公开(公告)号：US06277969B1

公开(公告)日：2001-08-21

申请号：US09133119

申请日：1998-08-12

Applicant: Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Daddona ,  John Ghrayeb ,  David Knight ,  Scott Siegel

IPC: C07H2104

CPC classification number: A61K39/3955 ,  A61K31/167 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/485 ,  A61K31/519 ,  A61K31/573 ,  A61K38/00 ,  A61K45/00 ,  A61K45/06 ,  A61K2039/505 ,  C07K14/525 ,  C07K16/241 ,  C07K16/30 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/00 ,  A61K2300/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-&agr; (TNF&agr;) and are useful in vivo diagnosis and therapy of a number of TNF&agr;-mediated pathologies and conditions, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFalpha）特异性的片段和区域，并且可用于许多TNFα介导的病理学和病症的体内诊断和治疗，以及编码鼠和嵌合体的多核苷酸 提供了免疫测定和免疫治疗方法中的抗体，抗体的制备方法，抗TNF抗体的使用方法或其片段，区域或衍生物。

公开(公告)号：US5656272A

公开(公告)日：1997-08-12

申请号：US192102

申请日：1994-02-04

Applicant: Junming Le ,  Jan Vilcek ,  Peter Dadonna ,  John Ghrayeb ,  David Knight ,  Scott A. Siegel

Inventor： Junming Le ,  Jan Vilcek ,  Peter Dadonna ,  John Ghrayeb ,  David Knight ,  Scott A. Siegel

IPC: A61K38/00 ,  C07K14/525 ,  C07K16/24 ,  A61K39/395 ,  C12P21/04 ,  C12P21/06 ,  C12P21/08

CPC classification number: C07K14/525 ,  C07K16/241 ,  A61K38/00 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2319/00

Abstract: Anti-TNF antibodies, fragments and regions thereof which are specific for human tumor necrosis factor-.alpha. (TNF.alpha.) and are useful in vivo for diagnosis and therapy of a number of TNF.alpha.-mediated pathologies and conditions, including Crohn's disease, as well as polynucleotides coding for murine and chimeric antibodies, methods of producing the antibody, methods of use of the anti-TNF antibody, or fragment, region or derivative thereof, in immunoassays and immunotherapeutic approaches are provided.

Abstract translation: 抗TNF抗体，其对人肿瘤坏死因子-α（TNFα）特异性的片段和区域，并且可用于体内诊断和治疗许多TNFα介导的病理和病症，包括克罗恩病，以及 提供编码鼠抗嵌合抗体的多核苷酸，制备抗体的方法，抗TNF抗体或其片段，区域或衍生物的使用方法，免疫测定法和免疫治疗方法。

公开(公告)号：US5336554A

公开(公告)日：1994-08-09

申请号：US62826

申请日：1993-05-14

Applicant: David Knight

Inventor： David Knight

IPC: B29D7/01 ,  B23K26/00 ,  B65B33/01

CPC classification number: B29D7/01 ,  B29K2007/00 ,  B29K2105/04 ,  B29K2995/0065 ,  Y10T428/24322 ,  Y10T428/249953

Abstract: Process for providing thin elastomeric sheet elements with air-permeability and with improved resistance to tearing as a result of being punctured while in stretched condition. The process comprises exposing the sheet to interrupted, high intensity, narrow laser beams to form a plurality of small, closely-spaced laser perforations, each having smooth walls which resist tearing.

Abstract translation: 用于提供薄的弹性片材元件具有透气性并且由于在拉伸状态下被刺穿而具有改进的撕裂阻力的方法。 该方法包括将片材暴露于间断的，高强度的窄激光束，以形成多个小的紧密间隔的激光穿孔，每个激光穿孔具有抵抗撕裂的光滑壁。

公开(公告)号：US4226329A

公开(公告)日：1980-10-07

申请号：US46464

申请日：1979-06-07

Applicant: David Knight

Inventor： David Knight

IPC: B24D11/00 ,  B65D83/08 ,  B65D85/62

CPC classification number: B24D11/008 ,  B65D83/08 ,  B65D85/62

Abstract: A sanding disc container is disclosed to include a generally cylindrical member substantially closed at one end and having a longitudinally extending opening through a portion of the length of one wall of the cylinder. Sanding discs are disposed within the cylindrical member having their abrasive sides facing the closed end of the cylinder to provide access to the wheel of a sanding machine through the open end of the cylinder.

