn ,  Thomas Zaengel ,  Nijs Cornelis van der Vaart

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Michael Harald Kuhn ,  Thomas Zaengel ,  Nijs Cornelis van der Vaart

    IPC分类号： A61B1/04 ,  G03B15/02

    CPC分类号： A61B1/00087 ,  A61B1/00165 ,  A61B1/00188 ,  A61B1/0019 ,  A61B1/041 ,  A61B1/042 ,  A61B1/043 ,  A61B1/06 ,  A61B5/0066 ,  A61B5/0071 ,  A61B5/0084 ,  A61B18/20 ,  A61B2018/00482 ,  A61B2018/00577 ,  A61B2018/00589 ,  A61B2018/00642 ,  A61B2018/00904 ,  A61N5/0601 ,  A61N5/0603 ,  A61N5/062 ,  A61N2005/0609 ,  G03B15/02

    摘要： The application relates to an ingestible capsule and method for in vivo imaging and/or treatment of one or more diseased areas of interest within the gastrointestinal tract of an animal or human being. The capsule comprises an image sensor; a lens system for focusing images onto the image sensor; at least one light source for illumination of the tissue area of interest, the at least one light source optionally being capable of providing optical therapeutic treatment to the diseased areas; a variable lens system located in front of the at least one light source, wherein the variable lens system comprises beam steering means and focusing means for directing and focusing the light beams from the at least one light source onto the diseased tissue areas, a control unit in communication with the image sensor, the at least one light source, and variable lens system, a power source for powering the image sensor, the at least one light source and the control unit; and a non-digestible, transparent outer protective shell configured to pass through the gastrointestinal tract, housing within the image sensor, the lens system, the at least one light source, the variable lens system, the control unit and the power source.

    摘要翻译： 本申请涉及用于体内成像和/或治疗在动物或人的胃肠道内的一个或多个感兴趣的感兴趣区域的可摄取胶囊和方法。 胶囊包括图像传感器; 用于将图像聚焦到图像传感器上的透镜系统; 用于照射所述组织区域的至少一个光源，所述至少一个光源任选地能够向所述患病区域提供光学治疗性治疗; 位于所述至少一个光源前面的可变透镜系统，其中所述可变透镜系统包括光束转向装置和用于将来自所述至少一个光源的光束引导和聚焦到所述病变组织区域上的聚焦装置，控制单元 与图像传感器，至少一个光源和可变透镜系统连通，用于为图像传感器供电的电源，至少一个光源和控制单元; 以及构造成穿过胃肠道，容纳在图像传感器，透镜系统，至少一个光源，可变透镜系统，控制单元和电源中的不可消化，透明的外保护壳。

    OPTICAL ARRANGEMENT
    136.
    发明申请
    OPTICAL ARRANGEMENT 审中-公开
    光学布置

    公开(公告)号：US20090161520A1

    公开(公告)日：2009-06-25

    申请号：US12391289

    申请日：2009-02-24

    申请人： Bernardus Hendrikus Wilhelmus Hendriks

    发明人： Bernardus Hendrikus Wilhelmus Hendriks

    IPC分类号： G11B7/00

    CPC分类号： G11B7/13922 ,  G11B7/1367

    摘要： An optical system is described for scanning optical record carriers of different types. The optical system includes a compensator having a number of optical elements (NPS1, NPS2). The optical elements (NPS1, NPS2) are non-periodic phase structures (NPS) having annular areas separated by steps, forming a non-periodic pattern of optical paths of different lengths. By including these multiple optical elements (NPS1, NPS2) having NPS surfaces in the lens system of an optical system, it is possible to compensate for the effect of variation of a parameters such as temperature, angle of incidence, polarisation of radiation incident on the system and wavelength of radiation, without causing sensitivity to variation of another such parameter.

