公开(公告)号：US11458136B2

公开(公告)日：2022-10-04

申请号：US16981325

申请日：2019-04-09

Applicant: BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Howard E. Gendelman ,  Benson Edagwa

IPC: C07D239/00 ,  A61K31/44 ,  A61K31/505 ,  A61K47/69 ,  A61P31/14 ,  A61K9/51 ,  A61K31/4439 ,  A61K31/496 ,  A61K31/536 ,  A61K31/551

Abstract: The present invention provides prodrugs and methods of use thereof.

公开(公告)号：US20140004148A1

公开(公告)日：2014-01-02

申请号：US13925210

申请日：2013-06-24

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard E. Gendelman ,  R. Lee Mosley ,  Ashley D. Reynolds

IPC: A61K39/39 ,  A61K39/21 ,  A61K39/00

CPC classification number: A61K39/0008 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0007 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55522 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/575 ,  C12N7/00 ,  C12N2740/16334 ,  C12N2740/16371

Abstract: Methods and compositions for treating central nervous system diseases and disorders are disclosed.

Abstract translation: 公开了治疗中枢神经系统疾病和病症的方法和组合物。

公开(公告)号：US20210060138A1

公开(公告)日：2021-03-04

申请号：US16812140

申请日：2020-03-06

Applicant: Temple University - of the Commonwealth System of Higher Education ,  BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Kamel Khalili ,  Howard E. Gendelman ,  Benson Edagwa

IPC: A61K38/46 ,  A61K35/761 ,  A61P31/18 ,  A61K31/5365 ,  A61K31/7068 ,  A61K31/7076 ,  A61K31/505 ,  A61K31/7105

Abstract: Methods of eliminating a retrovirus from a subject utilize nanoformulated anti-retroviral compounds and gene editing agents. Compositions comprise at least one anti-retroviral compounds, at least one gene-editing agent, or combinations thereof.

公开(公告)号：US09782464B2

公开(公告)日：2017-10-10

申请号：US15040076

申请日：2016-02-10

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard E. Gendelman ,  R. Lee Mosley ,  Ashley D. Reynolds

IPC: A61K39/00 ,  A61K39/21 ,  A61K39/39 ,  C12N7/00

CPC classification number: A61K39/0008 ,  A61K39/00 ,  A61K39/0005 ,  A61K39/0007 ,  A61K39/21 ,  A61K39/39 ,  A61K2039/55511 ,  A61K2039/55516 ,  A61K2039/55522 ,  A61K2039/57 ,  A61K2039/572 ,  A61K2039/575 ,  C12N7/00 ,  C12N2740/16334 ,  C12N2740/16371

Abstract: Methods and compositions for treating central nervous system diseases and disorders are disclosed.

公开(公告)号：US20170165271A1

公开(公告)日：2017-06-15

申请号：US15116038

申请日：2015-02-24

Applicant: The Board of Regents of the University of Nebraska

Inventor： Howard E. Gendelman ,  Xin-Ming Liu

IPC: A61K31/5365 ,  A61K31/4985 ,  A61K45/06

CPC classification number: A61K31/5365 ,  A61K9/0019 ,  A61K9/10 ,  A61K9/146 ,  A61K9/5146 ,  A61K31/4985 ,  A61K45/06

Abstract: The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.

公开(公告)号：US12257306B2

公开(公告)日：2025-03-25

申请号：US18050351

申请日：2022-10-27

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard E. Gendelman ,  Benson Edagwa

IPC: A61K47/55 ,  A61K9/14 ,  A61P31/18

Abstract: The present invention provides prodrugs and methods of use thereof.

公开(公告)号：US20220194990A1

公开(公告)日：2022-06-23

申请号：US17310245

申请日：2020-01-31

Applicant: Board of Regents of the University of Nebraska

Inventor： Howard E. Gendelman ,  Jonathan Herskovitz ,  Mahmudul Hasan ,  Bhavesh Kevadiya

IPC: C07K14/005

Abstract: The present invention provides virus-like particles and methods of manufacture and use thereof. In accordance with the instant invention, virus-like particles (VLPs), particularly human immunodeficiency virus (HIV) VLPs, are provided. The HIV VLPs comprise at least one HIV structural protein and the HIV envelope protein, but lacks the HIV genome and lacks functional reverse transcriptase and integrase.

公开(公告)号：US20190117735A1

公开(公告)日：2019-04-25

申请号：US16092561

申请日：2017-04-24

Applicant: Board of Regents of the University of Nebraska ,  The Scripps Research Institute

Inventor： Howard E. Gendelman ,  R. Lee Mosley ,  Gary Suizdak ,  Erica Forsberg

IPC: A61K38/19 ,  G01N33/50 ,  A61K38/22 ,  G01N33/68 ,  G01N33/94

Abstract: The present invention provides novel biomarkers for regulatory T cells (Treg) function and Parkinson's disease.

公开(公告)号：US20170304308A1

公开(公告)日：2017-10-26

申请号：US15517581

申请日：2015-10-09

Applicant: The Board of Regents of the University of Nebraska

Inventor： Howard E. Gendelman ,  Xin-Ming Liu ,  Benson Edagwa

IPC: A61K31/52 ,  A61K9/51 ,  A61K9/00 ,  A61K47/69 ,  A61K31/513 ,  A61K47/64

CPC classification number: A61K31/52 ,  A61K9/0019 ,  A61K9/5146 ,  A61K31/513 ,  A61K47/542 ,  A61K47/551 ,  A61K47/64 ,  A61K47/6901 ,  A61K47/6907 ,  A61K47/6921 ,  A61K47/6929 ,  C07D411/04 ,  C07D473/16

Abstract: The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.

公开(公告)号：US20160346222A1

公开(公告)日：2016-12-01

申请号：US15111046

申请日：2015-01-14

Applicant: THE BOARD OF REGENTS OF THE UNIVERSITY OF NEBRASKA

Inventor： Howard E. Gendelman ,  Xin-Ming Liu

IPC: A61K9/51 ,  A61K45/06 ,  A61K31/46

CPC classification number: A61K9/5153 ,  A61K9/5123 ,  A61K31/46 ,  A61K45/06 ,  A61K47/24

Abstract: The present invention provides compositions and methods for the delivery of antivirals to a cell or subject.