公开(公告)号：US20060210596A1

公开(公告)日：2006-09-21

申请号：US11367006

申请日：2006-03-02

Applicant: Michael Wolf ,  Laurie Yunker ,  Paul Trescony

Inventor： Michael Wolf ,  Laurie Yunker ,  Paul Trescony

IPC: C12N5/08 ,  C12M3/00 ,  A61F13/02

CPC classification number: A61L27/3808 ,  A61F2/062 ,  A61L27/16 ,  A61L27/507 ,  Y10S623/915 ,  Y10S623/916 ,  C08L27/18

Abstract: Apparatus and methods for seeding an implantable medical device, such as a vascular prosthesis, with cells, such as endothelial cells, are described. The invention supports techniques for seeding a luminal surface of the device with axial centrifugation. Cells are introduced in suspension into the lumen of the device. The introduction of the cells may occur after a blood centrifugation product, such as platelet-poor plasma, is applied to the luminal surface. After the cells are introduced, the device is then subjected to centrifugation around a longitudinal axis defined by the lumen. Axial centrifugation causes the cells to concentrate toward and adhere to the luminal surface. Shortly after axial centrifugation, the seeded device can be presented for implantation in a patient. The implantable medical device may be inserted into a protective sleeve prior to seeding the device with cells, and the sleeve may or may not be removed prior to implantation.

Abstract translation: 描述了可植入医疗装置（例如血管假体）与细胞例如内皮细胞接种的装置和方法。 本发明支持用轴向离心法将装置的腔表面接种的技术。 将细胞悬浮液引入装置的内腔。 在血液离心产物（如贫血小板血浆）应用于管腔表面后，细胞的引入可能发生。 导入细胞后，将该装置围绕由内腔限定的纵向轴进行离心。 轴向离心导致细胞浓缩并附着在管腔表面。 在轴向离心后不久，可以将接种的装置用于植入患者体内。 可植入的医疗装置可以在将装置与细胞接种之前插入保护套管中，并且在植入之前套筒可以被移除也可以不被移除。

公开(公告)号：US20060205708A1

公开(公告)日：2006-09-14

申请号：US11429181

申请日：2006-05-08

Applicant: Hans-Michael Eggenweiler ,  Norbert Beier ,  Pierre Schelling ,  Michael Wolf

Inventor： Hans-Michael Eggenweiler ,  Norbert Beier ,  Pierre Schelling ,  Michael Wolf

IPC: A61K31/501 ,  A61K31/53 ,  C07D403/02

CPC classification number: C07D401/12 ,  C07D237/04 ,  C07D403/12

Abstract: Aryl oxime derivatives of the formula (I), in which R1, R2, R3, X and B are as defined in Claim 1, act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS.

Abstract translation: 式（I）的芳基肟衍生物，其中R 1，R 2，R 3，X和B如权利要求中所定义， 1，作为磷酸二酯酶IV抑制剂，可用于治疗骨质疏松症，肿瘤，恶病质，动脉粥样硬化，类风湿性关节炎，多发性硬化，糖尿病，炎症过程，过敏，哮喘，自身免疫性疾病，心肌疾病和艾滋病。

公开(公告)号：US20060184235A1

公开(公告)日：2006-08-17

申请号：US11402509

申请日：2006-04-12

Applicant: Nicolas Rivron ,  Paul Trescony ,  Michael Wolf

Inventor： Nicolas Rivron ,  Paul Trescony ,  Michael Wolf

IPC: A61F2/06

CPC classification number: A61F2/07 ,  A61F2/06 ,  A61F2310/00389

Abstract: In general, the invention is directed to devices and methods that are useful for surface preparation of implantable medical devices. In the case of a vascular graft, the invention presents devices and methods that enhance endothelial cell seeding by providing recesses in the luminal surface that can receive endothelial cells. When the device is constructed of a material such as expanded polytetrafluoroethylene (ePTFE), the recesses may be created by physical processing of the microstructures of the material. The physical processing lifts nodes from the surface, forming recesses that can receive endothelial cells.

