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公开(公告)号:US20160206569A1
公开(公告)日:2016-07-21
申请号:US14913455
申请日:2014-08-21
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Keiichiro TSURUSHIMA , Yasuhisa KOSE , Seiichiro TSURU , Shinji YAMASOTO , Takaaki YOSHINAGA
IPC: A61K9/70
CPC classification number: A61K9/7061 , A61L15/225 , A61L15/585 , A61L15/60 , C08F220/14 , C08L33/02 , C08L71/00 , C08L33/08 , C08F2220/1858
Abstract: A gel patch comprising a plaster layer on a support, the plaster layer comprising a mixture of at least a neutralized polyacrylic acid, a poly(methyl acrylate/2-ethylhexyl acrylate) emulsion, and water, wherein the poly(methyl acrylate/2-ethylhexyl acrylate) emulsion is an emulsion having an evaporation residue of 57 to 61% by heating at or above the boiling point of the medium and is present in an amount of at least 2.5 times and preferably at least 3 times the mass of the neutralized polyacrylic acid.
Abstract translation: 一种凝胶贴片,其包含支撑体上的膏药层,所述膏药层包含至少中和的聚丙烯酸,聚(丙烯酸甲酯/丙烯酸2-乙基己酯)乳液和水的混合物,其中所述聚(丙烯酸甲酯/ 丙烯酸乙基己酯)乳液是通过在介质沸点以上加热而蒸发残留物为57〜61%的乳液,其存在量为中和的聚丙烯酸的质量的至少2.5倍,优选至少3倍 酸。
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公开(公告)号:US20210154152A1
公开(公告)日:2021-05-27
申请号:US17167498
申请日:2021-02-04
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Seiichiro TSURU , Masayoshi MAKI
IPC: A61K9/70 , A61K47/10 , A61K47/32 , A61K31/192 , A61K45/00
Abstract: A method for producing a gel patch comprising an adhesive mass layer on a backing fabric, comprising a step of applying a composition comprising a physiologically active substance, a water-soluble polymer, glycerin, and water to the backing fabric to form the adhesive mass layer, wherein a loss tangent of the composition in dynamic viscoelasticity measurement at 1 Hz at a time of application to the backing fabric is 0.75 to 1.
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公开(公告)号:US20160361281A1
公开(公告)日:2016-12-15
申请号:US15121534
申请日:2015-02-26
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Seiichiro TSURU , Masayoshi MAKI , Shinji YAMASOTO , Takaaki TERAHARA
IPC: A61K31/192 , D03D15/00 , A61K47/10 , A61K31/12 , A61K9/70
CPC classification number: A61K31/192 , A61K9/0014 , A61K9/7023 , A61K9/7069 , A61K31/12 , A61K47/10 , D03D15/00
Abstract: The invention provides a gel patch comprising a support and an adhesive layer on the support, wherein the adhesive layer comprises 1.5 to 2.5 mass % of ketoprofen, 1.5 to 2.5 mass % of 4-tert-butyl-4′-methoxydibenzoylmethane and 12 to 18 mass % of propylene glycol, based on the total mass of the adhesive layer.
Abstract translation: 本发明提供一种凝胶贴片,其包含载体和载体上的粘合剂层,其中粘合剂层包含1.5至2.5质量%的酮洛芬,1.5至2.5质量%的4-叔丁基-4'-甲氧基二苯甲酰甲烷和12至18 丙二醇的质量%,基于粘合剂层的总质量。
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公开(公告)号:US20220105060A1
公开(公告)日:2022-04-07
申请号:US17429683
申请日:2020-02-13
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Tatsuya SAKAKURA , Satoshi KIMURA , Seiichiro TSURU
IPC: A61K31/192 , A61K31/045 , A61K9/70 , A61K47/10
Abstract: The present invention provides a gel patch having a paste layer on a support, wherein the paste layer comprising ketoprofen or a pharmaceutically acceptable salt thereof, propylene glycol, 1-menthol, and water, wherein the mass of propylene glycol in the paste layer is 3-fold the mass of ketoprofen or less, and wherein the content of 1-menthol based on a total mass of the paste layer is 0.1 to 0.5 mass %.
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公开(公告)号:US20180036255A1
公开(公告)日:2018-02-08
申请号:US15551916
申请日:2016-02-17
Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
Inventor: Seiichiro TSURU , Masayoshi MAKI
IPC: A61K9/70 , A61K47/10 , A61K47/32 , A61K31/192
CPC classification number: A61K9/7038 , A61K9/70 , A61K31/192 , A61K45/00 , A61K47/10 , A61K47/32
Abstract: A method for producing a gel patch comprising an adhesive mass layer on a backing fabric, comprising a step of applying a composition comprising a physiologically active substance, a water-soluble polymer, glycerin, and water to the backing fabric to form the adhesive mass layer, wherein a loss tangent of the composition in dynamic viscoelasticity measurement at 1 Hz at a time of application to the backing fabric is 0.75 to 1.
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