公开(公告)号：US20230002345A1

公开(公告)日：2023-01-05

申请号：US16642824

申请日：2019-08-15

Applicant: Genentech, Inc.

Inventor： Aijun LU ,  Sushant Malhotra ,  Alan G. Olivero ,  Cheng Shao ,  Yamin Zhang ,  Steven Do

IPC: C07D401/04 ,  C07D403/04 ,  C07D239/94 ,  C07D405/04 ,  C07D403/12 ,  C07D403/14 ,  C07D401/14 ,  C07D413/12 ,  C07D471/04

Abstract: Provided are fused ring compounds of Formula (I), Formula (II), or Formula (III), as further detailed herein, which are used for the inhibition of Ras proteins, as well as compositions comprising these compounds and methods treatment by their administration.

公开(公告)号：US20220397346A1

公开(公告)日：2022-12-15

申请号：US17832372

申请日：2022-06-03

Applicant: Purdue Research Foundation ,  Genentech, Inc.

Inventor： Andrew Strongrich ,  Alina Alexeenko ,  Fredric John Lim ,  Lokesh Kumar

IPC: F26B5/06

Abstract: A lyophilization method for lyophilizing products inside one or more vials within a lyophilization chamber is disclosed which includes humidifying a charge gas to a predetermined relative humidity, cooling shelves in the lyophilization chamber to a predetermined temperature, pressurizing the chamber with the humidified charge gas to a pressurization threshold to thereby achieving a target relative humidity level within the lyophilization chamber, and suddenly releasing pressure within the lyophilization chamber until a depressurization threshold is reached in a short time interval up to about 4 seconds, during the depressurization, product inside one or more vials nucleate.

公开(公告)号：US11519912B2

公开(公告)日：2022-12-06

申请号：US15914099

申请日：2018-03-07

Applicant: Genentech, Inc.

Inventor： Feny Gunawan ,  Yi-Chun Hsiao ,  Denise C. Krawitz ,  Margaret S. Lin ,  Martin Vanderlaan ,  Rajesh Vij ,  Inn H. Yuk ,  Judith Zhu-Shimoni

IPC: G01N33/577 ,  G01N33/573 ,  C07K16/40

Abstract: Monoclonal and polyclonal antibodies that bind hamster phospholipase B-like 2 are provided. Also provided are methods for detecting and quantifying hamster phospholipase B-like 2, for example, in recombinant polypeptide preparations, as well as kits for carrying out such methods. Methods of screening or selecting host cell lines or recombinant polypeptide-expressing cell lines that express low levels of hamster phospholipase B-like 2 are also provided.

公开(公告)号：US11512143B2

公开(公告)日：2022-11-29

申请号：US16543818

申请日：2019-08-19

Applicant: Genentech, Inc.

Inventor： Robert F. Kelley ,  Daniel K. Kirchhofer ,  Joyce Lai ,  Chingwei V. Lee ,  Wei-Ching Liang ,  Michael T. Lipari ,  Kelly M. Loyet ,  Tao Sai ,  Menno Van Lookeren Campagne ,  Yan Wu ,  Germaine Fuh

IPC: C07K16/40 ,  A61K39/395 ,  A61K39/00

Abstract: The present invention provides anti-HtrA1 antibodies (including bispecific anti-HtrA1 anti-Factor D antibodies) and methods of making and using the same, for example, in methods of treating HtrA1-associated disorders, ocular disorders, and/or complement-associated disorders.

公开(公告)号：US20220363772A1

公开(公告)日：2022-11-17

申请号：US17677820

申请日：2022-02-22

Applicant: Genentech, Inc.

Inventor： Craig SMITH ,  Peter S. CHIN

IPC: C07K16/28 ,  A61K39/00 ,  G06Q99/00 ,  A61B5/055 ,  A61K39/395 ,  G01N33/68 ,  A61K9/00 ,  A61K45/06

Abstract: The present invention concerns methods for treating progressive multiple sclerosis (MS) in a patient, and an article of manufacture with instructions for such use.

公开(公告)号：US20220351387A1

公开(公告)日：2022-11-03

申请号：US17864227

申请日：2022-07-13

Applicant: Genentech, Inc.