Abstract translation: 公开了一种砂盘容器，其包括在一端基本上封闭的大致圆柱形的构件，并且具有穿过圆筒的一个壁的长度的一部分的纵向延伸开口。 砂轮盘设置在圆柱形构件中，其磨料侧面朝向气缸的封闭端，以通过气缸的开口端提供对磨床机轮的通路。

公开(公告)号：US09053136B2

公开(公告)日：2015-06-09

申请号：US12985972

申请日：2011-01-06

Applicant: Aditya Kuruganti ,  Sanjaya Lai ,  Samatha Sanikommu ,  David Knight

Inventor： Aditya Kuruganti ,  Sanjaya Lai ,  Samatha Sanikommu ,  David Knight

IPC: G06F15/16 ,  G06F17/30

CPC classification number: G06F17/30306

Abstract: A system and method of identifying users of a multi-tenant database and application service is provided. The system and method is configured to generate a list of contacts from a contact database of a multi-tenant database and application service. Each contact in the list of contacts is sent a message that includes a link to web site that includes a query. Specifically, each contact visiting the web site is queried to determine if the contact is a user of a multi-tenant database and application service. Additionally, contacts are queried to determine if they are an administrator user, and if not, who is an associated administrator user. The contact database is updated to indicate contacts that are users of the multi-tenant database and application service when approved of by the associated administrator.

Abstract translation: 提供了一种识别多租户数据库和应用服务的用户的系统和方法。 系统和方法被配置为从多租户数据库和应用服务的联系人数据库生成联系人列表。 联系人列表中的每个联系人都会发送一条消息，其中包含指向包含查询的网站的链接。 具体来说，访问该网站的每个联系人被查询以确定联系人是否是多租户数据库和应用程序服务的用户。 此外，查询联系人以确定他们是否是管理员用户，如果不是，则是谁是关联的管理员用户。 更新联系人数据库，以便在由相关管理员批准时指示作为多租户数据库和应用程序服务的用户的联系人。

公开(公告)号：US20140255388A1

公开(公告)日：2014-09-11

申请号：US13799476

申请日：2013-03-13

Applicant: Jill M. Carton ,  Shizhong Chen ,  Mark Cunningham ,  Anuk Das ,  Karen Duffy ,  Jill Giles-Komar ,  Theresa Goletz ,  David Knight ,  Roberta Lamb ,  Lamine Mbow ,  Gopalan Raghunathan ,  Lani San Mateo ,  Robert Sarisky ,  Nicole Stowell ,  Raymond Sweet ,  Shanrong Zhao

Inventor： Jill M. Carton ,  Shizhong Chen ,  Mark Cunningham ,  Anuk Das ,  Karen Duffy ,  Jill Giles-Komar ,  Theresa Goletz ,  David Knight ,  Roberta Lamb ,  Lamine Mbow ,  Gopalan Raghunathan ,  Lani San Mateo ,  Robert Sarisky ,  Nicole Stowell ,  Raymond Sweet ,  Shanrong Zhao

IPC: C07K16/28

CPC classification number: C07K16/2866 ,  A61K2039/505 ,  C07K16/2896 ,  C07K2317/24 ,  C07K2317/74 ,  C07K2317/76

Abstract: Toll Like Receptor 3 (TLR3) antagonists, polynucleotides encoding TLR3 antagonists or fragments, and methods of making and using the foregoing are disclosed.

Abstract translation: Toll样受体3（TLR3）拮抗剂，编码TLR3拮抗剂或片段的多核苷酸，以及制备和使用前述物质的方法。

公开(公告)号：US08578465B2

公开(公告)日：2013-11-05

申请号：US12506321

申请日：2009-07-21

Applicant: Sihai Xiao ,  Zheng Yuan ,  David Knight

Inventor： Sihai Xiao ,  Zheng Yuan ,  David Knight

IPC: G06F21/00

CPC classification number: H04L67/141 ,  H04L63/0236 ,  H04L67/14

Abstract: In one embodiment, a client device may send one or more sub-session requests to one or more corresponding session controllers through a computer network to obtain one or more corresponding sub-session tokens that indicate in which sub-sessions of an online collaborative computing session the client device is permitted to participate. The client device may then receive particular sub-session tokens (e.g., based on certain permissions), which may then be sent to a collaboration server to establish one or more permitted sub-sessions of the online collaborative computing session with the client device as indicated by the received sub-session tokens.

