公开(公告)号：US20200041386A1

公开(公告)日：2020-02-06

申请号：US16653662

申请日：2019-10-15

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  MBD KOREA, CO., LTD.

Inventor： Hyo Jeong KUH ,  Ji Hoon KANG ,  Dong Wo LEE

IPC: G01N1/04 ,  C12M1/12 ,  C12M1/34

Abstract: A method for producing a sample slice includes providing a disk, providing a jig on the disk for supporting side portions of a material, providing the material inside the jig, providing a pillar assembly on the jig, the pillar assembly that includes a first base member having a plurality of through holes, a second base member detachably mounted to said first base member, and a plurality of pillars supported between said first and second base members and arranged to be exposed through the plurality of holes, inserting the plurality of pillars into the material, solidifying the material, separating the jig and the pillar assembly to remove the material from the jig, and cutting a sample slice from the material with a cutter.

公开(公告)号：US20200015961A1

公开(公告)日：2020-01-16

申请号：US16512400

申请日：2019-07-16

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  ADVANCED TECHNOLOGY INC.

Inventor： Ho Jeong JEON ,  Myoung Ryul OK ,  Yu Chan KIM ,  Hyun Kwang SEOK ,  Choun Ki JOO ,  Byoung Chan CHOI

IPC: A61F2/16

Abstract: There is provided an intraocular lens including an optic portion having a circular shape from one side thereof and including a first pattern which includes a ridge and a groove, and a plurality of haptic portions extending from an outer circumferential edge of the optic portion and each including a second pattern which includes a ridge and a groove, in which at least one of the ridges included in the first pattern and the second pattern and at least one of the grooves included in the first pattern and the second pattern includes a section in which a width is formed differently.

公开(公告)号：US20190388212A1

公开(公告)日：2019-12-26

申请号：US16481262

申请日：2018-01-26

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  UNIVERSITY-INDUSTRY FOUNDATION, YONSEI UNIVERSITY ,  RESEARCH COOPERATION FOUNDATION OF YEUNGNAM UNIVERSITY

Inventor： U-Syn HA ,  Jongbaeg KIM ,  Won Gun KOH ,  Jin Ho KIM

IPC: A61F2/04 ,  A61L27/48 ,  A61L27/52

Abstract: Provided is an artificial bladder including: a main body which includes an inlet port, an outlet port, and a predetermined reservoir portion configured to store urine between the inlet port and the outlet port and is formed of a biocompatible polymer that is expandable so that a volume of the reservoir portion changes according to the amount of urine; a sensor which is attached to an outer wall of the main body, has a surface having a wrinkled structure, and is provided so that, when the volume of the reservoir portion increases, the wrinkled structure stretches out and resistance of the sensor changes; and an actuator which is provided at the outlet port and is configured to discharge the urine according a result detected by the sensor.

公开(公告)号：US10481148B2

公开(公告)日：2019-11-19

申请号：US15444335

申请日：2017-02-28

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Jin-Sung Choi ,  Jeong Hee Choi

IPC: A61K35/12 ,  G01N33/50 ,  C07K14/705 ,  G01N33/487 ,  G01N33/68

Abstract: Provided are a cell line stably expressing voltage-gated sodium channel (Nav1.5), wherein a SCN5A gene (NCBI accession no. NM_198056) encoding Nav1.5 and a puromycin selection marker are inserted into a chromosome of a host cell, and a method of measuring cardiotoxicity of a test substance comprising: (1) contacting a test substance to the cell line of claim 1; and (2) measuring magnitude of voltage-gated sodium channel (Nav1.5) in the cell line in contact with the test substance.

公开(公告)号：US20190328685A1

公开(公告)日：2019-10-31

申请号：US16445996

申请日：2019-06-19

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Mi-La Cho ,  Chul-Woo Yang ,  Dong-Yun Shin ,  Min-Jung Park ,  Seon-Yeong Lee ,  Sung-Hee Lee ,  Eun-Ji Yang ,  Hye-Jin Son ,  Eun-Kyung Kim ,  Jae-Kyung Kim

IPC: A61K31/155 ,  C07C279/26 ,  C07C279/18

Abstract: The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-α, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.