Abstract translation: 通常，本发明涉及可用于可植入医疗装置的表面制备的装置和方法。 在血管移植物的情况下，本发明提供了通过在可以接受内皮细胞的腔表面中提供凹陷来增强内皮细胞接种的装置和方法。 当装置由诸如膨胀聚四氟乙烯（ePTFE）的材料构成时，可以通过对材料的微观结构的物理加工来产生凹陷。 物理加工从表面提升节点，形成可以接收内皮细胞的凹槽。

公开(公告)号：US20060117591A1

公开(公告)日：2006-06-08

申请号：US11295321

申请日：2005-12-06

Applicant: Michael Wolf ,  Bernhard Seiferling ,  Axel Heinrich ,  Peter Hagmann ,  Thomas Richter

Inventor： Michael Wolf ,  Bernhard Seiferling ,  Axel Heinrich ,  Peter Hagmann ,  Thomas Richter

IPC: F26B3/00

CPC classification number: B29D11/00432 ,  B29C33/72

Abstract: In a method of drying molds or mold parts for the manufacture of optical lenses, in particular ophthalmic lenses and especially contact lenses, the mold or mold part to be dried is exposed to drying air. For this purpose, humid pressurized air (T) is used to which the mold or mold part is exposed.

Abstract translation: 在干燥用于制造光学透镜的模具或模具部件的方法中，特别是眼镜片，特别是隐形眼镜，待干燥的模具或模具部件暴露于干燥空气中。 为此，使用潮湿的加压空气（T），模具或模具部件暴露在其中。

公开(公告)号：US20050209240A1

公开(公告)日：2005-09-22

申请号：US10517438

申请日：2003-05-16

Applicant: Hans-Michael Eggenweiler ,  Norbert Beier ,  Pierre Schelling ,  Michael Wolf

Inventor： Hans-Michael Eggenweiler ,  Norbert Beier ,  Pierre Schelling ,  Michael Wolf

IPC: A61K31/50 ,  A61K31/501 ,  A61P1/04 ,  A61P1/16 ,  A61P3/10 ,  A61P5/14 ,  A61P7/04 ,  A61P7/06 ,  A61P9/10 ,  A61P11/00 ,  A61P11/06 ,  A61P11/08 ,  A61P13/02 ,  A61P13/12 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P19/06 ,  A61P19/10 ,  A61P21/00 ,  A61P21/04 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/24 ,  A61P25/28 ,  A61P25/30 ,  A61P27/02 ,  A61P27/16 ,  A61P29/00 ,  A61P31/04 ,  A61P31/10 ,  A61P31/16 ,  A61P31/18 ,  A61P31/22 ,  A61P33/06 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61P37/00 ,  A61P37/02 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D237/04 ,  C07D401/12 ,  C07D403/12 ,  A61K31/53 ,  C07D43/02

CPC classification number: C07D401/12 ,  C07D237/04 ,  C07D403/12

Abstract: Aryl oxime derivatives of the formula (I), in which R1, R2, R3, X and B are as defined in claim 1, act as phosphodiesterase IV inhibitors and can be employed for the treatment of osteoporosis, tumours, cachexia, atherosclerosis, rheumatoid arthritis, multiple sclerosis, diabetes mellitus, inflammatory processes, allergies, asthma, autoimmune diseases, myocardial diseases and AIDS.

Abstract translation: 式（I）的芳基肟衍生物，其中R 1，R 2，R 3，X和B如权利要求中所定义， 1，作为磷酸二酯酶IV抑制剂，可用于治疗骨质疏松症，肿瘤，恶病质，动脉粥样硬化，类风湿性关节炎，多发性硬化，糖尿病，炎症过程，过敏，哮喘，自身免疫性疾病，心肌疾病和艾滋病。

公开(公告)号：US20050078684A1

公开(公告)日：2005-04-14

申请号：US10935275

申请日：2004-09-08

Applicant: Michael Wolf ,  Dieter Beller

Inventor： Michael Wolf ,  Dieter Beller

IPC: H04J3/16 ,  H04Q11/00 ,  H04L12/28

CPC classification number: H04Q11/0066 ,  H04J3/1617 ,  H04Q11/0071

Abstract: A burst mode optical signal is transported as payload of a framed continuous bit-stream optical signal through an optical transport network. The optical bursts are all generated at a common nominal bitrate which equals substantially the payload bitrate of the continuous bit-stream optical signal. The bursts are converted into a continuous bit stream by filling gaps between the bursts with a predefined pattern. The continuous bit stream thus created is then mapped into frames to generate the framed continuous bit-stream optical signal for transmission.

