公开(公告)号：US07067633B2

公开(公告)日：2006-06-27

申请号：US10787603

申请日：2004-02-26

Applicant: Rakesh Kumar ,  Ratna Vadlamudi

Inventor： Rakesh Kumar ,  Ratna Vadlamudi

IPC: C07K1/00 ,  C07K14/00 ,  C07K17/00

CPC classification number: C07K14/4716 ,  A61K38/00

Abstract: Methods of modulating macropinocytosis in cells of a target cell population by modulating the binding of Pak1 to DLC1/PIN are disclosed. In addition, the invention provides for methods of screening for modulators of macropinocytosis that involve determining whether a candidate substance inhibits or promotes the binding of Pak1 to DLC1/PIN. Also disclosed are methods of reducing cell proliferation in a target cell population, methods of inhibiting growth and survival of a cancer cell, methods of inhibiting the invasiveness of a cancer cell, and methods of treating viral infection using an agent that modifies the binding of Pak1 to DLC1/PIN.

Abstract translation: 公开了通过调节Pak1与DLC1 / PIN的结合来调节靶细胞群体细胞中巨噬细胞增多症的方法。 此外，本发明提供筛选大细胞增多症调节剂的方法，其涉及确定候选物质是否抑制或促进Pak1与DLC1 / PIN的结合。 还公开了减少靶细胞群体中的细胞增殖的方法，抑制癌细胞的生长和存活的方法，抑制癌细胞侵袭的方法，以及使用修饰Pak1结合的试剂治疗病毒感染的方法 到DLC1 / PIN。

公开(公告)号：USPP16474P3

公开(公告)日：2006-04-25

申请号：US10749906

申请日：2003-12-29

Applicant: Suman Preet Singh Khanuja ,  Nirmal Kumar Patra ,  Ajit Kumar Shasany ,  Birendra Kumar ,  Soni Gupta ,  Rakesh Kumar Upadhyay ,  Togarrati Padma Priya ,  Anil Kumar Singh ,  Mahendra Pandurang Darokar ,  Virendra Kumar Singh Tomar ,  Janak Raj Bahal ,  Raj Kishori Lal

Inventor： Suman Preet Singh Khanuja ,  Nirmal Kumar Patra ,  Ajit Kumar Shasany ,  Birendra Kumar ,  Soni Gupta ,  Rakesh Kumar Upadhyay ,  Togarrati Padma Priya ,  Anil Kumar Singh ,  Mahendra Pandurang Darokar ,  Virendra Kumar Singh Tomar ,  Janak Raj Bahal ,  Raj Kishori Lal

IPC: A01H5/00

CPC classification number: A01H5/12

Abstract: The present invention relates to a new and distinct mint plant of Mentha piperita ‘Cim Indus’, selected through screening, field trial and analysis of monoterpene constituents of the essential oil of the germplasm, possessing the characters of producing high amount of menthofuran ranging between 22 to 30% of total oil content, high amount pulegone ranging between 9.0 to 18% of total oil content, with essential oil content ranging between 0.32 to 0.40% of the total oil content.

Abstract translation: 本发明涉及一种通过筛选，现场试验和分析种质精油单萜成分选择的薄荷椒仁新鲜不同的薄荷植物，具有生产大量薄荷呋喃的特点，范围在22 至总含油量的30％，高含量范围在总油含量的9.0〜18％之间，精油含量在总油含量的0.32〜0.40％之间。

公开(公告)号：US07020351B1

公开(公告)日：2006-03-28

申请号：US09680669

申请日：2000-10-06

Applicant: Rakesh Kumar ,  Harpreet S. Sawhney ,  Keith Hanna

Inventor： Rakesh Kumar ,  Harpreet S. Sawhney ,  Keith Hanna

IPC: G06K9/54

CPC classification number: G06K9/00711 ,  G06F17/30793 ,  G06F17/30811 ,  G06F17/30858 ,  G06K9/00228 ,  G06K9/6857 ,  Y10S707/99936 ,  Y10S707/99943 ,  Y10S715/968

