公开(公告)号：US20250064749A1

公开(公告)日：2025-02-27

申请号：US18862002

申请日：2023-05-19

Applicant: MARUZEN PETROCHEMICAL CO., LTD. ,  THE UNIVERSITY OF TOKYO

Inventor： Takao NISHIURA ,  Kanjiro MIYATA ,  Kento FUJIURA

IPC: A61K9/50 ,  A61K9/48 ,  A61K33/242 ,  A61K33/243 ,  A61K33/38 ,  A61K47/60

Abstract: [Problem] Provided is a cell-adhesive composition including an oxyethylene chain-containing polymer having excellent biocompatibility and excellent reactivity.
[Solution]A cell-adhesive composition according to the present invention includes an oxyethylene chain-containing polymer represented by the following general formula (1): (wherein, in the general formula (1), R1 is —(CH2)p—SH, —(CH2)p—N3, —(CH2)p—NH2, or —(CH2)p—COOH, and p is an integer of 1 to 5; R2 to R4 are each independently hydrogen or a C1-10 alkyl group; R5 is a C1-10 alkyl group; R6 is hydrogen or a C1-5 alkyl group; R7 is a C1-10 alkyl group; n is an integer of 5 to 1000; m is an integer of 1 to 10; and q is an integer of 0 to 5).

公开(公告)号：US12230023B2

公开(公告)日：2025-02-18

申请号：US18511920

申请日：2023-11-16

Applicant: The University of Tokyo ,  OSAKA UNIVERSITY

Inventor： Sadao Ota ,  Issei Sato ,  Katsuhito Fujiu ,  Satoko Yamaguchi ,  Kayo Waki ,  Yoko Itahashi ,  Ryoichi Horisaki

IPC: G01N15/14 ,  C12M1/34 ,  G01N15/1404 ,  G01N15/1429 ,  G01N15/1434 ,  G01N21/01 ,  G01N21/27 ,  G01N21/64 ,  G01N21/65 ,  G06F18/21 ,  G06F18/28 ,  G06V10/772 ,  G06V10/778 ,  G06V10/82 ,  G06V20/69 ,  G01N15/10

Abstract: An analysis device includes an analysis unit configured to receive scattered light, transmitted light, fluorescence, or electromagnetic waves from an observed object located in a light irradiation region light-irradiated from a light source and analyze the observed object on the basis of a signal extracted on the basis of a time axis of an electrical signal output from a light-receiving unit configured to convert the received light or electromagnetic waves into the electrical signal.

公开(公告)号：US20250046779A1

公开(公告)日：2025-02-06

申请号：US18784928

申请日：2024-07-26

Applicant: Prime Planet Energy & Solutions, Inc. ,  THE UNIVERSITY OF TOKYO

Inventor： Shinya SUZUKI ,  Takanari OUCHI

IPC: H01M4/04 ,  H01M4/02 ,  H01M4/505 ,  H01M4/525 ,  H01M10/0525

Abstract: A manufacturing method disclosed herein includes a preparing step of preparing a collection target containing at least one of Ni and Co as a valuable metal, a heating step of heating the collection target at 500° C. or more so that at least a part of the valuable metal is reduced to a state of a metal simple substance, and an ammonia leaching step of immersing the collection target after the heating step in an ammonia aqueous solution in which ammonia, a pH buffer, and an oxidant are mixed, thereby obtaining a metal solution including the valuable metal.

公开(公告)号：US12213377B2

公开(公告)日：2025-01-28

申请号：US17382961

申请日：2021-07-22

Applicant: FUJIFILM Corporation ,  The University of Tokyo

Inventor： Eiji Fukuzaki ,  Tetsuya Watanabe ,  Yoshihisa Usami ,  Yukio Tani ,  Toshihiro Okamoto ,  Junichi Takeya

IPC: H10K85/60 ,  C07D471/06 ,  C07D471/22 ,  C07D491/22 ,  H01L29/786 ,  H10K10/84 ,  H10K10/46

Abstract: Provided are an organic thin film transistor, an organic semiconductor film, a compound, an organic thin film transistor-forming composition, and a method of manufacturing the organic thin film transistor. The organic thin film transistor includes the organic semiconductor film. The organic semiconductor film includes a compound represented by a specific formula. The organic semiconductor film, the compound, and the organic thin film transistor-forming composition can be preferably used in the organic thin film transistor. The method of manufacturing the organic thin film transistor includes a step of forming an organic semiconductor film by applying the organic thin film transistor-forming composition to a substrate.