    摘要翻译： 描述了用于扫描不同类型的光学记录载体的光学系统。 光学系统包括具有多个光学元件（NPS1，NPS2）的补偿器。 光学元件（NPS1，NPS2）是具有由台阶隔开的环形区域的非周期相位结构（NPS），形成不同长度的光路的非周期性图案。 通过在光学系统的透镜系统中包括具有NPS表面的这些多个光学元件（NPS1，NPS2），可以补偿参数的变化的影响，诸如温度，入射角，入射的辐射极化 系统和辐射波长，而不会对另一个此类参数的变化产生敏感性。

    METHOD AND APPARATUS FOR ELEVATION FOCUS CONTROL OF ACOUSTIC WAVES
    137.
    发明申请
    METHOD AND APPARATUS FOR ELEVATION FOCUS CONTROL OF ACOUSTIC WAVES 有权
    用于高音重点控制声波的方法和装置

    公开(公告)号：US20090122639A1

    公开(公告)日：2009-05-14

    申请号：US12297902

    申请日：2007-04-27

    申请人： Christopher Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

    发明人： Christopher Hall ,  Chien Ting Chin ,  Jan Frederik Suijver ,  Bernardus Hendrikus Wilhelmus Hendriks ,  Stein Kuiper

    IPC分类号： G03B42/06

    CPC分类号： G10K11/30

    摘要： An acoustic probe (100) includes an acoustic transducer (20) including a plurality of acoustic transducer elements arranged in a one-dimensional array; and a variably- refracting acoustic lens (10) coupled to the acoustic transducer. The variably-refracting acoustic lens has at least a pair of electrodes (150, 160) adapted to adjust the focus of the variably-refracting acoustic lens in response to a selected voltage applied across the electrodes. In one embodiment, the variably-refracting acoustic lens includes a cavity, first and second fluid media (141, 142) disposed within the cavity, and the pair of electrodes. The speed of sound of an acoustic wave in the first fluid medium is different than the speed of sound of the acoustic wave in the second fluid medium. The first and second fluid media are immiscible with respect to each other, and the first fluid medium has a substantially different electrical conductivity than the second fluid medium.

    摘要翻译： 声探针（100）包括声换能器（20），其包括以一维阵列排列的多个声换能器元件; 以及耦合到声换能器的可变折射声透镜（10）。 可变折射声透镜具有至少一对电极（150,160），其适于响应于施加在电极上的选定电压来调节可变折射声透镜的焦点。 在一个实施例中，可变折射声透镜包括空腔，设置在空腔内的第一和第二流体介质（141,142）和一对电极。 第一流体介质中声波的声速不同于第二流体介质中声波的声速。 第一和第二流体介质相对于彼此是不混溶的，并且第一流体介质具有与第二流体介质基本上不同的导电性。

    Birefringent optical system
    140.
    发明授权
    Birefringent optical system 失效
    双折射光学系统

    公开(公告)号：US07440075B2

    公开(公告)日：2008-10-21

    申请号：US10599068

    申请日：2005-03-14

    申请人： Bernardus Hendrikus Wilhelmus Hendriks ,  Coen Theodorus Hubertus Fransiscus Liedenbaum ,  Sjoerd Stallinga ,  Stein Kuiper

    发明人： Bernardus Hendrikus Wilhelmus Hendriks ,  Coen Theodorus Hubertus Fransiscus Liedenbaum ,  Sjoerd Stallinga ,  Stein Kuiper

    IPC分类号： G02B27/12

    CPC分类号： G02B26/005 ,  G02B3/14 ,  G02B5/06 ,  G02B5/3083 ,  G11B7/1378 ,  G11B7/13927

    摘要： The invention relates to an optical system comprising a fluid chamber 1 and a birefringent part. The fluid chamber comprises first and second fluids 10, 12 having different indices of refraction, the interface between the fluids forming a meniscus 14. The birefringent part is capable of varying characteristics of a first radiation beam 3b and a second radiation beam 3c, the first and second radiation beams having different polarisations. Variation in the configuration of the meniscus causes variation in the characteristics of the first radiation beam and the second radiation beam. Variation in the configuration of the meniscus may be controlled by electrowetting.

    摘要翻译： 本发明涉及一种包括流体室1和双折射部分的光学系统。 流体室包括具有不同折射率的第一和第二流体10,12，形成弯液面14的流体之间的界面。 双折射部分能够改变第一辐射束3b和第二辐射束3c的特性，第一和第二辐射束具有不同的极化。 弯液面的构造的变化导致第一辐射束和第二辐射束的特性的变化。 弯液面的构型的变化可以通过电润湿来控制。