公开(公告)号：US20190382775A1

公开(公告)日：2019-12-19

申请号：US16342319

申请日：2017-10-17

Applicant: NANYANG TECHNOLOGICAL UNIVERSITY ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Meng How TAN ,  Kean Hean OOI

IPC: C12N15/74 ,  C12N9/22 ,  C07K16/12

Abstract: The present invention relates to a polypeptide comprising at least one at least one deletion selected from the group consisting of ΔHNH (Δ775-909), ARuvCIII-b (Δ1002-1074), AREC1-a (Δ510-655), AREC1-b (Δ525-587), AREC1-c (Δ662-710), AREC2 (Δ180-308), AREC2-a (Δ212-244), AREC2-b (Δ244-276), AREC2-c (Δ276-308), AREC2-d (Δ199-283), AREC2-e (Δ198-257), AREC2-f (Δ235-286), AREC2-g (Δ217-266), AREC3 (Δ498-712) and combinations thereof, wherein the position numbering is in accordance with SEQ ID NO: 1 encoding for S. pyogenes Cas9, and wherein the polypeptide has CRISPR-Cas DNA-binding activity. The polypeptide may further comprises a missense mutations selected from G12R, T13K, T13R, N14K, N497K, T657K, T657R, N767K, T770K, T770R, Q920K, Q920R, S1109R, D1135K, D1135R, S1338R and combinations thereof. Also claimed are nucleic acid molecules encoding for said polypeptides, compositions and method of site-directed engineering of a target DNA thereof.

公开(公告)号：US20190356476A1

公开(公告)日：2019-11-21

申请号：US16482703

申请日：2018-01-31

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Lilei ZHENG ,  Ying ZHANG ,  Vrizlynn THING

IPC: H04L9/06 ,  H04K1/02

Abstract: A method and an apparatus for generating cover images for steganography are provided. The steganographic framework is designed based on an image generation system. The apparatus may encode a message to obtain a binary sequence. The apparatus may obtain a plurality of binary segments of a particular length based on the binary sequence. For each binary segment of the plurality of binary segments, the apparatus may select an image of a semantic content (e.g., a numeral digit) from a dictionary of images of random semantic contents (e.g., random numeral digits) based on the binary segment. The apparatus may combine the selected images to form at least a portion of a cover image denoting a combination of the semantic contents of the selected images (e.g., a plurality of numeral digits).

公开(公告)号：US10481166B2

公开(公告)日：2019-11-19

申请号：US15970952

申请日：2018-05-04

Applicant: Agency for Science, Technology and Research ,  Singapore Health Services Pte Ltd.

Inventor： Sai Kiang Lim ,  Kok Hian Tan

IPC: C12N1/00 ,  G01N33/68 ,  G01N33/50

Abstract: We describe a method of monitoring the state of a cell, tissue, organ or organism. The method comprises establishing, for a sample of micro-particles from the cell, tissue, organ or organism, a ratio. The ratio is of a selected polypeptide in microparticles which comprise GM1 gangliosides, preferably which bind to Cholera Toxin B (CTB) (“GM1 ganglioside microparticle polypeptide”) to the selected polypeptide in microparticles which comprise exposed phos—photidylserine, preferably which bind to Annexin V (“Annexin V microparticle polypeptide”). The GM1 ganglioside microparticle polypeptide to Annexin V microparticle polypeptide ratio so established may be indicative of the state of the cell, tissue, organ or organism.

公开(公告)号：US10472421B2

公开(公告)日：2019-11-12

申请号：US15750425

申请日：2016-08-05

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Cheng-I Wang ,  Peter Brauer ,  Siok Ping Yeo ,  Hwee Ching Tan ,  John Edward Connolly

IPC: A61K39/395 ,  C07K16/28 ,  C07K16/46 ,  A61K47/68 ,  C07K16/10 ,  A61K39/00 ,  A61K38/17

Abstract: Anti-CD122 and/or γc antibodies and fragments thereof are disclosed. Also disclosed are compositions comprising such antibodies and fragments, and uses and methods using the same.

公开(公告)号：US10470104B2

公开(公告)日：2019-11-05

申请号：US15568457

申请日：2016-04-20

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： Ser Wah Oh ,  Yugang Ma ,  Chu Yeow Edward Peh ,  Yiyang Pei

IPC: H04W48/10 ,  H04H60/50 ,  H04W16/14 ,  H04H60/23 ,  H04H60/43 ,  H04L5/00 ,  H04N21/61 ,  G06F16/29

Abstract: Embodiments of the invention relate to method of operating television white space (TVWS) geo-location database (GLDB). The method comprises: embedding a plurality of data signals in a plurality of radio frequency (RF) broadcast signals of at least one existing television or radio channel, wherein the data signals comprise at least one of TVWS GLDB data, time reference data and broadcast transmitter data which comprises at least one of transmitter location data and transmitter identification; and transmitting, over a RF network which is other than an internet protocol (IP) network, the RF broadcast signals together with the embedded data signals to a plurality of white space devices.