公开(公告)号：US12195608B2

公开(公告)日：2025-01-14

申请号：US17394962

申请日：2021-08-05

Applicant: TOPPAN INC. ,  THE UNIVERSITY OF TOKYO

Inventor： Nao Nishijima ,  Shuji Fujisawa

IPC: C08L1/02 ,  C08B37/00 ,  C08B37/08 ,  C08F2/16 ,  C08F2/22 ,  C08F2/44 ,  C08F12/36 ,  C08J3/12 ,  C08L5/08

Abstract: What is provided is a method for producing a composite-particle composition including a first step of obtaining a dispersion liquid of fine fibers; a second step of coating a surface of liquid droplets of a polymerizable monomer or a polymer with the fine fibers in the dispersion liquid to stabilize the liquid droplets as an emulsion; a third step of polymerizing the liquid droplets of the polymerizable monomer or the polymer to obtain composite particles including the polymer coated with the fine fibers; and a fourth step of adsorbing a compound that forms an ionic bond in a pair with an ionic functional group of the fine fibers onto the fine fibers in the surface of the composite particles.

公开(公告)号：US20240424271A1

公开(公告)日：2024-12-26

申请号：US18692290

申请日：2022-06-30

Applicant: LINTEC CORPORATION ,  The University of Tokyo

Inventor： Yosuke KOMA ,  Beomjoon KIM ,  JongHo PARK

IPC: A61M37/00 ,  A61B5/00 ,  A61B5/145

Abstract: A microneedle structure of the present invention comprises: a liquid-impermeable base material that has a through-hole; a liquid-absorbable absorbent material that fills the through-hole; a needle-shaped portion that is provided on one surface side of the base material and has a flow channel formed therein; and a functional member that is provided on the other surface side of the base material. The needle-shaped portion and the absorbent material are connected to each other, and the absorbent material and the functional member are connected to each other.

公开(公告)号：US20240409960A1

公开(公告)日：2024-12-12

申请号：US18702120

申请日：2022-10-20

Applicant: The University of Tokyo

Inventor： Moritoshi SATO ,  Fuun KAWANO

IPC: C12N15/90 ,  C12N9/22 ,  C12N15/11

Abstract: It is an object of the present invention to provide a method of reliably chemogenetically controlling the activity of a protein, and to provide a protein used in the present method. Specifically, the present invention relates to a plurality of protein fragments, which recover the activity of the protein when the plurality of protein fragments assemble, and in which each of the plurality of protein fragments is tagged with a degradation domain (DD) sequence. In addition, the present invention also relates to a method of regulating the activity of a protein in a cell, comprising: a step of introducing into a cell, a fusion of a DD sequence, and each fragment of a protein that has been split into fragments, such that the fragments recover the activity of the protein when they assemble; and a step of introducing a DD sequence-specific stabilizing factor into the cell.

公开(公告)号：US20240399070A1

公开(公告)日：2024-12-05

申请号：US18804706

申请日：2024-08-14

Applicant: The University of Tokyo

Inventor： Tomoki TODO

IPC: A61M5/32

Abstract: An endoscopic puncture needle unit is an endoscopic puncture needle unit for administering a virus formulation to a tumor site, including a sheath to be inserted through a forceps channel of an endoscope, a cannula to be inserted into the sheath and having a distal end portion processed into a puncture needle, and a grip member configured to support a sheath proximal end portion which is a proximal end portion of the sheath and a cannula proximal end portion which is a proximal end portion of the cannula, a syringe configured to hold the virus formulation being attachable to the grip member. The cannula is formed integrally from an attachment portion to be directly attached to a connection base of the syringe to the puncture needle configured to discharge the virus formulation.

公开(公告)号：US20240393342A1

公开(公告)日：2024-11-28

申请号：US18695747

申请日：2022-09-27

Applicant: The University of Tokyo ,  RIKEN

Inventor： Sadao OTA ,  Ken WATANABE ,  Fumiko KAWASAKI ,  Yuka MORI

IPC: G01N33/58 ,  G01N33/53

Abstract: A cell labeling molecule comprising a particle 101 having an identifiable property, an identification sequence 102 that is identifiable and corresponds to the property of the particle 101, a cleavable linker 103 that binds the particle 101 and the identification sequence 102, and a binding molecule 104 for binding to a cell, the binding molecule being bound to the identification sequence 102.

公开(公告)号：US20240369706A1

公开(公告)日：2024-11-07

申请号：US18685961

申请日：2022-08-26

Applicant: THE UNIVERSITY OF TOKYO

Inventor： Ichiro SAKUMA ,  Naoki TOMII ,  Takumi NODA ,  Takashi AZUMA

IPC: G01S15/89 ,  G01S7/52

Abstract: An ultrasonic imaging device has a learning result as a relationship between the ultrasonic reception data and the shape data obtained by deep learning using the ultrasonic reception data of an imaging target obtained by transmitting and receiving ultrasonic signals by the plurality of element and the shape data of the pedestal (arrangement of multiple elements). Then the ultrasonic imaging device obtains the estimated shape data as the estimated shape data of the pedestal (estimated arrangement of multiple elements) by applying the learning result to the ultrasonic reception data, and constructs an image of the imaging target based on the estimated shape data and the ultrasonic reception data.