公开(公告)号：US20210190669A1

公开(公告)日：2021-06-24

申请号：US17115657

申请日：2020-12-08

Applicant: ThinkCyte, Inc. ,  University of Tokyo ,  Osaka University

Inventor： Sadao Ota ,  Ryoichi Horisaki ,  Yoko Kawamura ,  Masashi Ugawa ,  Issei Sato

IPC: G01N15/14

Abstract: The present disclosure provides methods and systems for ghost cytometry (GC), which may be used to produce an image of an object without using a spatially resolving detector. This may be used to perform image-free ultrafast fluorescence “imaging” cytometry, based on, for example, a single pixel detector. Spatial information obtained from the motion of cells relative to a patterned optical structure may be compressively converted into signals that arrive sequentially at a single pixel detector. Combinatorial use of the temporal waveform with the intensity distribution of the random or pseudo-random pattern may permit computational reconstruction of cell morphology. Machine learning methods may be applied directly to the compressed waveforms without image reconstruction to enable efficient image-free morphology-based cytometry. Image-free GC may achieve accurate and high throughput cell classification as well as selective sorting based on cell morphology without a specific biomarker, which have been challenging using conventional flow cytometers.

公开(公告)号：US20210187002A1

公开(公告)日：2021-06-24

申请号：US16767929

申请日：2018-11-28

Applicant: OSAKA UNIVERSITY

Inventor： Hisashi ARASE ,  Fumiji HIRAYASU ,  Kouyuki HIRAYASU

IPC: A61K31/7088 ,  G01N33/15 ,  C07K14/445 ,  C07K14/705 ,  A61P33/06

Abstract: The present invention provides a new antimalarial drug. The antimalarial drug of the present invention includes: a binding inhibitor that inhibits binding between a RIFIN protein and a leukocyte immunoglobulin-like receptor subfamily B member 1 (LILRB1) protein; an inducer of the binding inhibitor; or an expression inhibitor of RIFIN or LILRB1.

公开(公告)号：US20210163608A1

公开(公告)日：2021-06-03

申请号：US16924902

申请日：2020-07-09

Applicant: OSAKA UNIVERSITY ,  KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION ,  CHUGAI SEIYAKU KABUSHIKI KAISHA

Inventor： Nobuyuki OHGURO ,  Yasuo TANO ,  Kohei SONODA ,  Tatsuro ISHIBASHI

IPC: C07K16/28 ,  A61K31/00

Abstract: The present invention relates to therapeutic and/or prophylactic agents for ocular inflammatory disease, which comprise an interleukin 6 (IL-6) receptor inhibitor as an active ingredient.

公开(公告)号：US20210145814A1

公开(公告)日：2021-05-20

申请号：US16626062

申请日：2018-06-27

Applicant: OSAKA UNIVERSITY

Inventor： Shoichi SHIMADA ,  Yukiko YAMAMOTO ,  Makoto KONDO

IPC: A61K31/4545 ,  A61P25/04

Abstract: The present invention provides a drug for preventing or treating chronic pain and a method for preventing or treating chronic pain. A pharmaceutical composition comprising a serotonin-3 receptor agonist such as a compound represented by the following formula (I): [wherein: m is an integer of 1 to 4; and R1 is each independently selected from the group consisting of a hydrogen atom, a halogen atom, a methyl group optionally substituted with 1 to 3 halogen atom(s), a methoxy group optionally substituted with 1 to 3 halogen atom(s), and a methylthio group optionally substituted with 1 to 3 halogen atom(s)] or a pharmaceutically acceptable salt thereof is useful for preventing or treating chronic pain. The above pharmaceutical composition is also useful for preventing or treating acute pain. Further, the present invention provides a method for screening a compound for preventing or treating chronic pain, the method comprising measuring a serotonin-3 receptor agonist activity.

公开(公告)号：US20210130793A1

公开(公告)日：2021-05-06

申请号：US16639639

申请日：2018-08-23

Applicant: The Research Foundation for Microbial Diseases of Osaka University

Inventor： Takao Fujimoto

IPC: C12N7/00

Abstract: Provided is a production method for reassortant influenza virus having genome segments of two or more kinds of influenza virus in the case where an antigenic strain and donor strain have similar antigenicities. The production method makes use of the first influenza virus containing an antigenic protein, the second influenza virus having an antigenic protein having antigenicity similar to that of the strain, and the third influenza virus having an antigenic protein having antigenicity different from that of the strain, and includes the steps of: coculturing the strain and the strain by infecting a host therewith, to produce reassortant influenza viruses; selecting influenza virus having the antigenic protein from the viruses; then coculturing the strain and the selected strain by infecting a host therewith; and selecting influenza virus having the antigenic protein from reassortant influenza viruses produced from the strain and the strain.

