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    MICROFLUIDIC SAMPLE LABELING
    141.
    发明申请
    MICROFLUIDIC SAMPLE LABELING 有权

    公开(公告)号：US20220146383A1

    公开(公告)日：2022-05-12

    申请号：US17417811

    申请日：2019-07-26

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Alexander Govyadinov ,  Viktor Shkolnikov

    IPC: G01N1/38 ,  B01L3/00 ,  C12Q1/6825 ,  G01N33/58

    Abstract: The present disclosure is drawn to a method of labeling and identifying microfluidic samples. The method can include tagging a first microfluidic sample with a first combination of markers to obtain a first labeled sample; tagging a second microfluidic sample with a second combination of markers that is different than the first combination of markers to obtain a second labeled sample; introducing a common variable to the first labeled sample and the second labeled sample. The common variable can generates a first interaction with the first labeled sample that is different than a second interaction or lack of interaction with the second labeled sample. The method can further include based on the first interaction, identifying the first labeled sample by assaying for the first combination of markers.

    Chip to chip fluidic interconnect
    142.
    发明授权
    Chip to chip fluidic interconnect 有权

    公开(公告)号：US11278892B2

    公开(公告)日：2022-03-22

    申请号：US16494856

    申请日：2017-04-21

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Michael W. Cumbie ,  Viktor Shkolnikov ,  Chien-Hua Chen

    IPC: B01L3/00 ,  B01L7/00 ,  G01N35/00 ,  G01N35/10

    Abstract: A device may include a substrate, a first fluid processing chip, a second fluid processing chip, a tapered channel, and a fluid actuator. The first fluid processing chip may be disposed on the substrate and may process a micro-volume of fluid. The second fluid processing chip may be disposed on the substrate and co-planar with the first fluid processing chip. The second fluid processing chip may process at least a portion of the micro-volume of fluid. The tapered channel may be disposed between the first and second fluid processing chips to transport the at least the portion of the micro-volume of fluid from the first fluid processing chip to the second fluid processing chip. The fluid actuator may be disposed proximate to the tapered channel and may control movement of the at least the portion of the micro-volume of fluid within the tapered channel.

    PARTICLE IMAGING
    143.
    发明申请
    PARTICLE IMAGING 有权

    公开(公告)号：US20220074844A1

    公开(公告)日：2022-03-10

    申请号：US17298481

    申请日：2019-05-30

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Fausto D'Apuzzo ,  Viktor Shkolnikov ,  Yang Lei

    IPC: G01N15/14

    Abstract: A particle imaging system may include a volume to contain a fluid having a suspended particle, electrodes proximate to the volume to apply an electric field to rotate the suspended particle, an optical sensor comprising a first region and a second region and a diffraction element to split an image of the suspended particle into a bright field image focused on the first region and a spectral image focused on the second region.

    PARTICLE MONITORING
    144.
    发明申请
    PARTICLE MONITORING 有权

    公开(公告)号：US20220057315A1

    公开(公告)日：2022-02-24

    申请号：US17312231

    申请日：2019-01-23

    Applicant: Hewlett-Packard Development COMPANY, L.P.

    Inventor： Fausto D'Apuzzo ,  Viktor Shkolnikov ,  Yang Lei

    IPC: G01N15/06

    Abstract: A particle monitoring system may include a volume for containing a fluid in which particles are suspended, a photosensitive layer, a light encoding layer sandwiched between the volume and the photosensitive layer and electrodes to apply an electric field to the fluid within the volume and proximate the photosensitive layer.

    CELL ANALYSIS SYSTEMS
    145.
    发明申请
    CELL ANALYSIS SYSTEMS 有权

    公开(公告)号：US20220056397A1

    公开(公告)日：2022-02-24

    申请号：US17414051

    申请日：2019-02-01

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Alexander Govyadinov ,  Viktor Shkolnikov

    IPC: C12M1/34 ,  G01N33/483 ,  B01L3/00 ,  C12M1/00 ,  C12M3/06 ,  C12M1/36 ,  C12N1/06

    Abstract: In one example in accordance with the present disclosure, a cell analysis system is described. The cell analysis system includes at least one cell analysis device. Each cell analysis device includes a channel to serially feed individual cells from a volume of cells into a lysing chamber. The cell analysis device also includes at least one feedback-controlled lysing element in the lysing chamber to agitate a cell. The cell analysis system also includes a controller to analyze the cell. The controller includes a lysate analyzer to analyze properties of the lysate and a rupture analyzer to analyze parameters of an agitation when a cell membrane ruptures.

    Particle separation and analysis
    147.
    发明授权
    Particle separation and analysis 有权

    公开(公告)号：US11230692B2

    公开(公告)日：2022-01-25

    申请号：US16605985

    申请日：2018-03-27

    Applicant: HEWLETT-PACKARD DEVELOPMENT COMPANY, L.P.

    Inventor： Viktor Shkolnikov ,  Alexander Govyadinov

    IPC: C12M1/00 ,  G01N33/543 ,  G01N33/569

    Abstract: An example system includes an input channel to receive particles through a first end, a separation chamber, at least two output channels, an integrated pump to facilitate flow through the separation chamber and a cell analysis portion. The separation chamber is in fluid communication with a second end of the input channel. The separation chamber has a passive separation structure including an array of columns spaced apart to facilitate separation of particles into at least two flow paths based on a size of the particles. The size associated with a first flow path of the at least two flow paths corresponds to a cell. A first output channel is to receive the first flow path corresponding to a cell. The cell analysis portion is coupled to the first output channel and is to perform at least one analysis associated with cells in the first output channel.

    DECISION TREE POLYMERASE CHAIN REACTION
    148.
    发明申请
    DECISION TREE POLYMERASE CHAIN REACTION 有权

    公开(公告)号：US20220010359A1

    公开(公告)日：2022-01-13

    申请号：US17294041

    申请日：2018-12-14

    Applicant: Hewlett-Packard Development Company, L.P.

    Inventor： Viktor Shkolnikov ,  Alexander Govyadinov

    IPC: C12Q1/686

    Abstract: Examples relate to conducting Polymerase Chain Reactions (PCR). An example device for conducting PCR includes a primer applicator to add a first multi-primer set of a primer library to a first test chamber of a test chamber array. The example device also includes an amplification analyzer to determine if amplification has occurred in the first test chamber. The example device includes a device controller to instruct the primer applicator to apply a second multi-primer set of the primer library to the first test chamber in response to a detection by the amplification analyzer that amplification has not occurred in the first test chamber. Example devices instruct the primer applicator to apply a first primer subset of the first multi-primer set to a second test chamber of the test chamber array in response to a detection by the amplification analyzer that amplification occurred in the first test chamber.

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