公开(公告)号：US20180311310A1

公开(公告)日：2018-11-01

申请号：US15914925

申请日：2018-03-07

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Melissa Alegria ,  Valeria Marquez ,  Eduardo Morales ,  Rodrigo Ortiz ,  Janet Torres ,  Paulo Covarrubias ,  Javier Gimpel ,  Ingrid Araya

IPC: A61K38/16

CPC classification number: A61K38/16

Abstract: Therapeutic compositions and an associated method for improving a Toll-like receptor (TLR)-related condition, including determining a set of peptide sequences associated with a microorganism-related modulator of a TLR, determining a first set of binding parameters for the set of peptide sequences in relation to the TLR, selecting a target subset of peptide sequences from the set of peptide sequences based on the first set of binding parameters, reengineering the target subset of peptide sequences based on mutating amino acid residues of the target subset of peptide sequences, determining a second set of binding parameters for the reengineered target subset of peptide sequences in relation to the TLR, and identifying a first peptide for use in a therapeutic composition for improving the TLR-related condition, based on the second set of binding parameters for the reengineered target subset of peptide sequences.

公开(公告)号：US10073952B2

公开(公告)日：2018-09-11

申请号：US15098027

申请日：2016-04-13

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman ,  Siavosh Rezvan Behbahani

IPC: G01N33/48 ,  G06F19/00 ,  C40B30/02 ,  G06F19/28 ,  G06F19/24 ,  G16H50/20 ,  G06G7/58

CPC classification number: G16H50/20 ,  G06F19/00 ,  G06F19/3418 ,  G16B35/00 ,  G16B40/00 ,  G16B50/00 ,  G16C20/60 ,  G16H40/67 ,  Y02A90/26

Abstract: A method for at least one of characterizing, diagnosing, and treating an autoimmune disorder in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the autoimmune condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the autoimmune condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US20180137930A1

公开(公告)日：2018-05-17

申请号：US15848779

申请日：2017-12-20

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: G06F19/24 ,  G06F19/28

CPC classification number: G16H10/40 ,  C12Q1/6883 ,  C12Q2600/112 ,  G01N2800/044 ,  G01N2800/32 ,  G06F19/3418 ,  G16B40/00 ,  G16B50/00 ,  G16H50/20 ,  H01L27/3211 ,  H01L27/322 ,  H01L27/3272 ,  H01L51/0097 ,  H01L51/5234 ,  H01L51/5265 ,  H01L51/5281 ,  H01L51/5284 ,  H01L2251/5338 ,  Y02A90/26

Abstract: A method for at least one of characterizing, diagnosing, and treating a cardiovascular disease condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the cardiovascular disease condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the cardiovascular disease condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US20180122510A1

公开(公告)日：2018-05-03

申请号：US15844139

申请日：2017-12-15

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Jessica Richman ,  Daniel Almonacid ,  Catalina Valdivia ,  Rodrigo Ortiz ,  Inti Pedroso ,  Victoria Dumas ,  Paz Tapia ,  Eduardo Morales

IPC: G06F19/28

CPC classification number: G16H50/20 ,  G06F19/28 ,  G16H10/40 ,  G16H20/60 ,  G16H50/70 ,  Y02A90/26

Abstract: Embodiments of a method and/or system for characterizing a diet-related condition for a user can include one or more of: generating a microbiome dataset for each of an aggregate set of biological samples associated with a population of subjects, based on sample processing of the biological samples; processing a supplementary dataset associated with one or more diet-related conditions for the set of users; and performing a diet-related characterization process for the one or more diet-related conditions, based on the supplementary dataset and/or microbiome features extracted from the microbiome dataset.

公开(公告)号：US20180070826A1

公开(公告)日：2018-03-15

申请号：US15815622

申请日：2017-11-16

Applicant: uBiome, Inc

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: A61B5/00 ,  G06F19/00 ,  G06F19/24 ,  G06F19/28 ,  C12Q1/68

CPC classification number: A61B5/0022 ,  A61B5/4836 ,  C12Q1/689 ,  C12Q2600/112 ,  G06F19/3418 ,  G16B40/00 ,  G16B50/00 ,  G16H40/67 ,  G16H50/20 ,  G16H50/80 ,  Y02A90/24 ,  Y02A90/26

Abstract: A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome-derived functional features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US20170372027A1

公开(公告)日：2017-12-28

申请号：US15679697

申请日：2017-08-17

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: G06F19/00 ,  G06F19/28 ,  G06F19/18

Abstract: A method for at least one of characterizing, diagnosing, and treating a locomotor system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the locomotor system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the locomotor system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US20170369933A1

公开(公告)日：2017-12-28

申请号：US15679821

申请日：2017-08-17

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: C12Q1/68 ,  G06F19/28 ,  G06F19/24 ,  G06F19/00

CPC classification number: C12Q1/689 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/158 ,  C12Q2600/16 ,  G06F19/3418 ,  G16B30/00 ,  G16B40/00 ,  G16B50/00 ,  G16H40/67 ,  G16H50/50 ,  Y02A90/26

Abstract: A method for at least one of characterizing, diagnosing, and treating a condition associated with microbiome functional features in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US20170329895A1

公开(公告)日：2017-11-16

申请号：US15655427

申请日：2017-07-20

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: G06F19/22 ,  G06F19/00 ,  G06F19/24 ,  G06F19/28 ,  C12Q1/68 ,  G06F19/12

CPC classification number: G16B30/00 ,  C12Q1/689 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/16 ,  G06F19/3418 ,  G06F19/3456 ,  G16B5/00 ,  G16B40/00 ,  G16B50/00 ,  G16H20/10 ,  G16H40/67 ,  G16H50/20 ,  Y02A90/26

Abstract: A method for at least one of characterizing, diagnosing, and treating an endocrine system condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the endocrine system condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the endocrine system condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US20170327864A1

公开(公告)日：2017-11-16

申请号：US15668636

申请日：2017-08-03

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: C12Q1/24 ,  G06F19/00 ,  C12Q1/04 ,  G01N33/569 ,  C12Q1/00

Abstract: A method for at least one of characterizing, diagnosing, and treating a mental health associated condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the mental health associated condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the mental health associated condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.

公开(公告)号：US20170327863A1

公开(公告)日：2017-11-16

申请号：US15668595

申请日：2017-08-03

Applicant: uBiome, Inc.

Inventor： Zachary Apte ,  Daniel Almonacid ,  Jessica Richman

IPC: C12Q1/24 ,  G06F19/00 ,  C12Q1/04 ,  G01N33/569 ,  C12Q1/00

Abstract: A method for at least one of characterizing, diagnosing, and treating a mental health associated condition in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the mental health associated condition based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the mental health associated condition; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.