Abstract translation: 突发模式光信号通过光传输网络作为成帧的连续比特流光信号的有效载荷传送。 光脉冲串全部以公共标称比特率产生，其基本上等于连续比特流光信号的有效载荷比特率。 通过用预定义的模式填充突发之间的间隙，将脉冲串转换成连续位流。 然后将如此创建的连续比特流映射到帧中以生成成帧的连续比特流光信号进行传输。

公开(公告)号：US20050055085A1

公开(公告)日：2005-03-10

申请号：US10656855

申请日：2003-09-04

Applicant: Nicolas Rivron ,  Paul Trescony ,  Michael Wolf

Inventor： Nicolas Rivron ,  Paul Trescony ,  Michael Wolf

IPC: A61F2/00 ,  A61F2/06

CPC classification number: A61F2/07 ,  A61F2/06 ,  A61F2310/00389

Abstract: In general, the invention is directed to devices and methods that are useful for surface preparation of implantable medical devices. In the case of a vascular graft, the invention presents devices and methods that enhance endothelial cell seeding by providing recesses in the luminal surface that can receive endothelial cells. When the device is constructed of a material such as expanded polytetrafluoroethylene (ePTFE), the recesses may be created by physical processing of the microstructures of the material. The physical processing lifts nodes from the surface, forming recesses that can receive endothelial cells.

Abstract translation: 通常，本发明涉及可用于可植入医疗装置的表面制备的装置和方法。 在血管移植物的情况下，本发明提供了通过在可以接受内皮细胞的腔表面中提供凹陷来增强内皮细胞接种的装置和方法。 当装置由诸如膨胀聚四氟乙烯（ePTFE）的材料构成时，可以通过对材料的微观结构的物理加工来产生凹陷。 物理加工从表面提升节点，形成可以接收内皮细胞的凹槽。

公开(公告)号：US20050023416A1

公开(公告)日：2005-02-03

申请号：US10871045

申请日：2004-06-21

Applicant: Michael Wolf ,  David Krebiehl ,  Forrest Seitz ,  Stanley Sasaki ,  Scott Long

Inventor： Michael Wolf ,  David Krebiehl ,  Forrest Seitz ,  Stanley Sasaki ,  Scott Long

IPC: A63H19/24 ,  B61L3/00

CPC classification number: A63H19/14 ,  A63H19/18 ,  A63H19/24 ,  A63H19/32 ,  A63H33/28

Abstract: A model train operating, sound and control system that provides a user with increased operating realism. A novel remote control communication capability between the user and the model trains. This feature is accomplished by using a handheld remote control on which various commands may be entered, and a Track Interface Unit that retrieves and processes the commands. The Track Interface Unit converts the commands to modulated signals in the form of data bit sequences (preferably spread spectrum signals) which are sent down the track rails. The model train picks up the modulated signals, retrieves the entered command, and executes it through use of a processor and associated control and driver circuitry. A speed control circuit located inside the model train that is capable of continuously monitoring the operating speed of the train and making adjustments to a motor drive circuit, as well as a novel smoke unit. Circuitry for connecting the Track Interface Unit to an external source, such as a computer, CD player, or other sound source, and have real-time sounds stream down the model train tracks for playing through the speakers located in the model train.