Abstract: A method and apparatus for indexing digital video and audio signals using a digital database. A user may index the digital images by content within the images, through annotation, and the like. The database can contain high resolution and low resolution versions of the audio-video content. The indexed video can be used to create web pages that enable a viewer to access the video clips. The indexed video may also be used to author digital video disks (DVDs). The video may be enhanced to achieve DVD quality or be accessed to enhancing the digital signals and indexing the digital signals. The user may choose to enhance the digital signals by combining frames into a panorama, enhancing the resolution of the frames, filtering the images, and the like.

Abstract translation: 一种使用数字数据库对数字视频和音频信号进行索引的方法和装置。 用户可以通过图像内的内容，通过注释等来索引数字图像。 该数据库可以包含音频视频内容的高分辨率和低分辨率版本。 索引的视频可用于创建网页，使观众能够访问视频剪辑。 索引的视频也可以用于创作数字视频盘（DVD）。 可以增强视频以实现DVD质量或被访问以增强数字信号和索引数字信号。 用户可以通过将帧组合成全景图，增强帧的分辨率，过滤图像等来选择增强数字信号。

公开(公告)号：US06985445B1

公开(公告)日：2006-01-10

申请号：US09495036

申请日：2000-01-31

Applicant: Ruibing Hao ,  David Lee ,  Rakesh Kumar Sinha

Inventor： Ruibing Hao ,  David Lee ,  Rakesh Kumar Sinha

IPC: H04L12/26

CPC classification number: H04M3/22 ,  H04L43/50 ,  H04M3/2254 ,  H04M7/0084

Abstract: A method of generating a set of test sequences for evaluating interoperability of a number of interconnected communication systems with respect to a desired mode of communication between a first end user and a second end user. A number of operational states that are required of the communication systems to implement the desired mode of operation between the two end users is determined, wherein each state pertains to a first operation of a first gateway system associated with the first end user and a corresponding second operation of a second gateway system associated with the second end user. The interconnected communication systems are tested by causing the systems to perform specified transitions between pairs of at least some of the operational states.

Abstract translation: 一种生成一组测试序列的方法，用于评估多个互连的通信系统相对于第一最终用户和第二终端用户之间的期望的通信模式的互操作性。 确定通信系统在两个最终用户之间实现期望的操作模式所需的多个操作状态，其中每个状态属于与第一终端用户相关联的第一网关系统的第一操作和对应的第二 与第二终端用户相关联的第二网关系统的操作。 通过使系统在至少一些操作状态的对之间执行指定的转换来测试互连的通信系统。

公开(公告)号：US20050243323A1

公开(公告)日：2005-11-03

申请号：US10825946

申请日：2004-04-16

Applicant: Stephen Hsu ,  Supun Samarasekera ,  Rakesh Kumar ,  Wen-Yi Zhao ,  Keith Hanna

Inventor： Stephen Hsu ,  Supun Samarasekera ,  Rakesh Kumar ,  Wen-Yi Zhao ,  Keith Hanna

IPC: G01B9/02 ,  G01B11/14 ,  G01C3/08 ,  G01J3/45 ,  G06T20060101

CPC classification number: G06T5/20 ,  G01S17/89 ,  G06K9/3241 ,  G06T5/002 ,  G06T7/30 ,  G06T7/33 ,  G06T2200/04 ,  G06T2207/10028 ,  G06T2207/20016 ,  G06T2207/30212 ,  G06T2207/30236

Abstract: A method and apparatus for high-resolution 3D imaging ladar system which can penetrate foliage and camouflage to sample fragments of concealed surfaces of interest is disclosed. Samples collected while the ladar moves can be integrated into a coherent object shape. In one embodiment, a system and method for automatic data-driven registration of ladar frames, comprises a coarse search stage, a pairwise fine registration stage using an iterated closest points algorithm, and a multi-view registration strategy. After alignment and aggregation, it is often difficult for human observers to find, assess and recognize objects from a point cloud display. Basic display manipulations, surface fitting techniques, and clutter suppression to enhance visual exploitation of 3D imaging ladar data may be utilized.