公开(公告)号：US20190334080A1

公开(公告)日：2019-10-31

申请号：US16478195

申请日：2018-01-17

Applicant: Agency for Science, Technology and Research

Inventor： Karim Ali Abdeltawwab Ahmed ,  Sunny Yan Hwee Lua ,  Fei Li

IPC: H01L43/02 ,  H01L43/12 ,  G11C11/16 ,  G11C11/56 ,  H01L27/22 ,  H01F10/32

Abstract: Various embodiments may relate to a memory cell. The memory cell may include a first cell electrode, a first insulator layer and a first magnetic free layer between the first cell electrode and the first insulator layer. The memory cell may also include a second cell electrode, a second insulator layer, and a second magnetic free layer between the second cell electrode and the second insulator layer. A magnetic pinned layer may be between the first insulator layer and the second insulator layer. A direction of magnetization of the first magnetic free layer may be changeable in response to a current flowing between a first end and a second end of the first cell electrode. A direction of magnetization of the second magnetic free layer may be changeable in response to a current flowing between a first end and a second end of the second cell electrode.

公开(公告)号：US20190322864A1

公开(公告)日：2019-10-24

申请号：US16457920

申请日：2019-06-28

Applicant: Agency for Science, Technology and Research

Inventor： Madhavan NALLANI ,  Eva-Kathrin SINNER ,  Madanagopal KUNNAVAKKAM

IPC: C08L71/02 ,  C08G65/329

Abstract: Disclosed is a vesicular system comprising a surface with a vesicle immobilized thereon. The immobilized vesicle has a circumferential membrane of an amphiphilic polymer. The vesicle is coupled to a surface by means of a molecule with a non-polar moiety. The non-polar moiety comprises a main chain of 3 to about 30 carbon atoms and 0 to about 12 heteroatoms selected from Si, O, S, and Se. The molecule with the non-polar moiety is coupled to the surface via a covalent or non-covalent bond. A portion of the non-polar moiety is integrated in the circumferential membrane.

公开(公告)号：US10453511B2

公开(公告)日：2019-10-22

申请号：US16079511

申请日：2017-02-16

Applicant: Agency for Science, Technology and Research

Inventor： Sunny Yan Hwee Lua ,  Aarthy Mani

IPC: G11C11/16 ,  H03K3/45 ,  H01L27/22 ,  H01L43/02

Abstract: Various embodiments may provide a circuit arrangement. The circuit arrangement may include a first spin-orbit torque magnetic tunnel junction cell, a second spin-orbit torque magnetic tunnel junction cell, a first driver circuit arrangement, a second driver circuit arrangement, and a read circuit arrangement. The circuit arrangement allows for the operation of a non-volatile flip-flop based on spin-orbit torque effect.

公开(公告)号：US20190315755A1

公开(公告)日：2019-10-17

申请号：US16432469

申请日：2019-06-05

Applicant: Agency for Science, Technology, and Research

Inventor： Kassoum Nacro ,  Athisayamani Jeyaraj Duraiswamy ,  Lohitha Rao Chennamaneni

IPC: C07D487/04 ,  A61P35/00 ,  A61K31/5025 ,  A61K31/5377 ,  A61K31/551 ,  A61K31/553 ,  C07D471/10 ,  A61K31/4545 ,  A61K31/496 ,  C07D519/00 ,  C07D471/04 ,  C07D235/06 ,  A61K31/4985 ,  A61K31/437 ,  A61K31/4184 ,  A61K45/06 ,  A61K31/519 ,  C07D491/107

Abstract: The present invention relates to certain compounds (e.g., imidazopyrazine, imidazopyridine, imidazopyridazine and imidazpyrimidine compounds) that act as inhibitors of the MAP kinase interacting kinases MNK2a, MNK2b, MNK1a, and MNK1b. The present invention further relates to pharmaceutical compositions comprising these compounds, and to the use of the compounds for the preparation of a medicament for the prophylaxis and treatment of diseases (e.g., proliferative diseases (e.g., cancer), inflammatory diseases, Alzheimer's disease), as well as methods of treating these diseases.

公开(公告)号：US10435466B2

公开(公告)日：2019-10-08

申请号：US15521514

申请日：2015-10-27

Applicant: Agency for Science, Technology and Research

Inventor： Cheng-i Wang ,  Hsueh Ling Janice Oh ,  Siok Ping Yeo ,  Yun Pei Sharon Goh

IPC: C07K16/28 ,  A61K39/395

Abstract: Anti-TIM-3 antibodies are disclosed, as well as pharmaceutical compositions comprising such antibodies, and uses and methods using the same, such as in the treatment of cancer or infectious disease or T-cell dysfunctional disorders. Bispecific antibodies against TIM-3 and other targets are also disclosed, with a preferred embodiment of a bispecific antibody against TIM-3 and CD3.