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    ANION GENERATING AND ELECTRON CAPTURE DISSOCIATION APPARATUS USING COLD ELECTRONS
    141.
    发明申请
    ANION GENERATING AND ELECTRON CAPTURE DISSOCIATION APPARATUS USING COLD ELECTRONS 有权
    使用冷电子的阴极生成和电子捕获装置

    公开(公告)号：US20140367568A1

    公开(公告)日：2014-12-18

    申请号：US14358809

    申请日：2011-11-28

    Applicant: KOREA BASIC SCIENCE INSTITUTE

    Inventor： Hyun Sik Kim ,  Seung Young Kim ,  Mo Yang

    IPC: H01J49/00 ,  H01J49/42

    CPC classification number: H01J49/08 ,  H01J27/028 ,  H01J43/04 ,  H01J43/246 ,  H01J49/0045 ,  H01J49/0054 ,  H01J49/10 ,  H01J49/147 ,  H01J49/38 ,  H01J49/426

    Abstract: The present invention relates to an anion generating and electron capture dissociation apparatus using cold electrons, which uses an MCP electron multiplier plate for generating an electron beam for ionization within an ion trap of a Fourier transform ion cyclotron resonance mass spectroscope, injects ultraviolet photons emitted from an ultraviolet diode across the entire surface of the MCP electron multiplier plate, uses an electron focusing lens to focus and inject an electron beam into the trap, and generates an ECD reaction by coupling electrons to molecules having multiple positive charges using a low energy electron beam emitting apparatus for the negative ionization of neutral molecules in the ion trap. The anion generating and electron capturing and analyzing apparatus of the present invention, which uses cold electrons and is configured of a cold electron generating module which generates a large number of cold electrons from ultraviolet photons emitted into a mass spectroscope in a high vacuum state, comprises a plurality of ultraviolet diodes emitting ultraviolet photons in the mass spectroscope, an MCP electron multiplier plate inducing and amplifying an initial electron emission of ultraviolet photons from the ultraviolet diodes, and generating a high capacity electron beam from a back plate, an electron focusing lens for focusing the electron beam amplified through the MCP electron multiplier plate, and a grid for adjusting the energy and current of electrons.

    Abstract translation: 本发明涉及一种使用冷电子的阴离子产生和电子捕获离解装置，其使用MCP电子倍增器板在傅里叶变换离子回旋共振质谱仪的离子阱内产生用于离子化的电子束，注入从 跨越MCP电子倍增器板的整个表面的紫外线二极管使用电子聚焦透镜将电子束聚焦并注入陷阱，并通过使用低能电子束将电子耦合到具有多个正电荷的分子来产生ECD反应 用于离子阱中的中性分子的负电离的发射装置。 本发明的阴离子产生和电子捕获和分析装置，其使用冷电子并且由在高真空状态下发射到质谱仪中的紫外光子产生大量冷电子的冷电子发生模块构成，包括 在质谱仪中发射紫外光子的多个紫外线二极管，MCP电子倍增器板，其从紫外二极管感应并放大紫外光子的初始电子发射，并从背板产生高容量电子束;电子聚焦透镜， 聚焦通过MCP电子倍增器板放大的电子束，以及用于调节电子的能量和电流的栅格。

    METHOD FOR DETECTING COMPOUND-BINDING PROTEIN
    142.
    发明申请
    METHOD FOR DETECTING COMPOUND-BINDING PROTEIN 审中-公开
    检测化合物结合蛋白的方法

    公开(公告)号：US20140335545A1

    公开(公告)日：2014-11-13

    申请号：US14310758

    申请日：2014-06-20

    Applicant: KOREA BASIC SCIENCE INSTITUTE

    Inventor： Zee-Won LEE ,  Soohyun Kim ,  Seung II Kim ,  Jung Me Hwang

    IPC: G01N33/50 ,  G01N33/58

    CPC classification number: G01N33/5035 ,  C12N15/1055 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/581 ,  G01N33/582 ,  G01N2333/90666 ,  G01N2333/912 ,  G01N2500/02 ,  G01N2500/10