Abstract translation: 在一个实施例中，客户机设备可以通过计算机网络向一个或多个对应的会话控制器发送一个或多个子会话请求，以获得指示在线协作计算会话的哪个子会话中的一个或多个相应的子会话令牌 允许客户端设备参与。 然后，客户端设备可以接收特定的子会话令牌（例如，基于某些许可），然后可以将其发送到协作服务器，以建立与所指示的客户端设备的在线协作计算会话的一个或多个允许的子会话 由接收到的子会话令牌。

公开(公告)号：US08501907B2

公开(公告)日：2013-08-06

申请号：US12950240

申请日：2010-11-19

Applicant: Robert Jordan ,  David Knight ,  Randall Brezski ,  Mary Ryan ,  Diane Petrone

Inventor： Robert Jordan ,  David Knight ,  Randall Brezski ,  Mary Ryan ,  Diane Petrone

IPC: A61K38/00 ,  C07K14/00

CPC classification number: C07K16/42 ,  A61K2039/505 ,  A61K2039/507 ,  C07K7/08 ,  C07K16/065 ,  C07K16/2848 ,  C07K16/36 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/50 ,  C07K2317/732 ,  C07K2317/734 ,  G01N33/6854 ,  G01N33/6857

Abstract: The invention relates to antibody compositions and use of the composition to detect disease processes associated with elaboration of proteases. The reagents are directed to assessing an IgG breakdown product that is the result of such proteolytic cleavage. The invention further relates to the use of a therapeutic immunospecific for IgG protease cleavage products to restore effector function to antibody compositions that are subject to protease cleavage.

Abstract translation: 本发明涉及抗体组合物和该组合物用于检测与精制蛋白酶相关的疾病过程的用途。 试剂用于评估作为这种蛋白水解切割结果的IgG分解产物。 本发明还涉及用于IgG蛋白酶切割产物的治疗免疫特异性用于恢复经受蛋白酶切割的抗体组合物的效应子功能的用途。

公开(公告)号：US08407289B2

公开(公告)日：2013-03-26

申请号：US11625710

申请日：2007-01-22

Applicant: Weidong Chen ,  Lei Zhu ,  Min Zhu ,  Chris Kangas ,  Matthew Sheppard ,  David Knight

Inventor： Weidong Chen ,  Lei Zhu ,  Min Zhu ,  Chris Kangas ,  Matthew Sheppard ,  David Knight

IPC: G06F15/16 ,  G06F15/173 ,  G06F17/00 ,  H04L12/16

CPC classification number: H04N7/15 ,  G06F21/6218 ,  G06F2221/2141

Abstract: In one embodiment, the methods and apparatuses detect shared content during a collaboration session; detect a content type based on the shared content; suggest an application based on the content type; and initiate the application during the collaboration session.

Abstract translation: 在一个实施例中，所述方法和装置在协作会话期间检测共享内容; 基于共享内容检测内容类型; 建议基于内容类型的应用程序; 并在协作会话期间启动应用程序。

公开(公告)号：US20120226806A1

公开(公告)日：2012-09-06

申请号：US13476427

申请日：2012-05-21

Applicant: David Knight ,  Jason Q. Zhang ,  Steffen Matt ,  Anand Ramanathan

Inventor： David Knight ,  Jason Q. Zhang ,  Steffen Matt ,  Anand Ramanathan

IPC: G06F9/46 ,  G06F15/16

CPC classification number: G06F9/4843

Abstract: In one embodiment, a first application detects a user's activity. Based on the user's activity detected by the first application, a type of user status is determined from among a plurality of different types of possible user status. One or more features are determined of a feature set of a second application that correspond to the type of user status detected by the first application. The corresponding one or more features of the feature set of the second application are limited to prevent the one or more features from interrupting the user's activity. One or more other features of the feature set of the second application that do not correspond to the type of user status detected by the first application are permitted.

Abstract translation: 在一个实施例中，第一应用程序检测用户的活动。 基于第一应用检测到的用户活动，从多种不同类型的可能的用户状态中确定用户状态的类型。 确定与第一应用检测到的用户状态类型相对应的第二应用的特征集的一个或多个特征。 限制第二应用的特征集的对应的一个或多个特征以防止一个或多个特征中断用户的活动。 允许第二应用的特征集的与第一应用检测到的用户状态类型不对应的一个或多个其他特征。