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公开(公告)号：US20210085964A1
公开(公告)日：2021-03-25
申请号：US16634632
申请日：2018-07-23
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Faisal ZAIDI , Sebastien OUCHOUCHE
IPC: A61N1/05
Abstract: An extravascular neural interface is disclosed including a device containing electrodes for neurostimulation of a vessel. The devices are housed in flexible substrates forming two flaps, an inner flap having a spinal portion for routing leads/conductors into the device for connection to the electrodes and an outer flap that overlaps the inner flap. The inner flap supports and positions the electrodes to be inward facing, i.e., extravascular designs. The electrodes may be circular or elliptical and include a plurality of wings for securing the electrodes within a flap.
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公开(公告)号：US20210069504A1
公开(公告)日：2021-03-11
申请号：US16771441
申请日：2018-12-11
Applicant: Galvani Bioelectronics Limited
Inventor： Gerald Edwin HUNSBERGER , Arun SRIDHAR
Abstract: Modulation of neural activity of a ganglion, by applying a signal to a sympathetic nerve adjacent to the ganglion, results in preferential reduction of sympathetic signals to an effector, thereby providing ways of treating and preventing conditions associated with exacerbated sympatho-excitation.
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公开(公告)号：US10933248B2
公开(公告)日：2021-03-02
申请号：US15803405
申请日：2017-11-03
Applicant: Galvani Bioelectronics Limited
Inventor： Rizwan Bashirullah
Abstract: Implantable systems are described that include a stimulation device positionable in vivo and configured to communicatively couple to electrodes configured to stimulate or block body tissue and an auxiliary device positionable in vivo and including one or more coils configured to wirelessly couple, in vivo, to the stimulation device and to wirelessly couple to an ex vivo device. The auxiliary device may include a coil driver and a power source controlled by a processor and memory for storing data instructions for the coil driver and for storing data received from the stimulation device. The auxiliary device may also include a radio transceiver and an antenna. The stimulation device may include a housing, a coil, a power source and an integrated circuit for controlling the electrodes. The stimulation device may be coupled to a cuff via a lead and physically coupled to the auxiliary device.
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公开(公告)号：US20200230421A1
公开(公告)日：2020-07-23
申请号：US16634620
申请日：2018-07-23
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Faisal ZAIDI , Sebastien OUCHOUCHE
Abstract: An extravascular neural interface is disclosed containing electrodes for neurostimulation of the vessel. The devices are housed in flexible substrates, each substrate having a spinal portion for routing leads/conductors into the device for connection to the electrodes. Extending from opposite sides of the spinal portion is a self-sizing inner flap that supports and positions the electrodes to be inward facing, i.e., extravascular designs, and one more rigid outer flap. The electrodes may be flexible multifilar coil electrodes.
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公开(公告)号：US20200230399A1
公开(公告)日：2020-07-23
申请号：US16619396
申请日：2018-07-23
Applicant: Galvani Bioelectronics Limited
Inventor： Faisal ZAIDI , Sabastien OUCHOUCHE , Paul MATTEUCCI, JR.
Abstract: An extravascular or intravascular neural interface is disclosed and can include three C-ring portions, with at least two including an electrode, an electrode pair or an electrode array. The portions are formed of a flexible material that is configured to enable the portions to self-size to fit around or against a surface of a target vessel when the neural interface is released at a position along the target vessel. A spinal portion configured to house electrical conductors for the electrodes is connected to one or more portions. The portions may be spaced sufficient apart to permit radial expansion and contraction of a target vessel around or within which the neural interface is placed, to reduce nerve compression, open trench low-pressure unrestricted blood-flow, and to enhance fluid exchange with the target vessel. The portions may be arranged in a low helix angle forming at least two full turns.
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Patent Agency Ranking
公开(公告)号：US20200179699A1
公开(公告)日：2020-06-11
申请号：US16320288
申请日：2017-07-25
Inventor： Arun SRIDHAR , Corey SMITH , Kyle WOLF , Georgy ZARKUA , Shyue-An CHAN
Abstract: Modulation of neural signaling of a branch of the GSN supplying the adrenal gland can regulate the secretion of signaling molecules from the adrenal medulla. In particular, epinephrine, norepinephrine and enkephalin release can be independently regulated.
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公开(公告)号：US10576172B2
公开(公告)日：2020-03-03
申请号：US15803496
申请日：2017-11-03
Applicant: Galvani Bioelectronics Limited
Inventor： Rizwan Bashirullah
Abstract: An implantable system is disclosed that includes an encapsulated housing including a radioactive source. The encapsulated housing is internally coated with a light-generating coating that converts the radioactive energy to light, that is then output in vivo to a photodiode positioned proximate to at least part of the encapsulated housing in vivo. The photodiode is configured to generate electrical current from the light, which electrical current is output to a power conditioning circuit that is configured to use the electrical current as an input electrical current and to output power to a load in vivo. The encapsulated may also be internally coated, at least in part, with a light directing coating that causes light to be directed toward an optical lens that focuses the light on the photodiode. The radioactive source may be a gas having a low half-life and which poses no health risk to a patient if released.
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公开(公告)号：US20200009384A1
公开(公告)日：2020-01-09
申请号：US16562139
申请日：2019-09-05
Inventor： Brendan J. CANNING , Michael John CARR , Marian KOLLARIK
Abstract: The invention provides devices and methods that can prevent or ameliorate bronchoconstriction. In particular, the invention provides devices and methods in which a signal is delivered to the vagus nerve or the pulmonary branches of the vagus nerves. The signal is able to treat bronchoconstriction and prevent and/or ameliorate bronchoconstriction.
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公开(公告)号：US20190247645A1
公开(公告)日：2019-08-15
申请号：US16309182
申请日：2017-06-12
Applicant: GALVANI BIOELECTRONICS LIMITED
Inventor： Dwight Sherod WALKER , Daniel John CHEW
CPC classification number: A61N1/0556 , A61B5/04001 , A61B5/6846
Abstract: Methods for fabricating implantable cuff electrodes for contacting or at least partially surrounding internal body tissue such as, e.g., nerves, smooth muscles, striated muscles, arteries, veins, ligamental tissues, connective tissues, cartilage tissues, bones, or other similar body tissues, structures and organs are disclosed. An example method includes preparing a substrate including an implantable cuff electrode shape, applying a mold material to the substrate, curing the mold material to form a mold, releasing the mold from the substrate, inserting at least one conductor into the mold that penetrates through the channel of the mold, pressing a formable material into the channel of the mold to form a body of an implantable cuff electrode about the at least one conductor, curing the body of the implantable cuff electrode, and releasing the body of the implantable cuff electrode from the mold.
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公开(公告)号：US20190184172A1
公开(公告)日：2019-06-20
申请号：US16328090
申请日：2017-08-25
Inventor： Jeffrey Laurence ARDELL , Kalyanam SHIVKUMAR , Arun SRIDHAR
CPC classification number: A61N1/36114 , A61N1/0556 , A61N1/36057 , A61N1/362
Abstract: Modulation, preferably inhibition, of neurosignaling of a cardiac-related sympathetic nerve in the extracardiac intrathoracic neural circuit is effective in stabilizing cardiac electrical and/or mechanical function, thereby providing ways of treating or preventing cardiac dysfunction such as arrhythmias.
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