    Abstract: A method for detecting the interactions of biomaterials by screening a prey that interacts with a bait includes preparing a cell which expresses a first construct including a translocation module, a first labeling material, and a first medium, and a third construct including a prey and a second labeling material; introducing a second construct into the prepared cell, the second construct including a bait and a second medium binding with the first medium; allowing the prey and the bait to interact each other; and confirming the interaction between the prey and the bait by detecting intracellular distributions of the first construct and the third construct.

    Abstract translation: 通过筛选与诱饵相互作用的猎物来检测生物材料的相互作用的方法包括制备表达包含易位模块，第一标记材料和第一培养基的第一构建体的细胞，以及包括猎物和第 第二标签材料; 将第二构建体引入所制备的细胞中，所述第二构建体包含诱饵和与所述第一培养基结合的第二培养基; 允许猎物和诱饵互相交流; 并通过检测第一构建体和第三构建体的细胞内分布来确认猎物和诱饵之间的相互作用。

    IMAGING SYSTEM USING OPTICAL FIBER ARRAY INTEGRATED WITH LENSES
    143.
    发明申请
    IMAGING SYSTEM USING OPTICAL FIBER ARRAY INTEGRATED WITH LENSES 审中-公开
    使用与镜片集成的光纤阵列的成像系统

    公开(公告)号：US20130146754A1

    公开(公告)日：2013-06-13

    申请号：US13708388

    申请日：2012-12-07

    Applicant: Korea Basic Science Institute

    Inventor： Ki Soo Chang ,  Seon Young Ryu ,  Sun Cheol Yang ,  Geon Hee Kim ,  Hae Young Choi

    IPC: G01J1/42 ,  G01J1/04

    CPC classification number: G01J1/42 ,  A61B5/0062 ,  A61B5/0071 ,  A61B5/0084 ,  G01J1/0488 ,  G01J3/0218 ,  G01J3/4406 ,  G01N21/645 ,  G01N2021/6484 ,  G02B6/2552 ,  G02B6/262

    Abstract: Provided is an imaging system using an optical fiber array probe integrated with lenses for emitting light transmitted from a light source to a sample, and guiding light generated from the sample. The imaging system includes an optical fiber array probe integrated with lenses including an optical fiber lens with a lens surface of a predetermined radius of curvature in which one ends of two optical fibers are integrally connected with each other by heating a predetermined region including the one ends of the two optical fibers using a heating means. Therefore, a compact imaging system may be realized while effectively improving optical coupling efficiency through a simple manufacturing process.

    Abstract translation: 提供了一种使用与透镜集成的光纤阵列探针的成像系统，用于发射从光源向样本透射的光，并且引导从样品产生的光。 成像系统包括与透镜组合的光纤阵列探针，该透镜包括具有预定曲率半径的透镜表面的光纤透镜，其中两个光纤的一端通过加热包括一端的预定区域而彼此一体地连接 的两根光纤。 因此，可以通过简单的制造过程有效地提高光耦合效率，实现紧凑的成像系统。

    Process for preparation of RNA using affinity column and DNAzyme
    144.
    发明申请
    Process for preparation of RNA using affinity column and DNAzyme 审中-公开
    使用亲和柱和DNAzyme制备RNA的方法

    公开(公告)号：US20040191872A1

    公开(公告)日：2004-09-30

    申请号：US10438992

    申请日：2003-05-16

    Applicant: Korea Basic Science Institute

    Inventor： Chaejoon Cheong ,  Chulhyun Lee ,  Hae-Kap Cheong ,  Jun-Soek Yoo ,  Eunha Hwang