公开(公告)号：US20210115377A1

公开(公告)日：2021-04-22

申请号：US17050734

申请日：2019-05-07

Applicant: TOPPAN PRINTING CO., LTD. ,  OSAKA UNIVERSITY

Inventor： Shiro KITANO ,  Shinji IRIE ,  Michiya MATSUSAKI

IPC: C12M1/12 ,  D01F8/02

Abstract: The present invention relates to an extracellular-matrix-containing composition comprising: a fragmented extracellular matrix component; and an aqueous medium.

公开(公告)号：US20210115148A1

公开(公告)日：2021-04-22

申请号：US17134775

申请日：2020-12-28

Applicant: Shionogi & Co., Ltd. ,  Osaka University

Inventor： Tetsuya Yoshida ,  Yujiro Kidani ,  Mitsunobu Matsumoto ,  Takayuki Kanazawa ,  Satomi Shinonome ,  Kanji Hojo ,  Naganari Ohkura ,  Shimon Sakaguchi ,  Atsushi Tanaka ,  Hisashi Wada ,  Atsunari Kawashima ,  Norio Nonomura

IPC: C07K16/28 ,  A61P35/00 ,  A61K47/68 ,  A61K47/60 ,  A61K47/64 ,  A61K35/17 ,  A61K9/00 ,  G01N33/50

Abstract: The present invention provides a pharmaceutical composition for cancer treatment comprising an antibody against CCR8.

公开(公告)号：US20210108371A1

公开(公告)日：2021-04-15

申请号：US17132375

申请日：2020-12-23

Applicant: OSAKA UNIVERSITY ,  DAIKIN INDUSTRIES, LTD.

Inventor： Akihiro OSHIMA ,  Yoshikage OHMUKAI ,  Yuko SHIOTANI ,  Kazuyuki SATOU ,  Michio MATSUDA ,  Tomohiro YOSHIDA ,  Ikuo YAMAMOTO

IPC: D21H19/20 ,  D21H21/16 ,  D21H27/10

Abstract: A method for producing a paper, which includes applying at least one of ionizing radiation and plasma to at least one of a paper base and a compound (A) selected from: a compound having a carbon-carbon unsaturated bond and containing no fluorine atom in a molecular structure, and a compound containing no fluorine atom in a molecular structure in which radicals are generated by irradiation of an electron beam to the compound, to introduce a layer formed from the compound (A) on a surface of the paper base.

公开(公告)号：US20210107789A1

公开(公告)日：2021-04-15

申请号：US17057007

申请日：2019-05-22

Applicant: The Research Foundation For Microbial Diseases of Osaka University

Inventor： Noriyuki Kanzawa ,  Shunsuke Kano ,  Hiroshi Miyatake

IPC: C01B25/36 ,  C07K1/14

Abstract: The present invention provides a substance which is useful as a carrier for protein purification. Since an aluminum phosphate compound that is obtained by a method for producing an aluminum phosphate compound, which comprises a step for obtaining a mixture that contains an aluminum phosphate compound by mixing an aqueous solution A containing a phosphate ion with an aqueous solution B containing an aluminum ion and a sulfate ion, and at least one of a potassium ion or a magnesium ion, exhibits excellent protein adsorption properties, this aluminum phosphate compound is useful as a carrier for protein purification.

公开(公告)号：US10964323B2

公开(公告)日：2021-03-30

申请号：US16301627

申请日：2017-05-19

Applicant: NIPPON TELEGRAPH AND TELEPHONE CORPORATION ,  OSAKA UNIVERSITY

Inventor： Hiroaki Sugiyama ,  Toyomi Meguro ,  Junji Yamato ,  Yuichiro Yoshikawa ,  Hiroshi Ishiguro

IPC: G10L15/22 ,  G10L15/18 ,  A63H11/00 ,  G10L13/00

Abstract: An acquisition method is a method performed by an acquisition system in order to acquire a speech set in which three speeches are associated with one another used to generate a second speech made by a dialog system, based on a speech set in which three speeches are associated with one another, in response to a speech made by a human in response to a first speech made by the dialog system. A storage part of the acquisition system stores a plurality of speech sets in which two speeches are associated with each other and the acquisition method includes a presentation step of presenting in order, a speech t(1) and a speech t(2) which are two consecutive speeches included in a certain speech set stored in the storage part of the acquisition system, a speech receiving step of receiving input of a third speech t(3) which is a human speech after presenting the speech t(2) and a storing step of storing the speech t(1), the speech t(2), and the speech t(3) associated with one another as a speech set in which three speeches are associated with one another in the storage part of the acquisition system.