Abstract translation: 模拟火车操作，声音和控制系统，为用户提供更多的操作现实感。 用户和模型列车之间的新型遥控通信功能。 该功能通过使用可以在其上输入各种命令的手持遥控器以及检索和处理命令的轨道接口单元来实现。 轨道接口单元将命令转换成以轨道轨道发送的数据比特序列（最好是扩展频谱信号）的形式的调制信号。 模型列车拾取调制信号，检索输入的命令，并通过使用处理器和相关的控制和驱动器电路执行它。 位于模型列车内部的速度控制电路，其能够连续地监视列车的运行速度并对马达驱动电路进行调节，以及新颖的烟雾单元。 用于将轨道接口单元连接到诸如计算机，CD播放器或其他声源的外部源的电路，并且具有实时声音流下模型列车轨道，以通过位于模型列车中的扬声器进行播放。

公开(公告)号：US06738579B2

公开(公告)日：2004-05-18

申请号：US09729782

申请日：2000-12-06

Applicant: Michael Wolf

Inventor： Michael Wolf

IPC: H04J1400

CPC classification number: H04J14/0282 ,  H04J14/0226 ,  H04J14/0232 ,  H04J14/0284 ,  H04L7/0008 ,  H04L7/0075 ,  Y10S370/907

Abstract: The synchronous digital communications system according to the invention serves to transmit electric signals optically. The electric signals to be transmitted are converted from electrical to optical form (E/O1, E/O2, E/On) and are transmitted using wavelength division multiplexing (WDM) or dense wavelength division multiplexing (DWDM). At least one optical connection is configured as a nonswitched connection using at least one wavelength per transmission section between optical network elements or optical and electrical network elements, and serves to transmit synchronization and information signals. This has the advantage that independently of the switched communication links, synchronization is constantly ensured throughout the network. Each network element (NE1, NE2, NE3) has at least one interface unit that is reserved for synchronization and that continuously receives signals at the wavelength (&lgr;1) reserved for synchronization.

Abstract translation: 根据本发明的同步数字通信系统用于光学发射电信号。 要发送的电信号从电转换为光学形式（E / O1，E / O2，E / On），并使用波分复用（WDM）或密集波分复用（DWDM）传输。 至少一个光学连接被配置为使用在光网络元件或光电网络元件之间的每个传输部分使用至少一个波长的非切换连接，并且用于发送同步信息信号。 这具有独立于交换通信链路的优点，整个网络中始终保证同步。 每个网元（NE1，NE2，NE3）具有至少一个保留用于同步的接口单元，并且连续地接收为保持同步的波长（λ1）的信号。

公开(公告)号：US06696446B1

公开(公告)日：2004-02-24

申请号：US10030477

申请日：2002-01-09

Applicant: Rochus Jonas ,  Michael Wolf ,  Norbert Beier

Inventor： Rochus Jonas ,  Michael Wolf ,  Norbert Beier

IPC: A61K3150

CPC classification number: C07D405/04 ,  C07D237/04

Abstract: Benzoyl derivatives of formula (I) and their physiologically acceptable salts and solvates, in which R1, R2, R3, R4, R5 and R6 have the meanings indicated, inhibit phosphodiesterase IV and can be used for the treatment of allergic diseases, asthma, chronic bronchitis, atopic dermatitis, psoriasis and other skin diseases, inflammatory diseases, auto-immune diseases such as rheumatoid arthritis, multiple sclerosis, Crohn's disease, diabetes mellitus or ulcerative colitis, osteoporosis, transplant rejection reactions, cachexia, tumoral growth or tumoral metastases, septicemia, memory defects, atherosclerosis and AIDS.

Abstract translation: 式（I）的苯甲酰基衍生物及其生理学上可接受的盐和溶剂化物，其中R 1，R 2，R 3，R 4，R 5和R 6具有所示的含义 抑制磷酸二酯酶IV，可用于治疗过敏性疾病，哮喘，慢性支气管炎，特应性皮炎，牛皮癣和其他皮肤病，炎症性疾病，自身免疫疾病如类风湿性关节炎，多发性硬化，克罗恩病，糖尿病或 溃疡性结肠炎，骨质疏松症，移植排斥反应，恶病质，肿瘤生长或肿瘤转移，败血病，记忆缺陷，动脉粥样硬化和艾滋病。