    IPC: C12P019/34 ,  C07H021/02

    CPC classification number: C12P19/34

    Abstract: A process for preparation of RNA using an affinity column and a DNAzyme is disclosed. By the process, a target RNA can be mass-produced with a high yield, a high resolution and a high purification efficiency. The process includes the steps of preparing a RNA adduct including a target RNA and a tail RNA sequence which is affixed to the 3null-terminal of the target RNA and can complementary combine with an oligo-dN sequence of an oligo-dN affinity column; purifying the RNA adduct by combining the RNA adduct to the oligo-dN affinity column; and obtaining the target RNA by cleaving the purified RNA adduct with a DNAzyme. Preferably, the process for preparation of RNA further includes the steps of removing a RNA fragment cleaved by the DNAzyme by using an affinity column; and decomposing the DNAzyme with a DNA nuclease, and then removing decomposed DNAzyme fragments with a gel filtration column.

    Abstract translation: 公开了使用亲和柱和DNAzyme制备RNA的方法。 通过该方法，可以高产率，高分辨率和高纯化效率大量生产靶RNA。 该方法包括制备包含目标RNA和尾RNA序列的RNA加合物的步骤，所述RNA加合物附着于靶RNA的3'末端，并可与oligo-dN亲和柱的oligo-dN序列互补结合; 通过将RNA加合物与oligo-dN亲和柱结合来纯化RNA加合物; 并通过用DNA酶切割纯化的RNA加合物来获得靶RNA。 优选地，RNA的制备方法还包括通过使用亲和柱除去DNA酶切割的RNA片段的步骤; 并用DNA核酸酶分解DNA酶，然后用凝胶过滤柱除去分解的DNA酶片段。

    Bobbin and coil assembly and electromagnet equipment including same
    147.
    发明授权
    Bobbin and coil assembly and electromagnet equipment including same 有权

    公开(公告)号：US10916368B2

    公开(公告)日：2021-02-09

    申请号：US16152568

    申请日：2018-10-05

    Applicant: KOREA BASIC SCIENCE INSTITUTE

    Inventor： Seung-Young Park ,  Jungmin Park

    IPC: H01F3/00 ,  H01F27/28 ,  H01F7/20 ,  H01F27/24 ,  H01F27/10 ,  H01F27/02 ,  H01F27/32

    Abstract: The present invention relates to a bobbin and a coil assembly and electromagnet equipment including the same, and the electromagnet equipment, which includes a bobbin and a coil, includes a coil assembly receiving a refrigerant so as to remove heat produced when magnetic field lines are formed by an electric current running through the coil while the coil is wound on a center shaft relative to the center shaft provided on a center of the bobbin; and a terminal block provided on a lower side of the coil assembly, the terminal block supporting the coil assembly and receiving a refrigerant from outside and supplying the refrigerant to the coil assembly.

    Fast parallel optical coherence tomographic image generating apparatus and method
    148.
    发明授权
    Fast parallel optical coherence tomographic image generating apparatus and method 有权

    公开(公告)号：US10765322B2

    公开(公告)日：2020-09-08

    申请号：US16164543

    申请日：2018-10-18

    Applicant: KOREA BASIC SCIENCE INSTITUTE

    Inventor： Kye Sung Lee ,  Ki Soo Chang

    IPC: A61B5/00 ,  G01B9/02 ,  A61B3/00 ,  A61B3/10

    Abstract: Provided is a fast parallel optical coherence tomographic image generating method including dispersing light into N spectral regions Δλ1 through ΔλN sequentially from a low frequency wavelength to a high frequency wavelength, the light being emitted from a broadband light source of a fast parallel optical coherence tomographic image generating apparatus, N being an integer greater than or equal to 2, splitting the light emitted from the broadband light source to be incident on a sample and a reference mirror, partitioning the sample into N image regions P1 through PN, discretely controlling a beam scanner such that the light emitted from the broadband light source is incident on the sample at a position changed by a preset distance, acquiring an interference spectral image through interference light formed in response to interference of measurement light and reference light, and generating a tomographic image of the sample using the interference spectral image.

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