公开(公告)号：US20220364269A1

公开(公告)日：2022-11-17

申请号：US17868519

申请日：2022-07-19

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Jingwei Xie

IPC: D01D5/00 ,  D01F8/14 ,  D04H3/011 ,  D06M23/10 ,  D01F6/62

Abstract: Expanded, nanofiber structures are provided as well as methods of use thereof and methods of making.

公开(公告)号：US20220339279A1

公开(公告)日：2022-10-27

申请号：US17721709

申请日：2022-04-15

Applicant: Board of Regents of the University of Nebraska

Inventor： Kenneth Bayles ,  Gloria Borgstahl ,  Siddappa Byrareddy ,  Chittibabu Guda ,  St. Patrick Reid ,  Mara Jana Broadhurst ,  Andrew Schnaubelt

IPC: A61K39/215 ,  C07K14/165 ,  A61P31/14 ,  G01N33/569

Abstract: Disclosed are recombinant proteins, compositions, vectors, kits, data analyses, and methods for inducing an immune response against, or detecting exposure to, SARS-CoV-2. In particular, the compositions, vectors, kits, data analyses and methods may be utilized to immunize subjects against disease associated with SARS-CoV-2 infection or to protect subjects from SARS-CoV-2 infection. In some embodiments, the recombinant proteins are useful in the production of antibodies against SARS-CoV-2, and for the detection of exposure to SARS-CoV-2.

公开(公告)号：US11458136B2

公开(公告)日：2022-10-04

申请号：US16981325

申请日：2019-04-09

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Howard E. Gendelman ,  Benson Edagwa

IPC: C07D239/00 ,  A61K31/44 ,  A61K31/505 ,  A61K47/69 ,  A61P31/14 ,  A61K9/51 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/536 ,  A61K31/551

Abstract: The present invention provides prodrugs and methods of use thereof.

公开(公告)号：US20220277667A1

公开(公告)日：2022-09-01

申请号：US17746100

申请日：2022-05-17

Applicant: Board of Regents of the University of Nebraska

Inventor： Ka-Chun Siu ,  Carl Nelson ,  Mohsen Zahiri ,  Dmitry Oleynikov

IPC: G09B23/28

Abstract: The present disclosure is directed to a system and method for surgical training with low cost, reusable materials and a highly customizable virtual environment for skill-building. According to various embodiments, a surgical training tool is usable in conjunction with a support structure configured to at least partially constrain the tool movement. Meanwhile, the tool is tracked in real-time with off-tool detectors to generate a tool path driving a virtual rendering of the surgical training tool in an operative environment. The virtual rendering may be visually observable via a display device and may include a customizable and/or selectable operative environment with one or more structures that can be operated on by the virtual surgical training tool. By tracking the virtual tool interaction with the virtual structures, a task path may be established for documenting and/or objectively assessing the performance of one or more operative tasks.

公开(公告)号：US20220273926A1

公开(公告)日：2022-09-01

申请号：US17625689

申请日：2020-07-08

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Ali TAMAYOL ,  Hossein DERAKHSHANDEH ,  Pooria MOSTAFALU

IPC: A61M37/00 ,  A61M5/142

Abstract: The disclosure relates to improved wound healing compositions, methods, and systems. Embodiments of the disclosure provide microneedle arrays and devices for treating wounds and bacterial infections. Also provided are methods of using microneedle arrays and devices to passively or actively deliver various therapeutic agents to target tissues including acute and chronic wounds.

公开(公告)号：US11427936B2

公开(公告)日：2022-08-30

申请号：US16647690

申请日：2018-09-19

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Jingwei Xie

IPC: C08J3/24 ,  C08J7/02 ,  C08J9/36 ,  D06M11/58 ,  D06M11/64 ,  D06M13/08 ,  D01D5/00 ,  D01F8/14 ,  D04H3/011 ,  D06M23/10 ,  D01F6/62 ,  D06M101/32 ,  B29K73/00

Abstract: Expanded, nanofiber structures are provided as well as methods of use thereof and methods of making.

公开(公告)号：US20220219340A1

公开(公告)日：2022-07-14

申请号：US17503456

申请日：2021-10-18

Applicant: Board of Regents of the University of Nebraska

Inventor： Shane Farritor ,  Thomas Frederick

IPC: B25J19/00 ,  B25J15/04 ,  A61B34/00 ,  A61B34/30 ,  A61B17/00 ,  H01R13/00 ,  H01R13/625 ,  H01R24/20

Abstract: The various embodiments herein relate to a coupling apparatus for a medical device having a coupler body, a cavity defined in the coupler body, a rotatable drive component disposed within the cavity and having at least two pin-receiving openings, and an actuable locking ring disposed around the cavity.

公开(公告)号：US11370769B2

公开(公告)日：2022-06-28

申请号：US16644188

申请日：2018-09-07

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA ,  The Brigham and Women's Hospital, Inc.

Inventor： Corey Hopkins ,  Anna Greka

IPC: C07D401/04 ,  A61P13/12 ,  C07D401/12

Abstract: Provided herein are TRPC5 inhibitors and methods of using the same, e.g., to protect podocytes and/or treat kidney disease.

公开(公告)号：US11357595B2

公开(公告)日：2022-06-14

申请号：US15821169

申请日：2017-11-22

Applicant: Board of Regents of the University of Nebraska

Inventor： Mark Reichenbach ,  Shane Farritor

IPC: A61B90/50 ,  A61B17/02 ,  A61B1/00 ,  A61B34/00 ,  A61B34/30 ,  A61B17/00

Abstract: Disclosed herein are gross positioning systems for use with robotic surgical devices to provide gross positioning of the robotic surgical devices. The gross positioning systems have a base, a first arm link operably coupled to the base, a second arm link operably coupled to the first arm link, a third arm link operably coupled to the second arm link, and a slidable coupling component slidably coupled to the third arm link.

公开(公告)号：US20220175936A1

公开(公告)日：2022-06-09

申请号：US17309435

申请日：2019-11-27

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard Gendelman ,  Benson Edagwa

IPC: A61K47/55 ,  A61P31/18 ,  A61K9/14

Abstract: The present invention provides prodrugs and methods of use thereof.