Abstract translation: 公开了一种用于高分辨率3D成像系统的方法和装置，其可以穿透叶子并伪装成对所关注的隐藏表面的碎片进行采样。 收集的样本可以集成到一个连贯的物体形状。 在一个实施例中，用于自动数据驱动的装载帧的注册的系统和方法包括粗搜索阶段，使用迭代最近点算法的成对精细注册阶段和多视图注册策略。 对齐和聚合后，人类观察者往往难以从点云显示中发现，评估和识别物体。 可以利用基本的显示操作，表面拟合技术和杂波抑制来增强3D成像数据的视觉利用。

公开(公告)号：US06880727B2

公开(公告)日：2005-04-19

申请号：US09850166

申请日：2001-05-08

Applicant: Peter Martin Pozniak ,  Charles Andre Provost ,  Rakesh Kumar Singh ,  Sau Van Vo ,  Benjamin Rush Roberts

Inventor： Peter Martin Pozniak ,  Charles Andre Provost ,  Rakesh Kumar Singh ,  Sau Van Vo ,  Benjamin Rush Roberts

IPC: B01F3/08 ,  B01F5/00 ,  B01F13/10 ,  B01F15/00 ,  B01F15/04 ,  B24B37/04 ,  B24B57/02 ,  H01L21/304 ,  B01F15/02

CPC classification number: B24B37/04 ,  B01F13/1055 ,  B01F15/00357 ,  B01F15/026 ,  B01F15/0441 ,  B24B57/02

Abstract: A system, apparatus and method is disclosed for providing a consistent liquid mixture according to a predetermined recipe for use at a point of use. The apparatus includes a plurality of liquid component reservoirs in which a constant gas pressure is maintained. A plurality of valves are provided, with individual valves connected to an outlet port of each reservoir. An electronic controller controls the valve actuation in a repetitive sequence to discharge predetermined doses of selected liquid components for mixing to form the consistent liquid mixture. A mixing section receives the sequence of doses to mix them together to form the liquid mixture.

Abstract translation: 公开了一种用于根据用于使用点的预定配方提供一致的液体混合物的系统，装置和方法。 该装置包括多个保持恒定气体压力的液体成分储存器。 提供多个阀，其中单个阀连接到每个储存器的出口。 电子控制器以重复的顺序控制阀致动以排出预定剂量的选定液体组分以进行混合以形成一致的液体混合物。 混合部分接收剂量序列以将它们混合在一起以形成液体混合物。

公开(公告)号：US06878454B1

公开(公告)日：2005-04-12

申请号：US10781404

申请日：2004-02-18

Applicant: Porter C. Shannon ,  Rakesh Kumar ,  Pradeep Pandurang Shirodkar ,  Fred David Ehrman ,  Mark B. Davis ,  Keith Wesley Trapp ,  Dongming Li

Inventor： Porter C. Shannon ,  Rakesh Kumar ,  Pradeep Pandurang Shirodkar ,  Fred David Ehrman ,  Mark B. Davis ,  Keith Wesley Trapp ,  Dongming Li

IPC: C08F210/16 ,  C08L23/08 ,  C08F10/02

CPC classification number: C08L23/0815 ,  C08F210/16 ,  C08L2205/02 ,  C08L2205/025 ,  C08L2666/06 ,  C08F210/08 ,  C08F2500/12 ,  C08F2500/02 ,  C08F2500/01 ,  C08F2500/05 ,  C08F2500/26

Abstract: A film comprising a polyethylene composition, the polyethylene composition in one embodiment comprising a high molecular weight component having a weight average molecular weight of greater than 50,000 amu and a low molecular weight component having a weight average molecular weight of less than 50,000 amu; the polyethylene composition possessing a density of between 0.940 and 0.970 g/cm3, and an I21 value of less than 20 dg/min; characterized in that the polyethylene composition extrudes at an advantageously high specific throughput at an advantageously low melt temperature, and wherein the film has a gel count of less than 100.