Inventor： Yury Anatolievich PETROV ,  Richard Alan Duray CARANO

IPC: G06T7/11 ,  G06T7/00 ,  G06V10/764

Abstract: A Generative Adversarial Network (GAN) can be trained, where the GAN includes an anomaly-removing Generator network configured to modify a medical image to remove a depiction of a biological anomaly and one or more Discriminator networks (each configured to discriminate between real and fake images). The anomaly-removing Generator network can then receive a medical image that depicts a particular biological anomaly (or pre-processed version thereof) and generate a modified image predicted to lack any depiction of the particular biological anomaly. The size of the particular biological anomaly may be estimated based on the modified image and the received image (or pre-processed version thereof).

公开(公告)号：US20220348593A1

公开(公告)日：2022-11-03

申请号：US17535124

申请日：2021-11-24

Applicant: Genentech, Inc.

Inventor： Jennafer Dotson ,  Robert Andrew Heald ,  Timothy Heffron ,  Graham Elgin Jones ,  Sussie Lerche Krintel ,  Neville James McLean ,  Chudi Ndubaku ,  Alan G. Olivero ,  Laurent Salphati ,  Lan Wang ,  BinQing Wei

IPC: C07D498/22 ,  C07D471/14 ,  C07D491/14 ,  C07D495/14 ,  C07D487/14 ,  C07D498/14 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K39/395 ,  C07D491/147 ,  C07D498/20 ,  C07K16/22

Abstract: Tricyclic PI3k inhibitor compounds of Formula I with anti-cancer activity, anti-inflammatory activity, or immunoregulatory properties, and more specifically with PI3 kinase modulating or inhibitory activity are described. Methods are described for using the tricyclic PI3K inhibitor compounds of Formula I for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, organisms, or associated pathological conditions. Formula I compounds include stereoisomers, geometric isomers, tautomers, and pharmaceutically acceptable salts thereof. The dashed lines indicate an optional double bond, and at least one dashed line is a double bond. The substituents are as described.

公开(公告)号：US20220340687A1

公开(公告)日：2022-10-27

申请号：US17642319

申请日：2020-08-31

Applicant: NOVARTIS AG ,  GENENTECH, INC.

Inventor： XAVIER JAUMONT ,  Oscar PALOMARES

IPC: C07K16/42 ,  A61K45/06 ,  A61K39/395 ,  A61P37/08

Abstract: The present disclosure relates to methods for modifying the course of a disease or disorder involving Treg cells dysfunctioning, in particular in patients having an allergic disease or condition.

公开(公告)号：US20220319008A1

公开(公告)日：2022-10-06

申请号：US17842542

申请日：2022-06-16

Applicant: Genentech, Inc.

Inventor： Nils Gustav Thomas BENGTSSON ,  Richard Alan Duray CARANO ,  Alexander James Stephen CHAMPION DE CRESPIGNY ,  Jill Osborn FREDRICKSON ,  Mohamed Skander JEMAA

IPC: G06T7/00 ,  G06T7/12 ,  G06T7/70 ,  G06T7/62 ,  A61B5/00

Abstract: Medical image(s) are input into a detection network to generate mask(s) identifying a set of regions within the medical image(s), where the detection network predicts that each region identified in the mask(s) includes a depiction of a tumor of one or more tumors within the subject. For each region, the region of the medical image(s) is processed using a tumor segmentation network to generate one or more tumor segmentation boundaries for the tumor present within the subject. For each tumor and by using a plurality of organ-specific segmentation networks, an organ is determined within which at least part of the tumor is located. An output is generated based on the one or more tumor segmentation boundaries and locations of the organs within which at least part of the one or more tumors are located.

公开(公告)号：US20220309666A1

公开(公告)日：2022-09-29

申请号：US17841610

申请日：2022-06-15

Applicant: Genentech, Inc.

Inventor： Zheng LI ,  Mandy Man Chu YIM ,  Bibi EPHRAIM ,  Dat TRAN ,  Xinyu LIU ,  David SHAW

IPC: G06T7/00 ,  G06T7/11 ,  G06T7/73 ,  G06V10/25 ,  G06V10/20 ,  G06V10/26 ,  G06V10/46

Abstract: A method includes, by a computing system, receiving a querying image depicting a sampling area, processing the querying image using a single cluster detection model to identify one or more regions of the querying image depicting a cluster in the sampling area, processing the one or more regions using a cluster verification deep-learning model to determine whether each depicted cluster is a cell cluster, and determining that exactly one of the identified one or more regions depicts a cluster that is a cell cluster. The method further includes processing the region depicting the cell cluster using a morphology deep-learning model to determine that there is only one cell in the cell cluster and to determine that die morphology of the cell is acceptable.