公开(公告)号：US20190315770A1

公开(公告)日：2019-10-17

申请号：US16325073

申请日：2017-08-11

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION ,  KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY

Inventor： Sang Chul LEE ,  Say June KIM ,  Kwan Young JEONG ,  Ok Hee KIM ,  Seok Jun JO ,  Min Jin YOO

IPC: C07D499/21 ,  G01N33/483 ,  G01N33/50 ,  C07D499/06

Abstract: The present invention relates to various compounds capable of temporarily hardening soft tissue for surgical suturing of the soft tissue. The compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, thereby improving the suturing efficiency during suturing of the soft tissue, thereby preventing aftereffects or the like from occurring due to insufficient anastomosis. In addition, the compounds according to the present invention can temporarily increase the hardness or tension of soft tissue, particularly pancreas, thereby increasing the suturing efficiency during pancreaticoduodenectomy and effectively preventing pancreatic leakage.

公开(公告)号：US20190314436A1

公开(公告)日：2019-10-17

申请号：US16347641

申请日：2016-11-04

Applicant: KOREA BIO MEDICAL SCIENCE INSTITUTE CO., LTD ,  THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Sung-Yeoun HWANG ,  Seung-Kew YOON ,  Jung-Hee KIM

IPC: A61K36/35 ,  A61P35/00 ,  A23L33/105

Abstract: A composition for prevention or treatment of liver cancer includes a Nardostachys jatamansi extract. The composition exhibits anti-cancer effects on liver cancer and/or specific liver cancer resistant to antibiotics. The composition can be included, for example, in a pharmaceutical composition or a health functional food.

公开(公告)号：US20190264292A1

公开(公告)日：2019-08-29

申请号：US16410461

申请日：2019-05-13

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Suk-Woo Nam ,  Hee-Doo Yang

IPC: C12Q1/6886 ,  G01N33/574 ,  G01N29/06 ,  G01N33/50 ,  C12N15/113

Abstract: The present disclosure relates to a use of H2AFZ as a hepatocellular carcinoma (HCC) biomarker and more particularly, to a marker for diagnosing hepatocellular carcinoma consisting of a H2AFZ gene or an expression protein H2A.Z.1 thereof, a composition for diagnosing or estimating prognosis of HCC, a method for diagnosing or estimating prognosis of HCC, a method of detecting a biomarker for diagnosing or estimating prognosis of HCC, a screening method of an HCC therapeutic agent, and a pharmaceutical composition for preventing or treating HCC.

公开(公告)号：US20190177690A1

公开(公告)日：2019-06-13

申请号：US16323459

申请日：2017-08-04

Applicant: THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

Inventor： Choun Ki JOO ,  Jee Won MOK ,  Hee Jung JU ,  Jun Sub CHOI

IPC: C12N5/079 ,  C12N5/00

Abstract: The present invention relates to a method for culturing corneal stem cell-like cell lines by inducing differentiation of induced pluripotent stem cells (iPSC). The method comprises the following steps: preparing a basal medium comprising DMEM F12, L-ascorbic acid, sodium selenite, and sodium chloride; adding additives for culturing induced pluripotent stem cells to the basal medium; preparing a feeder free culture medium by coating the basal medium with Vitronectin recombinant human protein; adding induced pluripotent stem cells to the feeder free culture medium and culturing them; adding additives for creating an environment for stem cell growth to the feeder free culture medium; adding BMP4 and Wnt3a sequentially to the feeder free culture medium in order to induce differentiation of the induced pluripotent stem cells into corneal stem cell-like cell lines; and culturing the cells differentiated from the induced pluripotent stem cells in PI culture fluid.

公开(公告)号：US20190127700A1

公开(公告)日：2019-05-02

申请号：US16091146

申请日：2017-04-05

Applicant: The Catholic University of Korea Industry-Academic Cooperation Foundation

Inventor： Il Hoan OH ,  Jin A KIM

IPC: C12N5/0775 ,  C12N5/071

Abstract: In the present invention, it was discovered that when vascular endothelial cells are co-cultured with mesenchymal stem cells, an improvement is brought about in the niche activity of mesenchymal stem cells and the self-renewal of hematopoietic or neural stem cells and particularly that the niche activity and the self-renewal of hematopoietic or neural stem cells can easily be controlled by regulating the stimulus (cytokines, etc.) of vascular endothelial cells to the mesenchymal stem cells. Therefore, the present invention can not only improve the self-renewal of stem cells, but also easily control it as needed, and thus is expected to expand the usefulness of mesenchymal stem cell-based cell therapy.