Abstract translation: 一种包含聚乙烯组合物的膜，一个实施方案中的聚乙烯组合物包含重均分子量大于50,000amu的高分子量组分和重均分子量小于50,000amu的低分子量组分; 聚乙烯组合物的密度为0.940〜0.970g / cm 3，I21值小于20dg / min; 其特征在于，所述聚乙烯组合物在有利的低熔融温度下以有利的高比生产量挤出，并且其中所述膜的凝胶计数小于100。

公开(公告)号：US20050064343A1

公开(公告)日：2005-03-24

申请号：US10945897

申请日：2004-09-22

Applicant: Filippo Romanato ,  Enzo Di Fabrizio ,  Rakesh Kumar

Inventor： Filippo Romanato ,  Enzo Di Fabrizio ,  Rakesh Kumar

IPC: G03F7/00 ,  G03F7/095 ,  G03F7/20

CPC classification number: G03F7/00 ,  G03F7/095 ,  G03F7/201 ,  G03F7/2014 ,  G03F7/203

Abstract: What is described is a lithographic method for fabricating three-dimensional structures on the micrometric and submicro-metric scale, including the operations of: depositing a layer of a first resist on a substrate; depositing a layer of a second resist on the layer of the first resist; forming a pattern of the second resist by lithography; depositing a further layer of the first resist on the previous layers; and forming a pattern of the first resist by lithography. The second resist is sensitive to exposure to charged particles or to electromagnetic radiation in a different way from the first; in other words, it is transparent to the particles or to the electromagnetic radiation to which the first resist is sensitive, and therefore the processes of exposure and development of the two resists are mutually incompatible to the extent that the exposure and development of one does not interfere with the exposure and development of the other.

Abstract translation: 描述的是用于在微米和亚微米度量上制造三维结构的光刻方法，包括以下操作：在衬底上沉积第一抗蚀剂层; 在第一抗蚀剂的层上沉积第二抗蚀剂层; 通过光刻形成第二抗蚀剂的图案; 在先前的层上沉积另一层第一抗蚀剂层; 以及通过光刻形成第一抗蚀剂的图案。 第二抗蚀剂以与第一抗蚀剂不同的方式对暴露于带电粒子或电磁辐射敏感; 换句话说，对于第一抗蚀剂敏感的颗粒或电磁辐射是透明的，因此两个抗蚀剂的曝光和显影的过程相互不相容，使得曝光和显影不会 干扰另一方的曝光和发展。

公开(公告)号：US20050053968A1

公开(公告)日：2005-03-10

申请号：US10812839

申请日：2004-03-30

Applicant: Lalit Bharadwaj ,  Awdhesh Shukla ,  Amol Bhondekar ,  Rakesh Kumar ,  Ram Bajpai

Inventor： Lalit Bharadwaj ,  Awdhesh Shukla ,  Amol Bhondekar ,  Rakesh Kumar ,  Ram Bajpai

IPC: G06F17/30 ,  G06N3/12 ,  G11B20/00 ,  G11C13/02 ,  C12Q1/68 ,  G06F19/00 ,  G01N33/48 ,  G01N33/50

CPC classification number: G06N3/123 ,  B82Y10/00 ,  G11B20/00086 ,  G11B20/0021 ,  G11C13/0014 ,  G11C13/0019 ,  G16B30/00

