公开(公告)号：USD929871S1

公开(公告)日：2021-09-07

申请号：US29723225

申请日：2020-02-05

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Kei Kubota ,  Shintaro Takeda ,  Shigeo Kusumi

公开(公告)号：US11077290B2

公开(公告)日：2021-08-03

申请号：US16488450

申请日：2018-02-20

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Toru Kobayashi ,  Toshiyuki Matsudo ,  Shinpei Nishimura ,  Seiji Tokumoto ,  Tetsuji Kuwahara

IPC: A61M37/00

Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.

公开(公告)号：US20210154152A1

公开(公告)日：2021-05-27

申请号：US17167498

申请日：2021-02-04

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Seiichiro TSURU ,  Masayoshi MAKI

IPC: A61K9/70 ,  A61K47/10 ,  A61K47/32 ,  A61K31/192 ,  A61K45/00

Abstract: A method for producing a gel patch comprising an adhesive mass layer on a backing fabric, comprising a step of applying a composition comprising a physiologically active substance, a water-soluble polymer, glycerin, and water to the backing fabric to form the adhesive mass layer, wherein a loss tangent of the composition in dynamic viscoelasticity measurement at 1 Hz at a time of application to the backing fabric is 0.75 to 1.

公开(公告)号：US10888532B2

公开(公告)日：2021-01-12

申请号：US16471692

申请日：2017-12-21

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoko Fujita ,  Takito Shima ,  Kazuya Kominami ,  Naoyuki Uchida

IPC: A61K9/70 ,  A61K31/485 ,  A61K47/10 ,  A61K47/14 ,  A61K47/34

Abstract: A patch comprising: a backing layer; and an adhesive layer, wherein the adhesive layer contains at least one drug selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof and a silicone-based adhesive base, and a mass per unit area of the adhesive layer is 30 to 90 g/m2.

公开(公告)号：US10716763B2

公开(公告)日：2020-07-21

申请号：US15565864

申请日：2016-04-15

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Naoyuki Uchida ,  Yasunari Michinaka

IPC: A61K9/70 ,  A61K47/18 ,  A61K31/4045

Abstract: The present invention provides a patch comprising a backing and an adhesive agent layer laminated on the backing, wherein the adhesive agent layer comprises ropinirole or a pharmaceutically acceptable salt thereof, an organic amine or an acid addition salt thereof, and an adhesive agent.

公开(公告)号：USD887842S1

公开(公告)日：2020-06-23

申请号：US29677103

申请日：2019-01-17

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Designer： Takuya Ikaida ,  Sayaka Mochizuki ,  Hiroyuki Kinoshita

公开(公告)号：US20200054575A1

公开(公告)日：2020-02-20

申请号：US16604311

申请日：2018-04-19

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Takito SHIMA ,  Toshiyuki MATSUDO ,  Kenji ISHIGAKI

IPC: A61K9/70 ,  A61K31/485 ,  A61K47/22 ,  A61K47/32 ,  A61K47/34

Abstract: A patch comprises a backing layer and an adhesive layer, wherein the adhesive layer contains at least one selected from the group consisting of butorphanol and pharmaceutically acceptable salts thereof, and contains an adhesive base and an antioxidant containing a sulfur atom in its molecule.

公开(公告)号：US10537723B2

公开(公告)日：2020-01-21

申请号：US15509398

申请日：2015-09-10

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Shinpei Nishimura ,  Seiji Tokumoto

IPC: A61M37/00 ,  A61K9/00 ,  A61K47/18 ,  A61L31/08 ,  A61L31/16

Abstract: The present invention provides a microneedle device comprising: a substrate; a microneedle disposed on the substrate; and a coating layer formed on the microneedle; wherein the coating layer comprises a physiologically active substance, arginine, and glycerin.

公开(公告)号：US20190117512A1

公开(公告)日：2019-04-25

申请号：US16061866

申请日：2016-12-01

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Yusuke SHIROTANI ,  Kazuki KURIYAMA ,  Seiji TOKUMOTO

IPC: A61J1/14 ,  A61J1/10 ,  A61M5/165 ,  A61M5/168 ,  A61M5/158

Abstract: A liquid bag according to one embodiment stores liquid containing an active ingredient to be transdermally administered. This liquid bag includes a bag body configured to store the liquid and feed the liquid toward an injection needle. The bag body includes a tubular portion. At least part of the tubular portion is bent with respect to the axial direction of the tubular portion with the liquid being stored in the tubular portion.

公开(公告)号：US20190009070A1

公开(公告)日：2019-01-10

申请号：US16061834

申请日：2016-12-06

Applicant: HISAMITSU PHARMACEUTICAL CO., INC.

Inventor： Ryusuke FUDOJI ,  Naoki YAMAMOTO

IPC: A61M37/00 ,  C08L67/04

Abstract: The microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet generally along a main surface of the sheet; a bending resistance of the sheet as measured in accordance with a 45° cantilever method defined by JIS L 1096:2010 is 4.2 cm to 12.5 cm; and a material of the sheet is a biodegradable polymer. The microneedles rise from the main surface when the sheet is bent, and the raised microneedles pierce the skin.