Abstract: DNA is a natural molecular level storage device. Molecular storage devices use each molecule or part of it for storing a character. Thus it is possible to store information million of times than presently used storage devices. For example a JPEG image (i.e. flag of India) having file size of 1981 Bytes can be encrypted using 7924 DNA bases which occupies about 2694.16 nanometers In other words flag of India can be encrypted 8.07×105 times in human genome which comprises 6.4×109 DNA bases and occupy a tiny volume of about 0.02 μm3. A method for storing information in DNA has been developed which includes software and a set of schemes to encrypt, store and decrypt information in terms of DNA bases. The main advantages of the present method over exiting art is that it addresses complete set of extended ASCII characters set and thereby, encryption of all kind of digital information (text, image, audio etc.). First of all, information is, encrypted along with carefully designed sequences known as header and tail primers at both the ends of actual encrypted information. This encrypted sequence is then synthesized and mixed up with the enormous complex denatured DNA strands of genomic DNA of human or other organism.

Abstract translation: DNA是一种天然分子水平的储存装置。 分子存储装置使用每个分子或其一部分来存储角色。 因此，可以将信息存储在当前使用的存储设备的百万次以上。 例如，具有1981字节的文件大小的JPEG图像（即印度的标志）可以使用7924个DNA碱基进行加密，占用约2694.16纳米。换句话说，印度的旗帜可以在包含6.4的人类基因组中加密8.07×10 5次 x10 <9> DNA碱基，占据体积约0.02μm3。 已经开发了一种用于在DNA中存储信息的方法，其中包括软件和一组用于基于DNA基因来加密，存储和解密信息的方案。 本方法优于现有技术的主要优点在于它解决了完整的扩展ASCII字符集，从而对所有类型的数字信息（文本，图像，音频等）进行加密。 首先，在实际加密信息的两端，信息被加密，并且精心设计的序列称为标题和尾部引物。 然后将该加密的序列合成并与人或其他生物体的基因组DNA的巨大复杂变性DNA链混合。

公开(公告)号：US06697335B1

公开(公告)日：2004-02-24

申请号：US09626427

申请日：2000-07-27

Applicant: Ayse Funda Ergun ,  Rakesh Kumar Sinha ,  Yihao Lisa Zhang

Inventor： Ayse Funda Ergun ,  Rakesh Kumar Sinha ,  Yihao Lisa Zhang

IPC: H04J116

CPC classification number: H04L45/12 ,  H04L45/121

Abstract: A method of determining an optimal path from a source node to a destination node over a number of links in an information network having n nodes. Each link has an associated cost-delay function, the optimal path is constrained to an overall delay of D, and a total cost of all links along the path is to be minimized at a value OPT. The method includes maintaining a range [L, U] for OPT, wherein L is a lower bound and U is an upper bound, and setting initial values for L and U. A cost value V is set corresponding to {square root over (U·L)}, and a scaled cost c′ is derived for each link wherein c′ corresponds to cn/V&egr;, c is an actual cost for each link, and &egr;>0. If a feasible path having a delay of at most D and a total cost of at most V is found not to exist, then the value of L is increased to V, a new cost value V is set and the link costs c′ are further scaled. The values of L and U are reset until U/L

Abstract translation: 一种通过具有n个节点的信息网络中的多个链路来确定从源节点到目的地节点的最佳路径的方法。 每个链路具有相关联的成本延迟功能，最优路径被约束到D的总体延迟，并且沿着路径的所有链路的总成本将被最小化为值OPT。 该方法包括维持用于OPT的范围[L，U]，其中L是下限，U是上限，并且设置L和U的初始值。成本值V被设置为对应于{平方根超过（UL ）}，并且对于每个链路导出对应于cn / Vepsilon的每个链路的缩放成本c'，c是每个链路的实际成本，ε> 0。 如果发现延迟最多为D且总成本最多为V的可行路径不存在，则L的值增加到V，设置新的成本值V，并且链路成本c'进一步 缩放 L和U的值被复位直到U / L <2并且可行路径继续存在。 然后将可行路径的链接标识为使用最后缩放的链路成本的最优路径。